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| Number | Title | Issue Date |
| 5160727 | Tumor cell sensitization method using quinazolinedione derivatives A method for sensitizing cancer cells which have become resistant to treatment with one or more anticancer agents which comprises treating said cells with a quinazolinedione compound.... | 11/03/1992 |
| 5153226 | Acat inhibitors for treating hypocholesterolemia The present invention are novel amino acid amide compounds of the following general formula which inhibit the enzyme acylcoenzyme A:cholesterol acyltransferase: ##STR1## wherein R is phenyl or 1- or 2-naphthyl which are unsubstituted or may be s... | 10/06/1992 |
| 5153223 | Biurets, aminocarbonyl carbamates, and aminocarbonyl thiocarbamates useful as ACAT inhibitors Novel compounds useful as ACAT inhibitors having the formula ##STR1## wherein Q is R5 O; R5 S-- or NR3 R4 ; wherein R is hydrogen or alkyl C1 -C20 or --CH2 Ph; wherein R1 | 10/06/1992 |
| 5142094 | Aryl substituted carbamate derivatives which are ACAT inhibitors This invention relates to novel compounds which are ACAT inhibitors rendering them useful in lowering blood cholesterol levels. The compounds are carbamates represented by the general formula ##STR1## wherein Ar and Ar' represent phenyl, naphthyl or ... | 08/25/1992 |
| 5118697 | Cyclic beta-ketoamide ACAT inhibitors Novel cyclic beta-ketoamides which contain an aryl moiety having utility as blood cholesterol lowering agents rendering them useful in the treatment of atherosclerosis.... | 06/02/1992 |
| 5116831 | Aminoalkyl-substituted cycloalkylamine platinum (II) complexes Square-planar four-coordinate complexes of cis-platinum (II) with neutral bidentate aminoalkyl-substituted cycloalkylamine ligands and bromo-, chloro-, iodo-, nitrato-, oxalato-, or malanato-ligands possess antimicrobial activity as well as activity again... | 05/26/1992 |
| 5106873 | ACAT inhibitors This invention relates to novel compounds which are ACAT inhibitors rendering them useful in lowering blood cholesterol levels. The compounds contain two urea or thiourea, amide, or amine moieties or combinations of said moieties and have the following ge... | 04/21/1992 |
| 5102893 | Trans-6-(2-(n-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl- or ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis Certain trans-6-[2-(N-heteroaryl-3,5-disubstituted) pyrazol-4-yl)ethyl]- or ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-ones and the corresponding ring-opened acids, esters and N-oxides derived therefrom which are potent inhibitors of the enzyme 3-hydroxy-3-m... | 04/07/1992 |
| 5098902 | Method of treating neurodegenerative diseases A method of treating a neurodegenerative disease which comprises administering 5-bromo-4-(4-morpholinyl)-2-pyrimidinamine or 4-(4-morpholinyl)-2-(1-piperazinyl)thieno[3,2-d]pyrimidine or a pharmaceutically acceptable salt thereof.... | 03/24/1992 |
| 5087726 | Carbamate ACAT inhibitors This invention relates to novel compounds which are ACAT inhibitors rendering them useful in lowering blood cholesterol levels. The compounds are carbamates represented by the general formula ##STR1## wherein Ar and Ar' represent phenyl or naphthyl e... | 02/11/1992 |
| 5084287 | Pharmaceutically useful micropellets with a drug-coated core and controlled-release polymeric coat A pharmaceutical preparation comprising drug micropellets containing a drug coated on a core material wherein each pellet ranges in size from about 70 microns to 750 microns and wherein each micropellet is coated with a controlled release coating.... | 01/28/1992 |
| 5075305 | Compound, composition and use A method of treating a neurodegenerative disease which comprises administering 5-bromo-4-(4-morpholinyl)-2-pyrimidinamine or 4-(4-morpholinyl)-2-(1-piperazinyl)thieno[3,2-d]pyrimidine or a pharmaceutically acceptable salt thereof.... | 12/24/1991 |
