In 1608, Dutch eyeglass maker Hans Lipperhey filed the first patent for a working telescope. The patent was denied.
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| Number | Title | Issue Date |
| 8172994 | Biomaterial measuring device and manufacturing method thereof A method of producing a biomaterial measuring device is disclosed. The method includes forming a plurality of reactions elements, to which an assay reagent is applied, on a first substrate, cutting the resulting first substrate in a unit of individual reaction eleme... | 05/08/2012 |
| 8164609 | Print head pulsing techniques for multicolor printers In one aspect of the invention there is disclosed a multicolor thermal imaging system wherein different heating elements on a thermal print head can print on different color-forming layers of a multicolor thermal imaging member in a single pass. The line-printing ti... | 04/24/2012 |
| 8088572 | Polynucleotides for the detection of O157:H7 and O157:NM verotoxin producers Polynucleotide primers and probes for the specific detection of E. coli 0157:H7 and/or E. coli 0157:NM which produces verotoxin in samples are provided. The primers and probes can be used in real time diagnostic assays for rapid detection of E. coli... | 01/03/2012 |
| 8084427 | Subcutaneous implants containing a degradation-resistant polylactide polymer The present invention refers to compositions comprising a LH-RH-analogue and/or pharmaceutically acceptable salts thereof in a low-dose and a degradation-resistant polylactide suitable for the preparation of subcutaneous implants. Sterilization of the polylactide vi... | 12/27/2011 |
| 8072644 | Image stitching for a multi-head printer Techniques are disclosed for stitching images printed by a multi-head printer in a manner that is relatively insensitive to misregistration of the image segments. When a pair of overlapping print heads print a pair of adjacent image segments which meet in a stitchin... | 12/06/2011 |
| 8068126 | Multicolor thermal imaging method and thermal printer A multicolor direct thermal imaging method wherein a multicolor image is formed in a thermal imaging member comprising at least first and second different image-forming compositions and a thermal printer for use in practicing the method. Heat is applied to at least ... | 11/29/2011 |
| 7998679 | Devices and methods for diagnosis of susceptibility to diseases and disorders The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include variou... | 08/16/2011 |
| 7993896 | α-galactosidases for removing immunodominant α-galactose monosaccharides from blood group B or AB reactive cells This invention relates to enzymatic removal of type A and B antigens from blood group A, B, and AB reactive cells in blood products, and thereby converting these to non-A and non-B reactive cells. The invention further relates to using unique α-N-acetylgalactosamin... | 08/09/2011 |
| 7993310 | Collection needle A needle structure having proximal and distal ends and including a collection needle section at a more proximal end of the needle structure and a skin plug retainer section at the very distal end and integral with the collection needle section. The collection needle... | 08/09/2011 |
| 7951552 | Method of preparing non-human tissues for xenotransplantation using α-galactosidase This invention relates to novel α-galactosidases for the enzymatic removal of the immunodominant monosaccharides on blood products and tissues. Specifically this invention provides a novel family of α3 glycosidases, used for the enzymatic removal of type B antigen... | 05/31/2011 |
| 7943820 | Genetically modified plants producing lactosylceramide and utilization thereof Plant expression vectors comprising an ORF of an isoform gene (β1,4GT5) of human β1,4-galactosyltransferase were constructed. Then, the vectors were introduced into tobacco using plant gene-recombination techniques, and transformed tobacco was made. Analysis of th... | 05/17/2011 |
| 7884184 | Regulatory T cell epitopes, compositions and uses thereof The invention is directed to T cell epitopes wherein said epitopes comprises a peptide or polypeptide chain comprising at least a portion of an immunoglobulin constant or variable region. The invention also relates to methods of using and methods of making the epito... | 02/08/2011 |
| 7875258 | Technetium-dipyridine complexes, and methods of use thereof One aspect of the invention relates to novel complexes of technetium (Tc) with various heteroaromatic ligands, e.g., pyridyl and imidazolyl ligands, and their use in radiopharmaceuticals for a variety of clinical diagnostic and therapeutic applications. Another aspe... | 01/25/2011 |
| 7858295 | Methods for prolonging survival of platelets using UDP-galactose The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical compo... | 12/28/2010 |
| 7833744 | Methods to evaluate cytochrome P450 2C19 isoenzyme activity using a breath test The present invention relates, generally to a method of determining and assessing cytochrome P450 2C19-related (CYP2Cl9) metabolic capacity in an individual mammalian subject via a breath assay, by determining the relative amount of 13CO2 exhal... | 11/16/2010 |
| 7830405 | Print head pulsing techniques for multicolor printers In one aspect of the invention there is disclosed a multicolor thermal imaging system wherein different heating elements on a thermal print head can print on different color-forming layers of a multicolor thermal imaging member in a single pass. The line-printing ti... | 11/09/2010 |
| 7829497 | Thermal imaging members and methods There are described thermal imaging members and thermal imaging methods utilizing unsymmetrical rhodamine compounds. The rhodamine color-forming compounds exhibit a first color when in a crystalline form and a second color, different from the first color, when in an... | 11/09/2010 |
| 7825945 | Thermal printer with auxiliary heat sink and methods for printing using same The present invention provides a thermal printer in which the temperature of the thermal printing head can be modulated by means of an auxiliary heat sink, and methods for printing using such a thermal printer. ... | 11/02/2010 |
| 7824661 | Technetium- and rhenium-bis(heteroaryl) complexes, and methods of use thereof One aspect of the invention relates to complexes of a radionuclide with various heteroaryl ligands, e.g., imidazolyl and pyridyl ligands, and their use in radiopharmaceuticals for a variety of clinical diagnostic and therapeutic applications. Another aspect of the i... | 11/02/2010 |
