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| Number | Title | Issue Date |
| 7406391 | System, method, and computer product for detection instrument calibration In one embodiment, a method of determining a drift value is described that includes performing one or more X-axis translations of an excitation beam over a probe array; measuring light responsive to the excitation beam from at least two positional reference elements... | 07/29/2008 |
| 7364895 | Bioarray chip reaction apparatus and its manufacture A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets | 04/29/2008 |
| 7323307 | Identification of molecular sequence signatures and methods involving the same Novel means and methods for analyzing hybridization data derived from hybridization assays between a target nucleic acid and differently sequenced polynucleotide probes involve selecting probe sets that define reference sequences for sequence signatures and deriving... | 01/29/2008 |
| 7317415 | System, method, and product for scanning of biological materials employing dual analog integrators In one embodiment, a system is described for reducing a dark period between successive data acquisition periods associated with the detection of one or more target molecules hybridized to at least one of a plurality of probes disposed upon a biological probe array. ... | 01/08/2008 |
| 7314595 | High throughput microarray spotting system and method A system is described for automatic retrieval of microplates from a carousel. The system includes an effector arm that retrieves a selected microplate from the carousel, a microplate retainer that receives the selected microplate from the effector arm, and a control... | 01/01/2008 |
| 7312919 | Wide field of view and high speed scanning microscopy A wide field of view scanning microscope includes a light source, a light detector, optics, a scanning assembly, a translation system, and a data collection control and processing unit. The scanning assembly is constructed to provide from the light source a light be... | 12/25/2007 |
| 7116809 | Computer software system, method, and product for scanned image alignment An image alignment tool is described for adjusting the alignment of a grid with an image. An initial grid aligner determines an initial, approximately aligned, position of the grid. An intensity scorer determines, for each of a plurality of test grid elements of the... | 10/03/2006 |
| 7095032 | Focusing of microscopes and reading of microarrays Microscopes, including viewing and other microscopic systems, employ a hinged, tiltable plate to adjust focus on a flat object such as a microscope slide or biochip by motion, achieved by tilting, which is substantially normal to the focus point on the plane of the ... | 08/22/2006 |
| 7062092 | System, method, and computer software product for gain adjustment in biological microarray scanner Systems, methods, and computer program products are described for adjusting the gain of a scanner. The scanner includes one or more excitation sources, an emission detector having a first gain, and a variable gain element having a second gain. One described method i... | 06/13/2006 |
| 7031846 | Method, system, and computer software for the presentation and storage of analysis results A computer program product, and related systems and methods, are described that processes emission intensity data corresponding to probes of a biological probe array. The computer program includes a genotype and statistical analysis manager that determines absolute ... | 04/18/2006 |
| 6996475 | Computer software products for nucleic acid hybridization analysis Methods and computer software products are provided for analyzing gene expression data. In one embodiment, multiple probes are used to detect a single transcript. The hybridization intensities of each probe is adjusted by dividing the intensities by the affinities o... | 02/07/2006 |
| 6985655 | Compositions and methods involving direct write optical lithography In one embodiment, fiber optic arrays or bundles are used as a light guide to transmit ultraviolet light to the substrate surface for photo-directed polymer synthesis. Digital Micromirror Array (DMA) is used as a switching device to reflect light onto the entry side... | 01/10/2006 |
| 6984828 | Quantified fluorescence microscopy The present invention relates to calibration apparatuses, methods or tools used in microscopy. A calibration tool for fluorescent microscopy includes a support, a solid surface layer including a fluorescent material, and a thin opaque mask of non-fluorescent materia... | 01/10/2006 |
| 6965704 | System, method, and computer software product for grid alignment of multiple scanned images Systems, methods, and computer program products are described for aligning multiple images of arrays of biological materials. One method includes aligning a grid with a first image, generating grid alignment data based on the alignment of the grid with the first ima... | 11/15/2005 |
| 6958225 | Complexity management of genomic DNA The presently claimed invention provides for novel methods and kits for reducing the complexity of a nucleic acid sample by providing non-gel based methods for amplification of a subset of the sequences in a sample. In a preferred embodiment, amplification of a subs... | 10/25/2005 |
| 6957149 | Computer-aided probability base calling for arrays of nucleic acid probes on chips A computer system for analyzing nucleic acid sequences is provided. The computer system is used to calculate probabilities for determining unknown bases by analyzing the fluorescence intensities of hybridized nucleic acid probes on biological chips. Additionally, in... | 10/18/2005 |
| 6954699 | System and method for programatic access to biological probe array data An applications programming interface is described that includes code libraries that enable transfer of pixel data, intermediate results data, or both, from a data structure or data file directly or indirectly to a user-provided application. The pixel data and inter... | 10/11/2005 |
| 6949638 | Photolithographic method and system for efficient mask usage in manufacturing DNA arrays Systems, methods, and products are described for synthesizing probe arrays of polymers. A mask is used that includes reticle areas, each of which includes a number of reticles associated with a same synthesis area on a substrate. A method includes (a) aligning the m... | 09/27/2005 |
| 6907146 | Methods, systems and computer software for detecting pixel stutter Embodiments of the invention provide methods, computer software products and systems for detecting pixel stutter of a scanner. In one embodiment, a numeric count of stuttered pixels in both the x (row) and y (column) directions and a graphic display of the stuttered... | 06/14/2005 |
