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Attorney: Needle & Rosenberg


Number of patents: 274
Last date: December 25, 2007

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NumberTitleIssue Date
D558394Surgical site marking apparatus
12/25/2007
7250152Supercritical fluids processing: preparation of protein microparticles and their stablilisation
A process for the co-precipitation of a substance with a stabilizer therefor, by a gas anti solvent process comprising introducing into a particle formation vessel a supercritical fluid pure or mixed with a modifier; and a solution comprising said substance and said...
07/31/2007
7153684Pluripotential embryonic stem cells and methods of making same
The present invention provides a non-mouse, including human, pluripotential embryonic stem cell which can: (a) be maintained on feeder layers for at least 20 passages; and (b) give rise to embryoid bodies and multi...
12/26/2006
7041441Phage display of intact domains at high copy number
Disclosed is a phage display system in which the molecules to be displayed (i.e., molecules of interest) are bound to dispensable capsid polypeptides such as SOC (small outer capsid) and HOC (highly antigenic outer capsid) polypeptides that are, in turn, bound to a ...
05/09/2006
7041480Generation of single-strand circular DNA from linear self-annealing segments
The present invention provides a method for the rapid simultaneous production of a plurality of single-stranded DNA circles having a predetermined size and nucleotide sequence using pre-designed hairpin oligonucleotides containing complementary sequences for directi...
05/09/2006
6855314AAV5 vector for transducing brain cells and lung cells
The present invention provides methods of delivering nucleic acids to specific regions, tissues and cell types of the CNS. More particularly the invention provides methods of delivering nucleic acids to cells of the CNS such as cerebellar cells and ependymal cells. ...
02/15/2005
6795207System and method for controlling print jobs in host based printers
A system and method for controlling a print job in a printer, such as canceling the print job held in the printer. The system includes a printer having a processor that receives print jobs, including one or more print data swaths, from one or more host computers, an...
09/21/2004
6660488Antibodies for the alpha platelet-derived growth factor receptor
Discoveries are disclosed that show particular aspects of recombinant DNA technology can be used successfully to produce a hitherto unknown type of human Platelet-Derived Growth Factor (PDGF) receptor protein free of other PDGF receptors. These proteins c...
12/09/2003
6653532Methods for influencing the flowering behavior of plants by enhancing the saccharose-cleaving activity in the apical meristem
The invention provides compositions and methods enabling the provision of plants showing an altered flowering behavior, and, particularly, genetically modified plants showing an early or delayed flower formation when compared to not correspondingly modifi...
11/25/2003
6294331Methods for assessing genetic and phenotypic markers by simultaneous multicolor visualization of chromogenic dyes using brightfield microscopy and spectral imaging
The present invention is directed to an improved method for detecting a genetic marker in a biological sample comprising contacting the biological sample with a nucleic acid probe linked to a detectable moiety, whereby the detectable moiety can be detecte...
09/25/2001
6274611Methods and compositions for inhibition of viral replication
The present invention comprises methods and compositions for treating viral infection by inhibiting the activity of host cellular enzymes. More specifically, methods and compositions comprising casein kinase II inhibitors and various related compounds suc...
08/14/2001
6183434Multiple mechanical microporation of skin or mucosa
A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagne...
02/06/2001
6141433System and method for segmenting image regions from a scene likely to represent particular objects in the scene
A system and method for extracting image information from a video frame for regions of a the video frame that likely are objects of interest in a scene. An initial region set is generated by comparing luminance image information and color image informatio...
10/31/2000
6122399Pattern recognition constraint network
The present invention provides a novel pattern recognition system that may be used to determine the likelihood that an unknown item belongs to a predefined class. The present invention provides improved functionality over prior art systems in that both fe...
09/19/2000
6064401User interface controls for adjusting the display of multi-dimensional graphical plots
The present invention provides a user interface mechanism for adjusting the view of two-dimensional graphical plots so users can make compromises between the amount of detail that is presented on an electronic display and the range of data that can be wit...
05/16/2000
6061088System and method for multi-resolution background adaptation
A multi-resolution background adaptation system and method wherein image information for a video frame is analyzed to update a background image in as great a resolution as possible. The video frame is partitioned into a plurality of cell levels, each cell...
05/09/2000
6054132Purified vacuolating toxin from Helicobacter pylori and methods to use same
This invention relates to a purified Helicobacter pylori vacuolating toxin and methods to use this toxin to produce protective antibodies against H. pylori infection. Antiserum to this antigen can be used to detect the toxin. Methods to detect anti-toxin ...
04/25/2000
6004354IceA gene and related methods
A purified IceA protein of Helicobacter pylori is provided. The protein is expressed as either an IceA 1 or an IceA 2 variant. A purified polypeptide fragment of the IceA protein is also provided. An antigenic fragment of IceA is provided. An isolated nuc...
12/21/1999
6002395System and method for building, testing and integrating a graphical touch user interface
A builder, tester, and runtime integration system and method for a graphical touch user interface, such as a point-of-sale (POS) touch screen interface system, is provided. The system and method may include a builder tool to create and modify the graphica...
12/14/1999
5965861Method and apparatus for enhancing security in a self-service checkout terminal
A system and method of providing security during operation of a self-service checkout terminal by detecting movement of an item within a scanner zone associated with the terminal with a video system and generating a scanning-attempt control signal in resp...
