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Patent No. 5983411

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Attorney: Merkling; John R.


Number of patents: 250
Last date: May 08, 2012

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NumberTitleIssue Date
8173027Method of separating a composite liquid into at least two components
Method for separating a volume of composite liquid into at least a first component and a second component including centrifuging a separation bag containing a volume of composite liquid and a volume of gas so as to sediment at least a first component and a second co...
05/08/2012
8163555Disposable tubing set for use with a cell expansion apparatus and method for sterile sampling
A disposable apparatus for cell expansion, having at least one bioreactor. The bioreactor has a cellular growth area and a supply area, the cellular growth area being separated from said supply area by a membrane. A fluid recirculation path in fluid communication wi...
04/24/2012
8139814Audio speaker with radial electromagnet
An audio speaker with at least two electric coils on opposite sides of at least one ferro-magnetic plate, the coils and plate forming a radial electro-magnet. A radial electro-magnet can offer many advantages in stereo loudspeakers. The coils are electrically driven...
03/20/2012
8123713System and method for collecting plasma protein fractions from separated blood components
Method and apparatus for separating plasma from blood in a separation vessel and further separator the separated plasma into desired plasma proteins in a plasma separator fluidly connected to the separation vessel to receive the separated plasma. ...
02/28/2012
8114003Methods for hemolysis detection in centrifugal blood separator
A centrifugal blood processing apparatus comprising a centrifuge rotor, a separation chamber, a tubing set for conducting blood components and fluids and having an inlet line, and an outlet line. Apparatus tests flow conditions using a red light-green light sensor t...
02/14/2012
8088090Extracorporeal blood processing methods with multiple alarm levels
This invention provides a method for controlling a fluid separation system, preferably a blood apheresis system having a leukocyte reduction chamber. The method utilizes at least a two-level alarm system. A first-level alarm condition is triggered in response to a p...
01/03/2012
8070665Method for separating discrete volumes of a composite liquid
A method for separating at least two discrete volumes of a composite liquid into at least a first component and a second component, comprising centrifuging at least two separation bags containing two discrete volumes of a composite liquid respectively, so as to sepa...
12/06/2011
8070663Blood processing apparatus with optical reference control
A density centrifuge blood processing system with automatic two-dimensional optical control of fluid separation by observing fluid characteristics in observation regions. The location of the regions is determined by monitoring an optical reference. Points representi...
12/06/2011
8066888Blood processing apparatus with controlled cell capture chamber trigger
A blood cell collection system having means for detecting when a cell separation chamber has filled with white blood cells, and flushing the cells out of the cell separation chamber into a collect bag. A red-green sensor senses the optical characteristics of fluid l...
11/29/2011
8062202Blood processing apparatus with incipient spill-over detection
A density centrifuge blood processing system comprising a separation chamber rotating about a central rotation axis, the separation chamber being coupled to an elutriation chamber, a first detector for the separation chamber to detect light from an observation regio...
11/22/2011
8057376Blood processing apparatus with sealed diffuser in optical control apparatus
A centrifugal blood separation apparatus having an optical camera control system with a focused, stationary light source. A diffusion plate mounted on a rotor, rather than on or near the light source, allows an intense light beam to be transmitted from the light sou...
11/15/2011
8048055Clamp assembly for displacing fluid from portions of fluid containers
Clamps and methods are disclosed for clamping portions of fluid containers and displacing fluid from portions of fluid containers. In one embodiment, a clamp has a first jaw having a photopermeable main body portion and a second jaw. The first and second jaws are op...
11/01/2011
8044051Methods and compositions for the production of high concentration alloxazine solutions
Methods are provided for preparation of compositions having an enhanced level of soluble alloxazine, as compared to compositions prepared using conventional techniques. Compositions and a riboflavin form having higher solubility in solution is also provided. ...
10/25/2011
8017110Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light
A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an...
09/13/2011
8016736Methods for washing a red blood cell component and for removing prions therefrom
A method for washing multiple units of blood product including providing a centrifuge having a wash cell for each unit of blood product, balancing the centrifuge to accommodate for differences in the wash cells, and transferring supernatant including any wash soluti...
09/13/2011
7985588Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light
A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an...
07/26/2011
7981019Apparatus and method for separating a composite liquid into at least two components
An apparatus for separating a volume of composite liquid into at least a first component and a second component comprising a centrifuge having a rotor with a turntable for supporting a separation bag; a central compartment for containing satellite bags, and fitted w...
07/19/2011
7964048Heat weld tubing connectors
The present invention provides thermoplastic tubes, thermoplastic melting plates, thermoplastic tube connecting apparatus, and methods for using the same. ...
06/21/2011
7963901Blood processing apparatus with cell capture chamber with protruding inlet
A disposable blood separation set of a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell ...
06/21/2011
7951059Blood processing apparatus with optical reference control
A density centrifuge blood processing system with automatic two-dimensional optical control of fluid separation by observing fluid characteristics in observation regions. The location of the regions is determined by monitoring an optical reference. Points representi...
05/31/2011
