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| Number | Title | Issue Date |
| 7833999 | Tetrahydroisoquinoline sulfonamide derivatives, the preparation thereof, and the use of the same in therapeutics The invention relates to tetrahydroisoquinoline sulfonamide compounds (of formula (1) as defined in the specification), their preparation and their use in therapies for the treatment of central nervous system diseases such as vigilance and sleep disorders, narcoleps... | 11/16/2010 |
| 7524887 | 2-amino-1,3-propanediol compounds for the treatment of acute pain The present invention relates to a method for the prophylaxis or treatment of pain using compounds of formula I, in which R, R2, R3, R4 and R5 have the meanings indicated in the specification. ... | 04/28/2009 |
| 7371770 | Acylaminothiazole derivatives and use thereof as β-amyloid inhibitors Compounds of formula (I) as defined herein: inhibit the formation of the β-amyloid peptide (β-A4) and are, therefore, useful in the treatment of pathologies in which a β-amyloid peptide (β-A4) formation inhibitor provid... | 05/13/2008 |
| 7335670 | Derivatives of N-[heteroaryl(piperidine-2-yl) methyl]benzamide, preparation method thereof and application of same in therapeutics Compounds of formula (I) as defined herein: are useful for treating behavioral disorders associated with dementia, psychoses, in particular schizophrenia (deficient form and productive form) and acute or chronic extrapyrami... | 02/26/2008 |
| 7259276 | Polyenecarboxylic acid derivatives, processes for preparing them, and their use The present invention relates to novel compounds, termed serpentemycins, of the formula (I) in which Y, R, R2, R3, R4, X, X2, X3, n, m and o are as defined i... | 08/21/2007 |
| 7227022 | Use of 2-amino-thiazoline derivatives as inhibitors of inducible no-synthase The present invention relates to a process for preparing 2-amino-thiazoline derivatives of formula (II): in which either Y is a methylene (CH2) and X is chosen from the following groups: O, NH, (C1–C... | 06/05/2007 |
| 7226917 | Derivatives of N-[phenyl(pyrrolidine-2-yl)methyl]benzamide and N-[(azepan-2-yl)phenylmethyl]benzamide, preparation, and use in treatment of schizophrenia Compounds of formula (I) as defined herein: are useful for treating behavioral disorders associated with dementia, psychoses, in particular schizophrenia (deficient form and productive form) and acute or chronic ... | 06/05/2007 |
| 7214798 | Derivatives of piperidinyl-and piperazinyl-alkyl carbamates, preparation methods thereof and application of same in therapeutics Compound corresponding to the general formula (I): in which A=N or CR2; R2=H, F, OH, CN, CF3, C1-6-alkyl, C1-6-alkoxy; n=2 or 3 and m=2 when A=N; n=1, 2 or 3... | 05/08/2007 |
| 7208504 | Bicyclic inhibitors of hormone sensitive lipase Benzotriazoles of formula I in which R1 to R8 have the abovementioned meanings and process for their preparation are described. The compounds show an inhibitory effect on hormone-sensitive lipase. ... | 04/24/2007 |
| 7196109 | Aminoindazole derivatives as medicaments and pharmaceutical compositions including them The present invention relates to the use of novel derivatives of general formula (I) in which R3 is a (1–6C)alkyl, aryl, aryl(1–6C)alkyl, heteroaryl, heteroaryl(1–6C)alkyl... | 03/27/2007 |
| 7179909 | Process for the manufacture of a product of the thiazolo [3,4,5-de] [4,1]benzothiazepine type Novel processes for the preparation of a compound of the thiazolo[3,4,5-de] [4,1]benzothiazepine type and in particular of 2-imino-9-trifluoromethyl-4,5-dihydro-2H,7H-thiazolo[3,4,5-de] [4,1]benzothiazepine 6,6-dioxide methanesulfonate and (R,S)-2-imino-9-trifluorom... | 02/20/2007 |
| 7166629 | Aminoindazole derivatives as medicaments and pharmaceutical compositions including them The present invention relates to novel derivatives of general formula (I) in which R3 is a (1–6C)alkyl, aryl, aryl(1–6C)alkyl, heteroaryl, heteroaryl(1–6C)alkyl, aryl or h... | 01/23/2007 |
