Moran; Tom M. - US Patent Attorneys and Agents

Attorney: Moran; Tom M.

Number of patents: 197
Last date: August 23, 2005

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Number	Title	Issue Date
6933302	Nitrogen-based homo-camptothecin derivatives (20) esters of camptothecin analogs are provided. The compounds are (20) esters of an aminoalkanoic acid or an imidoalkanoic acid and homocamptothecin, which is optionally substituted at the 7, 9, 10, 11, and 12 positions of the homocamptothecin ring. The compounds ...	08/23/2005
4867915	16-Substituted polyunsaturated hexadecanoic fatty acids Sixteen carbon atom carboxylic acids having 16-phenoxy or 16-phenylthio substituents, and 0, 1, or 4 triple bonds, methods of preparing them, and pharmaceutical preparations containing them. These compounds are useful as lipoxygenase inhibitors....	09/19/1989
4868153	Treatment of allograft rejection with mycophenolic acid, its morpholinoethylester and derivatives thereof The compounds and pharmaceutical compositions of Formula A, wherein Z is hydrogen or --C(O)R, Y is hydrogen or morpholinoethyl, and where R is lower alkyl or aryl, and the pharmaceutically acceptable salts thereof, are useful as immunosuppressive agents, ...	09/19/1989
4868187	Anti-viral N-substituted pyrimidines Nucleoside analogues having a ring-open structure, of general formula: ##STR1## where R and R' may be hydrogen, silyl groups, substituted alkyl groups, benzyl groups and the like, and X is an optionally substituted base such as guanine or adenine, ha...	09/19/1989
4861776	Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof, compositions and use Heterocyclic aminoalkyl esters of mycophenolic acid, and the derivatives and pharmaceutically acceptable salts thereof, are useful as immunosuppressive agents, anti-inflammatory agents, anti-tumor agents, anti-viral agents, and anti-psoriatic agents....	08/29/1989
4859765	Synthetic peptide sequences useful in biological and pharmaceutical applications and methods of manufacture The present invention relates to novel synthetic antigens, conjugates and antibodies based upon specific peptide sequences and the production thereof. More particularly, the invention relates to a polypeptide which is a determinant site of a protein, the ...	08/22/1989
4857316	Synergistic antiviral composition Combinations of 9-(1,3-dihydroxy-2-propoxymethyl) guanine or a pharmaceutically acceptable salt thereof, with ଲ-interferon show a surprisingly high degree of synergism in their activity against viral infections....	08/15/1989
4857318	Bordetella bronchiseptica pilus subunit protein vaccine effective against bordetella pertussis A vaccine derived from Bordetalla bronchiseptica effective against Bordetella pertussis infection is disclosed herein....	08/15/1989
4847269	Method for treating intraocular hypertension Intraocular hypertensive diseases such as glaucoma are treated with compounds represented by formula I ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein R1 is alkyl of two to four carbon atoms; and R2 is a...	07/11/1989
4840965	Naphthalene anti-psoriatic agents Naphthalenes of the formula: ##STR1## wherein: m is 1 or 2; n is 1, 2, or 3; R1 is alkyl of one to seven carbon atoms or an optionally substituted phenyl; R2 is hydrogen, lower alkyl, lower alkoxy, optionally substituted phenyl,...	06/20/1989
4837239	Cardiotonic phosphodiesterase inhibitors complexed with water soluble vitamins This invention is directed to a formulation of cardiotonic phosphodiesterase inhibitors with a water-soluble vitamin, comprising a lyophilization step performed on a solution of the complex in an aqueous/organic solvent system. The formulation results in ...	06/06/1989
4833155	3-(ω-(3,5,-di-t-butyl-4-hydroxyphenyl)-alkanoyl)pyrroles, and anti-inflammatory uses thereof 3-[ω-(3,5-Di-t-butyl-4-hydroxyphenyl)alkanoyl]-pyrroles and their de-oxy analogs, for example, 3-(3,5-di-t-butyl-4-hydroxybenzyl)pyrrole, 2-chloro-4-(3,5-di-t-butyl-4-hydroxybenzoyl)pyrrole, 3-(3,5-di-t-butyl-4-hydroxybenzoyl)pyrrole and 3-[2-(3,5-d...	05/23/1989
4829065	Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives Substituted imidazolyl-alkyl-piperazine and diazepine derivatives of Formula A: ##STR1## wherein: R1 is aryl, lower alkyl, cycloalkyl or hydrogen; R2 is aryl, lower alkyl or hydrogen; R3 is lower alkyl, hydroxy, or hydroge...	05/09/1989
