Did You Know...
...that in 1800 ether was first used by partyers as a fun diversion? Sniffing the gas led to hilarious and raucous laughter as people watched each other become more and more intoxicated and silly. Several doctors independently realized the value ether would have to anesthetize surgery patients. Of those who claimed rights to the "discovery," none had a happy ending. One had a seizure and died defending his rights. Another spent his life in an asylum because he had been denied acclaim. A third became addicted to chloroform and, in a New York City jail, he soaked a cloth in the drug, severed an artery and bled to death.
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| Number | Title | Issue Date |
| 6437128 | Cribrostatins 3-5 The blue marine sponge Cribrochalina sp., collected in the Republic of Maldives was found to contain new cell growth inhibitors denominated cribrostatin 3, cribrostatin 4 and cribrostatin 5 which were found to be active against the NCI human melanoma pane... | 08/20/2002 |
| 6324740 | Universal joint disassembly tool A simple, compact and lightweight tool for the disassembly of the universal joints used in automobiles, trucks, recreational vehicles, buses, boats, farm machinery, and other machinery. The tool directs pressure specifically to the point where it is neede... | 12/04/2001 |
| 6300458 | High molecular weight polymers and copolymers of BHMDO for biomedical application Hydroxypolycarbonates (HPC) offer to the biomedical area hydroxyl functional polymers not now readily available to bind drugs, proteins, or carbohydrate polymers chemically or via hydrogen bonding to facilitate drug delivery and utility with subsequent bi... | 10/09/2001 |
| 6281196 | Isolation and structural elucidation of the human cancer cell growth inhibitory compound denominated agelagalastatin A human cancer cell line bioassay-directed investigation of the Western Pacific marine sponge agelas sp. led to isolation of a trace (7.42×10-6 % yield) cancer cell growth inhibitor (lung NCI-H460 GI50 0.77 μg/ml to ovary OVCAR-3 G... | 08/28/2001 |
| 6239104 | Isolation and structural elucidation of the cytostatic linear and cyclo-depsipeptides dolastatin 16, dolastatin 17, and dolastatin 18 Cytostatic linear and cyclo-depsipeptides, "Dolastatin 16", "Dolastatin 18", and "Dolastatin 17", are disclosed which are obtained from Indian Ocean shelless mollusk Dolabella auricularia. Methods of using the substances to inhibit malignant cell growth a... | 05/29/2001 |
| 6209765 | Coin holding accessory A coin-holder accessory for use at casinos and like establishments comprising an adjustable belt adapted to circumscribe the user's waist and be lockable in place thereabout and having a strip portion secured thereto. The strip portion has a obverse surfa... | 04/03/2001 |
| 6152733 | Automated hands free oral cleansing device with bite block and computer control An automated hands-free personalized cleansing device for oral hygiene is described in which a robotic cleansing head is mounted for reciprocatable movement on a mounting base and is powered and controlled by a computer module to provide multiple movement... | 11/28/2000 |
| 6147623 | Smart cross programmable vehicle and pedestrian signage with electronic display and infrared remote control A smart cross electronic traffic sign for the control of vehicle and pedestrian traffic with programming and control by infrared remote control. The device is lightweight and easily portable. Messages can be displayed in the color of the normal traffic si... | 11/14/2000 |
| 6108852 | Oral hygiene devices and manufacturing methods therefor A comprehensive oral hygiene device preferably having a multi-headed oral care brush disposed at one end of an elongated handle and a manufacturing process therefor. The oral care brush of the present invention has at least one head and preferably two hea... | 08/29/2000 |
| 6099591 | Method and composition for hair coloring using green tea polyphenols A hair coloring composition, and a method for using the composition in which a natural plant-derived chemical of the formula ##STR1## is employed as a coupler-modifier in a composition containing a primary intermediate and a customary coupler. The no... | 08/08/2000 |
| 5925679 | Topical vehicles containing solubilized and stabilized azelaic acid A completely solubilized alcohol-free topical composition of azelaic acid in a glycol base which is stable at normal temperatures and which is useful as a commercial substitute for dispersed azelaic acid preparations. The composition has a pH of 4.0 or gr... | 07/20/1999 |
