"Flight by machines heavier than air is unpractical and insignificant, if not utterly impossible."
Simon Newcomb, astronomer ; Said in 1902, less than two years before the first flight at Kitty Hawk
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| Number | Title | Issue Date |
| 7858658 | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof Compounds of Formula (I), are provided where T is CHO, COR8, or C(OH)R1R2; R1 and R2 are hydrogen, optionally substituted lower alkyl, CF3, optionally substi... | 12/28/2010 |
| 7842718 | Heterocyclic sulfonamide inhibitors of beta amyloid production Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt... | 11/30/2010 |
| 7776885 | Benzimidazolone compounds having 5-HT4 receptor agonistic activity This invention provides a compound of the formula (I): or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and the use of such compounds for the manufacture of medicament for gastroesop... | 08/17/2010 |
| 7617795 | Methods and apparatus for injecting and sampling material through avian egg membranes An injection apparatus for injecting and/or removing substances from subjects, such as avian eggs, includes an injection needle having a body portion and a tapered portion that terminates at a tip. A tube is attached to and extends around the injection needle in sub... | 11/17/2009 |
| 7611277 | Methods and apparatus for candling avian eggs via thermal cameras Egg candling methods and apparatus are provided wherein non-live eggs, inverted egg, and side air cell eggs can be quickly identified. A method of candling eggs includes exposing a plurality of incubated eggs to an environment having a temperature different from a t... | 11/03/2009 |
| 7573566 | Methods and apparatus for maintaining effective operation of apparatus for candling avian eggs Egg candling methods and apparatus are provided wherein the optical path between a light source and light detector is monitored for obscuring debris and/or malfunctions. A method of candling eggs includes illuminating an egg with light from a light source; receiving... | 08/11/2009 |
| 7479559 | Benzyl(idene)-lactam derivatives The present invention relates to novel benzyl(idene)-lactam derivatives, compounds of the formula I wherein R1 is a group of the formula G1 or G2 depicted below, | 01/20/2009 |
| 7273936 | Oxazole and thiazole compounds as transforming growth factor (TGF) inhibitors Novel oxazole and thiazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of tran... | 09/25/2007 |
| 7176311 | Process for preparing pharmaceutically active compounds A process for the preparation of Compounds of the formula (1): wherein R1, R2, R4 and R13 are as defined or a pharmaceutically or veterinarily acceptable salt or polymo... | 02/13/2007 |
| 7129234 | Phenyl heterocyclyl ethers The invention relates to compounds of formula I ... | 10/31/2006 |
| 7087617 | Substituted pyrimidine derivatives This invention relates to compounds of Formula I, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, or a pharmaceutically acceptable salt of a prodrug thereof. The compounds i... | 08/08/2006 |
| 7029887 | Methods related to gene directing the ratio of B2:B1 avermectins The present invention relates to polynucleotide molecules comprising sequences encoding avec gene products, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of Streptomyces avermiti... | 04/18/2006 |
| 7022684 | Treatment of rumen acidosis with α-amylase inhibitors The invention described herein relates to: the use of an effective inhibitor of a bacterial α-amylase and/or α-glucosidase in the manufacture of a composition for the treatment of rumen acidosis; a method of treatment of rumen acidosis which comprises administrati... | 04/04/2006 |
| 7005520 | Process for the preparation of pyrazolopyrimidinones There is provided a process for the production a compound of general formula I: wherein A, R1, R2, R3 and R4 have meanings given in the description, which process comprises th... | 02/28/2006 |
| 6964780 | Controlled-release pharmaceutical formulations The invention provides controlled-release formulations for oral administration containing a cGMP PDE-5 inhibitor. The formulations are useful, inter alia, in the treatment or prevention of sexual dysfunction. ... | 11/15/2005 |
| 6949536 | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents This invention provides a compound of the formula: or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated ... | 09/27/2005 |
