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| Number | Title | Issue Date |
| 7981433 | Targeted delivery of botulinum toxin to the sphenopalatine ganglion Botulinum toxin, among other presynaptic neurotoxins is used for the treatment and prevention of migraine and other headaches associated with vascular disorders. Presynaptic neurotoxins are delivered focally, targeting the sphenopalatine ganglion. Exemplary delivery... | 07/19/2011 |
| 7846456 | Methods for breast treatment A method for treating a mammary gland disorder, including hyperplastic, hypertonic, cystic and/or neoplastic mammary gland tissue by local administration of a botulinum toxin to or to the vicinity of the afflicted breast tissue. ... | 12/07/2010 |
| 7824694 | Methods for enhancing therapeutic effects of a neurotoxin The present invention relates to methods for enhancing the therapeutic effects of a neurotoxin, e.g., a botulinum toxin, where the methods comprise a “wash-down” (e.g., a decreased intake) of a current pain medication and an administration of a neurotoxin... | 11/02/2010 |
| 7820183 | Botulinum toxin in treatment of clubfoot relapse Botulinum toxin, or other neuromuscular inhibitors, injected into the lower leg muscle of infants, less than a year old, with idiopathic clubfoot is shown to be an effective therapy in correcting this physical deformity. Following a protocol of manipulations, castin... | 10/26/2010 |
| 7794386 | Methods for facilitating weight loss The present invention provides methods for facilitating weight loss in a patient. In some embodiments, the methods comprise the steps of locally administering a botulinum toxin to a stomach tissue of an obese patient, and deploying a gastric band around the stomach ... | 09/14/2010 |
| 7780967 | Reduced toxicity Clostridial toxin pharmaceutical compositions A Clostridial toxin pharmaceutical composition comprising a Clostridial toxin, such as a botulinum toxin and a polysaccharide, such as a hydroxyethyl starch, wherein the pharmaceutical composition has a reduced toxicity. The Clostridial toxin pharmaceutical composit... | 08/24/2010 |
| 7758873 | Polysaccharide containing botulinum toxin pharmaceutical compositions and uses thereof This invention relates to the use of a composition comprising a polysaccharide and a botulinum toxin for reducing a skin wrinkle. In some embodiments, the polysaccharide comprises disaccharides. In some embodiments, the average molecular weight of a disaccharide uni... | 07/20/2010 |
| 7758871 | Transdermal botulinum toxin administration Pharmaceutical compositions for transdermal administration of neurotoxins to a patient include a neurotoxin, such as a botulinum toxin, and an enhancing agent that facilitates absorption of the neurotoxin through the skin of the patient and does not eliminate the bi... | 07/20/2010 |
| 7749515 | Targeted delivery of botulinum toxin to the sphenopalatine ganglion Botulinum toxin, among other presynaptic neurotoxins is used for the treatment and prevention of migraine and other headaches associated with vascular disorders. Presynaptic neurotoxins are delivered focally, targeting the sphenopalatine ganglion. Exemplary delivery... | 07/06/2010 |
| 7731977 | Use of a botulinum neurotoxin to alleviate various disorders Methods for treating obsessions and compulsions by local administration of a Clostridial toxin. The obsessions or compulsions can be eye poking, body rocking, finger biting, counting, checking and related disorders treated by low dose, intramuscular administration o... | 06/08/2010 |
| 7704524 | Transdermal botulinum toxin administration for the treatment of spastic muscle pain Pharmaceutical compositions for transdermal administration of neurotoxins to a patient include a neurotoxin, such as a botulinum toxin, and an enhancing agent that facilitates absorption of the neurotoxin through the skin of the patient and does not eliminate the bi... | 04/27/2010 |
| 7704511 | Methods for treating headache The present invention features methods for selecting a patient with an enhanced therapeutic response to a botulinum toxin treatment of a headache. In some embodiments, the methods comprise the step of identifying a patient who is not using a prophylactic head... | 04/27/2010 |
| 7691381 | Stabilized biodegradable neurotoxin implants Biodegradable neurotoxin implants and methods of making and using such implants are provided. Biodegradable neurotoxin implants include a neurotoxin, a biodegradable polymer component, and an acidity regulating component. The biodegradable polymer component is effec... | 04/06/2010 |
| 7655244 | Targeted delivery of botulinum toxin for the treatment and prevention of trigeminal autonomic cephalgias, migraine and vascular conditions Botulinum toxin, among other presynaptic neurotoxins is used for the treatment and prevention of migraine and other headaches associated with vascular disorders. Presynaptic neurotoxins are delivered focally, targeting the nerve endings of the trigeminal nerve, the ... | 02/02/2010 |
| 7579010 | Botulinum toxin pharmaceutical compositions with a recombinant human serum albumin A botulinum toxin pharmaceutical formulation free of animal derived proteins, comprising a botulinum toxin and a recombinant albumin, suitable for therapeutic administration to a human patient, and methods for treating patients with various diseases and afflictions ... | 08/25/2009 |
| 7560251 | Media for bacterium Animal product free (APF) media and processes for the culture and fermentation of botulinum toxin producing Clostridium botulinum bacteria. The botulinum toxin obtained can be used for formulating and compounding botulinum toxin pharmaceutical compositions. T... | 07/14/2009 |
| 7501130 | Methods for treating myofascial pain A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount of a neurotoxin selected from a group consisting of Botulinum toxin ty... | 03/10/2009 |
