Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 8178104 | Methods and compositions for targeting gC1qR/p32 Disclosed are compositions and methods useful for targeting gC1q/p32 receptors. The disclosed targeting is useful for delivering therapeutic and detectable agents to cancerous cells, and to areas of inflammation. ... | 05/15/2012 |
| 8158682 | Instillation administration of capsaicinoids for the treatment of pain This present invention relates to methods for treating or attenuating pain in a patient. Specifically, the invention provides a method for attenuating pain in proximity to the site of an open wound or surgical incision comprising instilling a pharmaceutical composit... | 04/17/2012 |
| 8153595 | B7-DC variants immunogenic compositions and methods of use thereof Compositions and methods for costimulating T cells (i.e., increasing antigen-specific proliferation of T cells, enhancing cytokine production by T cells, stimulating differentiation ad effector functions of T cells and/or promoting T cell survival) are provided. Sui... | 04/10/2012 |
| 8143368 | Disposable medical supplies from hydrolytically biodegradable plastics Hydrolytically degradable polymers in the form of biodegradable disposable medical devices for use in medicine and laboratories such as syringes, test tubes, catheters, tubing, trays, medical fabrics, and gloves are described. The devices are formed in whole or in p... | 03/27/2012 |
| 8143042 | Biodegradable elastomers The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-link... | 03/27/2012 |
| 8133733 | Nonviral vectors for delivering polynucleotides to target tissues Methods and compositions for delivering polynucleotides are provided. One embodiment provides a non-viral vector comprising a recombinant polynucleotide-binding protein comprising a protein transduction domain operably linked to a targeting signal. ... | 03/13/2012 |
| 8129425 | Small organic molecule regulators of cell proliferation The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodim... | 03/06/2012 |
| 8124794 | Method for the asymmetric synthesis of beta-lactone compounds The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inh... | 02/28/2012 |
| 8119694 | High concentration local anesthetic formulations A transdermal topical anesthetic formulation, which can be used to ameliorate or inhibit pain, has been developed. In the preferred embodiment, the topical anesthetic is a local anesthetic such as lidocaine, most preferably lidocaine free-base in a gel, and the dosa... | 02/21/2012 |
| 8119693 | Tissue non-specific alkaline phosphatase inhibitors and uses thereof for treating vascular calcification Disclosed herein are compounds that are tissue-nonspecific alkaline phosphatase inhibitors. The disclosed compounds are used to treat, prevent, or abate vascular calcification, arterial calcification and other cardiovascular diseases. ... | 02/21/2012 |
| 8119404 | Inhibitor of apoptosis proteins and nucleic acids and methods for making and using them The invention provides polypeptides comprising inhibitor of apoptosis protein (IAP) family members, such as BmIAP initially derived from Bombyx mori BmN cells, and nucleic acids encoding them, and methods for making and using these compositions, including the... | 02/21/2012 |
| 8119354 | Cell-free assay product and method of use thereof for measuring activity of frizzled receptors The present invention relates to cell free assays for measuring receptor activity, especially for measuring a constitutive or a non-constitutive activity of frizzled re-ceptors and uses thereof. The present invention further concerns a method for measuring a constit... | 02/21/2012 |
| 8118791 | Medical device A medical device for example a wound dressing having antibacterial and optionally, antifungal properties, are provided together with methods for making the device. An exemplary dressing includes a layer of silver-containing fabric, (optionally) a layer of absorbent ... | 02/21/2012 |
| 8114643 | Polyhydroxyalkanoate production from polyols Organisms are provided which express enzymes such as glycerol dehydratase, diol dehydratase, acyl-CoA transferase, acyl-CoA synthetase β-ketothiolase, acetoacetyl-CoA reductase, PHA synthase, glycerol-3-phosphate dehydrogenase and glycerol-3-phosphatase, which are ... | 02/14/2012 |
| 8114431 | Biomolecular coating for implants Methods and compositions are provided for improving tissue growth and device integration in vivo. Substrates and devices coated with an α2β1 or α5β1 integrin-specific ligand are provided. The substrates and devices coa... | 02/14/2012 |
| 8110217 | Sphingomyelin liposomes for the treatment of hyperactive bladder disorders The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to prevent, manage, ameliorate and/or treat disorders involving neuropathic pai... | 02/07/2012 |
| 8097588 | Trophinin-binding peptides and uses thereof Disclosed herein are compositions and methods useful for promoting sperm motility, promoting embryonic stem cell formation, promoting trophoblast formation, or promoting neuronal growth. The compositions and methods are based on peptide sequences that bind trophinin... | 01/17/2012 |
| 8093444 | Multilayer conductive appliance having wound healing and analgesic properties A dressing for promoting healing and pain relief of the body of a living organism having a pathologic condition has at least one layer of conductive material having a resistance no greater than 1000 Ω/cm2. When placed proximate a portion of the body of t... | 01/10/2012 |
| 8093261 | Rapid release mini-tablets provide analgesia in laboratory animals Pellets containing an analgesic uniformly dispersed in a lipid carrier such as cholesterol mixed with fatty acid esters, can be used to provide long term pain relief. 5 mg cholesterol-tryglyceride-buprenorphine pellets released the majority of drug in 24-48 hours af... | 01/10/2012 |
