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| Number | Title | Issue Date |
| 7011972 | Fusion polypeptide comprising two ligand binding domains Single chain, monomeric polypeptide gene switches are provided. The gene switches include ligand binding domains and at least one functional domain. Preferred functional domains are DNA binding domains and transcriptional regulating domains. Methods of regulating ge... | 03/14/2006 |
| 6939973 | Glycoluril core molecules for combinatorial libraries The present invention provides novel glycoluril derivatives for use as core molecules in combinatorial chemistry. Core molecules of the present invention can contain from one to six building blocks. Preferred building blocks are substituted amine radicals. Combinato... | 09/06/2005 |
| 6930222 | In vivo animal model of human leukemia The present invention provides a process for making an in vivo model of human leukemia. The process includes the steps of: pre-conditioning an immunodeficient rodent by administering to the rodent a sub-lethal dose of irradiation and injecting the rodent with an eff... | 08/16/2005 |
| 6677435 | Prodrug activation using catalytic antibodies The present invention provides a compound that includes an active therapeutic agent attached to a blocking moiety that is sensitive to the catalytic action of molecules having retro-aldol and retro-Michael catalytic activity, methods for making such compo... | 01/13/2004 |
| 6610512 | Zinc finger binding domains for GNN Zinc finger-nucleotide binding polypeptides having binding specificity for target nucleotides containing one or GNN triplets are provided. Compositions containing such polypeptides and the use of such polypeptides and compositions for regulating gene expr... | 08/26/2003 |
| 6589766 | Aldol consensations by catalytic antibodies Catalytic antibodies, including 38C2 and 33F12, are capable of efficiently catalyzing a wide variety of ketone-ketone, ketone-aldehyde, aldehyde-ketone, and aldehyde-aldehyde intermolecular aldol reactions, and in some cases to catalyze their subsequent d... | 07/08/2003 |
| 6586236 | Modulation of polypeptide display on modified filamentous phage use A modified filamentous phage that contains a gene for a wild type phage coat protein and a gene for a synthetic phage coat protein is provided. Uses of the modified phage and kits containing the phage are also provided.... | 07/01/2003 |
| 6326176 | Aldol condensations by catalytic antibodies Catalytic antibodies, including 38C2 and 33F12, are capable of efficiently catalyzing a wide variety of ketone-ketone, ketone-aldehyde, aldehyde-ketone, and aldehyde-aldehyde intermolecular aldol reactions, and in some cases to catalyze their subsequent d... | 12/04/2001 |
| 6323004 | Modulation of polypeptide display on modified filamentous phage A modified filamentous phage that contains a gene for a wild type phage coat protein and a gene for a synthetic phage coat protein is provided. Uses of the modified phage and kits containing the phage are also provided.... | 11/27/2001 |
| 6309881 | Antibody catalysis of enantio- and diastereo-selective aldol reactions Nine efficient aldolase antibodies were generated using hapten 2. This hapten combines, in a single molecule, structural components employed for reactive immunization with structural components employed for forming a transition state analog of the aldol r... | 10/30/2001 |
| 6281354 | Analogs of duocarmycin and cc-1065 The field of this invention is antitumor antibiotics. More particularly, the present invention relates to analogs of duocarmycin and CC-1065, which analogs have antitumor antibiotics activity.... | 08/28/2001 |
| 6268488 | Prodrug activation using catalytic antibodies The present invention provides a compound that includes an active therapeutic agent attached to a blocking moiety that is sensitive to the catalytic action of molecules having retro-aldol and retro-Michael catalytic activity, methods for making such compo... | 07/31/2001 |
| 6251931 | Inhibitors of gap junction communication Oleamide is an endogenous fatty acid primary amide that possesses sleep-inducing properties in animals and has been shown to effect seratonergic systems and block gap junction communication in a structurally specific manner. Certain agents can serve both ... | 06/26/2001 |
| 6190908 | Modulation of polypeptide display on modified filamentous phage A modified filamentous phage that contains a gene for a wild type phage coat protein and a gene for a synthetic phage coat protein is provided. Uses of the modified phage and kits containing the phage are also provided.... | 02/20/2001 |
| 6175001 | Functionalized pyrimidine nucleosides and nucleotides and DNA's incorporating same Modified pyrimidine nucleotides derivatized at C5 to contain a functional group that mimics the property of a naturally occurring amino acid residues are provided. DNA molecules containing the modified nucleotides are also provided.... | 01/16/2001 |
| 6140081 | Zinc finger binding domains for GNN Zinc finger-nucleotide binding polypeptides having binding specificity for target nucleotides containing one or GNN triplets are provided. Compositions containing such polypeptides and the use of such polypeptides and compositions for regulating nucleotid... | 10/31/2000 |
| 6110462 | Enzymatic DNA molecules that contain modified nucleotides The present invention discloses catalytic or enzymatic DNA molecules that contain a modified nucleotide and that are capable of cleaving nucleic acid sequences or molecules, particularly RNA, in a site-specific manner, as well as compositions including sa... | 08/29/2000 |
| 6060596 | Encoded combinatorial chemical libraries The present invention describes an encoded combinatorial chemical library comprised of a plurality of bifunctional molecules having both a chemical polymer and an identifier oligonucleotide sequence that defines the structure of the chemical polymer. Also... | 05/09/2000 |
| 5939268 | Combinatorial libraries of molecules and methods for producing same This invention features methods of synthesizing combinatorial libraries of chemical compounds, and combinatorial libraries of chemical compounds formed by the methods of this invention. Specifically, Diels-Alder chemistry is utilized to generate libraries... | 08/17/1999 |
