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"That the automobile has practically reached the limit of its development is suggested by the fact that during the past year no improvements of a radical nature have been introduced."
Scientific American ; Jan. 2 edition, 1909
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| Number | Title | Issue Date |
| 8119611 | Treatment of neurodegenerative disease through intracranial delivery of SIRNA The present invention provides devices, small interfering RNA, and methods for treating a neurodegenerative disorder comprising the steps of surgically implanting a catheter so that a discharge portion of the catheter lies adjacent to a predetermined infusion site i... | 02/21/2012 |
| 8114634 | Methods, systems and reagents for improved immunodetection The instant invention provides methods, systems and reagents for immunodetection involving novel epitope tags and antibodies which recognize these new epitope tags as well as the antibodies which detect the FLAG epitope tag. Fusion proteins comprising the epitope ta... | 02/14/2012 |
| 8080301 | Anti-fomitic devices A sanitary hypo-allergenic latex-free disposable anti-fomitic device is provided. The anti-fomitic device comprises a sheet of a microorganism-impenetrable material comprising a first side and a second side, and a pressure-sensitive adhesive, such as, for example, a... | 12/20/2011 |
| 8058251 | Devices, systems and methods for improving memory and/or cognitive function through brain delivery of siRNA The present invention relates to devices, systems, and methods for improving memory and/or cognitive function by brain delivery of compositions of small interfering RNA or vectors containing the DNA encoding for small interfering RNA. Such compositions can be admini... | 11/15/2011 |
| 8017737 | Diagnostic methods for diseases by screening for hepcidin in human or animal tissues, blood or body fluids; monoclonal antibodies specific to human hepcidin and associated uses therefor The present invention concerns antibodies specific for the C-terminus of human hepcidin, and related methods and kits for diagnosing and/or treating a disease condition characterized by non-physiological levels of hepcidin protein, including prohepcidin and fragment... | 09/13/2011 |
| 8003338 | Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor The present invention concerns methods and kits for diagnosing a disease condition characterized by non-physiological levels of hepcidin protein, including prohepcidin and fragments thereof, comprising obtaining a tissue or fluid sample from a subject; contacting th... | 08/23/2011 |
| 7998995 | LXR and FXR modulators Compounds of the invention are disclosed, such as compounds of formulae LX-LXIV, and pharmaceutically acceptable salts, isomers, or prodrugs thereof, which are useful as modulators of the activity of liver X receptors (LXR) and Farnesoid X receptors (FXR), where R | 08/16/2011 |
| 7998986 | Modulators of LXR Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of nuclear receptors, including liver X receptor (LXR) and orphan nuclear receptors. In ... | 08/16/2011 |
| 7998691 | Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor The present invention concerns methods and kits for diagnosing a disease condition characterized by non-physiological levels of hepcidin, comprising obtaining a tissue or fluid sample from a subject; contacting the sample with an antibody or fragment thereof that sp... | 08/16/2011 |
| 7994149 | Method for treatment of Huntington's disease through intracranial delivery of sirna The present invention provides devices, small interfering RNAs, and methods for treating a neurodegenerative disorder comprising the steps of surgically implanting a catheter so that a discharge portion of the catheter lies adjacent to a predetermined infusion site ... | 08/09/2011 |
| 7988668 | Microsyringe for pre-packaged delivery of pharmaceuticals A microsyringe includes a body, a barrier movable within the body, and a flow regulator. The body includes a pressurizable chamber, an inlet fluidly connected to the pressurizable chamber, an outlet fluidly connected to the pressurizable chamber, and a cannula fluid... | 08/02/2011 |
| D638734 | Watch face | 05/31/2011 |
| 7943345 | Methods, systems and reagents for improved immunodetection The instant invention provides methods, systems and reagents for immunodetection involving novel epitope tags and antibodies which recognize these new epitope tags as well as the antibodies which detect the FLAG epitope tag. Fusion proteins comprising the epitope ta... | 05/17/2011 |
| 7932483 | Household appliance with an electric control system and an accessory part The invention relates to a household appliance with an electric control system (20), which is connected to an accessory part (12) for the household appliance in a signal-transmitting fashion, wherein the accessory part (12) can be moved back and... | 04/26/2011 |
| 7928190 | Methods and compositions for tumor vaccination and therapy The present invention relates to peptide vaccines, pharmaceutical compositions thereof, and associated methodologies that promote the immune-mediated regression of tumors expressing an onconeural antigen, e.g. a cdr-2 antigen, HuD antigen. The cancer peptide vaccine... | 04/19/2011 |
| 7924545 | Apparatus for controlling atmospheric humidity An apparatus for modification of the atmospheric humidity profile via creating updrafts of moistened air is provided. The apparatus is based on a capacitor of a Van der Graaf generator which, with the aid of air ionizers comprising a source of alpha particles, produ... | 04/12/2011 |
| 7902352 | Isolated nucleic acid duplex for reducing huntington gene expression Disclosed herein are sequences, molecules and methods used to suppress the expression of HD genes encoding for huntingtin protein in primates including Macaca mulatta and Homo sapiens. These sequences, molecules and methods aid in the study of the path... | 03/08/2011 |
| 7888461 | Snapin and methods for regulation of microtubule assembly and dendrite growth and branching Fragments of snapin important for interaction with cypin and thus regulating microtubule assembly are provided. Also provided are methods of use of said fragments and kits to facilitate said methods. ... | 02/15/2011 |
