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| Number | Title | Issue Date |
| 7993835 | BRCA2 mutations and use thereof Genetic variants in the BRCA2 gene are disclosed which are useful as diagnosis biomarkers. ... | 08/09/2011 |
| 7981618 | Diagnostic and therapeutic methods and compositions involving PTEN and breast cancer Patients with ErbB2-overexpressing cancers can be given an ErbB2 targeting agent as a therapeutic regimen but not all patients are responsive. The present invention concerns the diagnostic, prognostic and therapeutic methods and compositions for evaluating potential... | 07/19/2011 |
| 7927803 | Human MutY A human mutY polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating diseases associated with ... | 04/19/2011 |
| 7838237 | Screening methods and sequences relating thereto A screening method for identifying an individual having a pre-disposition towards having a cancer is disclosed, which screening method comprises the steps of: (a) obtaining a test sample comprising a nucleotide sequence comprised in the MYH gene of the ... | 11/23/2010 |
| 7794933 | Depression-related gene The invention relate to the discovery of a depression associated AKAP9 predisposing variant. The invention provides for detecting the variant. The invention also provides methods for screening for antidepressants based on modulating AKAP9 mediated signaling. ... | 09/14/2010 |
| 7732576 | Tumor suppressor designated TS10Q23.3 A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region ... | 06/08/2010 |
| 7670776 | MYH gene variants and use thereof Variants in MYH gene are disclosed which can result in abnormal synthesis of MYH proteins and alteration of MYH activities. The invention provides methods for detecting the newly discovered genetic variants. Use of MYH genetic variants as biomarkers in diagnosing ca... | 03/02/2010 |
| 7662566 | Gene copy number profiling The invention relates to copy number profile analysis. Specifically, copy number profile analysis is used to determine whether two or more separate tumors in a single individual are derived from a common source. ... | 02/16/2010 |
| 7595401 | Therapeutic compounds and their use in cancer The invention relates to compounds of Formula I and their therapeutic uses, wherein substituent A is chosen from a substituted or unsubstituted aryl, heteroaryl, heterocyclic, or carboxylic group, B is chosen from a substit... | 09/29/2009 |
| 7141401 | COX1-interacting proteins and use thereof Protein complexes are provided comprising COX1 and one or more proteins selected from the group consisting of THR S14 and Opa1. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes and in treati... | 11/28/2006 |
| 7129040 | Tumor suppressor designated TS10q23.3 A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region ... | 10/31/2006 |
| 7125872 | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins There are disclosed β-sheet mimetics and methods relating to the same for imparting or stabilizing the β-sheet structure of a peptide, protein or molecule. In one aspect, β-sheet mimetics are disclosed having utility as protease inhibitors in general and, more sp... | 10/24/2006 |
| 7097998 | Aβlowering agents The invention provides a method of preventing, delaying, or reversing the progression of Alzheimer's disease by administering an Aβ42 lowering agent to a mammal under conditions in which levels of Aβ42 are selectively reduced, levels of Aβ | 08/29/2006 |
| 7091173 | FAP48-interacting proteins and use thereof Protein complexes are provided comprising FAP48 and one or more FAP48-interacting proteins. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes and in treating and/or preventing diseases and di... | 08/15/2006 |
| 7067312 | PN7718 nucleic acids and use thereof Novel PN7718 protein and nucleic acids encoding PN7718 are provided. PN7718-containing protein complexes formed by PN7718 and a PN7718-interacting protein (e.g., cyclophilin C) are also provided. Cyclophilin C and PN7718 may be involved in common biological processe... | 06/27/2006 |
| 7052853 | Depression gene The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human depression predisposing gene, specifically the apoptotic protease activating factor 1 (APA... | 05/30/2006 |
