Mitchell; Kenneth F. - US Patent Attorneys and Agents

Attorney: Mitchell; Kenneth F.

Number of patents: 105
Last date: May 15, 2012

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Number	Title	Issue Date
8178529	Imidazole substituted pyrimidines Imidazole substituted pyrimidines and pharmaceutically acceptable salts thereof; pharmaceutical formulations containing such pyrimidines; the use of such compounds in therapy; the use of such compounds for the treatment of conditions associated with glycogen synthas...	05/15/2012
8158618	Dibenzothiazepine derivatives and uses thereof—424 Compounds the following formula: wherein Z is as described in the specification, pharmaceutically acceptable salts thereof, compositions comprising the same, and methods of treating bipolar disorder, an anxiety disorder, a ...	04/17/2012
8153638	Metabotropic glutamate-receptor-potentiating isoindolones Compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined in the description, processes for th...	04/10/2012
8148406	Polymorph of N,N-diethyl-4-(3-fluorophenyl-piperidin-4-ylidene-methyl)-benzamide hydrochloride salt Polymorphs of N,N-diethyl-4-(3-fluorophenyl-piperidin-4-ylidene-methyl)-benzamide hydrochloride salt, methods of making these polymorphs and uses thereof are described. ...	04/03/2012
8148372	Metabotropic glutamate receptor isoxazole ligands and their use as potentiators—286 Compounds in accord with Formula I: wherein R1, R2, R3 and R4 are as defined in the specification, pharmaceutically acceptable salts, methods of making, pharmaceutical composition...	04/03/2012
8143408	N-(8-heteroaryltetrahydronaphtalene-2yl) or N-(5-heteroarylchromane-3-yl) carboxamide derivatives for the treatment of pain The present invention relates to new compounds of formula (I) and to pharmaceutical composition containing said compounds and to the use of said compounds in therapy. The present invention further relates to processes for the preparation of said compounds and to new...	03/27/2012
8129393	Diarylmethyl piperazine derivatives, preparations thereof and uses thereof Compounds of general formula: as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain, depression and a...	03/06/2012
8101750	Process for the manufacturing of the compound 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-indole-5-carbonitrile 701 The present invention relates to a new process for the manufacture of the compound 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]1H-indole-5-carbonitrile as a free base and pharmaceutically acceptable salts thereof, particularly the 2-hydroxy-3-[5-(morpholin-4-y...	01/24/2012
8071621	Alkylsulphonamide quinolines Compounds of Formula I wherein R1, A, R2, R3, R4, R5, R8, n, m, q and r are as described in the specification, pharmaceutically-acceptable salts, methods of ...	12/06/2011
8063215	Cyclopropyl amide derivatives Disclosed herein is at least one cyclopropyl amide derivative, at least one pharmaceutical composition comprising at least one cyclopropyl amide derivative disclosed herein, and at least one method of using at least one cyclopropyl amide derivative disclosed herein ...	11/22/2011
8013165	Ethanamine compounds and methods of using the same 545 The present invention is directed to ethanamine compounds, pharmaceutical compositions comprising the same, and methods of treating depression by administering the ethanamine compound. ...	09/06/2011
8008294	Citrate salt of an indole derivative and its pharmaceutical use The salt, the 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]1H-indole-5-carbonitrile citrate, a process for its preparation, pharmaceutical formulations containing it and the use of it in therapy, and particularly in the therapy of GSK3 related conditions and di...	08/30/2011
7968570	Isoindolone compounds and their use as metabotropic glutamate receptor potentiators The present invention is directed to compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined...	06/28/2011
7888353	Metabotropic glutamate receptor isoxazole ligands and their use as potentiators Compounds in accord with Formula I: wherein R1, R2, R3 and R4 are as defined in the specification, pharmaceutically acceptable salts, methods of making, pharmaceutical composition...	02/15/2011
7868008	Substituted isoindolones and their use as metabotropic glutamate receptor potentiators The present invention is directed to compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined...	01/11/2011
7816354	Oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators The present invention is directed to compounds of Formula I: Wherein R1, R2, Y, m and n are further defined in the description. The invention also relates to processes for the preparation of the compou...	10/19/2010
7807706	Metabotropic glutamate-receptor-potentiating isoindolones Compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined in the description, processes for th...	10/05/2010
7799792	Metabotropic glutamate receptor oxadiazole ligands and their use as potentiators 841 Compounds of Formula I: wherein R1, R2, R3, R4 and Q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmace...	09/21/2010
7790760	Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 286 Compounds in accord with Formula I: wherein R1, R2, R3 and R4 are as defined in the specification, pharmaceutically acceptable salts, methods of making, pharmaceutical composition...	09/07/2010
