In 1608, Dutch eyeglass maker Hans Lipperhey filed the first patent for a working telescope. The patent was denied.
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| Number | Title | Issue Date |
| 7932236 | Glycolipids Novel synthetic gangliosides and pharmaceutical compositions containing such synthetic gangliosides are described. Methods of making the novel synthetic ganglioside compounds and compositions as well as their use in the field of neuroprotection is also described. | 04/26/2011 |
| 7902252 | Inhibitors of D-amino acid oxidase The present invention provides novel inhibitors of the enzyme D-amino acid oxidase. The compounds of the invention are useful for treating or preventing diseases and/or condition, wherein modulation of D-serine levels, and/or its oxidative products, is effective in ... | 03/08/2011 |
| 7892802 | Fibrinogen-based tissue adhesive containing an elastase inhibitor The present invention provides a fibrinogen-based tissue adhesive which contains an elastase inhibitor. ... | 02/22/2011 |
| 7888356 | Antibiotics containing borinic acid complexes and methods of use The structure and preparation of antibiotics incorporating borinic acid complexes are disclosed, especially hydroxyquinoline, imidazole and picolinic acid derivatives, along with compositions of these antibiotics and methods of using the antibiotics and compositions... | 02/15/2011 |
| D632578 | Bottle and cap | 02/15/2011 |
| 7884124 | Fluoro-substituted inhibitors of D-amino acid oxidase This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. The invention also provides methods for the treatment and prevention of neurological disorders, such as neuro... | 02/08/2011 |
| 7868157 | Water soluble fluorescent compounds The invention provides a novel class of fluorescent compounds. Also provided are conjugates of the fluorescent compounds, methods of using the fluorescent compounds and their conjugates as well as kits including the fluorescent compounds and their conjugates. ... | 01/11/2011 |
| 7851593 | Binding proteins as biosensors The invention is directed to compositions of mutated binding proteins containing reporter groups, analyte biosensor devices derived therefrom, and their use as analyte biosensors both in vitro and in vivo. ... | 12/14/2010 |
| 7842677 | Synthetic ganglioside derivatives and compositions thereof Novel synthetic gangliosides and pharmaceutical compositions containing such synthetic gangliosides are described. Methods of making the novel synthetic ganglioside compounds and compositions as well as their use in the field of neuroprotection and cancer treatment ... | 11/30/2010 |
| 7833625 | Materials, methods and systems for separating and identifying proteins from mixtures Materials, apparatuses, methods, and systems for isolating and identifying mixture components on the basis of isoelectric point (“pI”). In one aspect, the materials are particles adapted to have a predetermined isoelectric point. The particles include a porous b... | 11/16/2010 |
| 7816344 | Boron-containing small molecules This invention provides, among other things, novel oxaboroles which are monosubstituted at the 3-, 6-, or 7-position, or disubstituted at the 3-/6- or 3-/7- positions, which are useful for treating bacterial infections, pharmaceutical compositions containing such ox... | 10/19/2010 |
| 7815783 | Multi-compartment filter and method of filtering using same Each embodiment includes a central sample reservoir and a plurality of satellite reservoirs. In a first embodiment, a first electrode in electrical contact with the central reservoir is charged and second electrodes in electrical contact with the satellite reservoir... | 10/19/2010 |
| 7815678 | Accommodating intraocular lens (AIOL), and AIOL assemblies including same An accommodating intraocular lens (AIOL) including a biasing mechanism for elastically deforming an elastically deformable shape memory disk-like optical element for affording the AIOL a natural positive diopter strength for near vision. The AIOL is intended to be i... | 10/19/2010 |
| 7805412 | Systems and methods for parallel reconstruction of files and objects Parallel reconstruction of file components following a failure of one or more of the storage devices is implemented in the context of a storage system that includes a plurality of storage devices for storing file components and a plurality of metadata managers. A st... | 09/28/2010 |
| 7803741 | Thermoset nanocomposite particles, processing for their production, and their use in oil and natural gas drilling applications Thermoset polymer particles are used in many applications requiring lightweight particles possessing high stiffness, strength, temperature resistance, and/or resistance to aggressive environments. The present invention relates to the use of two different methods, ei... | 09/28/2010 |
| 7803740 | Thermoset nanocomposite particles, processing for their production, and their use in oil and natural gas drilling applications Thermoset polymer particles are used in many applications requiring lightweight particles possessing high stiffness, strength, temperature resistance, and/or resistance to aggressive environments. The present invention relates to the use of two different methods, ei... | 09/28/2010 |
| D616900 | DVD player | 06/01/2010 |
| D615947 | Mobile phone | 05/18/2010 |
| 7705150 | Cyanine dyes The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dye... | 04/27/2010 |