| 7846744 | Methods of identifying anti-inflammatory compounds A mammalian C-type lectin receptor type is identified which is shown to bind IgG antibodies or Fc fragments, thus inducing IVIG-related reversal of inflammation associated with various immune disorders. The identification of a DC-SIGN receptor type which interacts w... | 12/07/2010 |
| D631524 | Surf riding device | 01/25/2011 |
| 7862802 | Patches for teeth whitening The present invention relates to a dry type tooth whitening patch comprising peroxide as a tooth whitening agent. In particular, disclosed is a dry type tooth whitening patch in which a peroxide is contained, as a teeth whitening agent, in a matrix type adhesive lay... | 01/04/2011 |
| 7837990 | In vivo expanded NKT cells and methods of use thereof This invention relates to the in vivo expansion of NKT cells by their exposure to mature dendritic cells expressing α-galactosyl ceramide and to methods of use thereof in modulating immune responses, such as anti-cancer responses, and enhancing memory responses. | 11/23/2010 |
| 7829694 | Treatment of neurodegenerative disease through intracranial delivery of siRNA The present invention provides devices, small interfering RNA, and methods for treating a neurodegenerative disorder comprising the steps of surgically implanting a catheter so that a discharge portion of the catheter lies adjacent to a predetermined infusion site i... | 11/09/2010 |
| 7819842 | Chronically implantable guide tube for repeated intermittent delivery of materials or fluids to targeted tissue sites A therapy delivery system for the intermittent delivery of biologics, chemicals, or pharmaceuticals into tissues involves a chronically implantable guide tube having a guide cannula with a proximal and a distal end, an access port mounted on the proximal end of the ... | 10/26/2010 |
| 7799522 | Specific double-stranded probes for homogeneous detection of nucleic acid and their application methods Double-stranded nucleic acid hybridization probes comprise a longer strand perfectly complementary to a preselected target sequence in an assay and a shorter second strand complementary to the longer strand. The strands are labeled with interactive labels such as a ... | 09/21/2010 |
| D623977 | Watch face | 09/21/2010 |
| 7790843 | Cypin polypeptide and fragments thereof Disclosed are novel materials and screening methods for diagnosing and monitoring cognitive disorders, as well as for identifying compounds for treating such disorders. ... | 09/07/2010 |
| 7785572 | Method and device for teeth whitening using a dry type adhesive A dry type adhesive device for teeth whitening in which a peroxide tooth whitening agent is stabilized is disclosed. The dry type adhesive device for tooth whitening comprises a matrix type adhesive layer and a backing layer wherein the adhesive layer contains a per... | 08/31/2010 |
| 7771949 | Homogeneous multiplex screening kits Kits for highly multiplexed homogeneous in vitro screening assays for numerous possible nucleic acid targets, any of which might be present in a sample, that utilize fluorescent hybridization probes that are combinatorially coded from a panel of fluorophores by subd... | 08/10/2010 |
| 7741031 | Optically decodable microcarries, arrays and methods A coding scheme for microcarriers suitable for use in distributed arrays includes labeling the carriers with quenched signaling hairpin molecules with any one of three to eight distinguishable fluorophores wherein the hairpins are of at least two types, most prefera... | 06/22/2010 |
| 7732591 | Compositions, devices and methods for treatment of huntington's disease through intracranial delivery of sirna The present invention provides devices, small interfering RNAs, and methods for treating a neurodegenerative disorder comprising the steps of surgically implanting a catheter so that a discharge portion of the catheter lies adjacent to a predetermined infusion site ... | 06/08/2010 |
| 7732145 | Method and devices for rapid diagnosis of foot-and-mouth disease A rapid immunoassay method and apparatus for detecting foot and mouth disease virus are disclosed. The method and test device permit pen-side testing of animals and provide test results within a relatively short time period. In a preferred embodiment, the method and... | 06/08/2010 |
| 7691419 | Compositions and methods for treating skin conditions in mammals A topical composition for treating skin diseases is provided. The composition comprises calendula, tea tree oil, eucalyptus oil, grape seed oil, and Aloe vera. In some embodiment, the composition may also include beeswax, vegetable oil, vitamin ... | 04/06/2010 |
| 7662550 | Assays for short sequence variants The invention provides assays that can detect multiple genetic variants of a gene (e.g., a mycobacterial gene) in a sample using a pool (e.g., 2, 3, 4, or more) of oligonucleotide hybridization probes. ... | 02/16/2010 |
| 7610708 | Chair rail picture frame A chair rail for displaying decorative items is disclosed. It comprises an elongated rigid body with at least one receptacle formed in the elongated body. At least one outlet is formed in the longitudinal body extending from the at least one receptacle to a top or a... | 11/03/2009 |
| 7605249 | Treatment of neurodegenerative disease through intracranial delivery of siRNA The present invention provides devices, small interfering RNA, and methods for treating a neurodegenerative disorder comprising the steps of surgically implanting a catheter so that a discharge portion of the catheter lies adjacent to a predetermined infusion site i... | 10/20/2009 |
| D598788 | Watch | 08/25/2009 |
| 7498307 | Combinations of DnaK inhibitors with known antibacterial agents Compositions, methods and kits are provided comprising (a) a therapeutically effective amount of a DnaK inhibitor; and (b) a therapeutically effective amount of a known antibacterial agent. Such compositions, methods and kits are useful in the treatment of various b... | 03/03/2009 |
| 7470404 | Fluid sample collection and isolation cup A collection and testing cup for fluid characterization is disclosed. The cup has a lid assembly with a tamper evident closure; a cylinder that extends into the fluid in the collection cup, also with a tamper evident closure; a piston with a conduit and one-way valv... | 12/30/2008 |
| 7464423 | Convertible nursing bag A nursing bag, which has a padded nursing surface that can gently support an infant, a cavity into which baby-care products may be placed, and optionally a stiffening system in the cavity that provides rigidity when the nursing surface is under the weight of an infa... | 12/16/2008 |
