Did You Know...
...that Robert Adler has the dubious distinction of being the Father of the Couch Potato? Back in 1955 Adler was employed by what was then Zenith Radio Corp., where he was charged to invent something that would allow viewers to turn down the TV volume without leaving their chairs. After a series of flops (such as a wired contraption that people tripped over), Adler hit on the idea of using sound waves. Thus the Remote Control was born...
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| Number | Title | Issue Date |
| 8172967 | Mouldable plastic explosives and inert simulants for mouldable plastic explosives A solvent-free process is used to make moldable plastic explosives or moldable plastic explosive simulant products. ... | 05/08/2012 |
| 8143418 | Dimeric small molecule potentiators of apoptosis Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an ef... | 03/27/2012 |
| 8110404 | Luminescent lanthanide binding chelates Lanthanide chelates derived from diazacrown ethers having two ethyliminodiacetic acid side chains have increased ability to bind lanthanide ions. ... | 02/07/2012 |
| 8026093 | Particulate substrates for improved recovery of microbes Specially modified microbial growth surfaces improve bacterial recovery or counts when testing for the presence or absence of microbial cells or performing microbial enumerations. ... | 09/27/2011 |
| RE42748 | Oral DTPA for radionuclide chelation A composition for oral radionuclide chelation therapy comprises a DTPA chelate selected from Zn-DTPA and Ca-DTPA and a permeation enhancer that preferentially increases jejunal uptake of the DTPA chelate. The composition has a DTPA chelate bioavailability of at leas... | 09/27/2011 |
| 8014953 | RNA surveillance among curated proteins Computational methods for systematically characterizing putative protein isoforms as apparent targets of nonsense-mediated decay (NMD) comprise: (a) identifying a dataset of target putative protein isoform sequences for characterization; (b) identifying from an mRNA... | 09/06/2011 |
| 8013015 | Small molecule inhibitors of ghrelin O-acyltransferase Ghrelin O-acyltransferase (GOAT) is inhibited with designed small molecules. Methods comprise contacting the GOAT with an inhibitor and detecting a resultant inhibition. ... | 09/06/2011 |
| 7989502 | Intranasal delivery of modafinil Modafinil is selectively delivered to the brain, minimizing delivery to the blood, of a person in need thereof by administering to the person a therapeutically-effective dosage of modafinil, wherein the dosage is less than 1 mg, formulated in a lipid microemulsion (... | 08/02/2011 |
| 7989482 | Indoline anti-cancer agents Indoline compounds having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders are provided. ... | 08/02/2011 |
| 7982051 | Methods for preparing diazonamides This invention relates to novel macrocyclic lactams intermediates useful for the preparation of diazonamide analogs. This invention also relates to a novel electrochemical oxidative cyclization for the preparation of such macrocyclic lactams, and their further eluci... | 07/19/2011 |
| 7964587 | Tocopherol and tocotrienol aerosols Anti-inflammatory compositions include medicaments comprising predetermined amounts of a phytyl substituted chromanol and a prostaglandin E2 inhibitor, wherein: said medicament is in unit dosage form suitable for pharmaceutical administration; said phytyl... | 06/21/2011 |
| 7960420 | Diazonamide analogs with improved solubility Diazonamide A analogs, and the salts, esters and conjugates thereof, having improved aqueous solubility are provided. Also provided are pharmaceutical compositions, and methods for preparing and using such compounds and compositions for the treatment of proliferativ... | 06/14/2011 |
| 7914767 | Oral DTPA for radionuclide chelation A composition for oral radionuclide chelation therapy comprises a DTPA chelate selected from Zn-DTPA and Ca-DTPA and a permeation enhancer that preferentially increases jejunal uptake of the DTPA chelate. The composition has a DTPA chelate bioavailability of at leas... | 03/29/2011 |
| 7906499 | Polycarboxylated porphyrins and use thereof in treatment of metal toxicities Metal binding polycarboxylated porphyrins, their precursors, or cofactors in the porphyrin biosynthetic pathway, are administered to individuals determined to be subject to or predisposed to a polycarboxylated porphyrin-binding metal toxicity to increase the level o... | 03/15/2011 |
| 7906343 | Surface-enhanced lanthanide chelates A lanthanide chelate is linked to a noble metal substrate at a proximity wherein the substrate enhances a fluorescent emission of the lanthanide by at least 20-fold when the chelate is illuminated at an excitation wavelength that induces a transition in the lanthani... | 03/15/2011 |
| 7884211 | Dimeric small molecule potentiators of apoptosis Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an ef... | 02/08/2011 |
| 7883851 | Common allele on chromosome 9 associated with coronary heart disease Disclosed are methods and compositions for determining whether a person carries an allele associated with increased risk for coronary atherosclerosis by determining whether the person has had RA-CHR9 allele, such as by determining whether the person has an RA-CHR9 a... | 02/08/2011 |
| 7879590 | Method to engineer MAPK signaling responses using synthetic scaffold interactions and scaffold-mediated feedback loops Synthetic scaffold interactions and scaffold-mediated feedback loops are used to engineer MAPK signaling responses in cells. ... | 02/01/2011 |
| 7863295 | Treatments for neuropathy Small fiber neuropathy is treated by topically administering to a subject in need thereof topically active quinoline compounds or pharmaceutically acceptable salts thereof under conditions effective to treat neuropathy in the subject. Glial cell-derived neurotrophic... | 01/04/2011 |
| 7854811 | Mouldable plastic explosives and inert simulants for mouldable plastic explosives A solvent-free process is used to make mouldable plastic explosives or mouldable plastic explosive simulant products. ... | 12/21/2010 |