| 7824558 | Processing bag for component separator system and method of removing separated components A centrifugal processing bag, system and method for separating the components of a mixed material is presented. The processing bag includes a hub and a first port for receiving the mixed material, where the first port includes an outlet positioned within the process... | 11/02/2010 |
| 7820370 | Multicolor thermal imaging method and thermal imaging member for use therein A multicolor direct thermal imaging method and an imaging member for use therein, wherein a multicolor image is formed in a thermal imaging member having at least two different image-forming compositions capable of forming two different colors. Heat is used to form ... | 10/26/2010 |
| 7808674 | Image stitching for a multi-head printer Techniques are disclosed for stitching images printed by a multi-head printer in a manner that is relatively insensitive to misregistration of the image segments. When a pair of overlapping print heads print a pair of adjacent image segments which meet in a stitchin... | 10/05/2010 |
| 7807607 | Color-forming compounds and use thereof in imaging members and methods There are described novel rhodamine color-forming compounds. The rhodamine color-forming compounds exhibit a first color when in a crystalline form and a second color, different from the first color, when in an amorphous form. Thermal imaging members containing thes... | 10/05/2010 |
| 7795024 | Apparatus and methods for amplification of blood stem cell numbers The present invention provides an apparatus and methods for expansion of hematopoietic stem cell numbers. The stem cells are cultured and differentiated cells and endogenous growth factors are removed (depleted), permitting long term culture and expansion of the ste... | 09/14/2010 |
| 7791626 | Print head pulsing techniques for multicolor printers In one aspect of the invention there is disclosed a multicolor thermal imaging system wherein different heating elements on a thermal print head can print on different color-forming layers of a multicolor thermal imaging member in a single pass. The line-printing ti... | 09/07/2010 |
| 7771403 | Uniform feed connector for devices for the delivery of active principles The feed connector (270) capable of interacting with a device for delivering active principles comprising a reservoir delimited by at least two lateral walls of substantially cylindrical shape and extending opposite one another, is characterized in that it in... | 08/10/2010 |
| 7767415 | Compositions and methods for modifying blood cell carbohydrates This invention relates to enzymatic removal of type A and B antigens from blood group A, B, and AB reactive cells in blood products, and thereby converting these to non-A and non-B reactive cells. The invention further relates to using unique αN-acetylgalactosamini... | 08/03/2010 |
| 7754913 | Synthesis of isotopically labeled alpha-keto acids and esters Isotopically labeled alpha-keto acids and esters are disclosed herein. Also disclosed are methods of synthesizing isotopically labeled alpha-keto acids and esters. ... | 07/13/2010 |
| 7704667 | Dyes and use thereof in imaging members and methods There are described novel rhodamine dye compounds and imaging members and imaging methods, including thermal imaging members and imaging methods, utilizing the compounds. The dye compounds exhibit a first color when in the crystalline form and a second color, differ... | 04/27/2010 |
| 7684857 | Device for medicine delivery by intraocular iontophoresis or electroporation The invention concerns a device for ocular delivery of an active principle by peroperative intraocular iontophoresis or electroporation comprising a reservoir (7) for receiving a solution comprising the active principle, means for diffusing (8, 6) the ... | 03/23/2010 |
| 7658910 | Preparation of radiolabelled haloaromatics via polymer-bound intermediates According to a first aspect of the invention, a process is disclosed for the preparation of radiolabelled haloaromatic compounds. According to a second aspect of the invention, intermediate precursor insoluble polymer compounds used in the preparation of the radiola... | 02/09/2010 |
| 7651457 | Expandable processing and expression chamber A flexible processing and/or expressor chamber for a biological cell processing apparatus is provided which may include a first side and a second side and having a expandable wall, wherein a first end of the expandable wall is attached to a circumference of the firs... | 01/26/2010 |
| 7645377 | Blood product transfer system A system for transferring blood product between a blood storage bag and a processing bag. The system includes an airtight containment chamber for supporting therein one or more blood storage bags. A door is provided for access to the chamber and there is included an... | 01/12/2010 |
| 7628781 | Medical usage connector assembly for the transfer of fluids The invention relates to a connector assembly (10) for the transfer of fluids, particularly fluids comprising an active agent from a reservoir to a medical device for dosage, comprising: a first connector element (20), pertaining to the reservoir with ... | 12/08/2009 |
| 7622250 | Clinically intelligent diagnostic devices and methods The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include variou... | 11/24/2009 |
| 7618154 | Compact reconfigurable illumination device Methods and apparatus providing a compact illumination device with interchangeable adaptable insert components and a light source heat sink feature are disclosed. A compact illumination device generates high quality illumination with interchangeable insert component... | 11/17/2009 |
| 7594663 | Rotating seals for cell processing systems The invention provides an improved rotating seal apparatus including a plurality of concentrically spaced annular rotating seals. The invention also provides a rotating seal apparatus including a pressurized annular chamber surrounding an annular rotating seal. ... | 09/29/2009 |
| 7566533 | Clinically intelligent diagnostic devices and methods The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include variou... | 07/28/2009 |
| 7556794 | Pendant fatty acid imaging agents The disclosure provides pendant fatty acid compounds for use in diagnostic imaging, (particularly the cardiovascular system), as well as kits comprised of the same. The disclosure also provides for a method administering a imaging agent with a high specificity for t... | 07/07/2009 |
| 7548778 | Irritation-reducing ocular iontophoresis device The invention provides an ocular iontophoresis device for delivering medication, the device comprising a medication reservoir suitable for being positioned on the eye, at least one medication in solution in the reservoir, an active electrode disposed in the reservoi... | 06/16/2009 |