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...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 8168665 | Substituted 2-phenyl-benzimidazoles and their use as pharmaceuticals The present invention relates to derivatives of 2-phenyl-benzimidazoles of the formula I, in which X, R, R1 to R3 and n have the meanings indicated in the claims, which modulate the transcription of endothelial nitric oxide... | 05/01/2012 |
| 8153637 | Phenyl-alkyl piperazines having TNF-modulating activity, preparation method, and therapeutic use thereof The present invention relates to phenyl-alkyl piperazines of formula (I): in which A, R1, R2 and R3 are as defined herein, having TNF-modulating activity. The invention also relates to the preparation thereof, pharmaceutica... | 04/10/2012 |
| 8076336 | Triazolopyridazines as PAR1 inhibitors, production thereof, and use as medicaments The invention relates to novel compounds of formula I where R1, R2, R3, R4, R5, R6, R7, R8, Q1, Q2 and Q3 are each as defined below. The compounds of formula I have antithrombotic activity and inhibit especially protease-ac... | 12/13/2011 |
| 8044074 | Substituted heterocycles, their use as medicament, and pharmaceutical preparations comprising them The invention relates to compounds of formula I in which R1, R2, R3, R4, R5, R6 and X have the meanings stated in the claims. The compounds are particularly suitable as antiarrhythmic active ingredients, in particular for t... | 10/25/2011 |
| 8034828 | Use of FGF inhibiting substituted 1,2,3 indolizine derivatives in the preparation of medicaments which can be used to treat diseases linked to pathological choroidal angiogenesis The present invention thus relates to the use of 1,2,3-substituted indolizine derivatives in the preparation of medicaments of use in the treatment of diseases related to pathological choroidal angiogenesis, which derivatives correspond to the following general form... | 10/11/2011 |
| 7923438 | Use of cyclipostin derivatives for the treatment of mycobacterial infectious diseases The invention relates to the use of a compound of the formula (I) for the treatment of bacterial infections caused by mycobacteria, nocardia or corynebacteria, wherein E is phosphorus; X1, X2 and X | 04/12/2011 |
| 7910606 | Pyrazole-derivatives as factor Xa inhibitors The present invention is directed to a compound of formula I, in which R0; R1; R2; R3; R4; Q; V, G and M have the meanings indicated below. The compound of formula I is... | 03/22/2011 |
| 7910584 | 3-spiroindolin-2-one derivatives, preparation and therapeutic use thereof The subject of the present invention is a compound of formula (I): in the base, hydrate or solvate state, in the form of cis/trans isomers or of mixtures thereof, preparation and therapeutic use thereof. ... | 03/22/2011 |
| 7910576 | Pyrrole derivatives as P2Y12 antagonists The present invention relates to compounds of the formula I, in which R1; R2; R3; R4; R5; R6; R7; R8; R9; R10; R11; R12; R13; A; B, D and E have the meanings indicated in the claims. The compounds of the formula I are valua... | 03/22/2011 |
| 7875646 | Derivatives of N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl] sulfonamide, their preparation and their application in therapeutics The present invention relates to compounds corresponding to the formula (I): In which R1, R2, R3, R4 and R5 are as described herein. The invention also relates to the m... | 01/25/2011 |
| 7863269 | Imino-imidazo-pyridine derivatives having antithrombotic activity The invention relates to compounds of the formula I having antithrombotic activity, which in particular inhibit the protease-activated receptor 1 (PAR1), processes for their preparation and use thereof as medicaments. ... | 01/04/2011 |
| 7842711 | Indazolecarboxamide derivatives for the treatment and prevention of malaria The invention relates to methods of treating or preventing malaria which comprises administering to a patient in need thereof, an effective amount of a 1H-indazole-3-carboxamide derivative of general formula (I), in the form of a base or of an addition salt with an ... | 11/30/2010 |
