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| Number | Title | Issue Date |
| 8445447 | B7-DC variants immunogenic compositions and methods of use thereof Compositions and methods for costimulating T cells (i.e., increasing antigen-specific proliferation of T cells, enhancing cytokine production by T cells, stimulating differentiation ad effector functions of T cells and/or promoting T cell survival) are provided. Sui... | 05/21/2013 |
| 8445222 | Predicting heart failure following myocardial infarction by protease and protease inhibitor profiling Disclosed herein are methods of detecting or predicting diastolic heart failure in a subject, comprising identifying a profile of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) from a body fluid of the subject that is ass... | 05/21/2013 |
| 8445006 | Biomolecular coating for implants Methods and compositions are provided for improving tissue growth and device integration in vivo. Substrates and devices coated with an α2β1 or α5β1 integrin-specific ligand are provided. The substrates and devices coa... | 05/21/2013 |
| 8444682 | Shape memory locking device for orthopedic implants A mechanism to connect the supporting portions of orthopaedic implants such as in the head, spine, upper limb and lower limb and thereby prevent loosening and fretting at the implant interface of an orthopaedic implant construct has been developed based on shape mem... | 05/21/2013 |
| 8440810 | Riboswitches, methods for their use, and compositions for use with riboswitches It has been discovered that certain natural mRNAs serve as metabolite-sensitive genetic switches wherein the RNA directly binds a small organic molecule. This binding process changes the conformation of the mRNA, which causes a change in gene expression by a variety... | 05/14/2013 |
| 8440610 | Mapkap kinase-2 as a specific target for blocking proliferation of P53-defective cells The present invention relates to compounds and pharmaceutical compositions for treating cellular proliferative disorders, e.g., in patients having one or more p53-deficient cells, screening assays for identifying such compounds, and methods for treating such disorde... | 05/14/2013 |
| 8440154 | Processes and uses of dissociating molecules A process has been developed to selectively dissociate target molecules into component products compositionally distinct from the target molecule, wherein the bonds of the target molecule do not reform because the components are no longer reactive with each other. D... | 05/14/2013 |
| 8435947 | Endothelial nitric oxide synthase antagonists and uses thereof for inhibiting oxygen toxicity Compositions and methods for inhibiting the interaction between eNOS and β-actin are provided for use in inhibiting or reducing lung injury from oxygen toxicity. One embodiment provides a synthetic or recombinant polypeptide having the β-actin binding domain of eN... | 05/07/2013 |
| 8431392 | Shortened Alk1 regulatory fragment Regulatory elements for controlling expression of transgenes in angiogenic tissue are provided. One embodiment provides an isolated nucleic acid having at least 80%, 85%, 90%, 95%, 97%, 99% or 100% sequence identity to SEQ ID NO:1, or a fragment thereof that causes ... | 04/30/2013 |
| 8425492 | In vivo device, system and usage thereof An in vivo device (1) for an at least temporary placement in a human or animal body (17), comprising an actuator (2) adapted to be actively triggered from the exterior in order to induce a local impact on the adjacent body area for in vivo treat... | 04/23/2013 |
| 8420600 | Injectable capsaicin The present invention is directed to compositions and methods for relieving pain at a site in a human or animal by administering at a discrete site in a human or animal a dose of capsaicin in an amount effective to denervate the discrete site without eliciting an ef... | 04/16/2013 |
| 8399402 | Polypeptide as standard for proteome analysis The present invention provides a polypeptide as standard for peptide analysis by mass spectrometry comprising at least 16 peptides selected from the group consisting of the peptides of SEQ ID NO: 1 to SEQ ID NO: 22 or variants thereof, together with an artificial pr... | 03/19/2013 |
| 8394410 | Soft polylactides Biodegradable polymeric compositions that are liquids or pastes at temperatures below 37° C. are described. Immersion of the compositions in aqueous medium, such as body fluids, increases the viscosity of the composition resulting in the formation of a semisolid ma... | 03/12/2013 |
| 8386027 | Skin permeation device for analyte sensing or transdermal drug delivery Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device c... | 02/26/2013 |
| 8367733 | Infiltration of capsaicin into surgical sites and open wounds The present invention is directed to methods for attenuating pain associated with a surgical site or an open wound by administration of single doses of a capsaicinoid formulation in proximity to a surgical site or wound opening. ... | 02/05/2013 |
| 8367621 | Methods and compositions related to internalizing RGD peptides Disclosed are compositions and methods useful for targeting tissue undergoing angiogenesis or to cells or tissue expressing αv integrins. The compositions and methods are based on peptide sequences that selectively bind to and home to tissue undergoing angiogenesis... | 02/05/2013 |
| 8367113 | Polymers for functional particles The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of... | 02/05/2013 |
| 8354384 | Anti-aging micrornas Methods and compositions for modulating aging genes or their targets for the treatment or prevention of senescence or symptoms thereof have been developed based on the discovery of naturally occurring inhibitory nucleic acids, in particular lin-4 miRNA, that downreg... | 01/15/2013 |
| 8350076 | Sodium channel blockers The present invention is directed to novel phenyloin derivative compounds and the use of such compounds as sodium channel blockers. Such compositions have utility as anti-cancer agents and can be used to limit or prevent PCa growth and/or metastasis. ... | 01/08/2013 |
| 8343498 | Adjuvant incorporation in immunonanotherapeutics The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that c... | 01/01/2013 |
| 8343497 | Targeting of antigen presenting cells with immunonanotherapeutics The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that c... | 01/01/2013 |