| 5801222 | Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11 Two new compounds which may be useful in the treatment of one or more neoplastic diseases through chemotherapy have been isolated from the Western Pacific Ocean marine sponge Phakellia sp. The cyclic octapeptides phakellistatin 10 and phakellistatin 11 ar... | 09/01/1998 |
| 5780588 | Elucidation and synthesis of selected pentapeptides The sea hare Dolabella auricularia has yielded many structurally distinct peptides which possess antineoplastic activity. Presently the compound denominated "dolastatin 10" represents the most important of such peptides because of its demonstrated potenti... | 07/14/1998 |
| 5752563 | Composite metal strip and methods of making same A method and apparatus for the continuous casting of composite metal members wherein molten metal is directly cast between two spaced generally parallel metal strips to form a composite member having enhanced surface qualities, formability, and strength. ... | 05/19/1998 |
| 5665860 | Human cancer inhibitory peptide amides This application discloses seven newly synthesized pentapeptide amides and our tetrapeptide amides. The synthesis utilized both naturally occurring and modified amino acids; the modified amino acids are constituents of the well known dolastatin 10 and dola... | 09/09/1997 |
| 5663149 | Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides The synthesis and elucidation of nineteen heterocyclic or halophenyl amide erivatives of dolastatin 10 are disclosed. These compounds and the methods of producing those compounds offer demonstrated significant in vitro activity against several human cancer... | 09/02/1997 |
| 5646246 | Isolation and structural elucidation of the human cancer cell growth inhibitory cyclic peptides phakellistatin 4, 5, 6, 7, 8 and 9 The cytostatic, cyclic peptides; phakellistatin 4, phakellistatin 5, phakellistatin 6, phakellistatin 7, phakellistatin 8 and phakellistatin 9 were isolated from the Western Pacific Ocean sponge Phakellia costata. Structural determination was accomplished... | 07/08/1997 |
| 5639881 | Synthesis and elucidation of pyrimido (4,5-Q) quinazoline derivatives Pyrimido[4,5-g]quinazoline quinone derivatives were synthesized as anthranone-like reductive alkylating agents. Like many naturally-occurring antibiotics, these quinone derivatives are designed to afford an alkylating quinone methide species upon reducti... | 06/17/1997 |
| 5636367 | N+0.5 wait state programmable DRAM controller CPU system performance is improved by reducing the time required to complete a DRAM access by microprocessors such as the 386DX, 386SX and 80286 by incorporating a programmable DRAM controller therewith which permits consecutive DRAM accesses to average N... | 06/03/1997 |
| 5635483 | Tumor inhibiting tetrapeptide bearing modified phenethyl amides New tetrapeptides bearing modified phenethyl amides are elucidated and syesized and found to exhibit tumor inhibiting effects when measured against the NCI screen for six major types of human cancer and against the murine P388 lymphocytic cell line. The ... | 06/03/1997 |
| 5615727 | Composite metal strip and methods of making same A method and apparatus for the continuous casting of composite metal members wherein molten metal is directly cast between two spaced generally parallel metal strips to form a composite member having enhanced surface qualities, formability, and strength. ... | 04/01/1997 |
| 5599902 | Cancer inhibitory peptides The sea hare Dolabella auricularia has yielded many structurally distinct ptides which possess antineoplastic activity. Presently the compound denominated "dolastatin 10" represents the most important of such peptides because of its demonstrated potential... | 02/04/1997 |
| 5569786 | Isolation, structural elucidation and synthesis of novel antineoplastic substances denominated "combretastatins" New antineoplastic substances have been isolated, structurally elucidated and synthesized having a general structural formula of: ##STR1## wherein: R1 is OH or OCH3 ; R2 is H or OCH3 ; or R1 R2 | 10/29/1996 |
| 5567487 | Moving art form and method of producing same A new art form providing a plurality of optical images and illusions by the novel coaction of at least two diverse line and curve patterns disposed in spaced generally parallel relationship to each other, at least one of said patterns being rotatable at a... | 10/22/1996 |
| 5561122 | Combretastatin A-4 prodrug Disclosed herein are Combretastatin A-4 Prodrugs, having the general strure set forth below, which are useful in the treatment of one or more neoplastic diseases by means of chemotherapy. ##STR1##... | 10/01/1996 |
