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| Number | Title | Issue Date |
| 8183341 | Antibacterial compounds and processes for its production This invention relates to a novel antibiotic compounds, pharmaceutically acceptable salts and derivatives thereof, and to methods for obtaining such compounds. ... | 05/22/2012 |
| 8183281 | CXC-chemokine receptor ligands The present invention relates to compounds of formula (I) with the substituents as defined herein, and uses thereof. ... | 05/22/2012 |
| 7582782 | Organic compounds Disclosed are δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amide compounds of formula (I) and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions comprising these compounds and... | 09/01/2009 |
| 7569571 | Substituted pyrazolo [3,4-d]pyrimidines as cytokine modulators Provided are bicyclic heterocycle-based p38 kinase, including p38α and p38β kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including methods of treatme... | 08/04/2009 |
| 7563881 | Nucleic acid encoding polypeptide involved in cellular entrance of the PRRS virus The present invention relates to a new polynucleotide that encodes a polypeptide involved in cellular entrance of PRRSV, to a recombinant vector comprising said polynucleotide, to a cell capable of expressing said polypeptide, a method of producing said polypeptide ... | 07/21/2009 |
| 7432293 | Heterocyclic compounds useful as Nurr-1 activators The present invention relates to compounds of formula (I): wherein R1 is hydroxy, C1-4 alkoxy, amino, C1-4 alkyl-amino, di C1-4alkylamino, benzyloxy or C2-C7 alkanoyl, R2 is C1-4 | 10/07/2008 |
| 7431930 | Infectious bursal disease virus (IBDV) mutant expressing virus neutralising epitopes specific for classic-and variant IBDV strains The present invention provides a classic IBDV mutant that additionally comprises virus neutralising epitopes 67 (specific for variant-E IBDV). ... | 10/07/2008 |
| 7341725 | Structural proteins of fish pancreatic disease virus and uses thereof The present invention relates to the structural proteins of the causative agent of Pancreatic Disease in fish, nucleotide sequences encoding said proteins, vaccines comprising said proteins or nucleotide sequences and diagnostic kits comprising said proteins or nucl... | 03/11/2008 |
| 7335366 | Attenuated bovine respiratory syncytial virus The present invention relates i.a. to Bovine Respiratory Syncytial Viruses that are not capable of expressing a functional SH-protein and/or G-protein due to a mutation in the genes encoding the said proteins. Also the invention relates to diagnostic test kits for d... | 02/26/2008 |
| 7247746 | Crystal forms of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine New crystal forms of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine, also known asnateglinide, may be produced by dissolving nateglinide in any of its forms, including solvates, in an organic solvent to form a solution followed by precipitation of nateglini... | 07/24/2007 |
| 7230075 | Coccidiosis poultry vaccine This invention relates to novel Eimeria proteins with immunogenic properties as well as to DNA sequences encoding these proteins. These proteins can be administered to poultry thereby protecting the birds against coccidiosis. In addition the DNA encoding thes... | 06/12/2007 |
| 7214706 | Chroman derivatives as estrogenic compounds The invention provides chroman compounds having Formula (1), wherein R1 is (1C–4C)alkyl, (2C–4C)alkenyl or (2C–4C)alkynyl, and independently R1 has a cis-orientation in relation to the exocyclic phenyl group at the 2-position of the skele... | 05/08/2007 |
| 7207289 | Method of feeding the cattle with feed additives that increases beef production and reduces liver abscess The present inventions relates to a method of increasing beef production in cattle with feed additives, comprising feeding cattle with feed, comprising an effective amount of an ionophore in combination with a macrolide antibiotic, and thereafter feeding cattle with... | 04/24/2007 |
| 7169769 | 17α-hydroxy-14β-steroids with hormonal effect This invention relates to steroidal compounds having the formula I wherein: R1 is O, (H,H), (H,OH), NOH, whereby OH is optionally etherified or esterified; R2 and R3 are independe... | 01/30/2007 |
| 7150873 | Coccidiosis vaccines The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers comprising such DNA-fragments or recombinant DNA molecules and host ce... | 12/19/2006 |
| 7126027 | N-[(1-dimethylaminocycloalkyl)methyl]benzamide derivatives The present invention relates to N-[(1-dimethylaminocycloalkyl)methyl]benzamide derivatives having the general formula I wherein n is 0, 1, 2 or 3; R1 and R2 are independently H, (C1-4 | 10/24/2006 |
| 7045122 | vaccine The present invention relates to live attenuated Salmonella strains comprising a first attenuating mutation, that are not capable of making functional RecA. The invention also relates to these bacteria for use in vaccines. Furthermore, the invention relates t... | 05/16/2006 |
| 7037508 | Pestivirus mutants and vaccines containing the same The present invention is directed to attenuated pestivirus mutants, which have a reduced ability to replicate as exhibited by a small plaque size. The mutations are in the 5′ nontranslated region of the viral genome. These mutant viruses are useful as live vaccine... | 05/02/2006 |
| 7026304 | 2-alkylated-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block Disclosed are 2-alkylated-cyclodextrin derivatives and pharmaceutically acceptable salts thereof. The 2-alkylated-cyclodextrin derivatives are suitable for use in the reversal of drug-induced neuromuscular block. ... | 04/11/2006 |
| 6949531 | 14 β, 16, 17-methylene steroids as novel androgens Disclosed are androgenic steroids of the (14β,17α)-17-(hydroxymethyl) type. The invention relates to an improvement thereof, which is based on the presence of a β-oriented, annellated cyclopropyl group which includes carbon atoms 16 and 17 of the steroid skeleton... | 09/27/2005 |
