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| Number | Title | Issue Date |
| 8134008 | Preparation of amorphous hydrous esomeprazole magnesium A hydrate of esomeprazole magnesium in the form of an amorphous solid is provided. Methods of preparation and use of, as well as formulation containing the hydrate of esomeprazole magnesium in the form of an amorphous solid are also provided. ... | 03/13/2012 |
| 8133994 | Preparation of aprepitant A process for preparing aprepitant. ... | 03/13/2012 |
| 8080668 | Thiazoles derivatives as AMPK activator The present application provides novel thiazole derivatives that are useful as activators of Adenosine 5′-Monophosphate-Activated Protein Kinase and pharmaceutical compositions containing such compounds. ... | 12/20/2011 |
| 8080559 | 5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin and its preparation and use for the treatment of cancer A 5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin diasterisomer is described which is a better inhibitor of topoisomerase I than either the diastereoisomeric mixture 5(RS)-(2′-hydroxyethoxy)-20(S)-camptothecin, or the 5(R)-(2′-hydroxyethoxy)-20(S)-camptothecin dias... | 12/20/2011 |
| 8063214 | Polymorphic forms of tadalafil A process for preparing crystalline Form A of tadalafil (I), comprising crystallization from a solution of tadalafil in a solvent comprising a C3-C7 ester, a ketone, dimethylformamide, dimethylsulfoxide, ethanol, acetonitrile, a chlorinated hyd... | 11/22/2011 |
| 8063074 | Polymorphic forms of esomeprazole sodium Polymorphic crystalline Forms J, K, L, M, and N of esomeprazole sodium. ... | 11/22/2011 |
| 8058438 | Eszopiclone process Eszopiclone is prepared by reacting zopiclone with an enatiomerically pure di-p-toluoyl tartaric acid, recovering a solid salt, and reacting a solid salt with a base. Zopiclone is prepared by reacting 6-(5-chloropyrid-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4-b]-... | 11/15/2011 |
| 8053000 | Compositions for drug delivery Substantially non-porous polymeric microparticles comprising a hydrophobic polymer and a plasticizer, and containing therein a bioactive or bioinactive agent. ... | 11/08/2011 |
| 8049021 | Process for the preparation of fluorotetraene There is provided a process for preparing 21-acetyloxy-6-alpha-fluoro-pregna-1,4,9(11),16-tetraene-3,20-dione compound of Formula I, which comprises reacting 21-acetyloxy-pregna-1,3,5,9(11),16-pentaene-3-oxo acetate with a fluorinating agent. ... | 11/01/2011 |
| 8039619 | Process for preparing (2R,3S/2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol Voriconazole is prepared by a process comprising condensing 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazole-1-yl)ethanone with 4-chloro-6-ethyl-5-fluoropyrimidine, in a ketone, ether, aliphatic hydrocarbon, or aromatic hydrocarbon solvent, to give (2R,3S/2S,3R)-3-(4-chl... | 10/18/2011 |
| 8013181 | Preparation of rivastigmine and its salts There are provided processes for making rivastigmine. In one embodiment, the process includes reacting S-(−)-[1-(3-hydroxyphenyl)ethyl]dimethylamine with N-ethyl-N-methyl carbamoyl chloride in the presence of an organic base to obtain a free base of rivastigmine. | 09/06/2011 |
| 8008328 | Methods for the treatment of diabetes-associated dyslipdemia Methods for the treatment of insulin resistance, diabetes, and/or diabetes associated dyslipidemia by administering niacin and meloxicam are disclosed. ... | 08/30/2011 |
| 8003820 | Process for preparing bisphosphonic acids A process for preparing a bisphosphonate compound comprises reacting a carboxylic acid with a phosphonating agent, in a cresol solvent. ... | 08/23/2011 |
| 7989463 | Biccyclic compounds as GATA modulators Novel bicyclic compounds of the formula (I), stereoisomers, and/or pharmaceutically acceptable salts of the novel bicyclic compounds, and/or pharmaceutically acceptable salts of the stereoisomers of the novel bicyclic compounds are provided. Additionally, methods of... | 08/02/2011 |
| 7977478 | Polymorphic forms of vardenafil Crystalline polymorphic forms of vardenafil and vardenafil hydrochloride, and processes for preparing them. ... | 07/12/2011 |
| 7943781 | Process for preparing telmisartan A process comprising cyclizing 3-amino-4-butyramido-5-methylbenzoic acid to form 2-n-propyl-4-methyl-benzimidazole-6-carboxylic acid. ... | 05/17/2011 |
| 7939513 | Tetracycline derivatives as antibacterial agents In accordance with one aspect, the present invention provides a compound of general formula (I), its stereoisomers thereof and/or its pharmaceutically acceptable salts thereof, which have antibacterial activity; with methods of treating infectious diseases in warm b... | 05/10/2011 |
