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| Number | Title | Issue Date |
| 7572905 | Depression gene The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human depression predisposing gene, specifically the apoptotic protease activating factor 1 (APA... | 08/11/2009 |
| 7563571 | MYH gene variants and use thereof Variants in MYH gene are disclosed which can result in abnormal synthesis of MYH proteins and alteration of MYH activities. The invention provides methods for detecting the newly discovered genetic variants. Use of MYH genetic variants as biomarkers in diagnosing ca... | 07/21/2009 |
| 7547804 | Compounds, compositions, and methods employing same Compounds and pharmaceutical compositions containing the same are provided, which are useful in therapeutic treatment or prevention of various diseases. ... | 06/16/2009 |
| 7511039 | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins There are disclosed β-sheet mimetics and methods relating to the same for imparting or stabilizing the β-sheet structure of a peptide, protein or molecule. In one aspect, β-sheet mimetics are disclosed having utility as protease inhibitors in general and, more sp... | 03/31/2009 |
| 7422853 | RNA interference using a universal target The present invention provides novel methods for manipulating levels of expression of gene products using RNA interference (RNAi). The methods disclosed can be used to investigate gene function, to create disease-resistant organisms, and to treat disease. ... | 09/09/2008 |
| 7410944 | Depression gene The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human depression predisposing gene, specifically the apoptotic protease activating factor 1 (APA... | 08/12/2008 |
| 7407952 | Reverse-turn mimetics and compositions and methods related thereto Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: wherein A, R1, R2 | 08/05/2008 |
| 7405283 | Screening methods and sequences relating thereto A screening method for identifying an individual having a pre-disposition towards having a cancer is disclosed, which screening method comprises the steps of: (a) obtaining a test sample comprising a nucleotide sequence comprised in a gene in a gene in a base excisi... | 07/29/2008 |
| 7405212 | Helix mimetics and composition and methods related thereto Compounds which mimic the secondary structure of helical regions of biologically active peptides and proteins having the following structure: including pharmaceutically acceptable salts and stereoisomers thereof, wherein Y,... | 07/29/2008 |
| 7374884 | Diabetes gene The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect human diabetes mellitus predisposing gene, specifically the angiotensinogen (AGT) gene, some mutan... | 05/20/2008 |
| 7371850 | Method and composition for reducing expression of ROCK-II Methods and pharmaceutical compositions for treating, and delaying the onset of, viral infection, are provided. ... | 05/13/2008 |
| 7338775 | Enzyme assay and use thereof An assay and kit for determining the activity of an enzyme such as kinase, ATPase and GTPase is disclosed. The assay and kit are useful in drug screening to select modulators of such an enzyme. ... | 03/04/2008 |
| 7335468 | TSG101-GAG interaction and use thereof Isolated protein complexes are provided comprising Tsg101 and HIV GAG or GAGp6. The protein complexes are useful in screening assays for selecting compounds effective in modulating the Tsg101-HIV GAG or GAGp6 interaction within the protein complexes. ... | 02/26/2008 |
| 7250497 | Large deletions in human BRCA1 gene and use thereof Large deletions have been identified in the BRCA1 gene in patients. The large deletions predispose the patients to breast cancer and ovarian cancer. Thus, methods for detecting the genetic variants are provided which can be used in detecting a predisposition to canc... | 07/31/2007 |
| 7202329 | Tsg101-GAGp6 interaction and use thereof Isolated protein complexes are provided comprising Tsg101 and HIV GAGp6. The protein complexes are useful in screening assays for selecting compounds effective in modulating the Tsg101-HIV GAGp6 interaction within the protein complexes. ... | 04/10/2007 |
| 7053214 | β-sheet mimetics and composition and methods relating thereto Compounds having the following structure: including pharmaceutically acceptable salts and stereoisomers thereof, wherein A, A′, B, X, Y, R2, R3, R4 and R5 are as defi... | 05/30/2006 |
| 7008941 | Reverse-turn mimetics and methods relating thereto Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: wherein A, B, X, R1 | 03/07/2006 |
| 6943157 | Reverse-turn mimetics and composition and methods relating thereto Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: wherein A, R1, R | 09/13/2005 |
| 6943167 | Helix mimetics and composition and methods related thereto Compounds which mimic the secondary structure of helical regions of biologically active peptides and proteins having the following structure: including pharmaceutically acceptable salts and stereoisomers thereof, where... | 09/13/2005 |
| 6911311 | Method of detecting protein-protein interactions An in vitro method for detecting protein-protein interactions is provided, in which two fusion proteins are prepared and allowed to interact with each other in a substantially cell free environment. The interaction between the two fusion proteins leads to protein tr... | 06/28/2005 |
