Mueller; Lisa V. - US Patent Attorneys and Agents

Attorney: Mueller; Lisa V.

Number of patents: 70
Last date: May 22, 2012

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Number	Title	Issue Date
8183237	Benzenesulfonanilide compounds suitable for treating disorders that respond to modulation of the serotonin 5-HTreceptor The present invention relates to novel benzenesulfonanilide compounds of the formulae I and I′ and physiologically tolerated acid addition salts and the N-oxides thereof. The compounds possess valuable therapeutic properties and are particularly suitable, for trea...	05/22/2012
8173158	Methods of treating gastrointestinal disorders independent of the intake of food The present invention relates to a method of treating a gastrointestinal disorder by administering to a patient in need of treatment thereof a pharmaceutical composition, wherein said pharmaceutical composition can be administered to the patient independent of the i...	05/08/2012
8168791	Aminomethyl azaadamantane derivatives and methods of use thereof The invention relates to compounds that are substituted aminomethyl azaadamantane derivatives, compositions comprising such compounds, and methods of using such compounds and compositions. ...	05/01/2012
8163916	Azaadamantane ester and carbamate derivatives and methods of use thereof The invention relates to compounds that are substituted azaadamantane ester and carbamate derivatives, compositions comprising such compounds, and methods of using such compounds and compositions. ...	04/24/2012
8163915	4-substituted azaadamantane derivatives and methods of use thereof The invention relates to compounds that are 4-substituted azaadamantane derivatives, compositions comprising such compounds, and methods of using such compounds and compositions. ...	04/24/2012
8163914	Acetamide and carboxamide derivatives of azaadamantane and methods of use thereof The invention relates to compounds that are acetamide and carboxamide derivatives of azaadamantane, compositions comprising such compounds, and methods of using such compounds and compositions. ...	04/24/2012
8163769	Antibacterial compounds Antibacterials having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods of prophyl...	04/24/2012
8148408	Selective substituted pyridine ligands for neuronal nicotinic receptors The present application describes selective ligands of formula (I) for neuronal nicotinic receptors (NNRs), more specifically for the α4β2 NNR subtype, compositions thereof, and methods of using the same, wherein X, R	04/03/2012
8129417	Substituted octahydrocyclopenta[C]pyrrol-4-amines as calcium channel blockers The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein L1, L2, R1, R2, and R3 are as defined in the specification. Th...	03/06/2012
8129389	Substituted oxindole derivatives, medicaments containing the latter and use thereof The invention relates to novel oxindole derivatives of general formula (I), in which the substituents A, B, R1, R2 and R3 are defined as cited in claim 1, to medicaments containing said derivatives and to the use of the latter...	03/06/2012
8119676	Substituted benzimidazolone derivatives, medicaments comprising them and their use The present invention relates to novel benzimidazolone derivatives of the general formula (I) in which the substituents R1, R2, R3, A1, A2, and B are as defined in claim 1, medicaments comprising these, a...	02/21/2012
8119635	Diazabicyclic central nervous system active agents Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals. ...	02/21/2012
8114875	Substituted N-heterocyclic compounds and their use as dopamine Dreceptor ligands The invention relates to substituted N-heterocyclic compounds of general formula (I.A) and to the tautomers of the compounds the physiologically acceptable salts of the compounds and the physiologically acceptable salts of ...	02/14/2012
8101754	Triazole compounds suitable for treating disorders that respond to modulation of the dopamine Dreceptor The invention relates to compounds of the formula I: wherein n is 1 or 2, Ar is a C-bound 1,2,4-triazol radical which carries a radical R1 on the remaining carbon atom and a radical R	01/24/2012
8084616	TRPV1 antagonists The present invention relates to compounds of formula (I) wherein X, R1, R2, R3, R4, R5, m, and n are defined in the specification are TRPV1 antagonists. Compositions c...	12/27/2011
8076350	Spirocyclic azaadamantane derivatives and methods of use The invention relates to compounds that are spirocyclic azaadamantane derivatives derivatives, particularly spirocyclic azaadamantanyl ether or amine derivatives, compositions comprising such compounds, methods of using such compounds and compositions, processes for...	12/13/2011
8076344	Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme The present invention relates to compounds of formula (I): wherein R1, R2, and R3, are defined herein. Pharmaceutical compositions and methods for treating DGAT-1 related diseases or ...	12/13/2011
8076326	N-phenyl- (piperazinyl or homopiperazinyl)-benzenesulfonamide or benzenesulfonyl-phenl-(piperazine or homopiperazine) compounds suitable for treating disorders that respond to modulation of the serotonin 5-HTreceptor The present invention relates to N-phenyl-(piperazinyl or homopiperazinyl)-benzenesulfonamide or benzenesulfonyl-phenyl-(piperazine or homopiperazine) compounds, pharmaceutical compositions containing them, and their use in therapy. The compounds possess valuable th...	12/13/2011
