In 1608, Dutch eyeglass maker Hans Lipperhey filed the first patent for a working telescope. The patent was denied.
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| Number | Title | Issue Date |
| 6156340 | Orally administrable time release drug containing products A time release orally administrable drug containing product comprising a core, a drug layer attached to the core, and first and second coating layers is disclosed. The first coating layer is directly adjacent to the drug layer, and has a limited permeabil... | 12/05/2000 |
| 6114339 | Derivatives of pyrido [2,3-D] and [3,2-D] pyrimidine method of using these derivatives The invention also discloses compounds and pharmaceutically acceptable salts having the generic formula (2) ##STR1## wherein X and Y may be the same or different and are selected from the group consisting of OH and NH2 ; wherein Z is one o... | 09/05/2000 |
| 6096750 | Furopyrimidines and methods of making and using the same derivatives This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii ... | 08/01/2000 |
| 6033641 | Catalyst for purifying the exhaust gas from the combustion in an engine or gas turbines and method of making and using the same This invention discloses a durable catalyst for internal combustion engine or power plant exhaust gas purification which is comprised of a zeolite as the support and Fe (II) base-exchanged cation as the active component for the NOx selective ca... | 03/07/2000 |
| 5998594 | Self-assembling, chromogenic receptors for the recognition of medically important substrates and their method of use A chromogenic receptor comprises a self-assembled chromogenic compound having at least one intrinsic binding site. The chromogenic compound is characterized by the property of producing a reversible color change responsive to binding a target substrate to... | 12/07/1999 |
| 5976098 | Support device method A support device for supporting and/or immobilizing the articulated or non-articulated areas of an anatomy. The support device comprises a flexible member having connecting ends, intermediate portions, a central portion, a pad member containing a viscous ... | 11/02/1999 |
| 5958930 | Pyrrolo pyrimidine and furo pyrimidine derivatives This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii ... | 09/28/1999 |
| 5951975 | Induction of CTLs specific for natural antigens by cross priming immunization The present invention relates to prophylactic and therapeutic methods of anti-tumor immunization. These methods are based on cross-priming a mammalian host to natural MHC class I restricted tumor antigens with an artificial tumor antigen. A primary tumor ... | 09/14/1999 |
| 5952294 | Peptidyl prodrugs and methods of making and using the same Peptidyl prodrugs of therapeutic agents having an activating function are sclosed. These therapeutic agents having activating functions include those having an amino, thiol, or hydroxyl function. Methods of making and using these prodrugs are also disclos... | 09/14/1999 |
| 5945500 | Non-volatile resorcinolic resins and methods of making and using the same Methods for preparing low free resorcinol resins are disclosed. These methods generally comprise reacting a resin with an aromatic olefinic compound; suitable resins include one or more resins selected from the group consisting of a dihydric phenol, a pol... | 08/31/1999 |
| 5939420 | Pyrrolo2,3d!derivatives Pyrrolo2,3-d!pyrimidine derivatives, and pharmaceutical acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness are disclosed.... | 08/17/1999 |
| 5936056 | Non-volatile resorcinolic resins and methods of making and using the same Methods for preparing low free resorcinol resins are disclosed. These methods generally comprise reacting a resin with an aromatic olefinic compound; suitable resins include one or more resins selected from the group consisting of a dihydric phenol, a pol... | 08/10/1999 |
| 5898004 | Polymerized crystalline colloidal array sensors Novel sensor devices composed of a crystalline colloidal array (CCA) polymerized in a hydrogel are disclosed. The hydrogels are characterized as being capable of shrinking and swelling in response to specific stimuli applied thereto. As the hydrogels shri... | 04/27/1999 |
| 5880115 | Steroid sulfatase inhibitors and methods for making and using the same Sulfatase inhibitor compounds having the formula: ##STR1## wherein X, Y, R1, R2 and R3 are as defined in the specification. The compounds are useful in the treatment of estrogen dependent illnesses. Methods for synthe... | 03/09/1999 |
| 5877178 | Pyrimidine derivatives and methods of making and using these derivatives This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii ... | 03/02/1999 |
| 5866603 | Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use This invention discloses compounds useful as steroid sulfatase inhibitors. The compounds comprise the formula (1) ##STR1## wherein (a) R is selected from the group consisting of hydrogen, a lower alkyl group, an alkoxy group, halogen, NH2,... | 02/02/1999 |
| 5866580 | Quinazoline derivatives and methods of using the same The present invention discloses compounds, and pharmaceutically acceptable salts thereof, having the following formula (5): ##STR1## wherein X and Y are the same or different and are either OH or NH2 ; wherein A is either nitrogen, CH or s... | 02/02/1999 |
| 5840426 | Method for fluorination of diamond surfaces and associated product An improved method for the fluorination of a diamond surfaces comprises condensing a layer of perfluorinated alkyl iodides consisting of Cn F2n+1 I (where n is a positive integer from 1 to 13) on the diamond surface, producing perflu... | 11/24/1998 |
| 5828494 | Glass panel unit for refracting and dispersing light A panel unit for use in a window, a partition, a free standing frame, or in a wall, and having a plurality of vertically stacked, elongated transparent elements arranged in a frame, whereby natural light or artificial light on one side of the panel reflec... | 10/27/1998 |
| 5794791 | Coal cleaning process Fine particle coal is beneficiated in specially designed dense medium cyclones to improve particle acceleration and enhance separation efficiency. Raw coal feed is first sized to remove fine coal particles. The coarse fraction is then separated into clean... | 08/18/1998 |
| 5776088 | Support device and associated method A support device for supporting and/or immobilizing the articulated or non-articulated areas of an anatomy. The support device comprises a flexible member having connecting ends, intermediate portions, a central portion, a pad member containing a viscous ... | 07/07/1998 |
| 5763492 | Methods for effecting memory enhancement mediated by non-steroidal sulfatase inhibitors This invention discloses a method for enhancing memory in a patient comprising administering a compound of formula ##STR1## wherein R1 and R2 are independently selected from the group consisting of hydrogen and a lower alkyl gro... | 06/09/1998 |