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Attorney: Munchhof; Martha G.


Number of patents: 35
Last date: December 28, 2010

NumberTitleIssue Date
7858658Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof
Compounds of Formula (I), are provided where T is CHO, COR8, or C(OH)R1R2; R1 and R2 are hydrogen, optionally substituted lower alkyl, CF3, optionally substi...
12/28/2010
7842718Heterocyclic sulfonamide inhibitors of beta amyloid production
Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt...
11/30/2010
7776885Benzimidazolone compounds having 5-HT4 receptor agonistic activity
This invention provides a compound of the formula (I): or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and the use of such compounds for the manufacture of medicament for gastroesop...
08/17/2010
7617795Methods and apparatus for injecting and sampling material through avian egg membranes
An injection apparatus for injecting and/or removing substances from subjects, such as avian eggs, includes an injection needle having a body portion and a tapered portion that terminates at a tip. A tube is attached to and extends around the injection needle in sub...
11/17/2009
7611277Methods and apparatus for candling avian eggs via thermal cameras
Egg candling methods and apparatus are provided wherein non-live eggs, inverted egg, and side air cell eggs can be quickly identified. A method of candling eggs includes exposing a plurality of incubated eggs to an environment having a temperature different from a t...
11/03/2009
7573566Methods and apparatus for maintaining effective operation of apparatus for candling avian eggs
Egg candling methods and apparatus are provided wherein the optical path between a light source and light detector is monitored for obscuring debris and/or malfunctions. A method of candling eggs includes illuminating an egg with light from a light source; receiving...
08/11/2009
7479559Benzyl(idene)-lactam derivatives
The present invention relates to novel benzyl(idene)-lactam derivatives, compounds of the formula I wherein R1 is a group of the formula G1 or G2 depicted below,
01/20/2009
7273936Oxazole and thiazole compounds as transforming growth factor (TGF) inhibitors
Novel oxazole and thiazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of tran...
09/25/2007
7176311Process for preparing pharmaceutically active compounds
A process for the preparation of Compounds of the formula (1): wherein R1, R2, R4 and R13 are as defined or a pharmaceutically or veterinarily acceptable salt or polymo...
02/13/2007
7129234Phenyl heterocyclyl ethers
The invention relates to compounds of formula I ...
10/31/2006
7087617Substituted pyrimidine derivatives
This invention relates to compounds of Formula I, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, or a pharmaceutically acceptable salt of a prodrug thereof. The compounds i...
08/08/2006
7029887Methods related to gene directing the ratio of B2:B1 avermectins
The present invention relates to polynucleotide molecules comprising sequences encoding avec gene products, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of Streptomyces avermiti...
04/18/2006
7022684Treatment of rumen acidosis with α-amylase inhibitors
The invention described herein relates to: the use of an effective inhibitor of a bacterial α-amylase and/or α-glucosidase in the manufacture of a composition for the treatment of rumen acidosis; a method of treatment of rumen acidosis which comprises administrati...
04/04/2006
7005520Process for the preparation of pyrazolopyrimidinones
There is provided a process for the production a compound of general formula I: wherein A, R1, R2, R3 and R4 have meanings given in the description, which process comprises th...
02/28/2006
6964780Controlled-release pharmaceutical formulations
The invention provides controlled-release formulations for oral administration containing a cGMP PDE-5 inhibitor. The formulations are useful, inter alia, in the treatment or prevention of sexual dysfunction. ...
11/15/2005
6949536Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
This invention provides a compound of the formula: or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated ...
09/27/2005
6916927Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3′,5′-monophosphate phosphodiesterase (cGMP-PDE5) for the treatment of sexual dysfunction
Compounds of formulae (IA) and (IB) or pharmaceutically or veterinarily acceptable salts thereof, or pharmaceutically or veterinarily acceptable solvates of either entity, wherein R1 is C1 to C3 alkyl substituted with C3 t...
