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| Number | Title | Issue Date |
| 7973031 | Staurosporine derivatives as inhibitors of FLT3 receptor tyrosine kinase activity The present invention relates to the use of staurosporines derivatives for the preparation of a drug for the treatment of diseases involving deregulated FLT3 receptor tyrosine kinase activity, especially for the curative and/or prophylactic treatment of leukemias an... | 07/05/2011 |
| 7759308 | Microparticles comprising somatostatin analogues Disclosed are microparticles comprising a somatostatin analogue embedded in a biocompatible pharmacologically acceptable polymer matrix for a long acting release and pharmaceutical compositions comprising such microparticles. ... | 07/20/2010 |
| 7749698 | p53 wild-type as biomarker for the treatment with mTOR inhibitors in combination with a cytotoxic agent Provided are biomarkers for determining the sensitivity of proliferative diseases such as cancer to therapeutic agents, in particular mTOR inhibitors in combination with a cytotoxic agent, in particular a cytotoxic agent which damages or affects the integrity of DNA... | 07/06/2010 |
| 7569566 | Inhibitors of tyrosine kinases The invention relates to compounds of formula wherein the substituents R1, R2 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, phar... | 08/04/2009 |
| 7402603 | Cyclooxygenase-2 inhibitor/histone deacetylase inhibitor combination The invention relates to a combination which comprises (a) a cyclooxygenase-2 inhibitor (“COX-2 inhibitor”) and (b) a histone deacetylase inhibitor (“HDAI”) for simultaneous, concurrent, separate or sequential use, especially for use in the treatment of pre-... | 07/22/2008 |
| 7326699 | 4-Amino-5-phenyl-7-cyclobutyl-pyrrolo(2,3-d)pyrimidine derivatives The invention relates to new 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives, processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof-alone or in combination with o... | 02/05/2008 |
| 7323469 | 7H-pyrrolo[2,3-d]pyrimidine derivatives The invention relates to 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula I wherein the symbols and substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical co... | 01/29/2008 |
| 7244729 | 4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives The invention relates to 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula I wherein the symbols and substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use ... | 07/17/2007 |
| 7192980 | Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors The present invention relates to certain substituted polyketides of formula I, wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and the use of said comp... | 03/20/2007 |
| 7169791 | Inhibitors of tyrosine kinases The invention relates to compounds of formula wherein the substituents R1, R2 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these comp... | 01/30/2007 |
| 7151106 | Crystal modification of a N-phenyl-2-pyrimidineamine derivative, processes for its manufacture and its use The invention relates to a new crystalline form of the methanesulfonic acid addition salt of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide of formula 1, which may be used for example for tumor therapy. | 12/19/2006 |
| 7148218 | Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors The present invention relates to certain substituted polyketides of formula I, wherein A, B and C are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds in tre... | 12/12/2006 |
| 7138432 | Arylsulfonamido-substituted hydroxamic acid derivatives α-Amino hydroxamic acid derivative of formula (I), in which R is C2–C7-alkyl, which is mono-, di- or trisubstituted by halogen, nitro, lower acyloxy, trifluoromethoxy, cyano, C3–C5-cycloalkyl or unsubstituted or subst... | 11/21/2006 |
| 7112611 | 1g(α)-amino-N-hydroxy-acetamide derivatives The invention relates to α-amino-N-hydroxy-acetamide derivatives of formula (I), wherein R is di-lower alkyl amino, 1,2,3-triazol-2yl or 1,2,4-triazol-4-yl, m represents an integer from 1 up to and including 10, and n represents an integer from 0 up to and includin... | 09/26/2006 |
| 7091224 | Anthranilic acid amides and their use as VEGF receptor tyrosine kinase inhibitors The invention relates to anthranilic acid amide derivatives of formula (I), wherein R1 represents H or lower alkyl, R2 represents H or lower alkyl, R3 represents perfluoro lower alkyl, and X is O or S, or an N-oxide or a tautomer the... | 08/15/2006 |
| 7091346 | Purine derivatives and processes for their preparation 2-Amino-6-anilino-purine derivatives of the formula 1 in which the symbols are as defined in claim 1 are described. These compounds inhibit p34cdc2/cyclin Bcdc13 kinase and can be us... | 08/15/2006 |
| 7067543 | Anthranilic acid amides and pharmaceutical use thereof The invention relates to anthranilic acid amide derivatives of formula (I), wherein Ar is represented by the subformula (Ia), wherein Ra represents H or lower alkyl, and R1 represents H or perfluoro lower alkyl, R2 represe... | 06/27/2006 |
| 7067551 | Deacetylase inhibitors The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties. ... | 06/27/2006 |
| 7045523 | Combination comprising N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and telomerase inhibitor A method of treating BCR-ABL positive leukemia in a warm-blooded animal comprising administering the combination of N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine, or a pharmaceutically acceptable salt thereof, an... | 05/16/2006 |
| 7030147 | Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative Epothilone derivatives are co-administered with an antidiarrheal agent, e.g., a DPP-IV inhibitor, in the treatment of a proliferative disease. ... | 04/18/2006 |
