Did You Know...
...that when IBM conducted a market study of Chester Carlson's invention in 1959, the company concluded that it would take only 5000 units of his new product to saturate the market? IBM therefore declined to be part of the new product introduction. Too bad for IBM. Carlson's invention was the xerography process, and his new product was the beginning of the Xerox Corporation. It is estimated that every day, worldwide, 3,000,000,000 copies are made!!
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| Number | Title | Issue Date |
| 4814501 | Process for preparing N,N-dimethyl 2-(methylthio) benzamides and analogs Pyrolysis of substituted salicylate O(N,N-dialkyl)thiocarbamates yielded the corresponding N,N-dialkyl-2-(methylthio)benzamide. Similarly, substituted 6-azasalicylate O(N,N-dialkyl)thiocarbamates yielded the corresponding N,N-dialkyl-2-(methylthio)-6-aza-... | 03/21/1989 |
| 4808718 | Fused polycyclic and bridged compounds useful as calcium channel blockers Novel fused polycyclic and bridged compounds are disclosed which are useful as calcium entry blockers.... | 02/28/1989 |
| 4800211 | 5-methylthio-3-hydroxybenzo [b]thiophene-2-carboxamide derivatives as cyclooxygenase and lipoxygenase inhibitors 3-Hydroxybenzo[b]thiophene-2-carboxamide derivatives have been prepared by: (1) treating a substituted 2-halobenzoate with a thioacetamide. (2) treating a substituted thiosalicylate with an appropriately substituted haloacetamide; and (3) further synthetic modifica... | 01/24/1989 |
| 4798823 | New cyclosporin analogs with modified "C-9 amino acids" New cyclosporin analogs with modified "C-9 amino acids" have been made and are found to be effective immunosuppressive agents.... | 01/17/1989 |
| 4778818 | Substituted 2-(heteroaryl-2-propenyl)phenols useful as anti-inflammatory agents Substituted cinnamyl-2,3-dihydrobenzofurans and analogs were prepared from the nucleophlic substitution of a cinnamylhalide with a 2,3-dihydrobenzofuran anion or an analog thereof. These compounds were found to be potent topical anti-inflammatory agents.... | 10/18/1988 |
| 4748153 | Compounds having somatostatin-like activity useful as local anti-inflammatory agents Compounds having somatostatin-like activity have been found to be useful as local anti-inflammatory agents in the treatment of such conditions as, for example, psoriasis, eczema, seborrhea, and other localized inflammatory and allergic conditions. Particu... | 05/31/1988 |
| 4743694 | Diastereocontrolled synthesis of 2-amino alcohols The addition of organolithium to dimethylhydrazones of certain ethers of a-hydroxyaldehydes results in the synthesis of threo- or erythro- intermediates readily convertible to threo- or erythro-2-amino alcohols.... | 05/10/1988 |
| 4735956 | Certain 1,4-dihydro-2,6-di-lower hydrocarbyl-4-heterocyclic-3,5-pyridine dicarboxylates which are useful as calcium channel blockers Novel substituted 4-heteroaryl-1,4-dihydropyridine compounds useful as calcium channel blockers, pharmaceutical compositions therof, and methods of treatment are disclosed.... | 04/05/1988 |
| 4731444 | Bicyclic lactams as antihypertensives There are disclosed bicyclic lactams and derivatives thereof which are useful as converting enzyme inhibitors and as antihypertensives.... | 03/15/1988 |
| 4680392 | Substituted caprolactam derivatives as antihypertensives The invention in its broad aspects relates to caprolactam derivatives which are useful as angiotensin converting enxyme inhibitors and as antihypertensives.... | 07/14/1987 |
| 4677102 | Substituted diazapines and derivatives thereof useful in the treatment of cardiovascular disorders There are disclosed novel diazapines and derivatives thereof which are useful in the treatment of cardiovascular disorders.... | 06/30/1987 |
| 4675321 | Substituted pyrimidines useful as calcium channel blockers Pharmaceutical compositions of specific substituted pyrimidines and methods of treatment of certain cardiovascular disorders are disclosed. Also disclosed are novel substituted acrylated pyrimidines which are useful as calcium channel blockers.... | 06/23/1987 |
