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| Number | Title | Issue Date |
| 5151423 | Heterocyclic n-oxide derivatives of substituted benzo[5,6]cycloheptapyridines, compositions and methods of use Heterocyclic N-oxide derivatives of substituted benzo[5,6]cycloheptapyridines, and pharmaceutically acceptable salts and solvates thereof are disclosed, which possess anti-allergic and anti-inflammatory activity. Methods for preparing and using the compou... | 09/29/1992 |
| 5089496 | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies Derivatives of benzo[5,6]cyclohepta pyridine, and pharmaceutically acceptable salts and solvates thereof are disclosed, which possess anti-allergic and anti-inflammatory activity. Methods for preparing and using the compounds are also described.... | 02/18/1992 |
| 5023265 | Substituted 1-H-pyrrolopyridine-3-carboxamides Substituted 1H-pyrrolopyridine-3-carboxamides and their use in pharmaceutical compositions and in treating inflammation are disclosed.... | 06/11/1991 |
| 4871538 | Insoluble copper-alpha interferon complex An insoluble copper-alpha interferon complex useful for injectable pharmaceutical compositions is disclosed.... | 10/03/1989 |
| 4866061 | Aryl-substituted naphthyridine and pyridopyrazine derivatives Aryl-substituted naphthyridines and pyridopyrazines are disclosed which are useful in treating allergic reactions, inflammation, peptic ulcers and/or hyperproliferative skin disease. Pharmaceutical compositions and methods of treatment employing such comp... | 09/12/1989 |
| 4863931 | Antihistaminic fluoro substituted benzocycloheptapyridines Certain benzocycloheptapyridine compounds with fluorine substitution across the exocyclic double bond are prepared and they are useful as antihistaminic agents.... | 09/05/1989 |
| 4859669 | Antiinflammatory and anti-hyperproliferative naphthyridin-4-ones Tricyclic pyrrolo naphthyridinone compounds and tricyclic pyrrolo pyrido pyrazines are disclosed, which are useful as antiinflammatory and anti-hyperproliferative agents.... | 08/22/1989 |
| 4857301 | Sulfonamide compounds, compositions and method of use Certain substituted sulfonamide quinolines and isoquinolines are disclosed having anti-allergic activity. A preferred use is for the treatment of chronic obstructive lung disease, and in particular, asthma.... | 08/15/1989 |
| 4853218 | Zinc-protamine-alpha interferon complex An insoluble zinc-protamine alpha interferon complex useful as an injectable sustained release dosage form for administering alpha interferon is disclosed.... | 08/01/1989 |
| 4853476 | Phosphorus containing compounds as inhibitors of enkephalinases Novel phosphorous containing compounds and compositions containing said compounds inhibit the actions of enkephalinases in mammals. Methods for preparing said compounds and compositions and methods for their use to elicit analgesia and treat mental disord... | 08/01/1989 |
| 4851220 | Stable oleaginous gel Stable oleaginous gels comprising water-in-oil emulsions in gels are disclosed. Sustained release injectable pharmaceutical formulations comprising such oleaginous gels are also disclosed, in particular such formulations comprising interferon.... | 07/25/1989 |
| 4847377 | Substituted-2,3-dihydro-6-substituted-pyrimido[2,1-F]-purine- 4,8(1H,9H)-diones Substituted 2,3-dihydro-6-substituted-pyrimido[2,1-f]purine-4,8(1H, 9H)-diones, their tautomers and salts, are disclosed for use as antihyperproliferative skin disease agents. Methods for their preparation and use are described.... | 07/11/1989 |
| 4840772 | Antiglaucoma compositions and methods The present invention relates to ophthalmological pharmaceutical compositions comprising (benzothiadiazine, benzamide and benzenesulfonyl)phenyl-substituted carboxyalkyl dipeptide compounds and to methods for using said composition in reducing intraocular... | 06/20/1989 |
