Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 7862825 | Method of controlling tight blood glucose by somatostatin receptor antagonists The present disclosure provides methods and uses for controlling tight blood glucose levels in a subject comprising administering an effective amount of a somatostatin inhibitor. The present disclosure provides methods and uses for treating or preventing hypoglycemi... | 01/04/2011 |
| 7807418 | Method for producing hybrid polyketide synthases A hybrid type I polyketide synthase gene typically containing a starter module and a plurality of heterologous extender modules is used to synthesise novel polyketides. It is preferably under the control of type II polypolyketide synthase promoter e.g. act I or S... | 10/05/2010 |
| 7781568 | Anti-mullerian inhibiting substance type II receptor (MISIIR) immunoconjugates to detect and treat cancer Compositions and methods for detecting and treating cancers expressing Mullerian inhibiting substance Type II receptor (MISIIR) are provided. ... | 08/24/2010 |
| 7750136 | Modified bouganin proteins, cytotoxins and methods and uses thereof The invention provides modified forms of bouganin protein having biological activity and a reduced propensity to activate human T cells as compared to the non-modified bouganin protein. The invention also provides T-cell epitope peptides of bouganin, and modified T-... | 07/06/2010 |
| 7705022 | IDO inhibitors and methods of use thereof Novel indoleamine 2,3-dioxygenase (IDO) inhibitors, compositions comprising the same, and methods of use thereof are disclosed. ... | 04/27/2010 |
| 7704736 | Compositions for the derivation of germ cells from stem cells and methods of use thereof Compositions and methods are provided for the reproducible derivation of germ cells and oocytes and spermatogonia therefrom. Also provide are methods of use of the same in reproductive and therapeutic cloning protocols. ... | 04/27/2010 |
| 7662551 | Synthesis of hybrid polynucleotide molecules using single-stranded polynucleotide molecules A method to make libraries of hybrid polynucleotide molecules of two parental polynucleotide molecules utilizing single-stranded DNA was invented. Example of the method comprises several steps: (i) preparation of two single-stranded polynucleotide molecules comprisi... | 02/16/2010 |
| PP20694 | plant named ‘Red Dragon’ A new and distinct cultivar of Corylus plant named ‘Red Dragon,’ characterized by its outwardly spreading plant habit, twisting stems, rich dark burgundy-colored leaves, burgundy color of the catkins and leaf buds, and resistance to eastern filbert blight... | 02/02/2010 |
| 7629122 | Methods and compositions for the diagnosis of Cornelia de Lange Syndrome Compositions and methods for the diagnosis of Cornelia de Lange Syndrome are disclosed. ... | 12/08/2009 |
| 7582062 | Methods of neural centre location and electrode placement in the central nervous system A method of locating the position of a selected neural centre in the central nervous system of an animal is disclosed. The method comprises the steps of (a) stimulating neurons at a first central nervous system position; (b) measuring the field potential evoked at a... | 09/01/2009 |
| 7572762 | Materials and methods relating to the induction of apoptosis in target cells Compositions, methods, uses and assemblages for the preferential induction of cell division cycle arrest and/or apoptosis, in a first population of cells compared to a second population of cells employ either: (i) an opioid or opioid-like agent and an NF-κB activat... | 08/11/2009 |
| 7553659 | CHD5 encoding nucleic acids, polypeptides, antibodies and methods of use thereof Nucleic acid sequences encoding chromodomain helicase DNA-binding (CHD) proteins, CHD proteins, and antibodies thereto and methods of use thereof are disclosed. ... | 06/30/2009 |
| 7521432 | Compositions and methods for identifying agents which regulate chromosomal stability, gene activation and aging Novel compositions and methods are provided for identifying agents which affect chromosomal stability and aging. ... | 04/21/2009 |
| 7521230 | Nucleic acid encoding a Brain Derived Tau Kinase polypeptide and methods of use thereof The present invention provides materials and methods for treating Alzheimer's disease and other tau related neurodegenerative disorders. A tau kinase, Brain Derived Tau Kinase (BDTK) is provided. BDTK can cause hyperphosphorylation of tau protein, which leads to for... | 04/21/2009 |
| 7491868 | Mannose binding lectin knock-out mice and methods of use thereof A transgenic non-human animal with alterations in the MBL gene is prepared by introduction of a gene encoding an altered MBL protein into a host non-human animal. Methods for using transgenic mice so generated to screen for agents that effect MBL's cellular modulati... | 02/17/2009 |
| 7482137 | Hybrid glycosylated products and their production and use The present invention relates to hybrid glycosylated products, and in particular, to natural products such as polyketides and glycopeptides, and to processes for their preparation. The invention is particularly concerned with recombinant cells in which a cloned micr... | 01/27/2009 |
| 7465784 | Antimicrobial peptides and methods of identifying the same Antimicrobial peptides and methods of identifying the same are provided. ... | 12/16/2008 |
| 7432083 | Method for in vitro molecular evolution of protein function The present invention relates to a method for in vitro creation of molecular libraries evolution of protein function. Particularly, it relates to variability and modification of protein function by shuffling polynucleotide sequence segments. A protein of desired cha... | 10/07/2008 |