| 7494654 | Compositions and methods for treating cardiovascular conditions with botulinum toxin The present invention provides for methods of treating cardiovascular diseases in a mammal. The methods include a step of administering an effective amount of a botulinum toxin directly to a blood vessel of a mammal thereby treating a cardiovascular disease. ... | 02/24/2009 |
| 7485624 | Method for treating cardiac muscle disorders Methods for treating cardiac muscle disorders, such as cardiac arrhythmias, by administration of a neurotoxin to cardiac muscle are disclosed. Bradycardia can be alleviated for several months by a single intrapericardial or intracardiac injection or infusion of a bo... | 02/03/2009 |
| 7479281 | Botulinum toxin for treating postherpetic neuralgia Methods for treating conditions in an animal or human subject. The conditions may be pain, skeletal muscle conditions, smooth muscle conditions, glandular conditions and cosmetic conditions. The methods comprise the step of administering a Clostridium neuroto... | 01/20/2009 |
| 7468189 | Neuropathic pain treatment method Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin. ... | 12/23/2008 |
| 7468188 | Multi-step therapy for injured muscles Methods for treating an injured muscle by local administration of a neurotoxin, such as a botulinum toxin, to promote healing and/or to reduce the pain associated with an injured muscle. ... | 12/23/2008 |
| 7465458 | Methods for treating eye disorders The present invention provides methods of treating an eye disorder. The methods comprise a step of locally administering a Clostridial toxin to the eye of a patient to treat the disorder. The eye disorder may be associated with an inflammation of the eye, inc... | 12/16/2008 |
| 7452697 | Chromatographic method and system for purifying a botulinum toxin Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium. ... | 11/18/2008 |
| 7445914 | Animal product free media and processes for obtaining a botulinum toxin Media and processes for the fermentation of Clostridium botulinum and obtaining a botulinum toxin for use in formulating botulinum toxin pharmaceutical compositions. The growth media can contain significantly reduced levels of meat or dairy by-p... | 11/04/2008 |
| 7438921 | Buttock deformity treatment Methods for treating a buttock deformity or for preventing development of a buttock deformity by local administration of a Clostridial toxin, such as a botulinum neurotoxin, to a buttock deformity or to the vicinity of a buttock deformity. ... | 10/21/2008 |
| 7429386 | Stretch mark treatment Methods for treating stretch marks by local administration of a Clostridial toxin, such as a botulinum toxin, to a patient with a stretch mark. ... | 09/30/2008 |
| 7422753 | Methods for treating trichotillomania Methods for treating trichotillomania by local administration of a Clostridial toxin. The local administration can be by intramuscular, transdermal, intradermal or subdermal administration of a low dose of botulinum toxin. ... | 09/09/2008 |
| 7419675 | Method for treating peritoneal adhesions Methods for treating peritoneal adhesions by local administration of a Clostridial toxin, such as a botulinum toxin, to a patient with a peritoneal adhesion. ... | 09/02/2008 |
| 7396535 | Therapy for obsessive compulsive head banging Methods for treating a head banging disorder by local administration of a Clostridial toxin. The local administration can be by intramuscular, transdermal, intradermal or subdermal administration of a low dose of botulinum toxin. ... | 07/08/2008 |
| 7393538 | Clostridial toxin treatment for dermatillomania Methods for treating a dermatillomania by local administration of a Clostridial toxin. The local administration can be by intramuscular, transdermal, intradermal or subdermal administration of a low dose of botulinum toxin. ... | 07/01/2008 |
| 7393537 | Botulinum toxin for treatment of obsessive compulsive finger biting disorder Methods for treating obsessions and compulsions by local administration of a Clostridial toxin. The obsessions or compulsions can be eye poking, body rocking, finger biting, counting, checking and related disorders treated by low dose, intramuscular administration o... | 07/01/2008 |
| 7384918 | Botulinum toxin for treating muscle contracture The invention provides for the use of a botulinum toxin to treat contracture, such as muscle contracture, in patients by transdermal administration of the botulinum toxin. ... | 06/10/2008 |
| 7381700 | Methods for treating pain associated with arthritis A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount of a neurotoxin selected from a group consisting of Botulinum toxin ty... | 06/03/2008 |
| 7374769 | Method for treating a trigeminal neuralgia by peripheral administration of a neurotoxin Methods for treating a trigeminal neuralgia by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin. ... | 05/20/2008 |
| 7361358 | Treatment of a facial pain by peripheral administration of a neurotoxin Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin. ... | 04/22/2008 |
| 7357934 | Intracranial botulinum toxin therapy for focal epilepsy Methods for treating and/or curing epilepsy by intracranial administration of a botulinum toxin. ... | 04/15/2008 |
| 7276245 | Method for treating hyperalgesia by peripheral administration of a neurotoxin Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin. ... | 10/02/2007 |
| 7270287 | toxin treatment for kinesia Methods for treating kinesia (motion sickness) by local administration of a Clostridial toxin, such as a botulinum toxin, to a cranial or neck area of a patient susceptible to motion sickness. ... | 09/18/2007 |
| 7255865 | Methods of administering botulinum toxin Methods for treating conditions in an animal or human subject. The conditions may be pain, skeletal muscle conditions, smooth muscle conditions, glandular conditions and cosmetic conditions. The methods comprise the step of administering a Clostridium neuroto... | 08/14/2007 |