| 5554725 | Synthesis of dolastatin 15 The present invention relates to the synthesis of natural (-)- dolastatin and the elucidation of the absolute configuration of this important sea hare constituent. A segment synthetic strategy was utilized for obtaining the Dolabella auricularia (Indian ... | 09/10/1996 |
| 5518970 | Nitride glasses and methods of making same The present invention relates generally to a novel and unique class of gly materials and methods of making such materials in which substantially all of the anions are nitride ions, in contrast to the oxide ions of conventional optical glasses, or the flu... | 05/21/1996 |
| 5514689 | Cribrostatins 1 and 2 The blue marine sponge Cribrochalina sp., collected in the Republic of the Maldives, was found to contain the new cell growth inhibitory isoquinolinequinones designated cribrostatin 1 (8.8×10-6 % yield) and 2 (3.1×10-6 % yield) whi... | 05/07/1996 |
| 5509300 | Non-contact force microscope having a coaxial cantilever-tip configuration The present invention comprises a highly sensitive non-contact force microscope having a coaxial cantilever-tip configuration and a method of forming such configuration. The non-contact microscope obtains high resolution graphical images of a sample surfa... | 04/23/1996 |
| 5494893 | Stylostatin 2 The cytostatic cycloheptapeptide stylostatin 2 was isolated respectively, from the South and Western Pacific Ocean sponges Stylotella sp. and Phakellia costata. Structural determination was accomplished by utilizing high-field (500 MHz) 2D-NMR experiments... | 02/27/1996 |
| 5455211 | Methods of making nitride glasses The present invention relates generally to a novel and unique class of gly materials and methods of making such materials in which substantially all of the anions are nitride ions, in contrast to the oxide ions of conventional optical glasses, or the flu... | 10/03/1995 |
| 5436400 | Isolation and structure of spongistatin 1 An Eastern Indian Ocean marine sponge in the genus Spongia was located in the Republic of the Maldives and found to contain a structurally unprecedented macrocyclic lactone named spongistatin 1. The new perhydropyran-containing structure, as shown below, ... | 07/25/1995 |
| 5430053 | Isolation and structure of dictyostatin 1 A new-type of macrocyclic lactone denominated "dictyostatin 1" bearing a membered ring system is isolated from a Republic of Maldives marine sponge in the genus Spongia sp. and found to strongly inhibit the growth of an important selection of U.S. Nation... | 07/04/1995 |
| 5426194 | Isolation and structure of Halistatin 1 An intensive long-term investigation of marine organisms as sources of new anticancer drugs has led to the isolation and structural elucidation (primarily by high field NMR and mass spectrometry) of halistatin 1, a new polyether macrolide of the halipyran... | 06/20/1995 |
| 5410024 | Human cancer inhibitory pentapeptide amides The synthesis of useful peptides presents a promising approach to new theeutic agents. The Dolastatins, a series of linear and cyclic antineoplastic and/or cytostatic peptides isolated from Indian Ocean sea hare Dolabella auricularia represent excellent ... | 04/25/1995 |
| 5409953 | Isolation, structural elucidation and synthesis of novel antineoplastic substances denominated "combretastatins" New antineoplastic substances have been isolated, structurally elucidated and synthesized having a general structural formula of: ##STR1## wherein: R1 is OH or OCH3 ; R2 is H or OCH3 ; or R1 R2 | 04/25/1995 |
| 5403161 | Air foil blade and methods of making same For use in rear turbine stabilized helicopters, a air foil blade comprising an integrally formed and readily replicated spar and blade in which the blade is created from compounded plastic having cellular structure and adherent to the spar. The air foil b... | 04/04/1995 |
| 5393897 | Isolation and structure of spongistatins 5,7,8 and 9 A Southwest Indian Ocean marine sponge Spirastrella spinispirulifera (bri colored reds and purples) has been found to contain new and exceptionally active cell (human cancer) growth inhibitors spongistatin 5, spongistatin 7, spongistatin 8 and spongistat... | 02/28/1995 |
| 5369371 | Electrical resistance test device with an attached comparison resistance set A megohm tester for determining resistance utilizing a relaxation oscillator which generates output pulses, at a rate dependent on an unknown resistance detected at a test site within an electronic apparatus, which can then be compared to known values pro... | 11/29/1994 |
| 5366069 | Modular coin storage assembly A modular coin storage assembly having a cover and a base member and a plurality of inter changeable species-specific rack members suspendible therein for substantially dust proof rattle free storage. Each rack member provides a plurality of coin holder c... | 11/22/1994 |