| 4670578 | Process for crystalline salts of L or (S)-3-(3,4-dihydroxyphenyl)-2-methylalanine esters Crystalline salts of (R,S)-pivaloyloxyethyl esters of (S)-3-(3,4-dihydroxyphenyl)-2-methylalanine and processes for their preparation are disclosed.... | 06/02/1987 |
| 4665094 | Oculoselective beta-blockers for treatment of elevated intraocular pressure Hydroxyalkyl-phenoxy-propan-2-olamines and novel esters thereof are oculoselective ଲ-blockers useful in the treatment of elevated intraocular pressure with little or no effect on the pulmonary or cardiovascular system.... | 05/12/1987 |
| 4656190 | Indene derivatives and their use as PAF-antagonists Indene derivatives have been found to have potent and specific PAF (Platelet-Activating-Factor) antagonistic activities and are thereby useful in the treatment of various diseases or disorders mediated by the PAF, for example, inflammation, cardiovascular... | 04/07/1987 |
| 4590201 | 5-amino or substituted amino 1,2,3-triazoles Novel 5-amino or substituted amino 1,2,3-triazoles are disclosed as having anticoccidial activity. The compounds are useful for controlling coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with a... | 05/20/1986 |
| 4581345 | Avermectin 8,9-cyclopropyl compounds, pharmaceutical composition and therapeutic methods of use There are disclosed novel avermectin 8,9-cyclopropyl compounds (also referred to as 8,9-dihydro-8,9-methano avermectin compounds). The 8,9-cyclopropyl compounds are prepared by treating an avermectin compound with an iodohalomethane compound in the presen... | 04/08/1986 |
| 4579864 | Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives There are disclosed novel avermectin and milbemycin compounds wherein the 13-position is oxidized to a keto function. The 13-keto derivatives are prepared from the 13-hydroxy compounds by oxidizing the 13-position with a suitable oxidizing agent. The aver... | 04/01/1986 |
| 4578390 | Hydroxybenzylamino derivatives as anti-inflammatory agents Hydroxybenzylamino derivatives have been prepared from an appropriate hydroxybenzaldehyde and an amine followed by reduction. These compounds are found to be active topical anti-inflammatory agents.... | 03/25/1986 |
| 4575500 | Antifungal substances and process for their production There is disclosed a series of macrolides isolated from the fermentation broth of a microorganism identified as MA-5000 which morphological analysis reveals to be a strain of Streptomyces hygroscopicus. The compound's structure is presented based upon ana... | 03/11/1986 |
| 4574125 | Naphtho-[1,2-b]-quinolizium derivatives as antidiarrheal agents There are disclosed certain naphtho-[1,2-b]-quinolizium compounds which have antidiarrheal activity. The compounds reduce fluid accumulation caused by enterotoxins produced by bacteria such as Vibrio cholerae or Escherichia coli.... | 03/04/1986 |
| 4573982 | Eye frame ophthalmic drug delivery device This invention relates to an eyeglass frame mounted unit dose ophthalmic drug delivery device. A unit dose of ophthalmic medicament is provided by either a preloaded disposable microsyringe, preloaded disposable tip or manually loaded calibrated microsyri... | 03/04/1986 |
| 4569724 | Sealing means for a vacuum distillation apparatus A sealing means for a vacuum distillation apparatus is provided having a vapor tube rotatably and sealably mounted within a vacuum tube through which vapor passes.... | 02/11/1986 |
| 4564635 | Allylsulfoxide enzyme inhibitors Organic sulfoxides having a latent allyl group bound to the sulfur are enzyme inhibitors of the suicide or Kcat type.... | 01/14/1986 |
| 4563476 | Substituted 5-hydroxy-2,3-dihydrobenzofurans and analogs thereof useful as anti-inflammatory agents Substituted 5-hydroxy-2,3-dihydrobenzofuran and analogs such as the substituted 6-hydroxy-2,3-dihydrobenzopyrans were prepared from an appropriately substituted (5-hydroxy-2,3-dihydrobenzofuran-6-yl) formaldehyde or analog thereof with an aryl amine follo... | 01/07/1986 |
| 4560677 | Synergistic avermectin combination for treating plant pests There is disclosed a novel combination of avermectin compounds and agricultural spray oil which has been found to be synergistic in such a manner as to allow for a drastic reduction in the amount of active ingredient which is fully effective and also a dr... | 12/24/1985 |