| 4834980 | Transdermal delivery of azatidine Compositions for the transdermal delivery of azatadine and the use of such compositions in the treatment of allergic reactions are disclosed.... | 05/30/1989 |
| 4831123 | Process for preparing netilmicin A high yielding process for converting 3,2',6'-tri-N-acetyl sisomicin to netilmicin comprising the step of silylating the starting material at the 5,2' positions, and optionally at the 4' position, converting the 1-amino substituent to a 1-N-imino substit... | 05/16/1989 |
| 4831193 | Synthesis of 3-amino-2-methylbenzotrifluoride This invention relates to a novel process for preparing 3-amino-2-methylbenzotrifluoride from benzotrifluoride. The process comprises nitrating benzotrifluoride to form 3-nitrobenzotrifluoride, reacting this compound with trimethyl sulphoxonium halide to ... | 05/16/1989 |
| 4826853 | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta( 1,2-B)pyridines and compositions and methods of use Derivatives of 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, and pharmaceutically acceptable salts and solvates thereof are disclosed, which possess anti-allergic and anti-inflammatory activity. Methods for preparing and ... | 05/02/1989 |
| 4824676 | Physiological means of enhancing transdermal delivery of drugs A method of enhancing transdermal delivery of a pharmaceutically active drug from a transdermal delivery system as well as a transdermal delivery system capable of providing a desirable flow interface between the delivery system and the skin surface are d... | 04/25/1989 |
| 4818541 | Transdermal delivery of enantiomers of phenylpropanolamine A method of inducing anorexia or nasal decongestion comprising transdermally administering an enantiomer of phenylpropanolamine is disclosed.... | 04/04/1989 |
| 4818749 | Carboxyalkyl dipeptides and medical use thereof in treating hypertension and congestive heart failure The present invention relates to carboxyalkyl dipeptides which are inhibitors of angiotensin-converting enzyme and are useful as antihypertensive agents and in the treatment of congestive heart failure. The compounds of the present invention are compounds of t... | 04/04/1989 |
| 4816458 | Method of treating hyperploliferative skin disease with substituted-2,3-dihydro-6-substituted -pyrimido[2,1]-purine-4,8(1H,9H)diones Substituted 2,3-dihydro-6-substituted-pyrimido[2,1-f]purine-4,8(1H,9H)-diones, their tautomers and salts, are disclosed for use as antihyperproliferative skin disease agents. Methods for their preparation and use are described.... | 03/28/1989 |
| 4810708 | Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives Novel polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives are disclosed which are useful for treating allergic reactions, inflammation, peptic ulcers, hypertension, and hyperproliferative skin diseases and for suppressing the immune respo... | 03/07/1989 |
| 4808573 | Carboxyalkyl dipeptides and anti-hypertensive use thereof The present invention relates to carboxyalkyl dipeptides which are inhibitors of angiotensin-converting enzyme and are useful as antihypertensive agents and in the treatment of congestive heart failure. The compounds of the present invention are compounds of t... | 02/28/1989 |
| 4803206 | Antihypertensive acylpyrazines Acylpyrazines useful in the treatment of hypertension are disclosed.... | 02/07/1989 |
| 4801609 | Mercapto-acylamino acid antihypertensives Novel mercapto-acylamino acids useful in the treatment of hypertension and combinations of mercapto-acylamino acids and atrial natriuretic peptides useful for treating hypertension are disclosed.... | 01/31/1989 |
| 4801589 | Method for suppressing the immune response A method and composition for suppressing the immune response are disclosed which employ an immunosuppressing effective amount of certain substituted quinoline, naphthyridine and pyrido-pyrazine derivatives.... | 01/31/1989 |
