Did You Know...
...that in 1800 ether was first used by partyers as a fun diversion? Sniffing the gas led to hilarious and raucous laughter as people watched each other become more and more intoxicated and silly. Several doctors independently realized the value ether would have to anesthetize surgery patients. Of those who claimed rights to the "discovery," none had a happy ending. One had a seizure and died defending his rights. Another spent his life in an asylum because he had been denied acclaim. A third became addicted to chloroform and, in a New York City jail, he soaked a cloth in the drug, severed an artery and bled to death.
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| Number | Title | Issue Date |
| 8178568 | Sulfone compounds which modulate the CB2 receptor Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain. ... | 05/15/2012 |
| 8178541 | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions The present invention relates to substituted xanthines of general formula wherein R1 to R3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts ther... | 05/15/2012 |
| 8178111 | GM-negative EHV-mutants without heterologous elements The present invention relates to the field of animal health and in particular of Equine Herpes Viruses (EHV) wherein the gene encoding the protein gM is absent, and which is free of heterologous elements. Further aspects of the invention relate to pharmaceutical com... | 05/15/2012 |
| 8175843 | Computer-implemented methods for evaluating, summarizing and presenting data on stability of drug substances and drug products and software-modified computers for such methods Computer-implemented methods for statistical analysis and summarization of a stability study on a pharmaceutical product using of a macro integrated into statistical analysis software. The method includes inputting and summarizing data observed for a stability study... | 05/08/2012 |
| 8173699 | Compounds for the treatment of inflammatory diseases Compounds of formula 1 and hetero derivatives thereof and the pharmacologically acceptable salts, enantiomers, racemates, hydrates, or solvates thereof, which are suitable for the treatment of respiratory or gastrointestina... | 05/08/2012 |
| 8173638 | Compounds which modulate the CB2 receptor Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treat... | 05/08/2012 |
| 8168752 | T cell proteins and nucleotides encoding the same The present invention relates to mouse and human J12 polynucleotides, polypeptide and anti J12 antibody molecules. The J12 is a cytokine that is preferentially expressed in Th2 cells. The polypeptides and/or antibodies described herein can be used in methods for det... | 05/01/2012 |
| 8163918 | Azaindazole compounds as CCR1 receptor antagonists Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. | 04/24/2012 |
| 8163911 | Arylsulfonylaminomethylphosphonic acid derivatives, the preparation thereof and the use thereof as pharmaceutical compositions The invention relates to substituted arylsulphonylaminomethylphosphonic acid derivatives of general formula (I) wherein the groups Ra to Rf, A and Z are defined as mentioned in the specification and claims, which are suitable for preparing a me... | 04/24/2012 |
| 8158641 | 2-anilino-4-aminoalkyleneaminopyrimidines The present invention relates to 2-arylamino-4-(aminoalkylene)aminopyrimidines inhibitors having the structure shown below: wherein R and R1 are as defined herein. The 2-arylamino-4 -(aminoalkylene)aminopyrimidin... | 04/17/2012 |
| 8158633 | Phenyl-substituted pyrazolopyrimidines The invention relates to novel phenyl-substituted pyrazolopyrimidines, process for their preparation, and their use for producing medicaments for improving perception, concentration, learning and/or memory. ... | 04/17/2012 |
| 8153660 | Piperidyl-propane-thiol CCR3 modulators One object of the present invention are novel substituted piperidyl-propane-thiols of the formula (1), wherein R1, R2, R3 and R4 are defined as below. Another object of the present invention is to provide agonists or antag... | 04/10/2012 |
| 8148403 | Substituted piperidyl-propane-thiols One object of the present invention are novel substituted piperidyl-propane-thiols of the formula (1), wherein R1, R2, R3 and D are defined as below. Another object of the present invention is to provide agonists or antagonists of CC... | 04/03/2012 |
| 8143247 | Combinations for the treatment of diseases involving cell proliferation Disclosed are pharmaceutical compositions for the treatment of diseases which involve cell proliferation. Also disclosed are methods for the treatment of said diseases, comprising co-administration of a compound 1 of Formula (I) ... | 03/27/2012 |
| 8138373 | Process for the manufacture of dihydropteridinones Disclosed are processes for preparing dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and in the specification. ... | 03/20/2012 |
| 8138341 | Intermediate compounds useful for the manufacture of dihydropteridinones Disclosed are processes and intermediate compounds for preparing dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and in the specification... | 03/20/2012 |
| 8119810 | Process for the preparation of a benzimidazole derivative The invention relates to a process for preparing the compound of formula 1, a valuable intermediate product in the synthesis of the pharmaceutical active substance dabigatran etexilate. ... | 02/21/2012 |
| 8119797 | Production method The present invention relates to a process for preparing compounds of general formula I wherein R1 and R2 are defined as in claim 1, the pharmaceutically acceptable salts and the solvates thereo... | 02/21/2012 |
| 8119648 | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions The present invention relates to substituted xanthines of general formula wherein R1 to R3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts ther... | 02/21/2012 |