| 4560553 | Use of eucalyptol for enhancing skin permeation of bio-affecting agents Eucalyptol is used to enhance skin permeation of bio-affecting agents.... | 12/24/1985 |
| 4559983 | Device for preparing and dispensing a solution The invention relates to a device for preparing and dispensing a solution. A bottle containing a substance to be disolved is closed by a disc-shaped base having a rigid rod thereon and a deformable head. A tube of solvent is closed by an apertured slidabl... | 12/24/1985 |
| 4558071 | Phenyl, trihalomethyl or heteroaryl sulfoxides having a latent allyl group bound to sulfur as enzyme inhibitors Organic sulfoxides having a latent allyl group bound to the sulfur are enzyme inhibitors of the suicide or Kcat type.... | 12/10/1985 |
| 4558067 | Phenylthiomethyl-6-hydroxy-2,3-dihydrobenzo-pyran and analogs thereof useful as anti-inflammatory agents Phenylthiomethyl-6-hydroxy-2,3-dihydrobenzopyran and analogs thereof were prepared from an appropriate (6-hydroxy-2,3-dihydro-benzopyran-7-yl) formaldehyde or analog thereof with a substituted thiophenol. These compounds were found to be potent anti-infla... | 12/10/1985 |
| 4551456 | Ophthalmic use of norfloxacin and related antibiotics Norfloxacin and related antibiotics are useful in the treatment of ocular infections by topical administration.... | 11/05/1985 |
| 4547371 | Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents Substituted cephalosporin sulfones are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.... | 10/15/1985 |
| 4547491 | C-8A-Oxo-avermectin and milbemycin derivatives, pharmaceutical compositions and method of use There are disclosed novel avermectin and milbemycin compounds wherein the 8a position is oxidized to a ketone group. The 8a-oxo compounds are prepared by oxidizing an avermectin or milbemycin compound. The avermectin and milbemycin 8a-oxo compounds have u... | 10/15/1985 |
| 4545492 | Device for maintaining dry conditions in vessels This invention relates to a device for maintaining vessels substantially free of moisture. The device is a cap or stopper having a hollow section to contain a drying agent, a nonporous top member having at least one pinhole therein and a porous bottom mem... | 10/08/1985 |
| 4546106 | Anti-inflammatory 2-methyl-3-hydroxy-4-alkenoylthiomethyl-5-vinyl-pyridine derivatives Mercaptoalkylpyridines carrying an ethenyl or ethynyl substituent are prepared from known pyridine compounds, principally pyridoxine, by known chemical procedures, and are useful in the treatment of rheumatoid arthritis and related inflammatory diseases.... | 10/08/1985 |
| 4544667 | 2-Sulfamoylbenzo[b]furan derivatives for the treatment of elevated intraocular pressure Novel 2-sulfamoylbenzo[b]furans and derivatives thereof are shown to be useful for the treatment of elevated intraocular pressure in compositions including opthalmic drops and inserts.... | 10/01/1985 |
| 4543415 | Process for preparing tricyclic indoles An improved process for preparing 5-keto-1,3,4,5-tetrahydrobenz[c,d]indole and 6(1H)-oxo-3,4,5,6-tetrahydrocyclohept[c,d]indole is disclosed.... | 09/24/1985 |
| 4542152 | 5-[Phenylsulfonyl(or sulfinyl)]thiophene-2-sulfonamides for the topical treatment of elevated intraocular pressure 5-[Phenylsulfonyl(or sulfinyl)]thiophene-2-sulfonamides are useful for the topical treatment of elevated intraocular pressure. Ophthalmic compositions including drops and inserts are disclosed.... | 09/17/1985 |
| 4542158 | Prodrug esters of diflunisal and related compounds 1-(Alkoxy or aroxy)carbonyloxyalkyl esters of diflunisal and related compounds are stable in aqueous medium and non-irritant to mucous membranes of mouth, throat, and stomach. Accordingly, they are useful Prodrugs of the analgesic and anti-inflammatory dr... | 09/17/1985 |
| 4540709 | Method for treatment of diseases mediated by PAF using 5-allyl-2-(3,4-Dimethoxyphenyl)-3a,-methoxy-3-methyl-2,3,3a,6-tet rahydro-6-oxobenzofuran 5-allyl-2-(3,4-dimethoxyphenyl)-3a,-methoxy-3-methyl-2,3,3a,6-tetrah ydro-6-oxobenzofuran and analogs thereof as PAF-antagonists have been isolated from Piper futokadsura Sieb. et Zucc. and its analogs prepared. These neolignan compounds are found t... | 09/10/1985 |