| 7002022 | N-Aryl (thio) anthranilic acid amide derivatives, their preparation and their use as VEGF Described are compunds of formula (I), wherein W is O or S; X is NR8; Y is CR9R10—(CH2)n wherein R9 and R10 are independently of each other hydrogen or lower alkyl, and n is an integer of from and i... | 02/21/2006 |
| 6974875 | Process for preparing intermediates for the manufacture of discodermolide and discodermolide analogues The invention relates to a process for the preparation of a substituted alkene of formula (I) wherein R1, R2 and R3 are independently of each other a protecting group for a hydroxy group or hydrogen and R4 is phenyl which ... | 12/13/2005 |
| 6946561 | Process for the isolation and purification of epothilones The invention relates to a desorption process for epothilones, especially epothilone A and/or epothilone B, from resins and new production, work-up or purification processes or manufacturing methods for epothilones comprising said desorption process, as well as the ... | 09/20/2005 |
| 6933290 | 2-{N-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl}-amino}-alkylboronic acid derivatives Disclosed are derivatives of 2-{[N-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl]-amino}-alkylboronic acid, processes for the preparation of such compounds, pharmaceutical preparations, and the use of such derivatives in the preparation of pharmaceutical compo... | 08/23/2005 |
| 6911440 | Phthalazine derivatives for treating inflammatory diseases The invention relates to the treatment of an inflammatory disease, especially an inflammatory rheumatoid or rheumatic disease, and/or pain with an inhibitor of the activity of VEGF receptor tyrosine kinase of the formula I, ... | 06/28/2005 |
| 6878720 | VEGF receptor tyrosine kinase inhibitors Described are compunds of formula (I), wherein W is O or S; X is NR8; Y is CR9R10—(CH2)n wherein R9 and R10 are independently of each other hydrogen or lower alkyl, and n is an integer of from and i... | 04/12/2005 |
| 6858404 | Genes for the biosynthesis of epothilones Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In th... | 02/22/2005 |
| 6833384 | Deacetylase inhibitors The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties. ... | 12/21/2004 |
| 6833367 | Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors The present invention relates to certain substituted polyketides of formula I, wherein A, B and C are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds in treating ... | 12/21/2004 |
| 6818661 | Anthranylalkyl and cycloalkyl amides and use thereof as VEGF receptor inhibitors The invention relates to substituted anthranylalkyl and cycloalkyl amides of general formula (I) and to their use as medicaments for treating diseases caused by persistent angiogenesis. ... | 11/16/2004 |
| 6767906 | 2-amino-6-anilino-purines and their use as medicaments This application discloses 2-amino-6-anilino-purine derivatives of the formula I in which q is 1-5, and R1 is α) —S(═O)k—NR6R7, in which k... | 07/27/2004 |
| 6743414 | Inhalation administration of biophosphonates The present invention relates to the treatment and prevention of bone diseases in humans, including osteoporosis in postmenopausal women, Paget's Disease and hypercalcemia, by administration of a bisphosphonate in an inhalation form. The invention also relates to ph... | 06/01/2004 |
| 6706731 | Pyridine derivatives inhibiting angiogenesis and/or VEGF receptor tyrosine kinase The invention relates to pyridine derivatives of formula I: wherein the substituents and symbols are defined as indicated in the description, processes for the preparation thereof, their usage in the preparation of a pha... | 03/16/2004 |
| 6631650 | Thief sampling probe A sample thief comprising: an outer hollow rod with an open end; a piston with a plunger end inserted within the outer hollow rod; and the outer hollow rod having an adjustable means. The thief operates by inserting the thief into a blend to be sampled ju... | 10/14/2003 |
| 6333409 | Process for the purification of a 3-cephem-4-carboxylic acid derivative The invention relates to a new process for the depletion of 7-amino-3-[(E)-1-propen-1-yl]-3-cephem-4-carboxylic acid in mixtures of 7-amino-3-[(Z)-1-propen-1-yl]-3-cephem-4-carboxylic acid and 7-amino-3-[(E)-1-propen-1-yl]-3-cephem-4-carboxylic acid, by m... | 12/25/2001 |
| 6313289 | Purification process Crystalline 2-(amninothiazol-4-yl)-2-(tert.butoxycarbonylmethoxyimino)acetic acid-S-mercapto-benzo-thiazolylester in form of an N,N-dimethylacetamide solvate; a crystalline salt of a 7-[2-(aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido]-3-vinyl-... | 11/06/2001 |
| 6284888 | Vinyl-ACA purification process A process for purification of vinyl-ACA of formula ##STR1## from a mixture of vinyl-ACA and 7-ADCA of formula ##STR2## is provided. The process comprises a) producing a mixture of a salt of vinyl-ACA and a salt of 7-ADCA in a solvent in which the salt of ... | 09/04/2001 |
| 6201153 | Synthesis of midodrine HCI from a novel intermediate 1-(2',5'-dimethoxyphenyl)-2-azidoethanone Midodrine hydrochloride, &#b1;1-(2',5'-dimethoxyphenyl)-2-glycineamido-ethanol-(1)-HCl, is prepared from a novel intermediate, 1-(2',5'-dimethoxyphenyl)-2-azidoethanone.... | 03/13/2001 |
| 6117945 | Low application temperature hot melt adhesive A low application temperature hot met adhesive composition and its use in carton, case or tray formation comprising from ethylene vinyl acetate with greater than 30 weight percent VA and having a melt index of at least 700; a thermoplastic hydrocarbon res... | 09/12/2000 |
| 6077527 | Enhancer tolerant pressure sensitive adhesives for transdermal drug delivery Pressure sensitive adhesive compositions for use in transdermal drug delivery systems comprising an adhesive composition which is tolerant to plasticization by cutaneous penetration enhancers contained in the transdermal drug formulation are disclosed. Sp... | 06/20/2000 |
