Did You Know...
...that in 1800 ether was first used by partyers as a fun diversion? Sniffing the gas led to hilarious and raucous laughter as people watched each other become more and more intoxicated and silly. Several doctors independently realized the value ether would have to anesthetize surgery patients. Of those who claimed rights to the "discovery," none had a happy ending. One had a seizure and died defending his rights. Another spent his life in an asylum because he had been denied acclaim. A third became addicted to chloroform and, in a New York City jail, he soaked a cloth in the drug, severed an artery and bled to death.
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| Number | Title | Issue Date |
| 7973029 | Inhaled aztreonam lysine for the treatment of deficits in health-related quality-of-life in lung diseases Provided is a method of treating the health-related quality-of-life (HRQOL) symptoms of a lung disease, comprising the administration of an inhalable aerosol of aztreonam lysine. The method is suitable for the short term and sustainable long term treatment of HRQOL ... | 07/05/2011 |
| 7345041 | Chemical compounds The invention relates to methods for the treatment of a sleep disorder comprising administering a compound of formula (I): wherein all variables are as defined herein. ... | 03/18/2008 |
| 7304068 | Substituted pyrazolo [1,5-A] pyrimidinyls and pharmaceutical uses therefore The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents. ... | 12/04/2007 |
| 7297683 | Crystalline forms of an antiviral benzimidazole compound The invention relates to Form physical forms of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole, pharmaceutical compositions comprising the same, and their use in medical therapy. ... | 11/20/2007 |
| 7294630 | Piperazinyl piperidine tachykinin antagonists The present invention provides compounds of formula (I): wherein each R independently represents a halogen atom or a C1-4 alkyl group; R1 ... | 11/13/2007 |
| 7276509 | Piperidine derivatives and their use as antagonists of tachykinins The present invention relates to piperidine derivatives of formula (I): wherein R represents halogen or C1-4 alkyl; R1 represents hydrogen or C1-4 alkyl;... | 10/02/2007 |
| 7247626 | Pyrazolopyrimidine derivatives and pharmaceutical compositions containing them The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents. ... | 07/24/2007 |
| 7214680 | 2-substituted 1-arylpiperazines as tachykinin antagonists and/or serotonin reuptake inhibitors The present invention relates to piperazine of formula (I) wherein R represents halogen, C1-4 alkyl, trifluoromethoxy or trifluoromethyl; R1 is trifluoromethyl, C | 05/08/2007 |
| 7199120 | Pyrazolo-pyridine derivatives as antiherpes agents The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceuti... | 04/03/2007 |
| 7189713 | Piperidine derivatives The present invention relates to piperidine derivatives of formula (I): R represents halogen or C1-4 alkyl R1 represents C1-4 alkyl;... | 03/13/2007 |
| 7186714 | Imidazo[1,2-α]pyridine derivatives for the prophylaxis and treatment of herpes viral infections The present invention provides compounds of formula (I) wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents ... | 03/06/2007 |
| 7166597 | Fused pyrazole derivatives being protein kinase inhibitors Compounds of Formula (I): salts or solvates or physiologically functional derivatives thereof, wherein Z is CH or N, and R1, R2, and R4 are various substituent groups, are protein kinase inhibitors | 01/23/2007 |
| 7163940 | Pyrazolopyridinyl pyrimidine therapeutic compounds The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceuti... | 01/16/2007 |
| 7160897 | Therapeutic compounds The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceuti... | 01/09/2007 |
| 7153863 | Therapeutic compounds based on pyrazolopyridline derivatives The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceuti... | 12/26/2006 |
| 7153855 | Pyrazolopyridinyl pyrimidine therapeutic compounds The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents. ... | 12/26/2006 |
| 7141569 | Antiviral pyrazolopyridine compounds The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents. ... | 11/28/2006 |
| 7119092 | Chemical compounds wherein R represents a halogen atom or a C1-4 alkyl group; R1 represents a C1-4 alkyl group; R2 represents hydrogen or a C1-4 | 10/10/2006 |
| 7109209 | Pyrazolopyridines, process for their preparation and use as therapeutic compounds The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceuti... | 09/19/2006 |
| 7101994 | Process for preparing substituted benzimidazole compounds The invention relates to new methods of preparing substituted benzimidazole compounds, such as 2-bromo-5,6-dichlorobenzimidazole, which are useful in the preparation of compounds having antiviral activity. ... | 09/05/2006 |