4826869	N-(lower alkyl)-2-(3'ureidobenzyl)pyrrolidines N-(lower alkyl)-2-(3'-ureidobenzyl)pyrrolidines and N-(lower alkyl)-2-(3'-ureidobenzyl)-5-(lower alkyl)pyrrolidines are useful for lowering intraocular pressure in mammals, for example, in the treatment of glaucoma....	05/02/1989
4816473	Aroyl benzofuran and benzothiophene acetic and propionic acids Novel aroyl-substituted benzofuran and benzothiophene acetic and propionic acids are disclosed herein. These compounds are useful as analgesic, anti-inflammatory, and antipyretic agents....	03/28/1989
4810706	Piperazine derivatives of theophylline and theobromine New compounds of formulas I and II ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein M is selected from the group consisting of hydrogen, morpholino, benzylamino, di-n-lower alkylamino, n-lower alkylamino and ##ST...	03/07/1989
4808592	Method of treating diseases by administering morpholinoethylester of mycophenolic acid and derivatives thereof The compounds and pharmaceutical compositions of Formula A, wherein Z is hydrogen or --C(O)R, where R is lower alkyl or aryl, and the pharmaceutically acceptable salts thereof, are useful as immunosuppressive agents, anti-inflammatory agents, anti-tumor a...	02/28/1989
4803271	Process for preparing guanine derivatives Compounds useful as antiviral agents are defined by the following formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R1 is hydrogen or --C(O)R7 wherein R7 is hydrogen, alkyl of one to...	02/07/1989
4803079	Controlled release naproxen and naproxen sodium tablets A controlled release tablet for once-daily oral administration of about 500-1200 mg of naproxen or naproxen sodium, said tablet comprising a homogeneous matrix comprising about 4-9 weight percent of hydroxypropyl methylcellulose having a number average mo...	02/07/1989
4803269	4-monosubstituted and 4,6-disubstituted N-(଱-phenylethyl)phenoxazines 4-Monosubstituted and 4,6-disubstituted phenoxazines, methods of preparing them and pharmaceutical compositions containing them. These compounds are useful as anti-inflammatories....	02/07/1989
4801577	Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists Synthetic nona- and decapeptide LHRH antagonist analogs are disclosed, having a sterically hindered guanidino-substituted arginyl or homoarginyl residue at position 8, with no arginyl substituent at position 6....	01/31/1989
4792556	Naphthalene anti-psoriatic agents Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R1 and R2 are the same and are lower alkoxy or optionally substituted phenoxy, R3 is lower alkyl, lower alkoxy...	12/20/1988
4792561	Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors The invention concerns a method of inhibiting both thromboxane synthetase and cyclic-AMP phosphodiesterase in a mammal having a disease characterized by elevated thromboxane levels or an imbalance of prostacyclin/thromboxane levels with a compound of the ...	12/20/1988
4792617	11-substituted-16-phenoxy and 16-substituted phenoxy-prostatrienioc acid derivatives This invention covers a compound of the formula ##STR1## wherein R is hydrogen, lower alkyl or a pharmaceutically acceptable, non-toxic salt of a compound wherein R is hydrogen; X is hydrogen, halo, trifluoromethyl, lower alkyl or lower alkoxy, Y is ...	12/20/1988
4791108	Sulfonyl-decahydro-8H-isoquino[2,1-G][1,6]-naphthyridines and related compounds useful as ଱₂ -blockers Compounds of formulas (1) and (2): ##STR1## in which: X and Y are independently hydrogen, hydroxy, lower alkyl, lower alkoxy or halo, or X and Y taken together is methylenendioxy or ethylene-1,2-dioxy, and R is lower alkyl, optionally substituted phe...	12/13/1988
4786652	Naphthalene anti-psoriatic agents Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R1 is lower alkoxy or optionally substituted phenoxy, R2 is the same as R1, or R2 is hydrogen, lower alk...	11/22/1988
4786637	Treatment of allograft rejection with mycophenolic acid morpholinoethylester and derivatives thereof The compounds and pharmaceutical compositions of Formula A, wherein Z is hydrogen or --C(O)R, Y is hydrogen or morpholinoethyl, and where R is lower alkyl or aryl, and the pharmaceutically acceptable salts thereof, are useful as immunosuppressive agents, ...	11/22/1988
