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| Number | Title | Issue Date |
| 6014213 | High dynamic range apparatus for separation and detection of polynucleotide fragments A high dynamic range apparatus for separation and detection of polynucleotide fragments has a housing adapted to receive an electrophoresis gel holder containing an electrophoresis gel loaded with fluorophore-labeled samples; one or more laser diodes for ... | 01/11/2000 |
| 6013436 | Compositions and methods for diagnosis of mutation in the von Hippel-Lindau tumor suppressor gene The instant invention relates to methods and products for the diagnosis of mutations in the von Hippel-Lindau tumor suppressor gene. More specifically, the products are DNA oligonucleotides for use in amplifying and sequencing genomic DNA and kits includi... | 01/11/2000 |
| 6007983 | Method and kit for evaluation of HIV mutations A streamlined, hierarchical method for obtaining information about the allelic type of a sample of genetic material derived from an HIV-infected sample relies on the observation that 93-95% of the known mutational variants of the reverse transcriptase and... | 12/28/1999 |
| 6005663 | Automated electrophoresis and fluorescence detection apparatus and method Improved detection methods and apparatus which may be used individually or in combinations enhance the ability of the electrophoresis apparatus to detect fluorophore-labeled materials in short periods of time. One such apparatus comprises a housing adapte... | 12/21/1999 |
| 6002067 | Transgenic mouse model for iduronidase deficiency and methods of making and using same A mouse which is homozygous for a disruption in the IDUA gene, but which has normal expression for the SAT-1 gene can be used for evaluating therapeutic agents for use in treating mucopolysaccharidosis Type I, by administering the therapeutic agent to the... | 12/14/1999 |
| 5995282 | Operation microscope In an operation microscope, when an observation velocity of an observation field of a main microscope body is set to a desired velocity and then an observation magnification of the observation field of the main microscope body is changed and the focal poi... | 11/30/1999 |
| 5989917 | Glucose monitor and test strip containers for use in same A test meter of the type which receives a disposable test strip and a sample of bodily fluid from a patient and performs an electrochemical analysis of the amount of an analyte such as glucose in the sample includes a receptacle for receiving a container ... | 11/23/1999 |
| 5984132 | Internally pressurized fluid container An internally pressurized fluid vessel, in particular for liquids and/or gases exerting pressure outwards from the container has a sandwich structure capable of withstanding the internal pressure. The vessel has an interior container, an outer jacket in w... | 11/16/1999 |
| 5981186 | Method and apparatus for DNA-sequencing using reduced number of sequencing mixtures The sequence of a target nucleic acid polymer can be determined by (a) performing a first chain-extension sequencing reaction on the target nucleic acid polymer in a reaction mixture containing first and second chain-terminators to produce a first product... | 11/09/1999 |
| 5977998 | Technique for communicating with electronic labels in an electronic price display system In a system for displaying prices in a retail store, an improved protocol is disclosed to permit improved communications between a host, or central computer and display devices. Such a protocol enables the host to effectively communicate messages to the d... | 11/02/1999 |
| 5964704 | Intraocular pressure measuring apparatus In the non-contact intraocular pressure measuring apparatus for measuring the intraocular pressure of the eye to be examined for a suitable measurement time, after alignment of the apparatus main body with the eye to be examined is performed, the time req... | 10/12/1999 |
| 5962711 | Hydrogenation of substrate and products manufactured according to the process A typical traditional reactor for hydrogenation consists of a tank filled with a liquid and a gas and a small particle catalyst. The reaction is carried out at high pressures and high temperatures. Lack of gas on the catalyst surface limits the velocity o... | 10/05/1999 |
| 5960447 | Word tagging and editing system for speech recognition A word tagging and editing system for speech recognition receives recognized speech text from a speech recognition engine, and creates tagging information that follows the speech text as it is received by a word processing program or other program. The bo... | 09/28/1999 |
| 5957454 | Jigsaw puzzles A jigsaw puzzle is made up from a plurality of pieces which can be assembled to form a picture. The pieces include a plurality of outer edge pieces which when assembled establish a perimeter of the puzzle and a plurality of interior pieces. The pieces are... | 09/28/1999 |
| 5929639 | Non-dipolar RF coil for NMR lock and homonuclear decoupling A single-tuned rf-gradient saddle coil is used for an internal NMR lock in a high-field NMR probe. The non-dipolar lock coil geometry is chosen such that its filling factor and Q are maximized subject to the constraint that its coupling coefficient to two... | 07/27/1999 |
| 5916747 | Method and apparatus for alignment of signals for use in DNA based-calling Data traces from four channels of an automated electrophoresis detection apparatus are aligned by identifying peaks in each of the four data traces; normalizing the heights of the peaks in each of the data traces to a common value to generate four normali... | 06/29/1999 |
| 5914721 | Visibility calculations for 3D computer graphics Disclosed is a method of reducing the complexity of hidden surface removal in 3D grapghic systems. A fuzzy projection (FF) of a surface (SU) as seen from a number of viewpoints (VP) in a bounding box (BB) is stored in a buffer (FA) having elements (FE). A... | 06/22/1999 |
| 5912127 | Method and kit for evaluating risk of ovarian cancer in carriers of a BRCA1 mutation The association between the presence of one or more rare (infrequent) alleles of the HRAS variable tandem repeat (VTR) polymorphism and the incidence of ovarian cancer in women who harbor a BRCA1 mutation can be used for evaluating risk of ovarian cancer ... | 06/15/1999 |
| 5910413 | Method and kit for amplification, sequencing and typing of classical HLA class I genes Amplification primer and sequencing primer sites have been identified which permit sequence-based typing of each of the classical HLA genes in highly robust and consistent reactions without allelic dropout. To determine the DNA sequence, and thus the type... | 06/08/1999 |
| 5903335 | Apparatus for displaying visual acuity chart with constant magnification In an apparatus for displaying a visual acuity chart table, in response to the change of the distance between an eye to be examined and an apparatus body, a concave mirror of a visual chart optical system is moved along a desired optical axis direction an... | 05/11/1999 |
| 5902292 | Eye drop applicator A bottle for administering liquid eye drops, comprising: (a) a container (10) for holding the liquid eye drops; (b) a dispensing assembly (11, 61), and (c) a closure assembly (12, 63). The dispensing assembly is coupled to the container and has a passage (13, 62) t... | 05/11/1999 |
| 5897842 | Method and apparatus for thermal cycling and for automated sample preparation with thermal cycling An apparatus and method for thermally cycling a reaction mixture in a reaction vessel to expose the mixture to the varying temperatures necessary to, for example, achieve PCR amplification or the preparation of sequencing fragments using a cycle sequencin... | 04/27/1999 |
| 5888736 | Method, compositions and kit for detection and identification of microorganisms Evaluation of a sample for the presence and qualitative nature of a microorganism can be performed in a single vessel by combining a natural abundance DNA sample with a sequencing mixture containing a primer pair, a thermally stable polymerase such as The... | 03/30/1999 |