7790717	Spiro-oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators Compounds in accord with Formula I: wherein R1, L, A, B, D, E, m, n, x and y are as defined in the description, processes for the preparation of such compounds and to new intermediates employed in the preparation...	09/07/2010
7781434	Metabotropic glutamate receptor isoxazole ligands and their use as potentiators—286 Compounds in accord with Formula I: wherein R1, R2, R3 and R4 are as defined in the specification, pharmaceutically acceptable salts, methods of making, pharmaceutical composition...	08/24/2010
7683067	3-heterocyclyl-indole derivatives as inhibitors of glycogen synthase kinase-3 (GSK-3) Compounds of formula Ia or Ib wherein P; R1; R2; m; and n are as defined in the application, salts thereof, processed for their preparation, new intermediates used therein, pharmaceutical formulations ...	03/23/2010
7615642	Therapeutic compounds Compounds of formula I or pharmaceutically acceptable salts thereof: wherein R1, R2, R3 and R4 are as defined in the specification as well as salts and pharmaceutical compositions...	11/10/2009
7608628	Alkylsulphonamide quinolines Compounds of Formula II wherein R1, A, R2, R3, R4, R5, R8, n, m and q are as described in the specification, pharmaceutically-acceptable salts, methods of ma...	10/27/2009
7595321	Compounds having selective inhibiting effect at GSK3 The present invention relates to new compounds of formula (I) wherein Z is N; Y is CONR5, NR5CO, SO2NR5, NR5SO2, CH2NR5, NR5, NR5CONR5, CH2	09/29/2009
7595319	Compounds having selective inhibiting effect at GSK3 Selective phenyl substituted aminopyrazine inhibitors of GSK3 useful for the prevention and/or treatment of cognitive disorders. ...	09/29/2009
7585853	Compounds having selective inhibiting effect at GSK3 The present invention relates to new compounds of formula (I) wherein: Z is N and X is CH or N; Y is CONR5; P is phenyl or a 5 or 6 membered heteroaromatic ring containing one or more heteroatoms selected from N, O or S; Q is phenyl or a 5 or 6 membered a...	09/08/2009
7576093	Method of treatment of bone-related disorders or conditions The present invention relates to a new use of a compound of the formula (I) wherein R1 is NH2, piperazin-1-yl, 4-methylpiperazin-1-yl,4-methyl-1,4-diazepan-1-yl or 4-ethylpiperazin-1-yl;	08/18/2009
7566727	2-(1-aza-bicyclo[2.2.2]oct-3-yl)-2,3-dihydro-isoindole-1-one/5,6-dihydro-furo[2,3-c] pyrrol-4-one derivative ligands for alpha 7 nicotinic acetylcholine receptor This invention encompasses nicotinic acetylcholine receptor reactive compounds in accord with formula (I) Wherein: D represents O; E represents CH2, NH, O or S; n is 1 or 2 and stereoisomers, enantiomers, in vivo-hydrolysable precursors and pharmaceutically-acceptab...	07/28/2009
7544693	Spirofuropyridine aryl derivatives Compounds of formula I: wherein Ar is a moiety of formula II or III: and pharmaceutically-acceptable salts thereof, wherein A, B, and R1 are as defined in the specifica...	06/09/2009
7514567	Oxazolidinone nicotinic acetylcholine receptor agonists Compounds of formula I: and pharmaceutically-acceptable salts thereof, wherein Q, Ar1, A and Ar2 are as defined in the specification, pharmaceutical compositions and formulations containing them, metho...	04/07/2009
7507744	Spiroazabicyclic heterocyclic compounds A pharmaceutical composition comprising a compound of formula wherein n, m, p, X, Y, W, A, G and D are as defined in the specification, enantiomers thereof, or pharmaceutically acceptable salts thereof, its use in therapy, ...	03/24/2009
7491734	2-(pyridine-4-yl)-N-(quinuclidin-2-yl)thiazole-4-carboxide nicotinic acetylcholine receptor ligands Compounds of formula I: wherein A, D, Ar1, E and Ar2 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially ...	02/17/2009
7482338	Non-amide nonanes Compounds of Formula I: and pharmaceutically-acceptable salts thereof, wherein Q, E and D are as defined in the specification, enantiomers, in vivo-hydrolysable precursors, pharmaceutical compositions and formulations conta...	01/27/2009
7417049	Furyl compounds Compounds of formula I: and pharmaceutically-acceptable salts thereof, wherein Ar and R are as defined in the specification, compositions containing such compounds and methods of using such compounds and compositions in the...	08/26/2008
7417050	Heterocyclic compounds Compounds of formula I: and pharmaceutically-acceptable salts thereof, wherein Ar and R are as defined in the specification, compositions containing such compounds and the use of such compounds and compositions for use in t...	08/26/2008
7402604	Positive modulators of nicotinic receptor agonists Compounds according to formula I: wherein R1, W, R2, R3, X, R4 and R5 are as described in the specification, enantiomers thereof, pharmaceutically acceptable salts ther...	07/22/2008
7399780	3-Heterocyclyl-indole inhibitors of glycogen synthase kinase-3 The present invention provides new compounds of formula Ia and Ib: as well as a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in ...	07/15/2008
7384954	4-substituted imidazoles Compounds of formula I: wherein A and R1 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or pro...	06/10/2008
7214688	Compounds Compounds of formula I: wherein A, D, Ar1, E and Ar2 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, ...	05/08/2007

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Attorney: Mitchell; Kenneth F.