Nakashima; Richard A. - US Patent Attorneys and Agents

Attorney: Nakashima; Richard A.

Number of patents: 95
Last date: May 01, 2012

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Number	Title	Issue Date
8168186	Therapeutic using a bispecific antibody Multivalent, multispecific molecules having at least one specificity for a pathogen and at least one specificity for the HLA class II invariant chain (Ii) are administered to induce clearance of the pathogen. In addition to pathogens, clearance of therapeutic or dia...	05/01/2012
8163887	Use of immunoconjugates to enhance the efficacy of multi-stage cascade boosting vaccines Humoral and cellular immune responses against tumor cells and infectious agents are induced in a mammal using a vaccine comprising immunoconjugates that comprise antibodies and anti-idiotype antibodies that mimic an epitope of an antigen that is associated with a tu...	04/24/2012
8163291	Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular embodiments concern homodimers comprising monomers that contain a dimeriz...	04/24/2012
8158573	Therapeutic and diagnostic conjugates for use with multispecific antibodies Disclosed are compounds that include two or more haptens conjugated by a spacer or a carrier. The haptens may include diethylenetriaminepentaacetate (DTPA), histimine-succinyl-glutamine (HSG), or combinations of DTPA and HSG. The compound also includes an effector m...	04/17/2012
8158129	Dimeric alpha interferon PEGylated site-specifically shows enhanced and prolonged efficacy in vivo The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using dock-and-lock technology, by attaching a therapeutic agent to a DDD sequen...	04/17/2012
8153433	Mammalian cell lines for increasing longevity and protein yield from a cell culture Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hamiones, an...	04/10/2012
8153101	Methods and compositions for F-18 labeling of proteins, peptides and other molecules The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. In particular embodiments, the labeled molecules may be peptides or proteins, although other types of molecules ...	04/10/2012
8153100	Methods and compositions for F-18 labeling of proteins, peptides and other molecules The present application discloses compositions and methods of synthesis and use of 18F or 19F labeled molecules of use in PET or MRI imaging. The labeled molecules may be peptides or proteins, although other types of molecules may be labeled. P...	04/10/2012
8147831	Anti-CD19 antibodies The present invention provides humanized, chimeric and human anti-CD19 antibodies, anti-CD19 antibody fusion proteins, and fragments thereof that bind to a human B cell marker. Such antibodies, fusion proteins and fragments thereof are useful for the treatment and d...	04/03/2012
8147800	Methods and compositions for F-18 labeling of proteins, peptides and other molecules The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. The labeled molecules may be peptides or proteins, although other types of molecules may be labeled by the descr...	04/03/2012
8147799	Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. In particular embodiments, the labeled molecules may be peptides or proteins, although other types of molecules ...	04/03/2012
8119101	Anti-CD74 immunoconjugates and methods of use Disclosed are compositions that include anti-CD74 immunoconjugates and optionally a therapeutic and/or diagnostic agent. In preferred embodiments, the immunoconjugates comprise one or more anti-CD74 antibodies or antigen-binding fragments thereof, conjugated to a li...	02/21/2012
8097252	Methods and compositions for administering therapeutic and diagnostic agents Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities. ...	01/17/2012
8084583	RS7 antibodies This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an e...	12/27/2011
8084029	Alpha-fetoprotein Immu31 antibodies and fusion proteins and methods of use thereof The present invention provides humanized, chimeric and human anti-alpha-fetoprotein antibodies, fusion proteins, and fragments thereof. The antibodies, fusion proteins, and fragments thereof, as well as combinations with other suitable antibodies, are useful for the...	12/27/2011
8080250	Immunoconjugates with an intracellularly-cleavable linkage The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making an...	12/20/2011
8076140	Mammalian cell lines for increasing longevity and protein yield from a cell culture Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, an...	12/13/2011
8067006	Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in the form of therapeutic-loaded polymers that may comprise many copies ...	11/29/2011
8062636	Antibody therapy The present invention provides a composition comprising naked humanized, chimeric, and human anti-CEA antibodies and a therapeutic agent, which is useful for treatment of CEA expressing cancers and other diseases, and methods of use in treatment using this compositi...	11/22/2011
8038983	Fluorinated carbohydrate conjugates Disclosed are novel conjugates that include fluorinated carbohydrate molecules and methods for synthesizing the conjugates. The fluorinated carbohydrate molecule may include a radioisotope. The method of synthesizing the conjugate is useful for labeling selected mol...	10/18/2011
8034352	Tetrameric cytokines with improved biological activity The present invention concerns methods and compositions for forming cytokine-antibody complexes using dock-and-lock technology. In preferred embodiments, the cytokine-MAb DNL complex comprises an IgG antibody attached to two AD (anchor domain) moieties and four cyto...	10/11/2011