| 7148254 | 2-Phenylbenzofuran derivatives, a process for preparing them, and their use The present invention relates to 2-phenylbenzofurans of formula (I) which are formed, during fermentation, by the microorganism Aspergillus flavipes ST003878 (DSM 15290), to a process for preparing them and to th... | 12/12/2006 |
| 7132414 | Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation The present invention relates to pharmaceutical compositions containing, as active ingredient, a compound of formula: in which R1 represents a radical —NHCOR4 or —N(R5)—Y—... | 11/07/2006 |
| 7112608 | Hydroxyphenylundecane, a process for their production and their use The present invention relates to novel hydroxyphenylundecane derivatives of the formula (I), a method for the preparation of said compounds by cultivation of the fungus Cryphonectria parasitica, DSM 14453,... | 09/26/2006 |
| 7041824 | Purine derivatives, preparation method and use as medicines The use of purine derivatives of formula (I): in which: Rx is —(Z)n—R1 wherein Z is a divalent radical selected from —CH2—, —SO2—... | 05/09/2006 |
| 7041661 | Use of thiazolobenzoheterocycles for treating multiple sclerosis The invention relates to the use of compound of Formula I in treating patients for inflammatory or neuropathic pain as well as various symptoms of multiple sclerosis ... | 05/09/2006 |
| 7019011 | Aminoindazole derivatives as medicaments and pharmaceutical compositions including them The present invention relates to novel derivatives of general formula (I) in which R3 is a (1–6C)alkyl, aryl, aryl(1–6C)alkyl, heteroaryl, heteroaryl(1–6C)alkyl, aryl or heteroar... | 03/28/2006 |
| 6989462 | Synthesis of 2-chloromethyl-6-methylbenzoic ester A process is described for preparing compounds of formula (I) where R is H, optionally halogen-substituted alkyl, cycloalkyl, aryl, alkyl-aryl or heteroaryl, and, in alkyl and cycloalkyl, one or more CH2 grou... | 01/24/2006 |
| 6953796 | Use of 2-amino-thiazoline derivatives as inhibitors of inducible No-synthase The present invention relates to the use of 2-amino-thiazoline derivatives of formula (I): in which either Y is a methylene (CH2) and X is chosen from the following groups: O, NH, (C1-C4) N-Alkyl, N—Bn, Nâ... | 10/11/2005 |
| 6927236 | Coniosulfides and their derivatives, processes for preparing them, and their use as pharmaceuticals The present invention relates to compounds of the formula which are formed during fermentation by the microorganism Coniochaeta ellipsoidea Udagawa, DSM 13856, or by one of its mutations and/or variants, and che... | 08/09/2005 |
| 6906084 | Indole derivatives as factor Xa inhibitors The present invention relates to compounds of formula I, in which R0; R1; R2; R3; R4; R5; R6; R7; Q; V, G and M have the meanings ... | 06/14/2005 |
| 6872740 | Use of 2-amino-4-heteroarylethyl-thiazoline derivatives as inhibitors of inducible no-synthase The present invention relates to the use of 2-amino-4-heteroarylethyl-thiazoline derivatives of formula (I) in which Het represents a thienyl, pyrimidyl, pyridyl or thiazolyl radical or pharmaceutically acceptable salt... | 03/29/2005 |
| 6872717 | Pharmacological uses of azetidine derivatives A method of treating or preventing obesity, this method comprising administering to a patient in need of such treatment an effective amount of a compound of formula in which R, R3 and R4 are as de... | 03/29/2005 |
| 6858603 | Acetindine derivatives, their preparation and medicaments containing them Disclosed are azetidine derivatives of formula: their optical isomers, their salts, their preparation and medicaments containing them. ... | 02/22/2005 |
| 6809177 | Process for the conversion of echinocandin class of peptides to their c4-homotyrosine monodeoxy analogues The invention relates to a process for the conversion of echinocandin class of peptides to their C4-homotyrosine monodeoxy analogues, particularly mulundocandin to deoxymulundocandin, which consists of a single step selective reduction of C4-htyr (homotyrosine) hydr... | 10/26/2004 |
| 6806277 | Quinolylpropylpiperidine derivatives, preparation process and intermediates, and compositions including them Quinolylpropylpiperidine derivatives of general formula (I) in which: R1 is NH2, alkylamino, dialkylamino, hydroxyamino, alkyl(alkyloxy)amino or alkyloxyamino, R2 is a carboxyl, car... | 10/19/2004 |