| 7825264 | Substituted heterocycles, their use as medicament, and pharmaceutical preparations comprising them The invention relates to compounds of formula I in which A, R1, R2, R3, R4, R5, R6, R7 and n have the meanings stated in the claims. The compounds are particularly suitable as antiarrhythmic active ingredients, in particula... | 11/02/2010 |
| 7803811 | 1,2,3-substituted indolizine derivatives, inhibitors of FGFs, method for preparing them and pharmaceutical compositions containing them The present invention relates to novel 1,2,3-substituted indolizine derivative which are inhibitors of fibroblast growth factors, to methods or preparing such derivatives, to pharmaceutical compositions comprising such derivatives, and to methods of treatment compri... | 09/28/2010 |
| 7799799 | Indolizine derivatives, method for preparing same, and therapeutic compositions comprising same The present invention is directed to compounds of formula (I): described as novel indolizine derivatives and to a method for their preparation along with pharmaceutical compositions thereof whose substituents are as describ... | 09/21/2010 |
| 7795277 | 7-(2-(4-(3-trifuloromethyl-phenyl)-1,2,3,6-tetrahydropyrid-1-yl)ethyl)isoquinoline besylate salt, preparation and therapeutic use thereof The present invention relates to the besylate salt of 7-(2-(4-(3-(trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyrid-1-yl)ethyl)isoquinoline, to its preparation and to its use in therapeutics. The salt may be represented by the formula (II) below. | 09/14/2010 |
| 7741341 | Benzimidazole-derivatives as factor Xa inhibitors The present invention relates to compounds of the formula I, wherein R0, R1, R2, Q, V, G and M are as defined herein. The compounds of the formula I are valuable pharmacologically active com... | 06/22/2010 |
| 7713963 | Acylated indanyl amines and their use as pharmaceuticals The present invention relates to acylated indanyl amines according to the general formula (I) wherein R1—R4 have the meanings given in the description, A is CH2, CHOH or CH—(C1 | 05/11/2010 |
| 7709463 | Idraparinux (SanOrg34006) for treatment of venous events in patients with deep venous thrombosis The invention relates to a dose of 2.5 mg of the pentasaccharide methyl O-(2,3,4-tri-O-methyl-6-O-sulfo-α-D-glucopyranosyl)-(1→4)-O-(2,3-di-O-methyl-β-D-glucopyranosyl uronic acid)-(1→4)-O-(2,3,6-tri-O-sulfo-α-D-glucopyranosyl)-(1→4)-O-(2,3-di-O-methyl-α-L... | 05/04/2010 |
| 7642249 | Dihydrogen phosphate salt of a prostaglandin D2 receptor antagonist The present invention is directed to dihydrogen phosphate salt 2-(3-{6-[2-(2,4-dichloro-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenyl)-2-methyl-propionic acid of Formula (III), a pharmaceutical composition comprising... | 01/05/2010 |
| 7612075 | Substituted oxoazaheterocyclyl compounds This invention is directed to oxoazaheterocycyl compounds which inhibit Factor Xa, to oxoazaheterocycyl compounds which inhibit both Factor Xa and Factor IIa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these comp... | 11/03/2009 |
| 7601863 | Use of PPAR agonists for the treatment of congestive heart failure The invention describes the use of PPAR agonists of the formulae (I) or (II) for the treatment of congestive heart failure (CHF). ... | 10/13/2009 |
| 7576071 | Antithrombotic compound The present invention relates compounds of the formula A oligosaccharide-spacer-GpIIb/IIIa antagonist (A). The compounds of the invention have antithrombotic activity and can be used in treating or preventing thrombotic diseases. ... | 08/18/2009 |
| 7575930 | Method for analyzing oligosaccharides from blood plasma The present invention relates to a method for analyzing oligosaccharides constituting the heparins of low molecular weight and the heparins of very low molecular weight from blood plasma. ... | 08/18/2009 |
| 7553845 | Substituted indolizine 1,2,3,6,7,8 derivatives, FGFs inhibitors, a method for the preparation thereof and pharmaceutical compositions containing said derivatives The invention is directed to a compound of formula I, wherein R, R1, R2, R3 and R4 are as defined herein, or a pharmaceutically acceptable salt thereof, and its pharmaceutically c... | 06/30/2009 |