4782047	Aqueous steroid formulations for nasal administration A non-stinging aqueous anti-inflammatory steroid formulation suitable for intranasal administration comprises: an anti-inflammatory steroid in an amount between about 0.01% and about 0.05% (w/v); propylene glycol in an amount between about 2% and about 10...	11/01/1988
4780480	Aroyl benzofuran and benzothiophene acetic and propionic acids Novel aroyl-substituted benzofuran and benzothiophene acetic and proprionic acids are disclosed herein. These compounds are useful as analgesic, anti-inflammatory, and antipyretic agents....	10/25/1988
4772466	Vaccines comprising polyoxypropylene-polyoxyethylene block polymer based adjuvants A vaccine contains an immunologically effective amount of an antigen, a polyoxypropylene-polyoxyethylene block polymer, a glycol ether-based surfactant, an immunopotentiating amount of an immunostimulating glycopeptide, and, optionally, a metabolizable no...	09/20/1988
4770874	Polyoxypropylene-polyoxyethylene block polymer based adjuvants An adjuvant composition contains an immunopotentiating amount of an immunostimulating glycopeptide, a polyoxypropylene-polyoxyethylene block polymer, a glycol ether-based surfactant, and, optionally, a metabolizable non-toxic oil....	09/13/1988
4761420	Antihypertensive dihydropyridine derivatives Compound of formula 1 are calcium entry antagonists useful for treating hypertension, congestive heart failure, angina, and vasospastic disorders: ##STR1## wherein n is an integer from 1 to 4; R1 and R2 are lower alkyl; R3...	08/02/1988
4761416	N-N-disubstituted-ω-[2-amino-3-(carbonylmethyl)-3, 4-dihydroquinazolinyl]oxyalkylamides and related compounds Pharmaceutical compositions comprising, or compositions consisting essentially of, compounds according to the formula ##STR1## or an optical isomer thereof are disclosed, wherein the substituents A, Z and R1 are defined herein. The inventi...	08/02/1988
4758587	Naphthalene anti-psoriatic agents Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R1 is lower alkoxy or optionally substituted phenoxy; R2 is hydrogen, lower alkyl, optionally substituted phenyl or optio...	07/19/1988
4755531	Thiol esters of 4,5-allenyl prostaglandins and use thereof as antigastric secretion agents Thiol esters of 4,5-allenyl prostaglandins, methods of making them, and pharmaceutical compositions containing them. These compounds are useful as gastric acid secretion inhibitors....	07/05/1988
4753935	Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions The compounds and pharmaceutical compositions of Formula A, wherein Z is hydrogen or --C(O)R, where R is lower alkyl or aryl, and the pharmaceutically acceptable salts thereof, are useful as immunosuppressive agents, anti-inflammatory agents, anti-tumor a...	06/28/1988
4752621	Arylalkyl amines useful for lowering intraocular pressure Intraocular hypertensive diseases such as glaucoma are treated with compounds represented by formula I ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein R1 is alkyl of two to four carbon atoms; R2 is ...	06/21/1988
4748173	Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof and pharmaceutical compositions Heterocyclic aminoalkyl esters of mycophenolic acid, and the derivatives and pharmaceutically acceptable salts thereof, are useful as immunosuppressive agents, anti-inflammatory agents, anti-tumor agents, anti-viral agents, and anti-psoriatic agents....	05/31/1988
4745116	2-oxy-4H-3,1-benzoxazin-4-ones and related compounds and pharmaceutical use 2-Oxy-4H-3,1-benzoxazin-4-ones, useful as serine protease inhibitors, represented by the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: a is an integer of 1 to 4; A is a bond, or alkylene having one to eight ca...	05/17/1988
4739056	N-N-disubstituted-omega-(2-amino-3-(carbonylmethyl)-3,4-dihy droquinazolinyl)oxy-alkylamides and related compounds Compounds are disclosed according to the formula ##STR1## or an optical isomer thereof. The compounds of Formula I are cyclic AMP phosphodiesterase inhibitors useful as antithrombotic and inotropic agents and the like in mammals....	04/19/1988

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Attorney: Moran; Tom M.