| 7704710 | Interleukin-9 receptor mutants This invention relates to the diagnosis, treatment and methods for discovery of new therapeutics for atopic asthma and related disorders based on variants of Asthma Associated Factor 2. One embodiment of the invention is a variant of AAF2 wherein codon 173 is delete... | 04/27/2010 |
| D614570 | Electrical connector | 04/27/2010 |
| 7696163 | Erythropoietin: remodeling and glycoconjugation of erythropoietin The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide. ... | 04/13/2010 |
| 7686673 | Working shape prediction method, working requirement determination method, working method, working system, method of manufacturing semiconductor device, computer program, and computer program storage medium The relationship between polishing conditions constituting elements and the worked shape (amount of polishing) obtained by way of these polishing conditions is input beforehand into polishing condition determining mechanism along with the type of the object of polis... | 03/30/2010 |
| 7652000 | Boron-containing compounds and methods of use Methods of treating and/or preventing surface infections, such as acne, in an animal, such as a human being, using antibiotics incorporating borinic acid complexes, especially picolinic acid derivatives, are disclosed, along with compositions of these antibiotics. | 01/26/2010 |
| 7645816 | Water-soluble compositions of bioactive lipophilic compounds Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula: {X—OOC—[(CH2)n—COO]m}p—Y (I) wherein: X is a ... | 01/12/2010 |
| 7635598 | Inducible fluorescence assay In one aspect, the invention provides fluorescent probes and assays. The probes include a fluorophore-quencher pair that undergoes a switch from dark to fluorescent in response to a reaction of the quencher. The switch of the probe from dark to fluorescent is typica... | 12/22/2009 |
| 7628819 | Prosthetic wrist implant A wrist implant requires minimal resection of the distal radius and preserves the sigmoid notch and articulation with the head of the distal ulna. The wrist implant generally includes a radius portion, a carpal portion and a carpal ball. The wrist implant includes a... | 12/08/2009 |
| 7625408 | Prosthetic wrist implant A wrist implant requires minimal resection of the distal radius and preserves the sigmoid notch and articulation with the head of the distal ulna. The wrist implant generally includes a radius portion, a carpal portion and a carpal ball. The wrist implant includes a... | 12/01/2009 |
| 7601546 | Diagnostic test devices A diagnostic test apparatus comprising: a shaft having a first end and a second end; a swab or a biopsy punch mounted on the first end of a shaft; and a cap for fitting over the first end of the shaft, said cap containing at least one diagnostic test reagent; wherei... | 10/13/2009 |
| 7585512 | Composition and method of using tumor cells The present invention is directed to a treatment for cancer. Compositions and methods of treating cancer are included in the scope of the present invention. The compositions of the present invention include a composition prepared from tumor cells or tumor cell extra... | 09/08/2009 |
| 7582621 | Boron-containing small molecules This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow t... | 09/01/2009 |
| 7579370 | Fused heterocycles This invention provides fused heterocycles having the formula: in which R1 is a member selected from the group consisting of H, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylal... | 08/25/2009 |
| 7544295 | Oil filter housing The present invention discloses an oil filter housing, comprising an upper bowl adapted to be mounted onto a filter-mounting base of an engine, a top end of the upper bowl being formed with oil inlets and an oil outlet, and a protruding structure being provided on a... | 06/09/2009 |
| 7198916 | Green fluorescent proteins and blue fluorescent proteins This invention relates to novel fluorescent GFPs and BFPs. A novel BFP according to this invention has an F64L mutation as well as a L236R mutation and is provided with improved fluorescence. Furthermore, another BFP has the F64L mutation with the characteristics as... | 04/03/2007 |
| 7078857 | Flat luminescent lamp and method for manufacturing the same A flat luminescent lamp includes first and second substrates attached to each other at a plurality of adhesive portions, a plurality of discharge spaces in regions other than the plurality of adhesive portions between the first and second substrates, first and secon... | 07/18/2006 |
| 7486865 | Substrates for performing analytical reactions Substrates, including zero mode waveguide substrates that have been fabricated to provide additional functional elements and/or components including increased volumes for positioning of active surfaces and/or components for the mitigation of negative electrochemical... | 02/03/2009 |
| 7473680 | Remodeling and glycoconjugation of peptides The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group a peptide. ... | 01/06/2009 |
| 7465836 | Hydrolytically-resistant boron-containing therapeutics and methods of use Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and comp... | 12/16/2008 |
| 7428045 | Raman spectral analysis of pathogens Raman scattering of radiation applied to a water sample is used to assess occurrence of a pathogen in the sample. The method is useful for detecting pathogens that are difficult to detect using other methods, such as protozoa. Examples of organisms that can be detec... | 09/23/2008 |
| D576687 | Dodecahedron die with musical pitches | 09/09/2008 |