Celebrity Inventors
Superstar singer Michael Jackson co-patented a "Method and means for creating anti-gravity illusion" in 1993.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8133702 | Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing Engineered nucleotide compositions, having polymerase interacting components that improve the interactivity of the polymerase and the nucleotide, particularly for nucleic acid sequencing applications. Compositions include the interactive polymerases along with the n... | 03/13/2012 |
| 8058031 | Labeled nucleotide analogs and uses therefor Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and various analyses based thereon, including DNA sequencing, single bas... | 11/15/2011 |
| 7973146 | Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing Engineered nucleotide compositions, having polymerase interacting components that improve the interactivity of the polymerase and the nucleotide, particularly for nucleic acid sequencing applications. Compositions include the interactive polymerases along with the n... | 07/05/2011 |
| 7968702 | Labeled reactants and their uses Labeled reactant compositions, and particularly labeled nucleic acid reaction compositions, that include structural components that maintain potentially damaging labeling components sufficiently distal from the reactant portion of the molecule such that damaging eff... | 06/28/2011 |
| 7901889 | Molecular redundant sequencing Methods, systems and compositions where a target nucleic acid includes a registration sequence disposed therein for identification of the number or relative position of determined sequence from the template sequence. Particularly preferred aspects include a registra... | 03/08/2011 |
| 7805081 | Methods and systems for monitoring multiple optical signals from a single source Methods and systems for monitoring a plurality of different optical signals from a single source of such signals, where each such different optical signal is spatially separated from other such signals and directed to different detectors or locations upon a single d... | 09/28/2010 |
| 7777013 | Labeled nucleotide analogs and uses therefor Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and various analyses based thereon, including DNA sequencing, single bas... | 08/17/2010 |
| 7767394 | Nucleotide compositions and uses thereof The present invention relates to preparation of nucleotide compositions and uses thereof for conducting nucleic acid analyses. The compositions and methods embodied in the present invention are particularly useful for nucleic acid analyses that require high-resoluti... | 08/03/2010 |
| 7763423 | Substrates having low density reactive groups for monitoring enzyme activity Reactive surfaces, substrates and methods of producing and using such substrates and surfaces are provided. The substrates and surfaces provide low density reactive groups preferably on an otherwise non-reactive surface for use in different applications including si... | 07/27/2010 |
| 7563574 | Methods, systems and compositions for monitoring enzyme activity and applications thereof Methods of monitoring enzyme mediated reactions, and particularly nucleic acid synthesis reactions such as pyrosequencing methods that employ enzymatic reporter systems. The methods and systems provide elevated signal levels as compared to conventional pyrosequencin... | 07/21/2009 |
| 7515333 | Nanotechnology-enabled optoelectronics Nanomaterials for use in optoelectronic applications, and particularly nanocomposite optical amplifiers. nanocomposite optical amplifiers (NOAs), e.g., provided on integrated optical chips, for cost-effective broadband amplification across the entire clear-window of... | 04/07/2009 |
| 7476503 | Apparatus and method for performing nucleic acid analysis The present invention relates to optical confinements, methods of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughpu... | 01/13/2009 |
| 6872645 | Methods of positioning and/or orienting nanostructures Methods of positioning and orienting nanostructures, and particularly nanowires, on surfaces for subsequent use or integration. The methods utilize mask based processes alone or in combination with flow based alignment of the nanostructures to provide oriented and p... | 03/29/2005 |
| 6695009 | Microfluidic methods, devices and systems for in situ material concentration Methods of concentrating materials within microfluidic channel networks by moving materials into regions in which overall velocities of the material are reduced, resulting in stacking of the material within those reduced velocity regions. These methods, d... | 02/24/2004 |
| 6632655 | Manipulation of microparticles in microfluidic systems Arrays of flowable or fixed particle sets are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets within a microfluidic system, as well as kits, apparatus a... | 10/14/2003 |
| 6620625 | Ultra high throughput sampling and analysis systems and methods Ultra-high throughput systems and methods are used for sampling large numbers of different materials from surfaces of substantially planar library storage components. The systems and methods typically employ: microfluidic devices having integrated capilla... | 09/16/2003 |
| 6613581 | Microfluidic analytic detection assays, devices, and integrated systems Methods of detecting a component of interest, such as a protein, in a microfluidic system are provided. The methods include the use of a component-binding moiety specific to the component of interest, such as an antibody, to detect the component of intere... | 09/02/2003 |
| 6613580 | Microfluidic systems and methods for determining modulator kinetics Methods, systems, kits, and apparatus for calculating kinetic and concentration information in microscale systems are provided. Dwell times for access by a microfluidic system are varied and the resulting modulation of signal profile information used to p... | 09/02/2003 |
| 6472141 | Kinase assays using polycations Methods, systems, kits for carrying out a wide variety of different assays that comprise providing a first reagent mixture which comprises a first reagent having a fluorescent label. A second reagent is introduced into the first reagent mixture to produce... | 10/29/2002 |
| 6468763 | Optical detection of transmembrane potential changes Compositions for monitoring transmembrane potential across cellular membranes. The compositions typically comprise a cell having a plasma membrane that comprises a first leaflet and a second leaflet, the membrane comprising first and second membrane assoc... | 10/22/2002 |