| 6884578 | Genes differentially expressed in secretory versus proliferative endometrium The present invention compares expression profiles from matched samples to identify differential gene expression. Samples are matched according to physiological, pharmacological and/or disease state. Comparison of matched samples eliminates gene expression differenc... | 04/26/2005 |
| 6881836 | Photocleavable protecting groups and methods for their use Novel compounds are provided which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. These compounds are generally photolabile and comprise protecting groups which can be removed by phot... | 04/19/2005 |
| 6872529 | Complexity management of genomic DNA The presently claimed invention provides for novel methods and kits for reducing the complexity of a nucleic acid sample by providing non-gel based methods for size fractionation. In a preferred embodiment, size fractionation can be accomplished by varying condition... | 03/29/2005 |
| 6864050 | Single-phase amplification of nucleic acids The amplification of nucleic acids in a single phase can reliably provide products at relatively low cost and labor. A single-phase amplification can also increase the amount of nucleic acids while preserving the relative abundance of the individual nucleic acid spe... | 03/08/2005 |
| 6850846 | Computer software for genotyping analysis using pattern recognition Methods, systems and computer software products are provided for determining genotype of a sample using a plurality of probes. In one preferred embodiment, a tentative genotype call is made based upon the relative allele signals. Pattern recognition is then used to ... | 02/01/2005 |
| 6841348 | Methods for identifying and using maintenance genes This invention provides methods for discovering maintenance genes and for using maintenance genes. In one embodiment, the expression of at least three maintenance genes are measured and used as reference (or control) for comparing the expression of target genes in t... | 01/11/2005 |
| 6830936 | Integrated nucleic acid diagnostic device The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several o... | 12/14/2004 |
| 6828104 | Nucleic acid affinity columns This invention provides nucleic acid affinity matrices that bear a large number of different nucleic acid affinity ligands allowing the simultaneous selection and removal of a large number of preselected nucleic acids from the sample. Methods of producing such affin... | 12/07/2004 |
| 6829376 | Computer software system, method, and product for scanned image alignment An image alignment tool is described for adjusting the alignment of a grid with an image. An initial grid aligner determines an initial, approximately aligned, position of the grid. An intensity scorer determines, for each of a plurality of test grid elements of the... | 12/07/2004 |
| 6803196 | Methods and compositions for detecting signals in binding assays using microparticles Methods and compounds are provided for detecting target molecules in a sample using specific binding assays. In particular, methods are provided for detecting a nucleic acid target in a sample. In one embodiment, the presently claimed invention provides a method of ... | 10/12/2004 |
| 6804679 | System, method, and user interfaces for managing genomic data A data manager is described for providing a publish database for access by data mining tools and other data processing software applications. The data manager includes a results-for-publication identifier that identifies synthesized probe array results and spotted p... | 10/12/2004 |
| 6800439 | Methods for improved array preparation Improved nucleic acid arrays are provided which have been prepared in a non-oxidizing atmosphere. ... | 10/05/2004 |
| 6794138 | Methods of small sample amplification The present invention relates to the amplification of nucleic acids, preferably from mRNA. A primer and promoter are added to a target sequence to be amplified and then the target is amplified in an in vitro transcription reaction and the product of this reaction is... | 09/21/2004 |
| 6789040 | System, method, and computer software product for specifying a scanning area of a substrate Systems, methods, and computer program products are described for specifying a scanning area of a substrate. In accordance with one method, steps include receiving location data corresponding to a plurality of probe-feature locations on the substrate, storing the lo... | 09/07/2004 |
| 6773888 | Photoactivatable silane compounds and methods for their synthesis and use In one aspect of the invention, photoactivatable silane compounds and methods for their synthesis and use are provided. In one embodiment, the photoactivatable silane compounds synthesized are represented by a formula: PG-LS-SN, wherein PG is a photoactivatable grou... | 08/10/2004 |
| 6733977 | Hybridization device and method A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets | 05/11/2004 |
| 6722395 | Depositing fluid specimens on substrates, resulting ordered arrays, techniques for analysis of deposited arrays For depositing fluid dots in an array, e.g., for microscopic analysis, a deposit device, e.g. a pin, cooperating with a fluid source defines a precisely sized drop of fluid of small diameter on a drop carrying surface. Transport mechanism positions the device precis... | 04/20/2004 |
| 6632611 | Method of target enrichment and amplification The presently claimed invention provides methods and kits for amplifying a target sequence from within a nucleic acid population. The presently claimed invention provides selection probes which are complementary to at least a portion of said target sequen... | 10/14/2003 |
| 6203989 | Methods and compositions for amplifying detectable signals in specific binding assays Methods and compounds are provided for detecting target molecules in a sample using specific binding assays. In particular, methods are provided for detecting a nucleic acid target in a sample. In one embodiment, the method comprises hybridizing a nucleic... | 03/20/2001 |
| 5972230 | Method for rejuvenation of filter elements used in the filtration of metalworking fluids Fines, that are present in lubricating oil, and their organo-metallic coatings are contacted with aqueous solutions of strong acids to solve the problems of plugged cartridge type filters. The present process employs a washing step whereby, following a fi... | 10/26/1999 |
| 5772802 | Method for making can end and tab stock Can or lid stock and a method for its manufacture in which a low alloy content aluminum alloy is strip cast to form a hot strip cast feedstock, the hot feedstock is rapidly quenched to prevent substantial precipitation, annealed and quenched rapidly to pr... | 06/30/1998 |