| 6942864 | Leporipox-based vector vaccines The present invention is directed to the use of a live, recombinant leporipox virus comprising exogenous DNA, which is operably linked to at least one expression control element and which is incorporated in a non-essential region of the virus genome, in the manufact... | 09/13/2005 |
| 6933293 | Use of mirtazapine for the treatment of sleep disorders The invention relates to the use of mirtazapine for the preparation of a medicine for a new method of treatment of a sleep disorder in a subject, which treatment comprises the administration of mirtazapine with a unit treatment dose comprising between 0.1 and 5 mg m... | 08/23/2005 |
| 6921535 | Attenuated Bovine Respiratory Syncytial virus The present invention relates i.a. to Bovine Respiratory Syncytial Viruses that are not capable of expressing a functional SH-protein and/or G-protein due to a mutation in the genes encoding the said proteins. Furthermore, the invention relates to vaccines based upo... | 07/26/2005 |
| 6908616 | Antigenic proteins of shrimp white spot syndrome virus and uses thereof The present invention relates to antigenic proteins derived from White Spot Syndrome virus having an estimated size of 19 kDa (VP 19) or 13 kDA (VP13), to the use of these proteins in vaccines and to vaccines on the basis of these proteins. Furthermore, the inventio... | 06/21/2005 |
| 6875755 | Antithrombotic compound The present invention relates to compounds of the formula (I), wherein R is independently SO3− or CH3; the spacer is a flexible spacer of a length of 13-25 atoms; the charge of the pentasaccharide residue is compensated by positive... | 04/05/2005 |
| 6841553 | Bicyclic heteroaromatic compounds useful as LH agonists The invention relates to a bicyclic heteroaromatic derivative compound according to general formula (II), or a pharmaceutically acceptable salt thereof. The compounds of the invention have LH receptor activating activi... | 01/11/2005 |
| 6835728 | Drug combination for the treatment of depression and related disorders comprising mirtazapine The invention relates to a combination comprising an amount of mirtazapine, or a pharmaceutically acceptable salt or solvate thereof, and an amount of gepirone, or a pharmaceutically acceptable salt or solvate thereof, optionally in association with one or more phar... | 12/28/2004 |
| 6797710 | Heterocyclic derivatives and their use as antithrombotic agents The present invention relates to antithrombotic compounds comprising the group Q, Q having formula (I), wherein the substructure (i) is a structure selected from (a, b and c), wherein X is O or S; X′ being independently CH or N; and m is 0, 1, 2 or 3; wherein the ... | 09/28/2004 |
| 6756375 | 10-Aryl-11h-benzo[b]fluorene derivatives and analogs for medicinal use The invention provides for a non-steroidal compound having the formula wherein Re and ′Re are OH, optionally independently etherified or esterified; Z is —CH2— or —CH2C... | 06/29/2004 |
| 6756366 | Orally active androgens Orally Active androgens are derivative of 7α-methyl-19-nortestosterone. The compounds satisfy formula (I) wherein R1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1-6)alkyl, or (C1-6)acyl; R2 is selected from the gro... | 06/29/2004 |
| 6719981 | Stable, attenuated rabies virus mutants and live vaccines thereof The present invention relates to recombinant rabies virus mutants comprising a mutation in the viral genome, whereby said mutation comprises at least a substitution of the Arg333 codon in the gene encoding the G protein with a codon that differs by three ... | 04/13/2004 |
| 6699479 | Recombinant newcastle disease virus as an embryo vaccine The present invention provides a NDV mutant which is suited as vaccine candidate for in ovo vaccination. The mutant expresses reduced levels of V protein and can safely be administered to chicken embryos before hatch.... | 03/02/2004 |
| 6682745 | Use of bacterium for manufacture of a vaccine The present invention relates to the use of live attenuated bacteria for the manufacture of a vaccine for submucosal administration.... | 01/27/2004 |
| 6680061 | Coccidiosis vaccines The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers comprising such DNA-fragments or recombinant DNA molecules and hos... | 01/20/2004 |
| 6677329 | Non-aromatic estrogenic steroids with a hydrocarbon substituent in position 11 Disclosed are novel, selective estrogens type having a steroid skeleton with a non-aromatic A-ring and a free or capped hydroxyl group at carbon atom No. 3. The estrogens satisfy general formula (I), in which R1 is H, (C1 -C3 | 01/13/2004 |
| 6660717 | Folliculogenesis The present invention relates to the use of GDF-9 in assisted reproduction and to kits comprising GDF-9. A method is provided to stimulate follicle and oocyte development and maturation. The method comprises administering GDF-9 in combination with gonadot... | 12/09/2003 |
| 6645973 | Spiro(2h-1-benzopyran-2,4-piperidine)derivatives as glycine transport inhibitors The present invention relates to spiro[2H-1-benzopyran-2,4'-piperidine] derivatives having general formula (I), wherein the substituents R1, R2, X and Y are ase defined in the claims or a pharmaceutically acceptable salt thereof. The... | 11/11/2003 |
| 6579864 | 3-methylene steroid derivatives The invention concerns a 3-methylene steroid derivative having general formula (1) wherein R1 is H or together with R3 forms a ଲ-epoxide or R1 is absent if there is a 5-10 or 4-5 double bond; R2 is (C... | 06/17/2003 |
| 6569863 | Bicyclic heteroamatic compounds useful as LH agonists The invention relates to a bicyclic heteroaromatic derivative compound according to general formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 is NR5 R6, OR5, SR5 or R7 ... | 05/27/2003 |
| 6552011 | (Androst-5-en-17beta -yl)alkyl sulfoxides and sulfones and their use for control of fertility ##STR1## The invention relates to (androst-5-en-17beta-yl)alkylsulfoxides and sulfones having general formula (I), wherein R1, R2, R3, X and Y are defined in the specification. The compounds of the invention have meiosis inhibiting activity and can be use... | 04/22/2003 |
