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| Number | Title | Issue Date |
| 8101645 | Thienopyrroles and pyrrolothiazoles as new therapeutic agents The present invention is directed to novel compounds of Formula (I) wherein the variables are defined as herein. The compounds of Formula (I) are useful as CRTH2 antagonists and as such would be useful in treating certain c... | 01/24/2012 |
| 7956195 | Process for the preparation and isolation of the individual stereoisomers of 1-amino, 3-substituted phenylcyclopentane-carboxylates The present invention discloses processes for the preparation and isolation of the individual stereoisomers of 1-amino, 3-substituted phenylcyclopentane-carboxylates. ... | 06/07/2011 |
| 7863444 | 4-aminopyrrolopyrimidines as kinase inhibitors Chemical compounds having structural formula I and physiologically acceptable salts thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases whose activity is inhibited by these compo... | 01/04/2011 |
| 7834039 | Oxadiazole compounds Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the S1P family of G protein-coupled receptors for treating diseases associated with modulation of S1P famil... | 11/16/2010 |
| 7829570 | Substituted 4-amino isoxazolo[5,4-d]pyrimidines as kinase inhibitors The present application is directed to compounds of the formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors. ... | 11/09/2010 |
| 7790741 | Imidazothiazoles and imidazoxazoles The present invention is directed to novel compounds of formula (I) wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain c... | 09/07/2010 |
| 7369946 | Method of identifying inhibitors of Tie-2 The present invention relates to polypeptides which comprise the ligand binding domain of Tie-2, crystalline forms of these polypeptides and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Tie-2. The inventi... | 05/06/2008 |
| 7332497 | Pyrazolopyrimidines as therapeutic agents The present invention provides compounds of Formula I, including pharmaceutically acceptable salts and/or prodrugs thereof, where G, Ra, R2, and R3 are defined as described herein... | 02/19/2008 |
| 7091227 | Benzothiazole derivatives The present invention is directed to a compound of formula (I), racemic-diastereomeric mixtures thereof, optical isomers thereof, prodrugs thereof, isotopes thereof or pharmaceutically-acceptable salts of said co... | 08/15/2006 |
| 7071199 | Kinase inhibitors as therapeutic agents The present application is directed to a compound of Formula (I) as defined herein which are useful as kinase inhibitors. ... | 07/04/2006 |
| 7060822 | 2-pyrazolin-5-ones Chemical compounds having structural formula I and physiologically acceptable salts thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the tyrosine kinases, whose activity is inh... | 06/13/2006 |
| 7049312 | Benzothiazinone and benzoxazinone compounds Q is —N=or CR2 X is S, O or NOR3 Y is —O—, —S—, —SO— or —SO2— R and R1 are each... | 05/23/2006 |
| 6992216 | Crystallization of amino acids using ultrasonic agitation A method for reducing the particle size of amino acid crystals using ultrasound is discussed. ... | 01/31/2006 |
| 6660744 | Pyrazolopyrimidines as therapeutic agents The present invention is directed to pyrazolopyrimidine derivatives which are useful as kinase inhibitors and as such are useful for affecting angiogenesis and diseases and conditions associated with angiogenesis.... | 12/09/2003 |
| 6534655 | Indeno[1,2-C]pyrazole derivatives for inhibiting tyrosine kinase activity Chemical compounds that are derivatives of indeno[1,2-c]pyrazole are inhibitors of tyrosine kinase activity. Several of the tyrosine kinases, whose activity is inhibited by these chemical compounds, are involved in angiogenic processes. Thus, these chemic... | 03/18/2003 |
