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| Number | Title | Issue Date |
| 7897600 | Amino pyrazole compound The present invention provides amino pyrazole compounds useful in the treatment of chronic myeloproliferative disorders and various cancers, e.g., glioblastoma, breast cancer, multiple myeloma, prostate cancer, and leukemias. ... | 03/01/2011 |
| 7872020 | TGF-β inhibitors The present invention provides crystalline 2-(6-methyl-pyridin-2-yl)-3-[6-amido-quinolin-4-yl)-5,6-dihydro -4H-pyrrolo[1,2-b]pyrazole monohydrate. ... | 01/18/2011 |
| 7834029 | Quinolinyl-pyrrolopyrazoles A compound according to formula II and the pharmaceutically acceptable salts thereof and the method of treating cancer in a patient in need thereof by administration of said compound. ... | 11/16/2010 |
| 7772209 | Antifolate combination therapies A method of administering an antifolate to a mammal in need thereof, comprising administering an effective amount of said antifolate in combination with a methylmalonic acid lowering agent. ... | 08/10/2010 |
| 7691827 | Amide prodrug of gemcitabine, compositions and use thereof The present invention relates to the gemcitabine prodrug 1-(2,2-difluoro-2-deoxy-β-D -ribofuranosyl)-4-(2-propyl-1-oxopentyl)aminopyrimidin-2-one useful as an oral drug for the treatment of cancer. ... | 04/06/2010 |
| 7671082 | Prodrugs of excitatory amino acids This invention relates to synthetic excitatory amino acid prodrugs and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurological disorders and psych... | 03/02/2010 |
| 7666879 | Imidazo[1,2-A]pyridine compounds as VEGF-R2 inhibitors The present invention provides compounds that are inhibitors of VEGF-R2 of the formula: (I) and methods of using these compounds. ... | 02/23/2010 |
| 7608618 | Urea or thiourea substituted 1,4-pyrazine compounds useful as anti-cancer agents and for inhibiting Chk1 Compounds of the formula wherein: Y′ is O or S, W′ is optionally substituted, Z′ is selected from the group consisting of | 10/27/2009 |
| 7560462 | Compounds useful for inhibiting CHK1 Substituted urea compounds useful in the treatment of diseases and C1-3alkyleneOR3 conditions related to DNA damage or lesions in DNA replication are disclosed formula (I), wherein X1 is null, —O—, —S—, —CH2—, ... | 07/14/2009 |
| 7414063 | Inhibitors of Akt (protein kinase B) The present invention relates to compounds Formula (I): as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections. ... | 08/19/2008 |
| 7230011 | Benzenesulfonic acid indol-5-yl esters as antagonists of the 5ht receptor The present invention relates to compounds of formula I: which are antagonists of 5-HT6 receptor. ... | 06/12/2007 |
| 7157488 | N-(2-Arylethyl) benzylamines as antagonists of the 5-HTreceptor The present invention provides compounds of formula I pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are antagonists of the 5-HT6 receptor. The present invent... | 01/02/2007 |
| 7138521 | Crystalline of N-[4-[2-(2-Amino-4,7-dihydro-4oxo-3H-pyrrolo[2,3-D]pyrimidin-5-YL)ethyl]benzoyl]-L-glutamic acid and process therefor The invention relates to the field of pharmaceutical and organic chemistry and provides an improved process for preparing the novel heptahydrate crystalline salt of multitargeted antifolate N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]be... | 11/21/2006 |
| 7053065 | Vitamin B12 and pemetrexed disodium combination therapies A method of administering an antifolate to a mammal in need thereof, comprising administering an effective amount of said antifolate in combination with a methylmalonic acid lowering agent. ... | 05/30/2006 |
| 6555518 | Gemcitabine as an immunosuppressive pharmaceutical agent The present invention provides the use of a compound of the formula I ##STR1## wherein: R1 is a base defined by one of the formulae ##STR2## R2 is hydrogen, C1 -C4 alkyl, bromo, fluoro, chloro or iodo; or a pharmaceu... | 04/29/2003 |
