O'Brien; Jonathan P. - US Patent Attorneys and Agents

Attorney: O'Brien; Jonathan P.

Number of patents: 71
Last date: May 08, 2012

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Number	Title	Issue Date
8172765	Method of assessment of airway variability in airway hyperresponsiveness The invention relates to a method of assessing airway variability in airway responsiveness or asthma by measuring the variation of resistance (Rrs) by a forced oscillation technique utilizing either a single or a plurality of input frequencies during a plurality of ...	05/08/2012
8163942	Salt of (2S, 3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid The invention relates to purification of (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid [hereinafter, referred to as the carboxylic acid] using the salt of the carboxylic acid with an organic amine selected from the group consis...	04/24/2012
8163917	Azaindoles useful as inhibitors of Janus kinases The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatm...	04/24/2012
8163772	Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxypheny1]-1,4-dihydro-4-oxoquinoline-3-carboxamide Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof. ...	04/24/2012
8158675	Compounds and methods for the treatment or prevention of infections Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, Y1, and Z are as defined herein, are useful for treating flaviv...	04/17/2012
8153211	Ink-jet-printable decorative paper Decorative paper for decorative coating materials comprising a base paper and an ink receiving layer dyed in such a way that the decorative paper has after impregnation with impregnating resins and pressing as laminate the same coloring as the coloring of a laminate...	04/10/2012
8143224	Oxidant resistant apolipoprotein A-1 and mimetic peptides A purified polypeptide includes an ApoA1 mimetic or fragment thereof that are resistant to oxidation. ...	03/27/2012
8129387	Substituted 5,6-dihydroimidazo[1,5-F]pteridines useful as protein kinase inhibitors The present invention relates to substituted 5,6-dihydroimidazo[1,5-f]pteridines of formula I: which are useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprisin...	03/06/2012
8110553	Methods and compositions for the treatment of gastrointestinal disorders The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), Crohn's di...	02/07/2012
8101767	Modulators of ATP-binding cassette transporters The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to metho...	01/24/2012
8101579	Methods and compositions for the treatment of gastrointestinal disorders Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, u...	01/24/2012
8080526	Methods and compositions for the treatment of gastrointestinal disorders The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), Crohn's di...	12/20/2011
8076357	Compositions of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide Pharmaceutical compositions including N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) and methods of using such compositions are described herein. ...	12/13/2011
8067450	Thiazolidinedione analogues for the treatment of metabolic diseases The present invention relates to thiazolidinedione analogues that are useful for treating hypertension, diabetes, and inflammatory diseases. Formula (I), wherein: each of R1 and R4 is independently selected from H, halo, aliphatic, and alkoxy, ...	11/29/2011
8067436	c-Met modulators and methods of use The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazo...	11/29/2011
8044062	Substituted pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors of phospatidylinositol 3-kinase alpha The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds. ...	10/25/2011
8039475	Co-crystals and pharmaceutical compositions comprising the same The invention relates to compositions and co-crystals each comprising (1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c...	10/18/2011
8003685	Thiophene analogues for the treatment or prevention of flavivirus infections Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, and Z are as defined herein, are useful for treating flaviviridae viral infections. ...	08/23/2011
8003660	Modulators of muscarinic receptors The present invention relates to benzo-spiro-azaheterocyclic compounds of formula I, wherein R1, R2a, Rsb, R3, R′3, R4, R′4, m, n, q and p are define herein. The compounds of this inven...	08/23/2011
7989622	Phosphatidylinositol 3-kinase inhibitors and methods of their use The present invention comprises small molecule inhibitors of phosphatidylinositol 3-kinase (PI3K), which is associated with a number of malignancies such as ovarian cancer, cervical cancer, breast cancer, colon cancer, rectal cancer, and glioblastomas, among others....	08/02/2011
7985769	Compounds and methods for the treatment or prevention of infections The present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating flaviviridae viral infection. ...	07/26/2011
7985762	Inhibitors of serine proteases The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3—NS4A protease.	07/26/2011
7977345	c-MET modulators and method of use A compound for modulating kinase activity according to Formula I, or a pharmaceutically acceptable salt thereof, Wherein J1, J2, J3, R2, J4, Z, Ar and R3 are...	07/12/2011
7973162	Modulators of muscarinic receptors The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases. ...	07/05/2011
7964624	Inhibitors of serine proteases The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof. These compounds inhibit serine protease, particularly the hepatitis C virus NS3-NS4A protease. ...	06/21/2011
7960544	Useful indole compounds Indoles that have activity as inhibitors of FAAH are described as are indoles and indole derivatives that have activity as inhibitors of DAO. ...	06/14/2011
7951929	Insecticidal compounds and methods for selection thereof A series of potent and highly specific insecticidal toxins characterized by an amino acid sequences SEQ ID NO: 2-35. ...	05/31/2011
7910546	Methods and compositions for the treatment of gastrointestinal disorders The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogas...	03/22/2011
7880060	Insecticidal polynucleotides and methods of use thereof A family of insecticidal polypeptides expressed in the venom gland of spiders of the genera Atrax and Hadronyche have been described. Also included are polynucleotides and expression vectors encoding the polypeptides and insect viruses and cells expres...	02/01/2011
7880007	Bicyclic substituted phenyl piperidine modulators of muscarinic receptors The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases. ...	02/01/2011
7879834	Spiroindoline modulators of muscarinic receptors The present invention relates to spiroindoline modulators of muscarinic receptors. The present invention also provides compositions comprising such spiroindoline modulators, and methods therewith for treating muscarinic receptor mediated diseases. ...	02/01/2011
7863449	Modulators of muscarinic receptors The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases. ...	01/04/2011
7858790	Modulators of muscarinic receptors The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases. ...	12/28/2010
7858635	Spiro compounds as modulators of muscarinic receptors The present invention relates to spiro compounds of formula XX as modulators of muscarinic receptors, wherein R1, R2, R3, Z1, Z2, L, G, n, m, t and p are defined herein. The present invention also provides compo...	12/28/2010
7834200	Processes and intermediates The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof. ...	11/16/2010
7827927	Anchoring system for watercraft vessels An anchoring system for a watercraft vessel, the anchoring system including an anchor bracket configured to be mountable on the watercraft vessel; a sleeve attached to the anchor bracket, the sleeve having an aperture disposed longitudinally therethrough; a sliding ...	11/09/2010
7820671	Peptidomimetic protease inhibitors The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective ...	10/26/2010
7807647	Methods and compositions for cancer therapy The present invention relates to methods and compositions for the inhibition of gene expression. In particular, the present invention provides oligonucleotide-based therapeutics for the inhibition of oncogenes involved in cancers. ...	10/05/2010
7794994	Enzyme-based system and sensor for measuring acetone Described are enzyme systems specific for acetone and methods of using these enzyme systems to detect acetone in biological or environmental samples. Biosensors containing these enzyme systems are disclosed, in which detection of acetone may be achieved by linking e...	09/14/2010
7786308	Muscarinic modulators The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases. ...	08/31/2010

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Attorney: O'Brien; Jonathan P.