Did You Know...
...that Thomas Edison's patent application on his phonograph was approved by the Patent Office in just seven weeks? In contrast, it took Gordon Gould, the inventor of the laser, 30 years to obtain his patent -- finally awarded in 1988!
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| Number | Title | Issue Date |
| 4855306 | Uses of dopamine receptor agonists Selective dopamine D1 receptor agonists for use in the treatment of primary degenerative dementia, depression, anxiety, obesity or schizophrenia.... | 08/08/1989 |
| 4855288 | Furanuronic acid derivatives, process for their production and their use 1'-desoxy-1'-(6-amino-9-purinyl)-ଲ-D-ribofuranuronic acid thioamides of formula ##STR1## wherein R1, R2 and R3 possess various definitions given in claim 2, are effective against raised blood pressure.... | 08/08/1989 |
| 4849423 | Purine derivatives, medicaments containing them and methods of treating cardiac insufficiencies and irregularities with them. The compounds of formula I, ##STR1## in free form or in salt form have cardiotonic and antiarrhythmic activity. They may be used as medicaments. They are obtained by means of appropriate 3-amino-2-hydroxy-propylation of purines.... | 07/18/1989 |
| 4835174 | Pilocarpine derivatives Pilocarpine derivatives of formula I, ##STR1## wherein R1 to R5 are as defined in the description, are useful in the treatment of senile dementia, Alzheimer's disease, confusional conditions in the elderly, myasthenia gravis, sc... | 05/30/1989 |
| 4826972 | Method for preparing crystalline cephalosporin derivative The invention provides crystalline (6R, 7R)-7-[[2-(2-Amino-4-thiazolyl)-(Z)-2-(1-diphenylmethoxycarbonyl-1-methyle thoxy)imino ]acetamido]-3-(1-pyridiniummethyl)-3-cephem-4-carboxylate and a process for its production.... | 05/02/1989 |
| 4804660 | Ergot cyclic peptide alkaloids having a venotonizing effect, useful for treating orthostatic hypotension 9-thia ergot cyclic peptide alkaloids produced by fermentation or synthetic methods have interesting anti-parkinson and other pharmacological activities.... | 02/14/1989 |
| 4800204 | Method of controlling tobacco use The control of tobacco use in humans with a direct dopamine receptor agonist.... | 01/24/1989 |
| 4795759 | Use of dibenz(CD,F)indoles 4,5,5a,6-tetrahydro-dibenz[cd,f]indole derivatives having at least one oxy substitutent in one or both of the fused benzene rings, for the prevention of alcohol abuse.... | 01/03/1989 |
| 4791116 | N,N-diethyl-N'-[(8)-1-ethyl-6-methyl-ergolin-8-yl]-sulfamide useful as prolactin secretion inhibitor, anti-parkinson agents and anti-depressant agents The present invention provides N,N-Diethyl-N'-[(8)-1-ethyl-6-methyl-ergolin-8-yl]-sulfamide, and N,N-Diethyl-N'-[(8)-1-isopropyl-6-methyl-ergolin-8-yl)-sulfamide useful as prolactin secretion inhibiton, anti-parkinson agents and anti-de... | 12/13/1988 |
| 4791115 | 2,6-dimethyl-8-pivaloylamino-9,10-didehydro-ergoline Compounds of formula I ##STR1## wherein R1 is hydrogen or C1-4 alkyl, R2 is hydrogen, chlorine, bromine or methyl, R3 is C1-5 alkyl or C3-5 alkenyl and R4 is C1-7... | 12/13/1988 |
| 4783464 | N-substituted ergoline- and 9,10-didehydro-ergoline-8-carboxamide-and-8-aminomethyl-derivatives, their production and their pharmaceutical composition Novel N-substituted ergoline- and 9,10-didehydro-8-carboxamide- and -8-aminomethyl-derivatives for the treatment of vascular headaches, especially migraine, and of orthostatic hypotension.... | 11/08/1988 |
| 4775691 | 4H-benzo[4,5]cyclohepta[1,2-b]thiophene derivatives [2-Halo-10-oxy-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene]acetic acids, for example of formula I ##STR1## wherein R1 is H or C1-4 alkyl and R2 is halogen, their physiologically-hydrolysable and -acceptable ester... | 10/04/1988 |