| 7851620 | Methods for preparing diazonamides This invention relates to novel macrocyclic lactams intermediates useful for the preparation of diazonamide analogs. This invention also relates to a novel electrochemical oxidative cyclization for the preparation of such macrocyclic lactams, and their further eluci... | 12/14/2010 |
| 7829278 | Polynucleotide barcoding A polynucleotide is barcoded using a method whereby an isolated, individual polynucleotide is immobilized on a solid phase and stretched, targets are labeled using target-specific hybridization probes, and an individual label of an unamplified probe at each of the l... | 11/09/2010 |
| 7824847 | Tissue preservation method with polyoxyethylene/polyoxypropylene copolymer Tissue preservation media comprising a polyoxyethylene/polyoxypropylene copolymer are used to preserve tissues and organs for storage and transplantation. In particular embodiments, the polyoxyethylene/polyoxypropylene copolymer is Pluronic F68 or FLOCOR (CRL-5861; ... | 11/02/2010 |
| 7816538 | Dimeric small molecule potentiators of apoptosis Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an ef... | 10/19/2010 |
| 7807699 | Dimeric pyrrolidine amide-containing small molecule apoptosis promoters The invention provides small molecule mimics of the Smac peptide that are dimer- or dimer-like compounds having two amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions co... | 10/05/2010 |
| 7776816 | Preserving hypoxic tissue Hypoxic tissue is preserved by prophylactically administering Stromal Derived Factor 1 Alpha (SDF-1α) before hypoxia induces cell death in the tissue. ... | 08/17/2010 |
| 7771944 | Methods for determining genetic haplotypes and DNA mapping Improved methods of genetic haplotyping and DNA sequencing and mapping, including methods for making amplified ssDNA, methods for allele determination, and a DNA barcoding strategy based on direct imaging of individual DNA molecules and localization of multiple sequ... | 08/10/2010 |
| 7745151 | Methods of determining binding between Nogo receptor and p75 neurotrophin receptor Inhibitors of Nogo Receptor (NgR)-p75 binding are used to reduce NgR-p75 binding mediated axon growth inhibition. Mixtures of NgR and p75 are used in pharmaceutical screens to characterize agents as inhibiting binding of NgR to p75 and promoting axon regeneration. | 06/29/2010 |
| 7744914 | Vascular implant device Vascular smooth muscle cells (VSMCs) adhere to and orient along micropatterned grooves having a depth of 1 to 10 μm and a width of 1 to 20 μm that are imposed on the surface of a vascular implant device. The VSMCs maintain an elongated morphology and reduced proli... | 06/29/2010 |
| 7741021 | Protein O-sulfonation Post-translational O-sulfonation of a serine or threonine residue of proteins is detected, optionally comparatively, wherein the detected O-sulfonation is detected under a first physiological condition, and is compared with a control O-sulfonation detected under a s... | 06/22/2010 |
| 7737293 | Amide forming chemical ligation An amide is formed by reacting an α-ketoacid or salt thereof in a decarboxylative condensation reaction with an amine or salt thereof comprising a nitrogen covalently bound to an atom selected from oxygen, nitrogen, and sulfur. The amide bond is formed between the ... | 06/15/2010 |
| 7718630 | MicroRNA1 therapies Delta protein expression in a cell is reduced by introducing miR-1 into the cell, and detecting a resultant reduction of Delta protein expression in the cell. ... | 05/18/2010 |
| 7691590 | Reducing myelin-mediated inhibition of axon regeneration Oligodendrocyte-myelin glycoprotein (OMgp)-specific binding agents are used to reduce OMgp-mediated axon growth inhibition. Mixtures of axons and OMgp and mixtures of Nogo receptor (NgR) and OMgp are used in pharmaceutical screens to characterize agents as inhibitin... | 04/06/2010 |
| 7667076 | Amide forming chemical ligation An amide is formed by reacting an α-ketoacid or salt thereof in a decarboxylative condensation reaction with an amine or salt thereof comprising a nitrogen covalently bound to an atom selected from oxygen, nitrogen, and sulfur. The amide bond is formed between the ... | 02/23/2010 |
| 7645732 | Treating hepatitis C virus infection Methods and compositions are provided to inhibit release of HCV from an HCV-infected cell by contacting the cell with a VLDL assembly inhibitor, and detecting a resultant inhibition of HVC release from the cell. The methods can be used to decrease serum viremia of a... | 01/12/2010 |
| 7645569 | NMR detection of foreign PAS domain ligands Specific binding of a foreign core ligand to a PAS domain, wherein the PAS domain is predetermined, prefolded in its native state, and comprises a hydrophobic core that has no NMR-apparent a priori formed ligand cavity, is determined using NMR spectra of the PAS dom... | 01/12/2010 |
| 7638544 | Dimeric small molecule potentiators of apoptosis Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an ef... | 12/29/2009 |
| 7629121 | Notch1 variants associated with cardiovascular disease Human individuals at increased risk for vascular pathology are identified by determining whether the individuals' genome comprises a Notch1 allele predetermined to be associated with an increased risk for vascular pathology. Notch1 alleles are identified as being as... | 12/08/2009 |
| 7625709 | Reducing NgR-p75 mediated inhibition of axon regeneration Inhibitors of Nogo Receptor (NgR)-p75 binding are used to reduce NgR-p75 binding mediated axon growth inhibition. Mixtures of NgR and p75 are used in pharmaceutical screens to characterize agents as inhibiting binding of NgR to p75 and promoting axon regeneration. | 12/01/2009 |
| 7622289 | Ornithine aminotransferase (OAT): a target for anticancer drugs Ornithine δ-aminotransferase (OAT) facilitates microtubule assembly in addition to its aminotransferase activity in mitochondria. An N-terminal proteolysis of the first 17 amino acids of OAT block its transport to the mitochondria. The resultant truncated protein (... | 11/24/2009 |