7943916Method for controlling a blood processing system by observing a separation region and an extraction port
The invention relates generally to methods of monitoring and controlling the processing of blood and blood samples, particularly the separation of blood and blood samples into its components with a two-dimensional optical measurement and control device. The method m...
05/17/2011
7935043Methods and apparatus for controlled addition of solutions to blood components
A centrifugal blood processing apparatus comprising a centrifuge rotor, a separation chamber, a tubing set for conducting blood components and fluids and having an inlet line, an outlet line and a storage solution line in fluid communication with the outlet line at ...
05/03/2011
7906771Predictive method for controlling a blood processing system
The invention relates generally to methods of monitoring and controlling the processing of blood and blood samples, particularly the separation of blood and blood samples into its components. In one aspect, the invention relates to optical methods for measuring two-...
03/15/2011
7901673Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light
A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an...
03/08/2011
7892535Preventing transfusion related complications in a recipient of a blood transfusion
This invention is directed toward a process for reducing transfusion related complications in a recipient of an allogeneic blood transfusion by adding to the blood to be transfused a photosensitizer comprising riboflavin, irradiating the blood and riboflavin with li...
02/22/2011
7857744Blood processing apparatus with flared cell capture chamber and method
A cell separation set for separating blood components, having a cell separation chamber with a first entry section having a wall with an outwardly flared curve, the entry section having an axial length and an inmost maximum diameter perpendicular to the axial length...
12/28/2010
7833185Apparatus for separating a volume of whole blood into at least three components
A method and apparatus for separating a volume of whole blood contained in a separation bag into at least three components comprising centrifuging the separation bag so as to separate therein a first inner layer comprising plasma, a second intermediate layer compris...
11/16/2010
7829867Apparatus for photo reduction of contaminants in blood and blood products with calibration means
An apparatus for irradiating blood or blood products, preferably with ultra violet or visible light, to reduce contaminants in the blood or blood products. A removable radiometer having light integrating chambers detects the light intensity, allowing the radiation c...
11/09/2010
7828709Blood processing apparatus with incipient spill-over detection
A density centrifuge blood processing system comprising a separation chamber rotating about a central rotation axis, the separation chamber being coupled to an elutriation chamber, a first detector for the separation chamber to detect light from an observation regio...
11/09/2010
7789847Methods and apparatus for leukoreduction of red blood cells
A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly provides for leukoreduction filtration concurrent with or soon after the red blood cell separation and collection procedure. Such procedures invol...
09/07/2010
7780618Extracorporeal blood processing apparatus and methods with pressure sensing
This invention provides an apparatus and method for controlling a fluid separation system, preferably a blood apheresis system, by sensing fluid pressure and comparing the sensed fluid pressure to a threshold value. ...
08/24/2010
7766809Apparatus for separating discrete volumes of a composite liquid
A method for separating at least two discrete volumes of a composite liquid into at least a first component and a second component, comprising centrifuging at least two separation bags containing two discrete volumes of a composite liquid respectively, so as to sepa...
08/03/2010
7718430Disposable tubing set for use with a cell expansion apparatus and method for sterile sampling
A disposable apparatus for cell expansion, having at least one bioreactor. The bioreactor has a cellular growth area and a supply area, the cellular growth area being separated from said supply area by a membrane. A fluid recirculation path in fluid communication wi...
05/18/2010
7708889Blood component processing system method
A method used in connection with processing of blood components, wherein blood products are then filtered via a filter rotating along with a centrifuge rotor and the sensed pressure may be used in connection with controlling the pumping of the blood products and/or ...
05/04/2010
7686779Extracorporeal blood processing methods and apparatus
A preconnected disposable and method for red blood collection is provided wherein the preconnected disposable includes a red blood cell collection assembly comprising a leukoreduction filter and a red blood cell storage bag. Such a red blood cell collection assembly...
03/30/2010
7686279Non-reopenable clamp for tubing sets
A non-reopenable, single-use clamp for receiving and pinching collapsible resilient tubing thus forming a mechanical tubing seal and having an open position for insertion of tubing, a neutral position for holding the tubing and a closed position for non-reopenably c...
03/30/2010
7682329Methods and apparatus for leukoreduction of red blood cells
A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly provides for leukoreduction filtration concurrent with or soon after the red blood cell separation and collection procedure. Such procedures invol...
03/23/2010
7671975Blood processing apparatus with dedicated stroboscopic controller for LED source
A centrifuge blood processing system for separating fluid components comprising a first light source comprising a plurality of light emitting diodes in optical communication with the centrifuge blood processing system for providing an incident light beam for illumin...
03/02/2010
7651474Method and apparatus for leukoreduction of red blood cells
A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly provides for leukoreduction filtration concurrent with or soon after the red blood cell collection procedure. The procedure preferably involves fi...
01/26/2010
7648699Preventing transfusion related complications in a recipient of a blood transfusion
This invention is directed toward a process for reducing transfusion related complications in a recipient of an allogeneic blood transfusion by adding to the blood to be transfused a photosensitizer comprising riboflavin, irradiating the blood and riboflavin with li...
01/19/2010
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