| 6916927 | Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3′,5′-monophosphate phosphodiesterase (cGMP-PDE5) for the treatment of sexual dysfunction Compounds of formulae (IA) and (IB) or pharmaceutically or veterinarily acceptable salts thereof, or pharmaceutically or veterinarily acceptable solvates of either entity, wherein R1 is C1 to C3 alkyl substituted with C3 t... | 07/12/2005 |
| 6914160 | Oxytocin inhibitors This invention relates to compounds of formula (I) ... | 07/05/2005 |
| 6849649 | N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R1 is optionally substituted C1-6alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, C1-6alk... | 02/01/2005 |
| 6833263 | AveC gene product from Streptomyces hygroscopicus The present invention relates to polynucleotide molecules comprising sequences encoding avec gene products, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of Streptomyces avermiti... | 12/21/2004 |
| 6831074 | Pharmaceutically active compounds The present invention provides a compound of formula (I): where Q is a group of formula: These compounds inhibit cyclic guanosine 3′,5′-monophosphate phosphodiesteras... | 12/14/2004 |
| 6825344 | Process for the preparation of cephalosporin compounds and synthetic intermediates There is provided a process for the preparation of a compound according to Formula (II): which includes the step of cyclising a compound of Formula (III): wherein R1... | 11/30/2004 |
| 6812241 | Nitrogen-containing heterocycles having parasiticidal properties Compounds of formula (I) wherein the substituents are as defined herein, are antiparasitic agents. ... | 11/02/2004 |
| 6809200 | Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-one compounds and intermediates thereof A process is provide for the preparation of compounds of formula (I) herein comprising reacting a compound of formula (III), (IV) or (V) wherein the variables are as defi... | 10/26/2004 |
| 6800652 | Diaryl compounds The invention relates to compounds of formula I ... | 10/05/2004 |
| 6794387 | Pharmaceutically active compounds Compounds of general formula (I): wherein R1, R2, R3, R4, X, Y and A have the meanings given herein which are useful in the curative and prophylactic treatment of a medical con... | 09/21/2004 |
| 6756373 | Pharmaceutically active compounds There is provided a compound of formula I: wherein X represents O or NR5 R4 represents H, halo, cyano, nitro, halo(loweralkyl), OR6, OC(O)R7, C(O)R8, ... | 06/29/2004 |
| 6753332 | Sulfonyl heteroaryl triazoles as anti-inflammatory/analgesic agents The present invention relates to compounds of the formula wherein R1, R3, R5 and A are defined as in the specification, to pharmaceutical compositions containing them and to their medicin... | 06/22/2004 |
| 6727238 | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents This invention provides a compound of the formula: or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated fi... | 04/27/2004 |
| 6720330 | Somatostatin antagonists and agonists that act at the SST subtype 2 receptor Compounds according to the formula A—Z—W as herein described, wherein A is selected from the groups consisting of: A′—(CH2)n—, A′—(CH2)nSO2—, and A′—(CH2)nCO—, where n... | 04/13/2004 |
| 6713286 | Compositions and methods for protecting animals from lentivirus-associated disease such as feline immunodeficiency virus The present invention is directed to a novel strain of feline immunodeficiency virus, designated herein as FIV-141, and to attenuated forms of the virus produced by mutating specific regions of the viral genome. The virus and mutated forms of the virus may be used t... | 03/30/2004 |
| 6696470 | Pyridylthiophene compounds A compound of the formula: ##STR1## and its pharmaceutically effective salts, wherein R1 and R2 are independently selected from the following: (a) hydrogen, halo, R5 --, C2-6 alkenyl, C2-6 alkynyl, ... | 02/24/2004 |
| 6646128 | Process for preparing heterocyclo-alkylsulfonyl pyrazole derivatives The invention relates to processes for preparing compounds of formula 1: ##STR1## as well as intermediates useful in such processes, wherein R1 -R4 are as defined herein. The compounds of formula 1 are useful in the treatment or ... | 11/11/2003 |
| 6624162 | Imidazopyridine compounds as 5-HT4 receptor modulators This invention provides a compound of the formula (I): ##STR1## or the pharmaceutically acceptable salts thereof wherein R1 is hydrogen, halo or alkyl; R2 and R3 are independently hydrogen, alkyl, alkenyl, alkynyl, aminoal... | 09/23/2003 |
| 6610518 | Enzymatic oxidations The following invention relates to a process for oxidizing alkyl groups attached directly or via a linker, to a sulfonamide moiety (II) by the use of cytochrome P450 enzymes, to give the corresponding alcohol or carboxylic acid (I). ##STR1## wherein ... | 08/26/2003 |