| 8093022 | Polyhydroxyalkanoate biopolymer compositions Several novel PHA polymer compositions produced using biological systems include monomers such as 3-hydroxybutyrate, 3-hydroxypropionate, 2-hydroxybutyrate, 3-hydroxyvalerate, 4-hydroxybutyrate, 4-hydroxyvalerate and 5-hydroxyvalerate. These PHA compositions can rea... | 01/10/2012 |
| 8084602 | Porphyrin derivatives and their use in photodynamic therapy A compound of formula I: wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4 and Z have meanings given in the description, and metallated forms of s... | 12/27/2011 |
| 8084420 | Rapid acting and long acting insulin combination formulations An injectable formulation containing a rapid acting insulin and a long acting insulin has been developed. The pH of the rapid acting insulin is adjusted so that the long acting insulin, remains soluble when they are mixed together. Preferably, the formulation is adm... | 12/27/2011 |
| 8076484 | Modified green tea polyphenol formulations Modified green tea polyphenols and methods of their use are provided. One aspect provides compounds and compositions containing green tea polyphenols with one on more ester-linked fatty acids. ... | 12/13/2011 |
| 8071355 | Polyhydroxyalkanoate production by coenzyme A-dependent aldehyde dehydrogenase pathways Organisms are provided containing genes encoding one or more enzymes, Coenzyme-A-dependent aldehyde dehydrogenase, acyl-CoA transferase, acyl-CoA synthetase, β-ketothiolase, acetoacetyl-CoA reductase and/or PHA synthase. In some cases one or more of these genes are... | 12/06/2011 |
| 8067572 | Hybrid interfering RNA The invention relates to a hybrid interfering RNA molecule comprising a duplex RNA and a single stranded DNA molecule and its use in the ablation of mRNA and in polymerase chain reactions. ... | 11/29/2011 |
| 8063268 | Transposable elements in rice and methods of use Disclosed are isolated transposable elements, or isolated DNA sequences which encode a transposase protein or a portion of a transposase protein. The isolated transposable elements or the isolated DNA sequences are members of the mPing/Pong family of transposable el... | 11/22/2011 |
| 8062891 | Nonviral vectors for delivering polynucleotides to plants Methods and compositions for delivering polynucleotides are provided. One embodiment provides a non-viral vector comprising a recombinant polynucleotide-binding protein comprising a protein transduction domain operably linked to a targeting signal. Methods for modif... | 11/22/2011 |
| D649033 | Container | 11/22/2011 |
| 8053558 | Dendritic cell co-stimulatory molecules A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transfo... | 11/08/2011 |
| 8053553 | Targeting host proteinases as a therapeutic strategy against viral and bacterial pathogens Disclosed are compositions and methods for preventing or reducing harm resulting from pathogen infection. For example, disclosed are peptides that inhibit the processing of toxins normally cleaved by proprotein convertase enzymes. ... | 11/08/2011 |
| 8053414 | Methods of using B7-DC molecules to induce or enhance an immune response A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transfo... | 11/08/2011 |
| 8049065 | Transgenic systems for the manufacture of poly(2-hydroxy-butyrate-co-3-hydroxyhexanoate) Methods for engineering transgenic organisms that synthesize polyhydroxyalkanoates (PHAs) containing 3-hydroxyhexanoate as comonomer have been developed. These processes are based on genetically engineered bacteria such as Escherichia coli or in plant crops a... | 11/01/2011 |
| 8048268 | Method of controlling organic contaminants in pulp and paper making processes Method for controlling the deposition of organic contaminants from the pulp and papermaking systems using water soluble aminoplast ether copolymers is described herein. The aminoplast ether copolymer can be used alone or in combination with one or more additives. Th... | 11/01/2011 |
| 8048262 | Rapid fatty acid assay for use in pulp pitch control Methods are provided for determining the surface fatty acid content in a wood pulp or whitewater sample. The methods comprise reacting free fatty acids which are present on the surface of the wood pulp fibers in the sample or in the whitewater with one or more reage... | 11/01/2011 |
| 8039587 | Methods and compositions for delivering polynucleotides Methods and compositions for delivering polynucleotides are provided. One embodiment provides a non-viral vector comprising a recombinant polynucleotide-binding protein comprising a protein transduction domain operably linked to a targeting signal. Methods for modif... | 10/18/2011 |
| 8039237 | Bioabsorbable polymer containing 2-hydroxyacid monomers Genetically engineered organisms for production of PHA copolymers containing 2-hydroxyacid monomers and the methods of making and using thereof have been developed. The copolymers containing 2-hydroxyacid monomers can be synthesized via biosynthesis by the action of... | 10/18/2011 |
| 8034618 | PTH containing cell growth matrix Proteins are incorporated into protein or polysaccharide matrices for use in tissue repair, regeneration and/or remodeling and/or drug delivery. The proteins can be incorporated so that they are released by degradation of the matrix, by enzymatic action and/or diffu... | 10/11/2011 |
| 8034330 | Modified organs and cells for xenotransplantation It has been discovered that there are at least two significant antigens present on the cells of animal species such as pigs that elicit an immune or inflammatory response immediately upon implantation into humans or contact with human serum. The first is an α-galac... | 10/11/2011 |
| 8034270 | Polyhydroxyalkanoate medical textiles and fibers Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate. These devices provide a wider range of in vivo st... | 10/11/2011 |
| 8026266 | Treatment of length dependent neuropathy Compositions, and methods of use thereof, are provided for the treatment of painful neuropathy by local or topical delivery of compounds that interact with α-adrenergic receptors, especially an alpha2 adrenergic agonist such as clonidine, to the entire p... | 09/27/2011 |