| 5073565 | Tetrazole ureas and thioureas and their use as ACAT inhibitors Novel ACAT inhibitors useful in the treatment of atherosclerosis which are N-aryl-N'-tetrazole ureas and thioureas.... | 12/17/1991 |
| 5073561 | Methods of treating depression and psychoses Certain N-substituted 1-(1,2,3,6-tetrahydro-3-pyridinyl)oximes and N-substituted 1-(1,2,3,6-tetrahydro-4-pyridinyl)oximes are useful as sigma binding agents for the treatment of depression, psychoses and/or inflammatory diseases.... | 12/17/1991 |
| 5030653 | Antihyperlipidemic and antiatherosclerotic compounds and compositions Certain N-2,6-dialkyl- or N-2,6-dialkoxyphenyl-N'-arylalkylurea compounds are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT), and are thus useful agents for the treatment of hypercholesterolemia or atherosclerosis.... | 07/09/1991 |
| 5015644 | Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds Certain substituted urea, thiourea, carbamate, and thiocarbamate compounds are potent inhibitors of the enzyme acyl-CoA: cholesterol acyltransferase and are thus useful agents for inhibiting the intestinal absorption of cholesterol, and for lowering blood... | 05/14/1991 |
| 4999373 | Antihyperlipidemic and antiatherosclerotic compounds and compositions Certain N-2,6-dialkyl- or N-2,6-dialkoxyphenyl-N'-arylalkylurea compounds are potent inhibitors of the enzyme acyl CoA: cholesterol acyltransferase (ACAT), and are thus useful agents for the treatment of hypercholesterolemia or atherosclerosis.... | 03/12/1991 |
| 4970324 | Aminoalkyl-substituted azetidine platinum(II) complexes Square-planar four-coordinate complexes of cis-platinum(II) with neutral bidentate aminoalkyl-substituted cycloalkylamine ligands and bromo-, chloro-, iodo-, nitrato-, oxalato-, or malanato-ligands possess antimicrobial activity as well as activity agains... | 11/13/1990 |
| 4957940 | Bicyclo heptane and bicyclo octane substituted inhibitors of cholesterol synthesis Certain bicyclo [2.2.1] heptane and bicyclo [2.2.2] octane substituted tetrahydro-2H-pyran-2-ones and the corresponding ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reduct... | 09/18/1990 |
| 4950675 | Pyridine di-mevalono-lactones as inhibitors of cholesterol biosynthesis Certain trans-6,6'-[[(substituted)pyridin-3,5-diyl]-dialkane- and dialkene-diyl]bis [tetrahydro-4-hydroxypyran]-2-ones and the corresponding ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methyl-glutaryl-coenzyme A red... | 08/21/1990 |
| 4948806 | Antihyperlipidemic and antiatherosclerotic compounds and compositions Certain N-2,6-dialkyl- or N-2,6-dialkoxyphenyl-N'-arylalkylurea compounds are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT), and are thus useful agents for the treatment of hypercholesterolemia or atherosclerosis.... | 08/14/1990 |
| 4929734 | Tetrahydropyridine oxime compounds Certain N-substituted 1-(1,2,3,6-tetrahydro-3-pyridinyl)oximes and N-substituted 1-(1,2,3,6-tetrahydro-4-pyridinyl)oximes are useful as sigma binding agents for the treatment of depression, psychoses and/or inflammatory diseases.... | 05/29/1990 |
| 4929620 | 5-pyrimidinyl-3,5-dihydroxy-6-heptenoic acid compounds useful as inhibitors of cholesterol biosynthesis Certain trans-6-[[(substituted)pyrimidin-5-yl]-ethyl]- and ethenyl]tetrahydro-4-hydroxypyran-2-ones and the corresponding dihydroxy ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HM... | 05/29/1990 |
| 4906657 | Bicyclo heptane and bicyclo octane substituted inhibitors of cholesterol synthesis Certain bicyclo [2.2.1] heptane and bicyclo [2.2.2] octane substituted tetrahydro-2H-pyran-2-ones and the corresponding ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reduct... | 03/06/1990 |
