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| Number | Title | Issue Date |
| 4665203 | Substituted dihydrobenzopyrans useful as leukotriene D4 inhibitors The invention relates to compounds of the formula: ##STR1## which are useful as leukotriene D4 (LTD4) inhibitors and therefore useful in the treatment of allergies and inflammatory conditions.... | 05/12/1987 |
| 4639524 | Monobasic disobutamide derivatives Compositions of matter are disclosed of compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein X represents a halo, lower alkyl, hydrogen, trifluoromethyl, phenyl, or lower alkoxy substituent; Y repr... | 01/27/1987 |
| 4617411 | 3-oxaprostaglandins This invention relates to novel 3-oxa-15-desoxy-16-hydroxy-16-alkyl prostaglandins of the E2 series and the 5,6-acetylene derivatives thereof. These compounds are useful for their gastric antisecretory, cytoprotective, antiulcer, and antihypert... | 10/14/1986 |
| 4603121 | Enkephalin analogs The invention relates to novel enkephalin analogs of the formula: ##STR1## which are useful as analgesic agents.... | 07/29/1986 |
| 4565882 | Substituted dihydrobenzopyran-2-carboxylates The invention relates to substituted dihydrobenzopyrans carboxylates of the formula: ##STR1## wherein A is a methylene chain having 1-10 carbon atoms, inclusive, optionally substituted by hydroxy; wherein V is: (a) hydrogen; (b) hydroxy; (c) .dbd.O; ... | 01/21/1986 |
| 4560754 | Substituted 5-phenyl-5-(aminoalkyl)-1,3-diazabicyclo[4.4.0]decan-4-ones and 5-phenyl-5-(aminoalkyl)-1,3-diazabicyclo[4.4.0]dec-2-en-4-ones This invention relates to 5-(substituted phenyl)-5-[(substituted amino)alkyl]-1,3-diazabicyclo[4.4.0]decan-4-ones and 5-(substituted phenyl)-5-[(substituted amino)-alkyl]-1,3-diazabicyclo[4.4.0]dec-2-en-4-ones that are useful as antiarrhythmic agents... | 12/24/1985 |
| 4559336 | 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(sulfinyl- and sulfonyl-containing acyl)hydrazides This invention relates to 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(sulfinyl- and sulfonyl-containing acyl)hydrazides that are useful as prostaglandin antagonists and analgesic agents.... | 12/17/1985 |
| 4559337 | 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(alkoxy-containing acyl)hydrazides This invention relates to 8-chlorodibenz[b,f][1,4]-oxazepine-10(11H)-carboxylic acid, 2-(alkoxy-containing acyl)hydrazides that are useful as prostaglandin antagonists and analgesic agents.... | 12/17/1985 |
| 4555362 | Method and intermediates for producing -L-aspartyl-L-phenylalanine This invention encompasses a method and intermediates for preparing a commercial sweetening agent, -L-aspartyl-L-phenylalanine methyl ester. The process involves reacting L-aspartic acid with diketene to form N-acetoacetyl-L-aspartic acid which is ... | 11/26/1985 |
| 4554353 | 2,5-Pyrrolidinedione derivatives useful as antiarrhythmic agents This invention encompasses compounds of the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof wherein n is 2 or 3 and R1 and R2 are n-propyl, isopropyl, or R1 and R2 together with... | 11/19/1985 |
| 4554359 | 3-Substituted pentanedioic acids and derivatives thereof This invention relates to methods of preventing or reducing the degradation of elastin and other proteins and thereby preventing or retarding the disease states caused by said degradation by administering compounds of the formula: ##STR1## or th... | 11/19/1985 |
| 4551279 | Protease inhibitors This invention relates to methods of preventing or reducing the degradation of elastin and other proteins and thereby preventing or retarding the disease states caused by said degradation by administering compounds, some of which are novel, of the formula... | 11/05/1985 |
| 4548806 | Psyllium hydrophilic mucilloid composition This invention relates to a method of increasing the dispersibility and mixability of psyllium hydrophilic mucilloid by applying a film of hydrolyzed starch oligosaccharide, a mono-or di-saccharide, a polyglucose, or a polymaltose.... | 10/22/1985 |
| 4545977 | Compositions and methods for treating severe acne with isotretinoin A therapeutically effective amount of isotretinoin is co-administered to patients suffering from severe cystic acne with a protective amount of taurine which reduces the side effects of isotretinoin.... | 10/08/1985 |
| 4536592 | 2-Substituted prostaglandins The present invention encompasses 16-alkyl, 16-hydroxy-2-substituted prostaglandins which exhibit cytoprotective and antisecretory activity with greatly reduced diarrhea side effects.... | 08/20/1985 |
| 4533739 | 2-[(Aminophenyl and amidophenyl)amino]-1-azacycloalkanes having antidiarrheal activity This invention relates to the novel use of certain aromatic substituted amidines as antidiarrheals.... | 08/06/1985 |
| 4529811 | Process for isolating organic compounds and lithium salt complexes useful in said process An improved process for isolating organic compounds from crude product or reaction mixtures by dissolving said crude product or reaction mixture in a suitable solvent, contacting the resulting solution with a lithium salt to form a solid metal salt comple... | 07/16/1985 |
| 4529812 | 3-Oxaprostaglandins This invention relates to novel 3-oxa-15-desoxy-16-hydroxy-16-alkyl prostaglandins of the E2 series and the 5,6-acetylene derivatives thereof. These compounds are useful for their gastric antisecretory, cytoprotective, antiulcer, and antihypert... | 07/16/1985 |
| 4523020 | Substituted 2-(3-aminophenoxymethyl)imidazolines This invention relates to novel substituted 2-(3-aminophenoxymethyl)imidazolines which are useful for the treatment of diarrhea and useful as analgesics.... | 06/11/1985 |
| 4514332 | Tetrapeptide adamantyl amides This invention relates to novel tetrapeptide adamantyl amides that are useful in the treatment of hypertension.... | 04/30/1985 |