8071762	Fused compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor The present invention discloses novel compounds of general formula (I) or a pharmaceutically acceptable salt or prodrug thereof (in which X1-X5, R5-R8b, Z1-Z2	12/06/2011
8062664	Process for preparing formulations of lipid-regulating drugs A process for preparing a formulation of a lipid-regulating drug is disclosed, the process comprising dissolving lipid-regulating drug in a solvent free of surfactant to form a solution, premixing an excipient to form an admixture, wet granulating the solution and a...	11/22/2011
8044079	Substituted oxindole derivatives, medicaments containing said derivatives and use thereof The invention relates to novel oxindole derivative of general formula (I), wherein the substituents R1, R2, A, B, and Y are defined as in Claim 1. The invention further relates to medicaments containing said derivatives, and use thereof ...	10/25/2011
8044069	Compounds as calcium channel blockers The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein Ar1, Ar2, L1, L2, n, R1, R4, X and Y are as defined...	10/25/2011
8034920	Nucleic acid primers and probes for detecting breast cells Polynucleotides are provided which are useful as amplification primers and hybridization probes for detecting BS106 target sequence in a test sample. The primers and probes can be employed in amplification based methods for detecting the presence of BS106 sequences ...	10/11/2011
8030504	Antagonists of the TRPV1 receptor and uses thereof The present application is directed to compounds that are TRPV1 antagonists and have formula (I) wherein variables Ar1, L1, R1, R2, R3, R4, R5, Y	10/04/2011
8026256	Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence, or bladder overactivity. ...	09/27/2011
8008488	Pyrimidin-2-one compounds and their use as dopamine Dreceptor ligands The invention relates to pyrimidin 2-one compounds of general formula (I), in addition to the derivatives and tautomers of (I) and the physiologically acceptable salts of said compounds. In said formula, A represents linear or branched C3-C6 al...	08/30/2011
7998993	TRPV1 antagonists Compounds of formula (I) wherein R1, R2, R4, and W are defined in the description are TRPV 1 antagonists with CNS penetration. Compositions comprising such compounds and methods for treating...	08/16/2011
7998982	Amide derivatives as TRPV1 antagonists The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, and R3, are defined in ...	08/16/2011
7998506	Nicotinic acid compositions for treating hyperlipidemia and related methods therefor An orally administered antihyperlipidemia composition according to the present invention includes from about 250 to about 3000 parts by weight of nicotinic acid, and from about 5 to about 50 parts by weight of hydroxypropyl methylcellulose. Also, a method of treatin...	08/16/2011
7998480	Human BNP immunospecific antibodies The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain ...	08/16/2011
7994160	Pyridazine compounds as glycogen synthase kinase 3 inhibitors Disclosed are pyridazine compounds of the formula I which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds:	08/09/2011
7988992	Superporous hydrogels for heavy-duty applications The present invention features modified superporous hydrogels (SPHs) and methods for their formation. The SPHs of the present invention are prepared by careful selection of the hydrophobic/hydrophilic reactive ingredients and by harmonizing the foaming and polymeriz...	08/02/2011
7981420	Therapeutic use of antibodies directed against repulsive guidance molecule (RGM) The present invention relates to the use of a modulator of a polypeptide having or comprising an amino acid sequence as disclosed herein or of a functional fragment or derivative thereof or of a polynucleotide encoding said polypeptide or fragment or derivative for ...	07/19/2011
D641864	Tablet	07/19/2011
D641863	Tablet	07/19/2011
RE42477	Carboxylic acid derivatives, their preparation and use Carboxylic acid derivatives where R-R6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases. ...	06/21/2011
7960386	Pyridin-2-one compounds and their use as modulators of the dopamine D3 receptor The invention relates to pyridin-2-one compounds of general formula (I) in which A represents a 4- to 6-membered hydrocarbon chain that can have 1 or 2 methyl groups as substituents, wherein 1 or 2 carbon atoms...	06/14/2011
RE42462	Carboxylic acid derivatives, their preparation and use Carboxylic acid derivatives where R-R6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases. ...	06/14/2011
7956093	Substituted amides, their preparation and use An amide of the formula I and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts. ...	06/07/2011
7951807	Substituted oxindol derivatives and medicaments containing the same The present invention relates to novel oxindole derivatives of the general formula (I), wherein the substituents A, B, R1, R2 and R3 are as defined in Claim 1, and medicaments contain...	05/31/2011

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Attorney: Mueller; Lisa V.