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| Number | Title | Issue Date |
| 7803835 | Substituted acetic acid derivatives The present invention relates generally to substituted acetic acid derivatives and methods of using them. ... | 09/28/2010 |
| 7781591 | Substituted 3-cyanopyridines as protein kinase inhibitors The present teachings provide compounds of formula I and their pharmaceutically acceptable salts, hydrates, and esters, wherein R1, R2, and X are as defined herein. The present teachings also provide m... | 08/24/2010 |
| 7754747 | Oxazolo-naphthyl acids The present invention relates to oxazolo-naphthyl acids of the formula and methods of using them to modulate PAI-1 expression and to treat PAI-1 related disorders. ... | 07/13/2010 |
| 7744890 | Methods and compositions with reduced opalescence Methods for reducing the opalescent appearance of a protein preparation by modifying the ionic strength of the preparation, as well as compositions, e.g., pharmaceutical compositions, of concentrated protein with decreased opalescence are disclosed. Purification met... | 06/29/2010 |
| 7683091 | Substituted indoles and methods of their use The present invention relates generally to substituted indoles and methods of using them. ... | 03/23/2010 |
| 7674818 | Aryl, aryloxy, alkyloxy substituted 1-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) Compounds of formula I are provided: wherein: R1, R2, and R3, are as defined herein, as well as pharmaceutical composition and methods using the compounds as inhibitors of plasminogen activator inhibitor (PAI-1) and... | 03/09/2010 |
| 7629377 | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R1, R2, R3, and R4 are each H, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R8,... | 12/08/2009 |
| 7605172 | Thiazolo-naphthyl acids The present invention relates to thiazolo-naphthyl acids of the formula and methods of using them to modulate PAI-1 expression and to treat PAI-1 related disorders. ... | 10/20/2009 |
| 7582773 | Substituted phenyl indoles The present invention relates generally to substituted phenyl indoles and methods of using them, for example as PAI-1 inhibitors. ... | 09/01/2009 |
| 7566791 | Substituted 3-carbonyl--indol-1yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) Substituted 3-carbonyl-1H-indol-1-yl acetic acid derivatives of formula I are provided: wherein: R1, R2, R3, R4 and R5 are as defined herein wh... | 07/28/2009 |
| 7534894 | Biphenyloxy-acids The present invention relates generally to substituted biphenyloxy acids (such as 4′-aryl-amido-biphenyl-4(3)-yloxy-acids and 4′-aryl-amidomethyl-biphenyl-4(3)-yloxy-acids) and methods of using them, for example, as PAI-1 inhibitors. ... | 05/19/2009 |
| 7459478 | Substituted dihydropyrano indole-3,4-dione derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) Compounds of formula (I) and II) are provided wherein: X is an alkali metal or a basic amine moiety; R1 is alkyl, cycloalkyl, —CH2-cycloalkyl, pyridinyl, —CH2-pyridinyl, phenyl or benzyl... | 12/02/2008 |
| 7446201 | Substituted heteroaryl benzofuran acids The present invention relates generally to substituted heteroaryl benzofuran acids and methods of using them. ... | 11/04/2008 |
| 7442805 | Substituted sulfonamide-indoles The present invention relates generally to substituted sulfonamide indoles such as substituted sulfonamide indoles, and methods of using them. ... | 10/28/2008 |
| 7420083 | Substituted aryloximes The present invention relates to substituted aryl oximes and methods of using them. ... | 09/02/2008 |
| 7411083 | Substituted acetic acid derivatives The present invention relates generally to substituted acetic acid derivatives and methods of using them. ... | 08/12/2008 |
| 7351726 | Substituted oxadiazolidinediones The present invention relates generally to substituted oxadiazolidinediones and methods of using them. ... | 04/01/2008 |
| 7351730 | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R1, R2, R3, and R4 are each H, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R8,... | 04/01/2008 |
| 7348351 | Substituted 3-alkyl and 3-arylalkyl -indol-1yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) The invention formula substituted 3-alkyl and 3-arylalkyl 1H indol-1yl acetic acid derivatives which are useful as inhibitors of plasminogen activator inhibitor (PAI-1) useful for treating fibrinolytic disorders, the compounds having the structure ... | 03/25/2008 |
| 7342039 | Substituted indole oximes The present invention relates to substituted indole oximes and methods of using them. ... | 03/11/2008 |
| 7332521 | Substituted indoles The present invention relates generally to substituted indoles such as substituted 1H-indole-2-carboxylic acid derivatives, and methods of using them. ... | 02/19/2008 |
| 7323483 | Processes and compounds for the preparation of substituted naphthylindole derivatives The present invention provides processes for the preparation of substituted naphthylindole derivatives that can be used as inhibitors of plasminogen activator inhibitor-1(PAI-1). In certain embodiments of the invention, the processes involve reactions that include o... | 01/29/2008 |