| 7071196 | Chemical compounds The invention relates to piperazine derivatives, to processes for their preparation, to pharmaceutical compositions containing them, and to their medical use. The novel compounds are antagonists of tachykinins, including substance P and other neurokinins. ... | 07/04/2006 |
| 7060702 | Chemical compounds The present invention provides compounds of formula (I): wherein each R independently represents a halogen atom or a C1-4 alkyl group; R1 represents a C1-4 | 06/13/2006 |
| 7034030 | Pyralopyridines, process for their preparation and use as therapeutic compounds The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents. ... | 04/25/2006 |
| 7030134 | Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical age... | 04/18/2006 |
| 7026327 | Pyrimidine derivatives useful as selective COX-2 inhibitors The invention provides the compounds of formula (I) in which: R1 is selected from the group consisting of H, C1-6alkyl, C1-2alkyl substituted by one to five fluorine atoms,... | 04/11/2006 |
| 7002012 | Substituted (1,3-bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9h-purin-8-YI)phenyl derivatives, their preparation and their use in the treatment of inflammatory conditions and immune disorders A method for the prophylaxis of an inflammatory condition or immune disorder associated with infiltration of leukocytes into inflamed tissue in a subject in need thereof, which method comprises administering to the subject a therapeutically effective amount of a com... | 02/21/2006 |
| 6962914 | Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents. ... | 11/08/2005 |
| 6951861 | Chemical compounds The invention relates to piperazine derivatives, to processes for their preparation, to pharmaceutical compositions containing them, and to their medical use. The novel compounds are antagonists of tachykinins, including substance P and other neurokinins. ... | 10/04/2005 |
| 6943176 | Heterocyclic derivatives The present invention relates to methods for the treatment of epilepsy and irritable bowel syndrome. ... | 09/13/2005 |
| 6919352 | Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical ag... | 07/19/2005 |
| 6861429 | 2,3-diaryl-pyrazolo[1,5-b]pyridazines derivatives, their preparation and their use as cyclooxygenase 2 (COX-2) inhibitors The invention provides a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, ester or salt or solvate of such ester, of a compound of formula (I) in which: | 03/01/2005 |
| 6861441 | Use of EP4 receptor ligands in the treatment of neuropathic pain and colon cancer The present invention relates to the use of an EP4 receptor ligand in the manufacture of a medicament for use in the treatment of neuropathic pain, colon cancer, migraine, and for increasing the latency of HIV infection. ... | 03/01/2005 |
| 6831097 | 2,3-diaryl-pyrazolo[1,5-B]pyridazines derivatives, their preparation and their use as cyclooxygenase 2 (COX-2) inhibitors The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof in which: R0 is halogen, C1-6alkyl, C1-6alkoxy... | 12/14/2004 |
| 6803463 | Process for the preparation of pyrazolopyridine derivatives A process for the preparation of a compound of formula (I) and pharmaceutically acceptable derivatives thereof in which: R0 is halogen, C1-6alkyl, C1-6 | 10/12/2004 |
| 6780869 | Pyrimidine derivatives The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof, in which: R1 and R2 are independently selected from H, C1-6 alkyl, C2-... | 08/24/2004 |
| 6780870 | Pyrimidine derivatives as selective inhibitors of COX-2 The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof, in which: R1 and R2 are independently selected from H, or C1-6alkyl; | 08/24/2004 |
| 6770267 | Methods of treating periodontal disease The present invention relates to methods of treating periodontal disease. ... | 08/03/2004 |
| 6759413 | Use of cox-2 inhibitors as gastroprokinetics The invention provides a COX-2 inhibitor or a pharmaceutically acceptable derivative thereof for use in the treatment of a disorder ameliorated by a gastroprokinetic. ... | 07/06/2004 |
| 6756498 | Process for the preparation of chemical compounds The invention provides a process for preparing a compound of formula (I) and pharmaceutically acceptable derivatives thereof wherein: R0 and R1 are independently selected from H, halogen, C | 06/29/2004 |
| 6713491 | Heterocyclic derivatives The present invention relates to a novel salt of enantiomer A of 7-chloro-4-(2-oxo-1-phenyl-3-pyrrolidinylidene)-1,2,3,4-tetrahydro-2-quinoline carboxylic acid or a solvate thereof, to processes for its preparation, to pharmaceutical compositions containing it and t... | 03/30/2004 |