| 4511504 | Carboxyalkyl peptide derivatives This invention encompasses novel carboxyalkyl peptide derivatives which are collagenase inhibitors.... | 04/16/1985 |
| 4510085 | Antihypertensive tetrapeptide amides This invention relates to novel tetrapeptide adamantyl amides that are useful in the treatment of hypertension.... | 04/09/1985 |
| 4501895 | [Halo-4-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-phenyl]octadecan-ols and -ones This invention relates to novel compounds for preventing or retarding the degradation of elastin or other proteins and therefore preventing or retarding the disease states caused by said degradation, of the formula: ##STR1## or its pharmacologically ... | 02/26/1985 |
| 4499289 | Octahydronapthalenes The invention relates to octahydronapthalenes which are useful in antiatherosclerotic agents.... | 02/12/1985 |
| 4499296 | Omega cycloalkyl prostaglandins This invention encompasses prostaglandins of the formula I ##STR1## wherein R'" represents hydroxymethyl, hydroxyacetyl or --CO2 R"" wherein R"" represents hydrogen or lower alkyl containing 1 to 6 carbon atoms; R' represents lower alkyl c... | 02/12/1985 |
| 4499295 | Protease inhibitors This invention relates to methods of preventing or reducing the degradation of elastin and other proteins and thereby preventing or retarding the disease states caused by said degradation by administering compounds of the formula: ##STR1## or th... | 02/12/1985 |
| 4496485 | Asymmetric 7-O-(substituted acetyl)-4-demethoxydaunomycinones This invention relates to novel diastereomeric 7-O-(substituted acetyl)-4-demethoxydaunomycinones that are useful in the preparation of optically pure 4-demethoxydaunorubicin, a drug used in the treatment of certain cancers.... | 01/29/1985 |
| 4480112 | Method and intermediates for producing -L-aspartyl-L-phenylalanine This invention encompasses a method and intermediates for preparing a commercial sweetening agent, -L-aspartyl-L-phenylalanine methyl ester. The process involves reacting L-aspartic acid with diketene to form N-acetoacetyl-L-aspartic acid which is ... | 10/30/1984 |
| 4473501 | Dihydro azino isoquinolines The invention provides novel 1,5-substituted isoquinoline derivatives of formula I which are useful in the treatment of hypertension.... | 09/25/1984 |
| 4472394 | Method for increasing weight in domestic animals The present invention relates to a method for promoting weight gain in a domestic farm animal which comprises subcutaneously implanting a slow-release implant which contains norgestomet in a quantity such that at least 75 mcg/day to a maximum of 200 mcg/d... | 09/18/1984 |
| 4469885 | Halogenated protease inhibitors This invention relates to novel compounds for preventing or retarding the degradation of elastin or other proteins and therefore preventing or retarding the disease states caused by said degradation, of the formula: ##STR1## or its pharmacologically ... | 09/04/1984 |
| 4459310 | Method for cholesterol lowering This invention encompasses a new use for 16-loweralkyl-16-hydroxy prostaglandins such as misoprostol. This class of prostaglandin has been found useful in lowering cholesterol blood levels in patients with hypercholesterolemia.... | 07/10/1984 |
| 4459280 | Psyllium hydrophilic mucilloid composition This invention relates to a method of increasing the dispersibility and mixability of psyllium hydrophilic mucilloid by applying a film of hydrolyzed starch oligosaccharide, a mono-or di-saccharide, a polyglucose, or a polymaltose.... | 07/10/1984 |
| 4459235 | 2-Cyanosteroids The invention relates to novel 2-cyanosteroids of Formula I which are useful for the induction of menses and the termination of pregnancy.... | 07/10/1984 |
| 4452994 | Process for isolating organic compounds and lithium salt complexes useful in said process An improved process for isolating organic compounds from crude product or reaction mixtures by dissolving said crude product or reaction mixture in a suitable solvent, contacting the resulting solution with a lithium salt to form a solid metal salt comple... | 06/05/1984 |
| 4439460 | Dipeptide sweetener sulfate and sulfonate salts Aspartyl dipeptide sweetener sulfate and alkyl sulfonate salts are described which have high thermal stability and a fast rate of dissolution in aqueous media. These salts can be almost universally substituted in place of sugar and are effective in baking... | 03/27/1984 |
| 4420568 | Fluorescent polarization immunoassay utilizing substituted triazinylaminofluoresceins An immunochemical method and reagent compounds for determining ligands in a sample. The reagent compounds are derivatives of a triazinylaminofluorescein and are represented by the structural formula ##STR1## wherein Y is halo or lower alkyl; and R is... | 12/13/1983 |
| 4379841 | Assimilation test for identifying yeasts The disclosure relates to a culture medium containing as a sole carbon source 4-hydroxybenzoic acid, 3,4-dihydroxybenzoic acid or a mixture thereof, and to an assimilation test for identifying yeasts utilizing such a culture medium.... | 04/12/1983 |
| 4341865 | Determination of thyroxine binding globulin This invention encompasses a method for measuring unsaturated thyroxine binding globulin in serum comprising intermixing with the serum: (i) thyroxine irreversible enzyme inhibitor conjugate which binds to the unsaturated thyroxine binding globulin thereby ina... | 07/27/1982 |
| 4340679 | Culture media for inactivation of bacterial growth inhibitors This invention encompasses methods and reagents for inactivation of bacterial growth inhibitors present in blood, serum or plasma. It has been found that salicylates and closely related compounds will neutralize bacterial growth inhibitors present in the ... | 07/20/1982 |