| 7935841 | Bisphospholanes for use as catalysts in asymmetric reactions The invention concerns an enantiomerically enriched compound of formula (1) or the opposite enantiomer thereof wherein each of Ar1—Ar4 represent the same or different aromatic groups of up to 20 carb... | 05/03/2011 |
| 7919633 | Process for preparation of celecoxib There is provided a process for preparation of celecoxib by reacting 4,4,4-trifluoro-1-[4-(methyl)phenyl]butane-1,3-dione with 4-sulphonamidophenylhydrazine or its salt in a solvent medium that contains an alkyl ester. There is also provided a process for the purifi... | 04/05/2011 |
| 7824919 | Method for analyzing activated polyethylene glycol compounds A chemical analysis method for the determination of RO(CH2CH2O)nH, RO(C2H4O)nA, and AO(C2H4O)nA in a mixture thereof, wherein R is an alkyl group, A is a functional gr... | 11/02/2010 |
| 7816484 | Method for making polyethylene glycol carbonates A method for preparing a polyalkylene glycol carbonate is disclosed comprising reacting a hydroxyl functional polyalkylene glycol and a reagent selected from carbonates and chloroformates in the presence of an aromatic solvent and an amine. ... | 10/19/2010 |
| 7723329 | Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor. ... | 05/25/2010 |
| 7713994 | Substituted isoquinoline-1,3(2,4)-diones, 1-thioxo,1,4-dihydro-2-isoquinoline-3-ones and 1,4-dihyro-3 (2)-isoquinolones and methods of use thereof This invention provides compounds of Formula (I), having the structure where G1, G2, G3, G4, A1, A2, Y1, Y2, L... | 05/11/2010 |
| 7713964 | Methods for treating asthmatic conditions This invention provides methods for treating in mammals asthma and asthmatic conditions using substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using th... | 05/11/2010 |
| 7709661 | Synthetic methodology for the reductive alkylation at the C-3 position of indoles A process for the reductive alkylation at the C-3 position of an indole compound in which the indole is treated with an aldehyde in the presence of a Lewis acid and a silicon hydride reducing agent. The process is useful for alkylating the C-3 position of indoles th... | 05/04/2010 |
| 7696164 | Substantially pure glycopeptide antibiotics AC-98-1 ; AC-98-2; AC-98-3; AC-98-4 and AC-98-5 The invention provides new substantially pure antibiotics designated AC-98-1, AC-98-2, AC-98-3, AC-98-4 and AC-98-5 derived from the microorganism Streptomyces hygroscopicus. ... | 04/13/2010 |
| 7671079 | Sulfonyltetrahydro-3H-benzo(e)indole-8-amine compounds as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of a CNS disorder related to or affected by the 5-HT6 receptor. ... | 03/02/2010 |
| 7638512 | Phenylaminopropanol derivatives and methods of their use The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and tr... | 12/29/2009 |
| 7608717 | Sulfonyldihydroimidazopyridinone compounds as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor. ... | 10/27/2009 |
| 7585873 | 1-(aminoalkyl)-3-sulfonylazaindoles as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor. ... | 09/08/2009 |
| 7576087 | Heterocyclyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor. ... | 08/18/2009 |
| 7557098 | 1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor. ... | 07/07/2009 |
| 7550456 | Substituted aryl cycloalkanoyl derivatives and methods of their use The present invention is directed to substituted aryl cycloalkanoyl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor sym... | 06/23/2009 |
| 7541370 | 1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor. ... | 06/02/2009 |
| 7541358 | 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor. ... | 06/02/2009 |
| 7531543 | Phenylpiperazine cycloalkanol derivatives and methods of their use The present invention is directed to phenylpiperazine cycloalkanol derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symp... | 05/12/2009 |
| 7524846 | Arylalkyl- and cycloalkylalkyl-piperazine derivatives and methods of their use The present invention is directed to arylalkyl- and cycloalkylalkyl-piperazine derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, va... | 04/28/2009 |
| 7491723 | Alkanol and cycloalkanol-amine derivatives and methods of their use The present invention is directed to alkanoyl and cycloalkanoyl-amine derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor s... | 02/17/2009 |
| 7419980 | Fused-aryl and heteroaryl derivatives and methods of their use The present invention is directed to fused-aryl and heteroaryl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms... | 09/02/2008 |
| 7402698 | Secondary amino-and cycloamino-cycloalkanol derivatives and methods of their use The present invention is directed to secondary amino- and cycloamino-cycloalkanol derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia,... | 07/22/2008 |