| 6800645 | Substituted azabicyclic compounds This invention is directed to physiologically active compounds of formula (I) wherein represents a bicyclic ring system, of about 10 to about 13 ring members, in which the ri... | 10/05/2004 |
| 6753409 | STABLE NON-HYGROSCOPIC CRYSTALLINE FORM OF N-[N-[N-(4-(PIPERIDIN-4-YL)BUTANOYL)-N-ETHYLGLYCYL]ASPARTYL]-L-β-CYCLOHEXYL ALANINE AMIDE, INTERMEDIATES THEREOF, AND PREPARATION THEREOF AND OF ANTITHROMBOTIC AZACYCLOALKYLALKANOYL PEPTIDES AND PSEUDOPEPTIDES The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)-β-cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharm... | 06/22/2004 |
| 6734176 | Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation The present invention relates to pharmaceutical compositions containing, as active ingredient, a compound of formula: in which R1 represents a radical —NHCOR4 or —N(R5)—Y—R6 | 05/11/2004 |
| 6673834 | Hydroperylene derivatives Compounds of the formula I ##STR1## are suitable for producing pharmaceuticals for the prophylaxis and therapy of diseases in which high blood platelet aggregations occur.... | 01/06/2004 |
| 6617316 | Oligosaccharides, their preparation and pharmaceutical compositions containing them The present invention relates to oligosaccharides of formula: ##STR1## to mixtures thereof, to diastereoisomers thereof, to a process for preparing them, to pharmaceutical compositions containing them, and to their use in preventing or treating a disease ... | 09/09/2003 |
| 6608042 | Pharmaceutical compositions containing oligosaccharides, the novel oligosaccharides and preparation thereof The present invention relates to pharmaceutical compositions containing as an active ingredient at least one oligosaccharide of formula: ##STR1## to novel oligosaccharides of formula (I), to mixtures thereof and to methods for their preparation.... | 08/19/2003 |
| 6579858 | Use of low-molecular-weight heparins for the prevention and treatment of cerebral edemas Cerebral edema is prevented and treated by administering an effective amount of a low molecular weight heparin.... | 06/17/2003 |
| 6569993 | Process for the preparation of resin-bound cyclic peptides This invention is directed to a process for the solid phase, fragment-based synthesis of resin-bound cyclic peptide analogs of parathyroid hormones and analogs of parathyroid hormone-related proteins, which analogs contain at least one bridge between the ... | 05/27/2003 |
| 6566356 | Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation The present invention relates to pharmaceutical compositions containing, as active ingredient, a compound of formula: ##STR1## in which R1 represents a radical --NHCOR4 or --N(R5)--Y--R6, Y is CO or SO2 | 05/20/2003 |
| 6545006 | Process for obtaining L-dihydroorotic acid and use thereof The invention relates to a process for obtaining L-dihydroorotic acid by chromatography on an anionic exchange material in a base water mixture under a pressure from about 1.1 MPa to about 40 MPa. The process can be used to investigate the in vitro and in... | 04/08/2003 |
| 6521252 | Transfecting compounds which are sensitive to reducing conditions, pharmaceutical compositions containing them and their applications The invention concerns a novel agent for transferring nucleic acids into cells. Said agent is particularly characterised in that it comprises one or several disulphide bonds sensitive to reducing conditions. The invention also concerns compositions compri... | 02/18/2003 |
| 6518264 | Azetidine derivatives, their preparation and medicaments containing them Disclosed are azetidine derivatives of formula: ##STR1## their optical isomers, their salts, their preparation and medicaments containing them.... | 02/11/2003 |
| 6472505 | Peptide parathyroid hormone analogs This invention is directed to cyclic and acyclic analogs of hPTH(1-34) and hPTHrP(1-34), to pharmaceutical compositions comprising these peptide compounds, and to a method of treating diseases associated with calcium regulation in the body.... | 10/29/2002 |