| 4771122 | Novel cyclosporins Cylosporins e.g. of formula II ##STR1## in which X is -MeBmt- or -dihydro-MeBmt- and Y is -u-, -Thr-, -Val- or -Nva-, wherein the residue at the 3-position, i.e. the residue Z in formula II, is an optically active, -N-methylated -am... | 09/13/1988 |
| 4767852 | New process for producing cephalosporin antibiotics, and novel intermediates for use in such process and their production Process for the production of known 2-oximinoacetamido-3-cephem-4-carboxylic derivatives comprising acylation of 7-amino-3-cephem-4-carboxylic acid derivatives with novel 2-oximinoacetic acid thio esters, as well as such thioesters and their producti... | 08/30/1988 |
| 4764503 | Novel cyclosporins Cyclosporins wherein the amino acid residue at the 8-position is a (D)-acyloxy--amino acid residue, typically of formula ##STR1## wherein X=--MeBmt-- or --dihydro--MeBmt--, Y=--u--, --Ala--, --Thr--, --Val-- or --Nva--, Z=--Val-- or -... | 08/16/1988 |
| 4764517 | 8-(N,N-diethylsulfamoylamino)-6-n-propyl ergoline useful as a prolactin secretion inhibitor, anti-parkinson, anti-depressant agent A compound of formula I ##STR1## wherein R1 is n-propyl, R2 is hydrogen or alkyl(C1-3), R3 is alkyl(C1-3), and R4 is hydrogen or methyl in free base form or in pharmaceutically acceptable acid a... | 08/16/1988 |
| 4758550 | Calcitonin derivatives A compound of formula I ##STR1## wherein R is H or R'CO wherein R'CO is an acyl radical of a carboxylic acid, Y1 is the radical linked to an alpha carbon atom an -amino acid, Y2 is the radical linked to an alpha carbon at... | 07/19/1988 |
| 4758423 | Certain ergot peptide alkaloids administered to the nasal mucosa The present invention provides a nasal pharmaceutical composition comprising as active agent a compound of formula I, ##STR1## wherein R1 is hydrogen or halogen, R2 is hydrogen or alkyl of 1 to 4 carbon atoms, either (i) R3 | 07/19/1988 |
| 4755534 | Propenylamines, pharmaceutical compositions containing them and their use as pharmaceuticals A compound of the formula: ##STR1## wherein the double bond is in the trans configuration and R1 is a radical of formula IIa, ##STR2## R2, R3, R5, R7 and R8 are each hydrogen, R | 07/05/1988 |
| 4753959 | Antibiotic lactone compound The compound of formula I ##STR1## known as S 39163/F-I which is effective e.g. as an antimicrobial and against herpes viruses.... | 06/28/1988 |
| 4742077 | Bicyclic allylether derivatives, processes for their production and their use Compounds of formula I ##STR1## wherein R1 represents a group of formula ##STR2## whereby R4 and R5 are the same or different and represent hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl and X ... | 05/03/1988 |
| 4740518 | 4H-benzo(4,5)cyclohepta(1,2-B)thiophene derivatives -[5H-dibenzo[a,d]cyclohepten-5-ylidene]-carboxylic acids e.g. of formula I ##STR1## wherein R1 is H, C1-4 alkyl or phenyl-(C1-4 alkyl), R2 is H or C1-4 alkyl and ring A is unsubstituted or... | 04/26/1988 |
| 4737516 | Benzothienylallylamines processes for their production and their use as pharmaceuticals Benzothienyldialkylallylamines wherein the amine side chain is attached to the ring via an alkyl radical and is either in 4-, 5-, 6- or 7-position or if not bears tertiary alkylethynyl or alkenylethynyl as its terminal group, which are useful, in particul... | 04/12/1988 |
| 4737499 | Ergotalkaloids for treating senile dementia An ergot 5'S-(2R-butyl) peptide alkaloid and its acid addition salts is a useful pharmaceutical for use as a prolactin secretion inhibitor, for increasing vigilance or for the treatment of senile dementia, hypertension, or stroke.... | 04/12/1988 |
| 4728638 | Somatostatine derivatives Somatostatine derivatives of the general formula ##STR1## wherein either (a) A is ##STR2## W is -CO-N(A4) or -N(A5)-CO- and Y1 and Y2 are H or together a bond or (b) A is H, alkyl, phenylalkyl or RCO a... | 03/01/1988 |
| 4721616 | Treatment of vernal conjunctivitis Vernal conjunctivitis is treated by administration of an intravenously injectable form of a polyvalent, intact immunoglobulin (IgG).... | 01/26/1988 |