8017736	Alpha-fetoprotein Immu31 antibodies and fusion proteins and methods of use thereof The present invention provides humanized, chimeric and human anti-alpha-fetoprotein antibodies, fusion proteins, and fragments thereof. The antibodies, fusion proteins, and fragments thereof, as well as combinations with other suitable antibodies, are useful for the...	09/13/2011
8003111	Dimeric alpha interferon pegylated site-specifically shows enhanced and prolonged efficacy in vivo The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using dock-and-lock technology, by attaching a therapeutic agent to a DDD sequen...	08/23/2011
7999083	Immunoconjugates with an intracellularly-cleavable linkage The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making an...	08/16/2011
7993626	Methods and compositions for F-18 labeling of proteins, peptides and other molecules The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. The labeled molecules may be peptides or proteins, although other types of molecules may be labeled by the descr...	08/09/2011
7981398	PEGylation by the dock and lock (DNL) technique The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using dock-and-lock technology, by attaching a target agent to a DDD sequence an...	07/19/2011
7951921	Multivalent carriers of bi-specific antibodies Provided herein are targetable constructs that are multivalent carriers of bi-specific antibodies, i.e., each molecule of a targetable construct can serve as a carrier of two or more bi-specific antibodies. Also provided are targetable complexes formed by the associ...	05/31/2011
7951369	Chimeric, human and humanized anti-granulocyte antibodies and methods of use The present invention provides humanized, chimeric and human MN3 antibodies, fusion proteins, and fragments thereof. The antibodies, fusion proteins, and fragments thereof, as well as combinations with other suitable antibodies, are useful for the treatment and diag...	05/31/2011
7943343	Production and use of novel peptide-based agents for use with bi-specific antibodies The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against a targetable conjugate. The targetable conjugate encompasses a hapten ...	05/17/2011
7932212	Inhibition of placenta growth factor (PlGF) mediated metastasis and/or angiogenesis The present invention concerns methods and compositions for inhibiting angiogenesis and/or tumor growth, survival and/or metastasis. In particular embodiments, the methods and compositions may concern ligands against placenta growth factor (PlGF), such as BP-1, BP-2...	04/26/2011
7931903	Internalizing anti-CD74 antibodies and methods of use The present invention provides humanized, chimeric and human anti-CD74 antibodies, CD74 antibody fusion proteins, immunoconjugates, vaccines and bispecific that bind to CD74, the major histocompatibility complex (MHC) class-II invariant chain, Ii, which is useful fo...	04/26/2011
7931890	Targeted combination immunotherapy of cancer and infectious diseases The present invention is directed to methods for treating cancer wherein more than one therapeutic agent is used, with each of the therapeutic agents having different tumor-killing capabilities, and wherein the therapeutic agents are delivered to the tumor sites usi...	04/26/2011
7919090	Antibody therapy The present invention provides a composition comprising naked humanized, chimeric, and human anti-CEA antibodies and a therapeutic agent, which is useful for treatment of CEA expressing cancers and other diseases, and methods of use in treatment using this compositi...	04/05/2011
7919087	Internalizing anti-CD74 antibodies and methods of use The present invention provides humanized, chimeric and human anti-CD74 antibodies, CD74 antibody fusion proteins, immunoconjugates, vaccines and bispecific that bind to CD74, the major histocompatibility complex (MHC) class-II invariant chain, Ii, which is useful fo...	04/05/2011
7914787	Production and use of novel peptide-based agents with bispecific antibodies The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable construct. The targetable construct comprises a carrier por...	03/29/2011
7906121	Methods and compositions for generating bioactive assemblies of increased complexity and uses The present invention concerns methods and compositions for making and using bioactive assemblies of defined compositions, which may have multiple functionalities and/or binding specificities. In particular embodiments, the bioactive assembly is formed using dock-an...	03/15/2011
7906118	Modular method to prepare tetrameric cytokines with improved pharmacokinetics by the dock-and-lock (DNL) technology The present invention concerns methods and compositions for forming cytokine-antibody complexes using dock-and-lock technology. In preferred embodiments, the cytokine-MAb DNL complex comprises an IgG antibody attached to two AD (anchor domain) moieties and four cyto...	03/15/2011
7902338	Anti-CD19 antibodies The present invention provides humanized, chimeric and human anti-CD19 antibodies, anti-CD19 antibody fusion proteins, and fragments thereof that bind to a human B cell marker. Such antibodies, fusion proteins and fragments thereof are useful for the treatment and d...	03/08/2011
7901680	Dock-and-lock (DNL) vaccines for cancer therapy The present invention concerns methods and compositions for forming anti-cancer vaccine DNL complexes using dock-and-lock technology. In preferred embodiments, the anti-cancer vaccine DNL complex comprises an antibody moiety that binds to dendritic cells, such as an...	03/08/2011
7892547	Methods and compositions for administering therapeutic and diagnostic agents Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities. ...	02/22/2011

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Attorney: Nakashima; Richard A.