| 6436646 | Methods of identifying nucleic acid sequences using polycations Methods, systems, kits for carrying out a wide variety of different assays that comprise providing a first reagent mixture which comprises a first reagent having a fluorescent label. A second reagent is introduced into the first reagent mixture to produce... | 08/20/2002 |
| 6384401 | Method and apparatus for detecting low light levels A method and apparatus for measuring very low light signals including integrating a signal from a photo diode, avalanche photo diode, photomultiplier tube or the like, digitally sampling the integrator output more than two times during each integration pe... | 05/07/2002 |
| 6379974 | Microfluidic systems The present invention generally provides microfluidic devices and systems that utilize electrokinetic material transport systems to selectively control and direct the transport of materials through and among complex arrangements of integrated, interconnec... | 04/30/2002 |
| 6379884 | Methods and systems for monitoring intracellular binding reactions Intracellular binding reactions, and particularly DNA/DNA binding protein reactions are detected in situ, using intracellular fluorescence polarization detection. The methods comprise providing a biological cell having at least a first component of a bind... | 04/30/2002 |
| 6337740 | Microfluidic devices for electrophoretic analysis of materials The present invention provides a microfluidic system for fast, accurate and low cost electrophoretic analysis or materials in the fields of chemistry, biochemistry, biotechnology, molecular biology and numerous other fields. Light from periodically spaced... | 01/08/2002 |
| 6322683 | Alignment of multicomponent microfabricated structures Microfluidic devices are fabricated by fabricating structures that are used to align elements that are to be attached to the devices or tools that are to be used in further fabrication steps on those devices. Elements to be attached include additional sub... | 11/27/2001 |
| 6316201 | Apparatus and methods for sequencing nucleic acids in microfluidic systems The present invention is generally directed to microfluidic systems and methods of using such systems in the determination of the nucleotide sequence of target nucleic acid sequences (referred to herein as the "target"). In particular, the present inventi... | 11/13/2001 |
| 6287520 | Electropipettor and compensation means for electrophoretic bias The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The subject materials are transported in regions of high ionic concentration, next to spacer material regio... | 09/11/2001 |
| 6287774 | Assay methods and system Methods, systems, kits for carrying out a wide variety of different assays that comprise providing a first reagent mixture which comprises a first reagent having a fluorescent label. A second reagent is introduced into the first reagent mixture to produce... | 09/11/2001 |
| 6274089 | Microfluidic devices, systems and methods for performing integrated reactions and separations Microfluidic devices for performing integrated reaction and separation operations. The devices include a planar substrate having a first surface with an integrated channel network disposed therein. The reaction region in the integrated microscale channel ... | 08/14/2001 |
| 6251343 | Microfluidic devices and systems incorporating cover layers The present invention provides microfluidic devices that comprise a body structure comprising at least a first microscale channel network disposed therein. The body structure has a plurality of ports disposed in the body structure, where each port is in f... | 06/26/2001 |
| 6235175 | Microfluidic devices incorporating improved channel geometries The present invention generally provides microfluidic devices which incorporate improved channel and reservoir geometries, as well as methods of using these devices in the analysis, preparation, or other manipulation of fluid borne materials, to achieve h... | 05/22/2001 |
| 6221226 | Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems The present invention generally provides methods and systems for monitoring and controlling electroosmotic flow rates in microfluidic systems. Generally, such methods and systems monitor flow rates in electroosmotically driven microfluidic systems by flow... | 04/24/2001 |
| 6167910 | Multi-layer microfluidic devices The present invention provides multi-layer microfluidic systems, by providing additional substrate layers, e.g., third, fourth, fifth and more substrate layers, mated with the typically described first and second layers. Microfabricated elements, e.g., gr... | 01/02/2001 |
| 6150119 | Optimized high-throughput analytical system Throughput rates for microfluidic serial analysis systems are optimized by maximizing the proximity and speed with which multiple different samples may be serially introduced into a microfluidic channel network. Devices are included that include optimized... | 11/21/2000 |
| 6123798 | Methods of fabricating polymeric structures incorporating microscale fluidic elements The present invention generally provides improved methods of fabricating polymeric microfluidic devices that incorporate microscale fluidic structures, whereby the fabrication process does not substantially distort or deform such structures. The methods o... | 09/26/2000 |
| 6107044 | Apparatus and methods for sequencing nucleic acids in microfluidic systems The present invention is generally directed to microfluidic systems and methods of using such systems in the determination of the nucleotide sequence of target nucleic acid sequences (referred to herein as the "target"). In particular, the present inventi... | 08/22/2000 |
| 6086740 | Multiplexed microfluidic devices and systems Multiplexed microfluidic devices include a plurality of modular microfluidic elements, all of which are attached to a common frame or substrate, which itself includes one or more common input elements that are connected to corresponding input elements wit... | 07/11/2000 |
| 6071478 | Analytical system and method An analytical or preparatory system comprised as a base unit, an adapter, and a substrate. The adapter is attached to an attachment region on the base unit, and the substrate is attached to an attachment region on the adapter. The adapter permits the base... | 06/06/2000 |
| 6048498 | Microfluidic devices and systems Microfluidic apparatus which include a planar device and polymeric holder assembly are provided. The polymeric holder assembly includes a cavity disposed through the holder, providing optical access to the top and bottom of the planar device when the devi... | 04/11/2000 |