| 7517889 | 2,6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin D2 receptor antagonists The present invention is directed to a compound of Formula (I) wherein Cy1, Cy2, L1, L2, and R1 are as defined herein, a pharmaceutical composition comprising a pharmac... | 04/14/2009 |
| 7514582 | 2′-substituted 1,1′-biphenyl-2-carboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them Compounds of the formula I, in which R(1), R(2), R(3), R(4), R(5), R(6), R(7), R(8), R(30) and R(31) have the meanings indicated in the claims, are very particularly suitable as novel and antiarrythmic active compounds, in ... | 04/07/2009 |
| 7482342 | Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors Compound corresponding to general formula (I): in which, R1 represents a hydrogen or halogen atom, an NH2, NHR2, NHCOR2, NO2, CN, CH2NH2 and CH | 01/27/2009 |
| 7465806 | Pyrrole-derivatives as factor Xa inhibitors The present invention relates to compounds of the formulae I and Ia, wherein R0; R1; R3; R4; R22, Q; V, G and M have the meanings indicated in the claims. The compounds of the formulae I and Ia are val... | 12/16/2008 |
| 7399770 | Thieno-imino acid derivatives for use as matrix metalloproteinase inhibitors The invention is directed to a compound of the formula I wherein the variables are as defined herein, or a stereoisomeric form thereof, mixture of stereoisomeric forms, in any ratio, or a salt thereof. Ano... | 07/15/2008 |
| 7358268 | Imidazole derivatives as factor Xa inhibitors This invention is directed to the compound of formula (I) which is useful for inhibiting the activity of Factor Xa. The present invention is also directed to compositions containing said compounds, processes for their preparation, their use, such as in inhibiting th... | 04/15/2008 |
| 7332608 | Anthranilamides and methods of their use The present invention is related to a process for preparing anthranilamides of formula I, in which R(1) to R(7) have the meanings indicated herein, a process for their preparation, their use as medicaments, and p... | 02/19/2008 |
| 7329675 | Substituted azabicyclic compounds This invention is directed to physiologically active compounds of formula (I) wherein represents a bicyclic ring system, of about 10 to about 13 ring members... | 02/12/2008 |
| 7244845 | Process for preparing cyclic N-substituted alpha-imino carboxylic acids The present invention relates to the novel methods of making matrix metalloproteinase inhibitors of Formula (I): ... | 07/17/2007 |
| 7235665 | Process for the production of piperidine derivatives The present invention relates to processes for preparing certain piperidine derivatives, including fexofenadine (F), the active ingredient in the non-sedating antihistamine sold in the U.S. under the designation “Allegra®”. This invention also relates to novel ... | 06/26/2007 |
| 7235690 | Anthranilamides and methods of their use The present invention is related to anthranilamides of formula I, in which R(1) to R(7) have the meanings indicated herein, a process for their preparation, their use as medicaments, and pharmaceutical preparations con... | 06/26/2007 |
| 7205315 | Bicyclic imino acid derivatives as inhibitors of matrix metalloproteinases The present invention is directed to a compound of formula (I), or a stereoisomer or a mixture of stereoisomer thereof in any ratio, or its physiologically tolerable salt, which is useful as an inhibitor of matrix metalloproteinase. The present invention is also dir... | 04/17/2007 |
| 7179839 | Acylated indanyl amines and their use as pharmaceuticals The present invention relates to acylated indanyl amines according to the general formula (I) wherein R1–R4 have the meanings given in the description, A is CH | 02/20/2007 |
| 7166609 | Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases Pyrimidine-4,6-dicarboxylic acid diamides of the formula I are suitable for selectively inhibiting collagenase (MMP 13). The pyrimidine-4,6-dicarboxylic acid diamides can therefore be used for treating degenerati... | 01/23/2007 |
| 7166616 | Substituted alkanoic acids The invention is directed to physiologically active compounds of general formula (I): wherein: represents (i) a saturated 3 to 6 membered carbocycle, optiona... | 01/23/2007 |