07/12/2005
6914160Oxytocin inhibitors
This invention relates to compounds of formula (I) ...
07/05/2005
6849649N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase
The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R1 is optionally substituted C1-6alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, C1-6alk...
02/01/2005
6833263AveC gene product from Streptomyces hygroscopicus
The present invention relates to polynucleotide molecules comprising sequences encoding avec gene products, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of Streptomyces avermiti...
12/21/2004
6831074Pharmaceutically active compounds
The present invention provides a compound of formula (I): where Q is a group of formula: These compounds inhibit cyclic guanosine 3′,5′-monophosphate phosphodiesteras...
12/14/2004
6825344Process for the preparation of cephalosporin compounds and synthetic intermediates
There is provided a process for the preparation of a compound according to Formula (II): which includes the step of cyclising a compound of Formula (III): wherein R1...
11/30/2004
6812241Nitrogen-containing heterocycles having parasiticidal properties
Compounds of formula (I) wherein the substituents are as defined herein, are antiparasitic agents. ...
11/02/2004
6809200Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-one compounds and intermediates thereof
A process is provide for the preparation of compounds of formula (I) herein comprising reacting a compound of formula (III), (IV) or (V) wherein the variables are as defi...
10/26/2004
6800652Diaryl compounds
The invention relates to compounds of formula I ...
10/05/2004
6794387Pharmaceutically active compounds
Compounds of general formula (I): wherein R1, R2, R3, R4, X, Y and A have the meanings given herein which are useful in the curative and prophylactic treatment of a medical con...
09/21/2004
6756373Pharmaceutically active compounds
There is provided a compound of formula I: wherein X represents O or NR5 R4 represents H, halo, cyano, nitro, halo(loweralkyl), OR6, OC(O)R7, C(O)R8, ...
06/29/2004
6753332Sulfonyl heteroaryl triazoles as anti-inflammatory/analgesic agents
The present invention relates to compounds of the formula wherein R1, R3, R5 and A are defined as in the specification, to pharmaceutical compositions containing them and to their medicin...
06/22/2004
6727238Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
This invention provides a compound of the formula: or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated fi...
04/27/2004
6720330Somatostatin antagonists and agonists that act at the SST subtype 2 receptor
Compounds according to the formula A—Z—W as herein described, wherein A is selected from the groups consisting of: A′—(CH2)n—, A′—(CH2)nSO2—, and A′—(CH2)nCO—, where n...
04/13/2004
6713286Compositions and methods for protecting animals from lentivirus-associated disease such as feline immunodeficiency virus
The present invention is directed to a novel strain of feline immunodeficiency virus, designated herein as FIV-141, and to attenuated forms of the virus produced by mutating specific regions of the viral genome. The virus and mutated forms of the virus may be used t...
03/30/2004
6696470Pyridylthiophene compounds
A compound of the formula: ##STR1## and its pharmaceutically effective salts, wherein R1 and R2 are independently selected from the following: (a) hydrogen, halo, R5 --, C2-6 alkenyl, C2-6 alkynyl, ...
02/24/2004
6646128Process for preparing heterocyclo-alkylsulfonyl pyrazole derivatives
The invention relates to processes for preparing compounds of formula 1: ##STR1## as well as intermediates useful in such processes, wherein R1 -R4 are as defined herein. The compounds of formula 1 are useful in the treatment or ...
11/11/2003
6624162Imidazopyridine compounds as 5-HT4 receptor modulators
This invention provides a compound of the formula (I): ##STR1## or the pharmaceutically acceptable salts thereof wherein R1 is hydrogen, halo or alkyl; R2 and R3 are independently hydrogen, alkyl, alkenyl, alkynyl, aminoal...
09/23/2003
6610518Enzymatic oxidations
The following invention relates to a process for oxidizing alkyl groups attached directly or via a linker, to a sulfonamide moiety (II) by the use of cytochrome P450 enzymes, to give the corresponding alcohol or carboxylic acid (I). ##STR1## wherein ...
08/26/2003
 
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