10/12/1999
5942252Method for delivering bioactive agents into and through the mucosally-associated lymphoid tissues and controlling their release
A method, and compositions for use therein capable, of delivering a bioactive agent to an animal entailing the steps of encapsulating effective amounts of the agent in a biocompatible excipient to form microcapsules having a size less than approximately t...
08/24/1999
5937084Knowledge-based document analysis system
A knowledge-based document analysis system and method for identifying and decomposing constrained and unconstrained images of documents is disclosed. Low level features are extracted within bitonal and grayscale images. Low level features are passed to a ...
08/10/1999
5904650Ball joint retractor
A retractor comprising a longitudinally-extending blade having a top surface, a bottom surface, a distal end, and an opposed proximal end, a receptacle adapted to support a predetermined surgical instrument and disposed adjacent the bottom surface of the ...
05/18/1999
5876943Helicobacter TagA gene fusion protein
The present invention provides an isolated nucleic acid encoding an approximately 120-128 kilodalton antigen of Helicobacter pylori, or an antigenic fragment thereof, wherein the antigen is associated with peptic ulceration. The present invention also pro...
03/02/1999
5845694Horizontal venetian blind
A venetian blind with individually adjustable slats. Each slat has multi-layered decorative slat extensions mounted in a slat extension holder. The individual slat extensions are mounted directly above one another in the unextended position. Each slat can...
12/08/1998
5832496System and method for performing intelligent analysis of a computer database
A system and method for performing intelligent analysis and for generating a report for a user which allows the user to make decisions, without requiring the user to understand or interpret data itself. A database computer includes a database containing t...
11/03/1998
5807746Method for importing biologically active molecules into cells
The present invention relates to the delivery of biologically active molecules, such as peptides, nucleic acids and therapeutic agents, into the interior of cells by administering to the cells a complex comprising the molecule linked to an importation com...
09/15/1998
5803884Abdominal exercise machine with curved back support
The present invention provides an abdominal exercise apparatus having an adjustable curved back support. The machine is used to produce an exercise that isolates, stretches, works, and develops the muscles of the abdominal wall (abs). The machine position...
09/08/1998
5734336Collision avoidance system
A system for preventing collisions between a vehicle and other objects, the vehicle having a blind side, an opposite driver side, a from end and an opposite rear end, has side ranging capability that determines the distance from the blind side of the vehi...
03/31/1998
5707974Method of synthesis of 2-O-desulfated heparin and use thereof for inhibition of elastase and cathepsin G
A method and medicament for the inhibition of neutrophil elastase and cathepsin G in mammals comprising administering a treatment effective amount of 2-O-desulfated heparin to a mammal in need thereof. The medicament preferably is administered by aerosoli...
01/13/1998
5672162Closure delivery system
A system for the introduction of a fluid to an internal volume of a suction canister. The canister is provided with sidewalls and a top, the latter possessing a circular opening and cylindrical duct. A fluid-containing vessel is provided having a tubular ...
09/30/1997
5668118Method of synthesis of 2-O-desulfated Heparin and use thereof for inhibition of elastase and Cathepspin G
A method and medicament for the inhibition of neutrophil elastase and cathepsin G in mammals comprising administering a treatment effective amount of 2-O-desulfated heparin to a mammal in need thereof. The medicament preferably is administered by aerosoli...
09/16/1997
5665345Methods of inhibiting viral replication using IL-10
The present invention provides a method of inhibiting the replication of human immunodeficiency virus in cells which are infected with HIV comprising administering to the cells a replication inhibiting amount of interleukin-10. Also provided is a parenter...
09/09/1997
5663477Hydrocarbon disposal method
A method for the disposal of a hydrocarbon. The hydrocarbon is intimately mixed with an aqueous solution. The aqueous solution includes a hydrophilic monomer, a cross-linking agent and an emulsifier. The emulsion is then solidified for disposal through th...
09/02/1997
5564861Thermal method of in-situ soil treatment
A thermal method of in-situ soil treatment using a charge of combustible substrate placed within the area to be treated and combusted with the use of oxidizer resulting in solid products and generating no gases. The substrate can be a metal, such as alumi...
10/15/1996
5538361Apparatus for forming a trench
A system for forming a single-walled trench comprising a pair of frame members, each having a horizontal section and a section depending from the horizontal section; a collapsing pair of wall pans having sidewalls interior to the depending portion of the ...
07/23/1996
5536658Chondroitinase attenuated Edwardsiella ictaluri and a vaccine for prevention of enteric septicemia (es) in fish
The present invention provides a chondroitinase attenuated Edwardsiella ictaluri bacteria. Further, this invention provides a vaccine comprising a protective amount of a chondroitinase attenuated strain of Edwardsiella ictduri bacteria and a method for pr...
07/16/1996
5531336Device for stabilizing containers in a gravity feed tray
Abutment stops for adapting a gravity-fed shelving unit of a type commonly used in refrigerated displays to accommodate bottles having a contoured profile and a higher center of gravity than common cylindrical cans is disclosed. One such abutment stop inc...
07/02/1996
5527685Antibodies to macrophage stimulating protein, bioassay and immunopurification method
A method of purifying macrophage stimulating protein. Antibodies to macrophage stimulating protein and a bioassay for the detection of antibodies which bind macrophage stimulating protein....
06/18/1996
5526820Catheter with integral pressure sensor
The invention provides a pressure sensing catheter having a housing with a body portion adapted to be hand-held, a pressure sensing means situated within the catheter housing and an elongated catheter tube with a lumen extending longitudinally therethroug...
06/18/1996
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