| 8119143 | Multivalent PCV2 immunogenic compositions and methods of producing such compositions An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. Also provided is recombinant PCV2 ORF2 protein, and immunogenic compositions comprising PCV2 ORF2 protein. Moreover, multivalent combination v... | 02/21/2012 |
| 8114878 | 6,7-dihydrothieno[3,2-d]pyrimidine for the treatment of inflammatory diseases The invention relates to new dihydrothienopyrimidine of formula 1, as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein X is SO or SO2, but p... | 02/14/2012 |
| 8114667 | Hybridoma producing antibodies to The present invention relates to the field of animal health and in particular to Lawsonia intracellularis. In particular, the invention relates to a method of diagnosing Lawsonia intracellularis infection and a diagnostic test kit using Lawsonia int... | 02/14/2012 |
| 8114666 | Hybridoma producing antibodies to The present invention relates to the field of animal health and in particular to Lawsonia intracellularis. In particular, the invention relates to a method of diagnosing Lawsonia intracellularis infection and a diagnostic test kit using Lawsonia int... | 02/14/2012 |
| 8110575 | Compounds The present invention relates to new CGRP-antagonists of general formula I wherein U, V, X, Y, R1, R2, R3 and R4 are defined as in the description, the tautomers, the isomers, the... | 02/07/2012 |
| 8106060 | 8-(3-amino-piperidin-1-yl)-xanthines, their preparation, and their use as pharmaceuticals The invention relates to 8-[3-amino-piperidin-1-yl]-xanthines and the physiologically acceptable salts thereof, particularly the hydrochlorides thereof. ... | 01/31/2012 |
| 8101765 | Process for preparing acyclic HCV protease inhibitors Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection: The disclosed processes use SNAr-ty... | 01/24/2012 |
| 8101763 | Method for producing scopine esters The invention relates to a novel method for producing scopine esters of the general formula (1), wherein X—, R, R1, R2, R3, R4, R3′, R4′, R6 and R6′ can have the meanings indicated in the claims and in the description. ... | 01/24/2012 |
| 8096971 | Dual chamber container for lyophilization, process for the filling up and use thereof Double chamber container for holding and combining, e.g., a lyophilizate and a liquid reconstitution medium, comprising an integral cylindrical body (15) with a closure (20, 60) at each of the two ends (5, 70), an upper... | 01/17/2012 |
| RE43115 | Process for the manufacture of fused piperazin-2-one derivatives Disclosed are processes for the preparation of fused piperazin-2-one derivatives of general formula (I) wherein the groups R1 to R5, A1 and A2 have the meanings given in the claim... | 01/17/2012 |
| 8093266 | Rho kinase inhibitors Substituted amide and urea derivatives useful as inhibitors of Rho kinase are described, which inhibitors can be useful in the treatment of various disorders such as cardiovascular diseases, cancer, neurological diseases, renal diseases, bronchial asthma, erectile d... | 01/10/2012 |
| 8088915 | Methods for modulating IKKα activity A method for modulating NF-κB dependent gene transcription in a cell comprised of modulating IKKα protein activity in the cell. The present invention also provides siRNA compositions and methods thereof for modulating NF-κB dependent gene transcription. ... | 01/03/2012 |
| 8088769 | Cyanopyrimidinones The invention relates to novel cyanopyrimidinones, process for their preparation, and the use thereof for producing medicaments for improving perception, concentration, learning and/or memory. ... | 01/03/2012 |
| 8087286 | Method for checking the permeability rate of a closed container In a method for checking the permeability rate of a closed container (3) with respect to a medium, in particular for checking the permeability rate of a film-type container for accommodating a film container for accommodating a pharmaceutical active constitue... | 01/03/2012 |
| 8084634 | Production method The present invention relates to a process for preparing compounds of general formula I wherein R1 and R2 are defined as in claim 1, the pharmaceutically acceptable salts and the solvates thereo... | 12/27/2011 |
| 8076365 | Viral polymerase inhibitors The present invention relates to compounds represented by formula (I) wherein A, B, D, E, R2, R3, R4, R5, R6, R9, a, b, d and e are as defined herein, their salt or ester and pharmaceutical compositio... | 12/13/2011 |
| 8071583 | Pyrrolo[3,2-D] pyrimidines as DPP-IV inhibitors for the treatment of diabetes mellitus The present invention relates to substituted pyrrolo[3,2-d]pyrimidines of formula (I), wherein R1 and R2 are defined as in claim 1, including the tautomers, stereoisomers, mixtures and salts thereof, which have valuable pharmacological properties, particularl... | 12/06/2011 |
| 8067617 | Indolinone derivatives and process for their manufacture The present invention relates to specific indolinone derivatives, namely the compounds of formula, in which R1 represents an hydrogen atom or a group, and R2 and R3 each represent an hydrogen atom or R2 and R3 t... | 11/29/2011 |
| 8067593 | Process for preparing aminocrotonylamino-substituted quinazoline derivatives The invention relates to an improved process for preparing aminocrotonylamino-substituted quinazoline derivatives of general formula (I) wherein the groups Ra, Rb, Rc and Rd have ... | 11/29/2011 |
| 8067590 | Pyridone derivates with MCH antagonistic activity and medicaments comprising these compounds The present invention relates to compounds of general formula I wherein the groups and radicals B, k, L, U, V, W, X, Y, Z, R1, R2, have the meanings given in claim 1. Moreover the invention rela... | 11/29/2011 |
| 8067438 | Hepatitis C inhibitor compounds Compounds of formula (I): wherein B, X, R3, L0, L1, L2, R2, R1 and RC are defined herein. The compounds are useful as inhibitors of HCV NS3 protea... | 11/29/2011 |