| 7416840 | Replication of hepatitis C virus in non-hepatic epithelial and mouse hepatic cells Cells and cell lines which replicate HCV of non-hepatic human and non human origin are disclosed. Also provided are methods of using such cells and cell lines to identify anti-HCV agents for the treatment of HCV infection. ... | 08/26/2008 |
| 7408028 | Peptides, antibodies thereto, and their use in treatment of central nervous system, damage The application provides peptides that interact with the inhibitory domains of the myelin proteins Nogo, TNR, and MAG. These may be used in the treatment of CNS damage, and for the development of further treatments. Also provided are methods and materials for immuni... | 08/05/2008 |
| 7405292 | Cellular genes regulated by HIV-1 infection and methods of use thereof This invention provides cellular gene products which have anti-apoptotic activity in HIV-1 infected cells and provides agents for the inhibition of the cellular gene products. ... | 07/29/2008 |
| 7402404 | Assay method for measurement of net cholesterol flux The present invention relates to an assay for determining net cholesterol flux from lipid loaded cells in the presence of an acceptor (e.g., serum). The present invention also relates to a method for evaluating efficacy of a therapeutic agent for stimulating or inhi... | 07/22/2008 |
| 7390895 | Production of polyketides and other natural products The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these... | 06/24/2008 |
| 7381546 | Polyketides and their synthesis and use The rapamycin gene cluster is an example of a gene cluster which includes a gene (rapL) leading to the formation of a precursor compound (pipecolic acid, in this case) which is required for inclusion in the larger product (rapamycin) produced by the enzymes encoded ... | 06/03/2008 |
| 7358336 | Fluorescent protein from mcFP encoding nucleic acids, polypeptides and antibodies immunologically specific therefore are disclosed. Methods of use thereof are also provided. ... | 04/15/2008 |
| 7358087 | Compositions and methods for enhancing immune responses mediated by antigen-presenting cells Molecular adjuvants are disclosed comprising an antigen presenting cell-targeting ligand linked to an immunogen. In particular, these molecular adjuvants are employed in compositions designed to deliver the specific immunogen to antigen presenting cells and simultan... | 04/15/2008 |
| 7339031 | Modified bouganin proteins, cytotoxins and methods and uses thereof The invention provides modified forms of bouganin protein having biological activity and a reduced propensity to activate human T cells as compared to the non-modified bouganin protein. The invention also provides T-cell epitope peptides of bouganin, and modified T-... | 03/04/2008 |
| 7312026 | MRP-related ABC transporter encoding nucleic acids and methods of use thereof Novel human MOAT genes and their encoded proteins are provided herein. The MRP-related ABC transporters encoded by the disclosed nucleic acid sequences play a pivotal role in the efflux of pharmacologically beneficial reagents from tumor cells. MOAT genes and their ... | 12/25/2007 |
| 7309688 | Topical anti-cancer compositions and methods of use thereof Described are skin-care compositions containing non denatured soy products and optionally other anti-cancer or anti-aging agents. The compositions can be applied topically to reduce the risk of UV-induced cutaneous tumors. ... | 12/18/2007 |
| 7300942 | Production of polyketides and other natural products The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these... | 11/27/2007 |
| 7291606 | Compositions and methods for identifying agents which regulate chromosomal stability, gene activation and aging Novel compositions and methods are provided for identifying agents which affect chromosomal stability and aging. ... | 11/06/2007 |
| 7291492 | Histone deacetylase 9 The identification and cloning of histone deacetylase 9 (HDAC9) is disclosed, and in particular full length HCAC9 polypeptides and HDAC9 polypeptides which have deacetylase activity, and to nucleic acid molecules encoding these polypeptides. The uses of these polype... | 11/06/2007 |
| 7288644 | Cellular genes regulated by HIV-1 infection and methods of use thereof This invention provides cellular gene products which have anti-apoptotic activity in HIV-1 infected cells. Other pro-apoptotic genes and methods of use thereof are also disclosed. The compositions of the invention may be used to advantage to develop novel therapeuti... | 10/30/2007 |
| 7282489 | Compositions and methods for performing reverse gene therapy The invention relates to compositions and methods for reverse gene therapy, wherein a gene therapy vector encoding a gene product (e.g. a protein) which is usually only expressed in cells of an abnormal tissue is delivered to a cell of an animal afflicted with a dis... | 10/16/2007 |
| 7282334 | Method for in vitro molecular evolution of protein function The invention provides a method for generating a polynucleotide sequence or population of sequences from parent single stranded polynucleotide sequences encoding one or more protein motifs, comprising the steps of a) providing sing... | 10/16/2007 |
| 7271278 | Application of chromium-amino acid complexes in the treatment of diabetes and other diseases Compositions comprising chromium (III) 1:3 complexes comprising amino acids and methods of use thereof are provided. ... | 09/18/2007 |
| 7198922 | Polyketides and their synthesis A polyketide synthase (“PKS”) of Type I is a complex multienzyme including a loading domain linked to a multiplicity of extension domains. The first extension module receives an acyl starter unit from the loading domain and each extension module adds a further k... | 04/03/2007 |
