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...During the Civil War, the Confederacy established its own Patent Office which issued 266 patents, a third of which concerned implements of war.
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| Number | Title | Issue Date |
| 5965436 | Method of isolating mesenchymal stem cells associated with isolated megakaryocytes by isolating megakaryocytes The present invention is directed to isolated and purified human mesenchymal stem cells, to a method for isolating, purifying, and culturally expanding human mesenchymal stem cells (i.e. mesenchymal stem cells or "MSCs"), and to the characterization of an... | 10/12/1999 |
| 5962644 | Porcine CD34 Porcine CD34, oligonucleotides encoding the porcine CD34, porcine CD34 antibodies and methods of making and using each are disclosed.... | 10/05/1999 |
| 5952004 | Emulsified drug delivery systems A pharmaceutical preparation comprising a stable, surface-active emulsion or dispersion of a pharmaceutical agent incorporated into an emulsion (i) having a hydrophobic discontinuous phase of a long chain carboxylic acid or ester or alcohol thereof disper... | 09/14/1999 |
| 5948407 | Oral induction of tolerance to parenterally administered non-autologous polypeptides Disclosed is a method for reducing an immune response to a parenterally administered non-autologous antigen in an individual who is immunologically responsive thereto by mucosally administering to the individual an amount of the antigen effective to reduc... | 09/07/1999 |
| 5942225 | Lineage-directed induction of human mesenchymal stem cell differentiation Methods for in vitro or ex vivo lineage directed induction of isolated, culture expanded human mesenchymal stem cells comprising contacting the mesenchymal stem cells with a bioactive factor effective to induce differentiation thereof into a lineage of ch... | 08/24/1999 |
| 5922601 | High efficiency gene trap selection of regulated genetic loci A gene trap construct for identification of genes whose activity is regulated upon a cellular transition event which comprises in downstream sequence (i) a cassette having a functional splice acceptor, a translation stop sequence and an internal ribosome ... | 07/13/1999 |
| 5919965 | Non-nucleotide phosphorus ester oligomers A phosphorus ester oligomer having the structure: ##STR1## wherein A can be the same or different in each monomeric unit and each is independently selected from the group consisting of oxygen, sulfur, lower alkyl, alkyl- or aryl-substituted amino and... | 07/06/1999 |
| 5908784 | In vitro chondrogenic induction of human mesenchymal stem cells Disclosed are a composition of chemically defined components which support the in vitro chondrogenesis of mesenchymal progenitor cells, a method for in vitro chondrogenic induction of such progenitor cells and a method of forming human chondrocytes in vit... | 06/01/1999 |
| 5908782 | Chemically defined medium for human mesenchymal stem cells A composition and method for maintaining the viability of human mesenchymal precursor cells in a serum-free environment which composition includes (1) a minimum essential medium; (2) serum albumin; (3) an iron source; (4) insulin or an insulin-like growth... | 06/01/1999 |
| 5897876 | Emulsified drug delivery system A pharmaceutical preparation comprising a stable, surface-active emulsion or dispersion of a pharmaceutical agent incorporated into an emulsion (i) having a hydrophobic discontinuous phase of a long chain carboxylic acid or ester or alcohol thereof disper... | 04/27/1999 |
| 5883103 | Oral acyclovir delivery A pharmaceutical preparation for oral acyclovir delivery comprising a stable, hydrophobic emulsion comprising continuous phase of a hydrophobic material selected from the group consisting of a long chain carboxylic acid or ester or alcohol thereof dispers... | 03/16/1999 |
| 5874437 | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses Disclosed are nitrosated and/or nitrosylated phosphodiesterase inhibitors having the formula NOn -PDE inhibitor wherein n is 1 or 2. The phosphodiesterase inhibitor can be nitrosylated or nitrosated through sites such as oxygen (hydroxyl conden... | 02/23/1999 |
| 5855895 | Polyphosphazene polyelectrolyte immunoadjuvants A polyphosphazene polyelectrolyte immunoadjuvant having improved water solubility, a vaccine composition of the immunoadjuvant and an antigen or immunogen and methods of their use in producing or enhancing an immunoprotective response in a host are disclo... | 01/05/1999 |
| 5837539 | Monoclonal antibodies for human mesenchymal stem cells The invention relates to isolated human mesenchymal stem cells, a method for isolating, purifying, and culturally expanding human mesenchymal stem cells (i.e. mesenchymal stem cells or "MSCs"), and characterization of (including by cytokine expression pro... | 11/17/1998 |
| 5824638 | Oral insulin delivery A pharmaceutical preparation for oral insulin delivery comprising a stable, hydrophobic emulsion comprising continuous phase of a hydrophobic material selected from the group consisting of a long chain carboxylic acid or ester or alcohol thereof dispersed... | 10/20/1998 |