| 4788211 | Antifungal compound and AFC complex produced from actinomadura SCC 1838 The invention relates to an antifungal compound of the following structural formula ##STR1## which is isolated from the AFC complex elaborated by the microorganism Actinomadura sp: nov SCC 1838, ATCC 53656.... | 11/29/1988 |
| 4783444 | Antiglaucoma compositions and methods The present invention relates to ophthalmological pharmaceutical compositions comprising (benzothiadiazine, benzamide and benzenesulfonyl)phenyl-substituted carboxyalkyl dipeptide compounds and to methods for using said composition in reducing intraocular... | 11/08/1988 |
| 4781919 | Sustained release dosage form Sustained release dosage forms are made of saponified starch-acrylonitrile graft copolymers and an active ingredient.... | 11/01/1988 |
| 4782082 | Method for treating allergic reactions with Forskolin Forskolin and its disclosed derivatives are useful as antiallergic agents. Certain of the derivatives are novel.... | 11/01/1988 |
| 4778795 | Carboxyalkyl dipeptides as antiglaucoma agents Methods and pharmaceutical compositions are disclosed for reducing intraocular pressure. The methods and compositions employ an active ingredient which comprises certain benzothiadiazinyl and quinazolinyl substituted carboxyalkyl dipeptides wherein the be... | 10/18/1988 |
| 4777050 | Controlled-release dosage form comprising acetaminophen, pseudoephedrine and dexbrompheniramine The invention relates to a controlled release dosage form comprising three actives: acetaminophen, pseudoephedrine and dexbrompheniramine.... | 10/11/1988 |
| 4775524 | Method of treating hyperproliferative skin disease with substituted heterospiro pyridine derivatives A method of treating a mammal for hyperproliferative skin disease is disclosed, using substituted heterospiro pyridine derivatives.... | 10/04/1988 |
| 4775686 | Naphthyridine derivatives and method for treating allergic reactions 1-Substituted naphthyridines and pyrido-pyrazines are disclosed which are useful in treating allergic reactions, inflammation, peptic ulcers and hyperproliferative skin diseases and in suppressing the immune response in mammals. Pharmaceutical composition... | 10/04/1988 |
| 4775529 | Steroid lotion An improved lotion formulation for the topical administration of corticosteroids in a hydro-alcoholic base containing propylene glycol.... | 10/04/1988 |
| 4765978 | Novel vaginal suppository An antifungal vaginal suppository is disclosed comprising cis-2-(1H-imidazolylmethyl)-3-(2',6'-difluorobenzyloxy)-2,3-dihydro-5-fluo robenzo[b]thiophene in a suppository base containing biocompatible polymers, a surfactant and an absorbent in a vegetable o... | 08/23/1988 |
| 4764381 | Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol Pharmaceutical preparations comprised of a pharmaceutically active ingredient and a carrier which comprises a percutaneous penetration enhancer comprised of 2-ethyl-1, 3-hexanediol alone or in combination with oleic acid is disclosed. The 2-ethyl-1, 3-hex... | 08/16/1988 |
| 4762827 | (5R,6S,8R )-6-(1-hydroxyethyl)-2-(3R-pyrrolidin-2-one-3-yl)thiopenem-3-carboxylic acid There is disclosed the compound (5R,6S,8R)-6-(1-hydroxyethyl)-2-(3R-pyrrolidin-2-one-3-yl)thiopenem-3-carb oxylic acid, and pharmaceutically acceptable salts and esters as well as compositions containing them and methods for their use.... | 08/09/1988 |
| 4760029 | Assay for D-1 antagonistic activity of neuroleptic drugs A method, reagents, and kit for determining the levels of D-1 receptor antagonistic activity of neuroleptic drugs. The method correlates competition between analyte and tritiated R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol ... | 07/26/1988 |
| 4760073 | Aryl-substituted naphthyridine and pyridopyrazine derivatives, useful as anti-allergic agents Aryl-substituted naphthyridines and pyridopyrazines are disclosed which are useful in treating allergic reactions, inflammation, peptic ulcers and/or hyperproliferative skin disease. Pharmaceutical compositions and methods of treatment employing such comp... | 07/26/1988 |