| 8334336 | Fluid activatable adhesives and fluids for activating same for use with liner-free labels Fluid activatable adhesive compositions and activating fluid(s) for activating the adhesive composition are described herein. The adhesive compositions contain at least two polymers with different hydrophilicities. The hydrophilic polymer has quick tack when exposed... | 12/18/2012 |
| 8334335 | Fluid activatable adhesives and fluids for activating same for use with liner-free labels Fluid activatable adhesive compositions and activating fluid(s) for activating the adhesive composition are described herein. The adhesive compositions contain at least two polymers with different hydrophilicities. The hydrophilic polymer has quick tack when exposed... | 12/18/2012 |
| 8333989 | Hydrophilic vehicle-based dual controlled release matrix system A hydrophilic vehicle-based dual controlled-release matrix system, suitable for encapsulation in hard or soft capsules, has been developed. The matrix is in the form of a solution or a suspension, which allows for easier formulation of low dose compounds. The matrix... | 12/18/2012 |
| 8324158 | Methods for inhibiting CLC-2 channel with GATX2 Compositions and methods of using scorpion venom peptide that is a ligand for ClC channels are provided. One aspect provides a pharmaceutical composition containing an amount of GaTx2 effective to inhibit ClC activity. Methods of treating a disorder or symptom of a ... | 12/04/2012 |
| 8323698 | Polymers for functional particles The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of... | 12/04/2012 |
| 8318674 | Local treatment of bone defects A method of local treatment of specific bone defects such as osteoporosis or bone cysts comprises the step of local administration of a formulation comprising a fusion peptide containing a first domain comprising PTH or BMP 2 or BMP 7, and a second domain comprising... | 11/27/2012 |
| 8318479 | Perfused three-dimensional cell/tissue disease models A system has been constructed that recapitulate the features of a capillary bed through normal human tissue. The system facilitates perfusion of three-dimensional (3D) cell monocultures and heterotypic cell co-cultures at the length scale of the capillary bed. A maj... | 11/27/2012 |
| 8313901 | Methods and compositions related to the modulation of riboswitches Disclosed herein are methods and compositions related to the detection of conformational changes and interactions with trigger molecules in riboswitches. ... | 11/20/2012 |
| 8309534 | Compositions comprising a GPR109 ligand for treating disorders of the digestive tract and/or cancer Pharmaceutical compositions containing an effective amount of a ligand for GPR109 to decrease intracellular cAMP levels of a subject in combination with an effective amount of a DNA methyl transferase inhibito to reduce or inhibit downregulation of GPR109 in the int... | 11/13/2012 |
| 8309518 | Drug delivery matrices to enhance wound healing Bioactive molecules are entrapped within a matrix for the controlled delivery of these compounds for therapeutic healing applications. The matrix may be formed of natural or synthetic compounds. The primary method of entrapment of the bioactive molecule is through p... | 11/13/2012 |
| 8309356 | Pseudocomplementary oligonucleotides for targeted gene therapy Compositions and methods for targeted gene therapy are disclosed. Compositions containing double duplex-forming pseudocomplementary oligonucleotides are administered in combination with a donor oligonucleotide that is homologous to a target sequence on a double-stra... | 11/13/2012 |
| 8309107 | Stable solutions of orlistat for pharmaceutical dosage forms Liquid orlistat-containing fill materials suitable for encapsulating in hard or soft capsules are described herein. The fill material contains orlistat dissolved in one or more medium chain triglycerides or medium chain partial triglycerides, one or more citrate est... | 11/13/2012 |
| 8299279 | Semi-synthetic process for the preparation of taxane derivatives This invention relates to an improved semi-synthetic process for the preparation of taxane derivatives like paclitaxel, docetaxel, canadensol and its derivatives, the process, which has shorten reaction route, simple procedure, high yield and low materials cost, the... | 10/30/2012 |
| 8293971 | Multi-gene expression constructs containing modified inteins Methods and constructs for the introduction of multiple genes into plants using a single transformation event are described. Constructs contain a single 5′ promoter operably linked to DNA encoding a modified intein splicing unit. The splicing unit is expressed as ... | 10/23/2012 |
| 8293964 | Multilayer laminate wound dressing A flexible, multilayer wound dressing with antibacterial and antifungal properties, together with methods for making the dressing. The dressing includes a layer of silver-containing fabric, a layer of absorbent material, and (optionally) a layer of flexible air-perm... | 10/23/2012 |
| 8293270 | Lipophilic vehicle-based dual controlled release matrix system A lipophilic vehicle-based dual controlled-release matrix, suitable for encapsulation in hard or soft capsules, has been developed. The matrix is in the form of a suspension, which allows for easier formulation of low dose compounds and/or compounds which are moistu... | 10/23/2012 |
| 8287923 | Compositions and methods for treating immune disorders Green tea polyphenol compositions and methods of their use are provided. Certain aspects provide methods for modulating expression of one or more autoantigens using the disclosed green tea polyphenol compositions. Representative green tea polyphenols include, but ar... | 10/16/2012 |
| 8287909 | Medical devices containing melt-blown non-wovens of poly-4-hydroxybutyrate and copolymers thereof Continuous processing methods for making absorbable polymeric non-wovens with one or more of the following properties: high burst strength, fine fibers of average diameter from 1 μm to 50 μm, and thickness from 10 μm to 50 mm, have been developed. Improved fiber ... | 10/16/2012 |
| 8287483 | Method and apparatus for enhancement of transdermal transport According to the present invention, a method for enhancing transdermal transport is disclosed. The method includes the steps of increasing a permeability of an area of a membrane with a permeabilizing device. The membrane may be, inter alia, biologic skin or synthet... | 10/16/2012 |