| 4703033 | Novel cyclosporins Cyclosporins e.g. of formula II ##STR1## in which X is -MeBmt- or -dihydro-MeBmt- and Y is -u-, -Thr-, -Val- or -Nva-, wherein the residue at the 3-position, i.e. the residue Z in formula II, is an optically active, -N-methylated -a... | 10/27/1987 |
| 4698331 | 2,3-diamino-2,3-didesoxyhexose derivatives and their use Compounds of formula I ##STR1## wherein R2 and R3 are the same or different and each represent unsubstituted or substituted acyl, and (a) R1 represents lower alkyl, aralkyl or the phosphate, pyrophosphate, phosphoryle... | 10/06/1987 |
| 4692453 | Pharmaceutical active 1,2,3,4,4A,5,10,10A-octahydrobenzo[g] quinoline derivatives, and their use A 6- or 8-monooxy- or 6,8-dioxy-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline in which the 3-position is unsubstituted, is useful as a pharmaceutical, in particular as a prolactin secretion inhibitor, dopaminergic agent and dopamine receptor stimula... | 09/08/1987 |
| 4681880 | Use of thio isosteres of ergot peptide alkaloids as vasaconstrictors 9-thia ergot cyclic peptide alkaloids produced by fermentation or synthetic methods have interesting anti-parkinson and other pharmacological activities.... | 07/21/1987 |
| 4681754 | Counteracting cyclosporin organ toxicity Improved cyclosporin therapy in particular for counteracting cyclosporin (e.g. Cyclosporine) organ toxicity, comprises adjunct administration of co-dergocrine.... | 07/21/1987 |
| 4681898 | N-N-disubstituted alkenamides and phenylalkenamides Compounds of the formula ##STR1## where n is 0 or 1, R is alkyl, phenyl or R4 -substituted phenyl, R2 and R3 are, independently, alkyl or R2 and R3 together with N is ##STR2## m is 1, 2 or 3, R | 07/21/1987 |
| 4680291 | Propenylamines, processes for their production and pharmaceutical compositions containing them The present invention provides propenylamines useful as anti-mycotic agents.... | 07/14/1987 |
| 4676982 | Treatment of chronic inflammatory disease with polyvalent immunoglobulins Chronic inflammatory disease of the bowel, e.g. ulcerative colitis and Cr's disease, is treated by infusion of an intravenously injectable form of a polyvalent, intact immunoglobulin (IgG).... | 06/30/1987 |
| 4656167 | Naphthoxazines and their use as psychostimulating and antidepressant agents 3,4,4a,5,10,10a-hexahydro-2H-naphth[2,3-b]-1,4-oxazines are useful as psychostimulating and antidepressant agents.... | 04/07/1987 |
| 4639434 | Novel cyclosporins Cyclosporins wherein the amino acid residue at the 8-position is a (D)-acyloxy--amino acid residue, typically of formula ##STR1## wherein X=-MeBmt- or -dihydro-MeBmt-, Y=-u-, -Ala-, -Thr-, -Val- or -Nva-, Z=-Val- or -Nva- and Q=R... | 01/27/1987 |
| 4634708 | Indolophenanthridines useful as dopaminergic and analgesic agents 4,6,6a,7,8,12b-hexahydro-indolo[4,3-ab]phenanthridines are useful as dopaminergic and analgesic agents.... | 01/06/1987 |
| 4609731 | Process for brominating ergot alkaloids The present invention provides an improved process for the production of a compound of formula I ##STR1## wherein R1 is carboxyl, alkoxy(C1-5)carbonyl, amido, alkyl(C1-5)amido, di(alkyl(C1-5)amido or an ami... | 09/02/1986 |
| 4609664 | Antiasthmatic piperidylidene derivatives Piperidylidene derivatives of formula ##STR1## wherein n is 2 or 3, R1 comprises a tricyclic nucleus and R2 is hydrogen or an acid residue, useful in the treatment and prophylaxis of asthmatic conditions.... | 09/02/1986 |
| 4609657 | Ergot peptide alkaloid derivatives, processes for their preparation and pharmaceutical compositions containing them This invention provides compounds of ##STR1## wherein R1 is benzyl or benzyl substituted by hydroxy, chlorine, fluorine, amino, amido, (C2-5) alkanoylamino, (C1-4) alkyl, (C1-4) alkylamino, (C1-4... | 09/02/1986 |
