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| Number | Title | Issue Date |
| 7883688 | Polycationic polyrotaxanes capable of forming complexes with nucleic acids A polycation capable of forming a complex with a nucleic acid for carriage thereof. The polycation comprising at least one cyclic compound having a cavity. A polymer backbone is threaded into the cavity of the cyclic compound. A pair of bulky moieties cap the termin... | 02/08/2011 |
| 7825084 | Methods and compositions for increasing the anaerobic working capacity in tissues Provided are compositions comprising beta-alanylhistidine peptides and beta-alanines, and methods for administering these peptides and amino acids. In one aspect, the compositions and methods cause an increase in the blood plasma concentrations of beta-alanine and/o... | 11/02/2010 |
| 7816372 | 6-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR. Also provided are methods of making such compounds and pharmaceutical compositions. ... | 10/19/2010 |
| 7727980 | Tricyclic androgen receptor modulator compounds and methods This invention relates to non-steroidal tricyclic compounds that are modulators of androgen receptors and to methods for making and using such compounds. ... | 06/01/2010 |
| 7700341 | Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon Provided herein is are polypeptides that include the protease domain of a type II transmembrane serine protease (MTSP) as a single chain. Methods using the polypeptides to identify compounds that modulate the protease activity of an MTSP are provided. Also provided ... | 04/20/2010 |
| 7696246 | Bicyclic androgen and progesterone receptor modulator compounds and methods The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agon... | 04/13/2010 |
| 7632858 | Open chain prolyl urea-related modulators of androgen receptor function The invention provides for a pharmaceutical composition capable of modulating the androgen receptor comprising a compound of formula I wherein R1, R2, R3, X, Y, Z and G are as described here... | 12/15/2009 |
| 7504376 | Methods and compositions for increasing the anaerobic working capacity in tissues The invention provides compositions comprising beta-alanylhistidine peptides and beta-alanines, and methods for administering these peptides and amino acids. In one aspect, the compositions and methods cause an increase in the blood plasma concentrations of beta-ala... | 03/17/2009 |
| 7414768 | Electro-optical transducer and jelly layer therefor, method for producing a jelly layer and a compound for carrying out said method The electrooptical converter comprises sequentially located on the optical axis: at least one optical lighter, a transparent support or M transparent supports, each in the form of at least one plane-parallel plate or at least one prism of total internal reflection, ... | 08/19/2008 |
| 7276364 | Nucleic acids encoding endotheliases, endotheliases and uses thereof Provided herein are endotheliases and portions, particularly, the protease domains, and nucleic acids that encode the endotheliases. The endotheliases are transmembrane proteases expressed in endothelial cells. The nucleic acids and encoded proteins and protease dom... | 10/02/2007 |
| 7259188 | Methods and pharmaceutical compositions for treatment of anti-estrogen resistant breast cancer using RXR modulators Methods and compositions for the treatment of anti-estrogen resistant breast cancer using retinoid compounds which are modulators of Retinoid X Receptors. ... | 08/21/2007 |
| 7214690 | Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods Novel non-steroidal tricyclic quinolinone and tricyclic quinoline compounds and compositions that are agonists, partial agonists and/or antagonists for androgen receptors (AR), their preparation and their uses are described. ... | 05/08/2007 |
| 7163946 | 5-substituted 7,9-difluoro-5H-chromeno[3,4-f]quinoline compounds as selective progesterone receptor modulator compounds The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by progesterone receptor. Also provided are methods of making such compounds and pharmaceutical compositions. ... | 01/16/2007 |
| 7115728 | Human peroxisome proliferator activated receptor γ The present invention relates to a novel human peroxisome proliferator activated receptor, hPPARγ. hPPARγ differs from the mouse peroxisome proliferator activated receptor γ in the nucleotide sequence and the amino acid sequence. The invention provides isolated, ... | 10/03/2006 |
| 7098025 | Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor This invention relates to the isolation and cloning of the promoter and other control regions of human PPARγ gene. It provides a method for identifying and screening for agents useful for the treatment of diseases and pathological conditions affected by the level o... | 08/29/2006 |
| 7084151 | 5-(1',1'-cycloalkyl/alkenyl)methylidene 1,2-dihydro--chromeno[3,4-ƒ]quinolines as selective progesterone receptor modulator compounds The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such compounds and pharmaceutical compositions. ... | 08/01/2006 |
| 7071205 | 5-cycloalkenyl 5H-chromeno[3,4-f]quinoline derivatives as selective progesterone receptor modulator compounds The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such compounds and pharmaceutical compositions. ... | 07/04/2006 |
| 7018395 | Photodynamic treatment of targeted cells The present invention is drawn to methods for photodynamic therapy (PDT) of a target cell, target tissue or target composition in a mammalian subject, using a therapeutically effective amount of a targeted substance, which is either a targeted photosensitizing agent... | 03/28/2006 |
| 6991903 | Solid phase sequencing of double-stranded nucleic acids Methods for detecting and sequencing of target double-stranded nucleic acid molecules, nucleic acid probes and arrays of probes useful in these methods, and kits and systems that contain these probes are provided. The methods involve hybridizing the nucleic acids or... | 01/31/2006 |
| 6979533 | Determination of endometrial receptivity toward embryo implantation Methods for detecting receptivity of mammalian endometrium to embryo implantation comprising obtaining a sample of the endometrium, contacting the endometrium with a monoclonal antibody for β3 and detecting β3 in the endometrium. The inventio... | 12/27/2005 |
| 6964973 | Bicyclic androgen and progesterone receptor modulator compounds and methods The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agon... | 11/15/2005 |
| 6960445 | Determination of endometrial receptivity toward embryo implantation Methods of diagnosing infertility in a mammal that include detecting the presence and level of a β3 integrin subunit in an endometrium sample of a mammal at a plurality of stages of the endometrial cycle and correlating delayed appearance or a reduced le... | 11/01/2005 |
