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| Number | Title | Issue Date |
| 4914240 | Gem-dihalo-1, 8-diamino-4-aza-octanes Gem-dihalo-1,8-diamino-4-aza-octane derivatives useful as antiproliferative or antitumor agents.... | 04/03/1990 |
| 4851448 | Gem-dihalo-1,8-diamino-4-aza-octanes Gem-dihalo-1,8-diamino-4-aza-octane derivatives useful as antiproliferative or antitumor agents.... | 07/25/1989 |
| 4783471 | N-aralkyl piperidine methanol derivatives and the uses thereof This invention relates to a new class of compounds having important biochemical and pharmacological properties. More particularly, this invention relates to N-aralkyl piperidinemethanol derivatives which are potent and selective inhibitors of the binding ... | 11/08/1988 |
| 4782042 | Antibiotic A 40926 mannosyl aglycon The present invention concerns a new antibiotic substance denominated antibiotic A 40926 mannosyl aglycon and the addition salts thereof, a process for preparing it from antibiotic A 40926 complex or a factor thereof, and its use in the treatment of infec... | 11/01/1988 |
| 4762849 | Cardiotonic alkanoylthiazolones Novel alkanoylthiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.... | 08/09/1988 |
| 4745222 | Novel aryloxycycloalkanolaminoalkylene aryl ketones This invention relates to aryloxycycloalkanolaminoalkylene aryl ketones to the processes for their preparation and to their use as antihypertensive agents.... | 05/17/1988 |
| 4719313 | Gem-dihalo and tetrahalo-1,12-diamino-4,9-diaza-dodecanes Gem-dihalo and gem-tetrahalo-1,12-diamino-4,9-diaza-dodecane derivatives useful as antiproliferative or antitumor agents.... | 01/12/1988 |
| 4699928 | Fluoroallylamine derivatives Fluoroallylamine derivatives of the following Formula I are novel MAO-inhibitors and at low dose levels selectively inhibit MAO-B: ##STR1## wherein: R1 and R2 independently represent hydrogen, chlorine or fluroine; R3... | 10/13/1987 |
| 4695654 | Gem-dihalo-1,8-diamino-4-aza-octanes Gem-dihalo-1,8-diamino-4-aza-octane derivatives useful as antiproliferative or antitumor agents.... | 09/22/1987 |
| 4670459 | Method of alleviating withdrawal symptoms The use of lofexidine and its pharmaceutically acceptable salts in alleviating the adverse symptoms of drug withdrawal, pre-menstrual tension and peri-menopausal flushing is disclosed.... | 06/02/1987 |
| 4588825 | Intermediates for the synthesis of 4-amino-4,5-dihydro-2-furancarboxylic acid This application relates to a stereospecific process for preparing specific enantiomers of 4-amino-4,5-dihydro-2-furancarboxylic acid and C1-6 lower alkyl esters thereof. These compounds are γ-aminobutyric acid transaminase inhibitors useful i... | 05/13/1986 |
| 4585866 | Treatment of migraine with substituted tropyl benzoate derivatives Migraine is treated with a tropyl benzoate derivative of the following general formula: ##STR1## wherein: R1 represents C1 -C4 alkyl, C1 -C4 alkoxy or halogen; R2 represents hydrogen, ... | 04/29/1986 |
| 4575510 | Method of alleviating withdrawal symptoms The use of lofexidine and its pharmaceutically acceptable salts in alleviating the adverse symptoms of tobacco withdrawal is disclosed.... | 03/11/1986 |
| 4568751 | 5-Acyl-2-(1H)-pyridinones Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-... | 02/04/1986 |
| 4563465 | Treatment of migraine with substituted tropyl benzoate derivatives Migraine is treated with a tropyl benzoate derivative of the following general formula: ##STR1## wherein: R1 represents C1 -C4 alkyl, C1 -C4 alkoxy or halogen; R2 represents hydrogen, ... | 01/07/1986 |
| 4560795 | -Halomethyl derivatives of -amino acids Novel halomethyl derivatives of -amino acids of the following general structure: ##STR1## wherein Y is F2 CH--, F3 C--, Cl2 CH--; Z is ଲ-methylthioethyl, ଲ-thioethyl, ଲ-benzylthioethyl; S... | 12/24/1985 |
| 4540582 | Treatment of seizure disorders and pharmaceutical compositions useful therein Glycine, sarcosine, or N,N-dimethylglycine exerts a synergistic effect upon gamma-vinyl GABA for the treatment of seizure disorders, in particular epilepsy.... | 09/10/1985 |
| 4533677 | Hypoglycemic N-(2-substituted-3-Dialkylamino-2-propenylidene)-N-alkylalkanaminium salts N-(3-Dialkylamino-2-propenylidene)-N-alkylalkanaminium salts substituted in the 2-position with an ether or thioether and having the formula ##STR1## are active as hypoglycemic agents.... | 08/06/1985 |
| 4529733 | Antihypertensive 3-furoyl-1,4-dihydropyridines Novel 1,4-dihydropyridine derivatives have the following general Formula: ##STR1## and are calcium antagonists, useful for treating cardiovascular diseases.... | 07/16/1985 |
| 4526979 | Carbamates and oxalamides of amino-N-(1H-tetrazol-5-yl)benzamides Alkoxycarbonyl and oxalyl derivatives of amino-N-(1H-tetrazol-5-yl)benzamides are described herein. The compounds involved are useful as antiallergic agents. These compounds can be prepared by the reaction of an amino-N-(1H-tetrazol-5-yl)benzamide with an... | 07/02/1985 |
| 4508730 | 1,7-Dihydro-pyrrolo[3,4-e][1,4]diazepin-2(3H)-one derivatives a process for preparing them and their use as anticonvulsant and anti-anxiety agents 1,7-Dihydro-pyrrolo[3,4-e][1,4]diazepin-2(3H)-one derivatives of the formula ##STR1## wherein R is (C1-4)alkyl, R1 stands for hydrogen, methyl, ethyl, phenyl, bromo, chloro or nitro, R2 is hydrogen or (C1-4... | 04/02/1985 |
| 4496588 | Method of treating psoriasis A novel method of treating psoriasis which comprises administering a halomethyl derivative of -amino acids of the following general structure: ##STR1## wherein Y is FCH2 --, F2 CH--, F3 C--, ClCH2 --... | 01/29/1985 |
| 4489011 | Hypoglycemic N-(2-substituted-3-dialkylamino-2-propenylidene)-N-alkylalkanaminium camsylate salts Camsylate salts of N-(3-dialkylamino-2-propenylidene)-N-alkylalkanaminium substituted in the 2-position with an ether or thioether and having the formula ##STR1## are active as hypoglycemic agents.... | 12/18/1984 |
| 4486441 | Pseudotropyl halogeno-benzoates and their use in migraine treatment Migraine is treated with a novel pseudotropyl benzoate derivative of the following general Formula I: ##STR1## wherein: R1 represents halogen, preferably chlorine; R2 represents hydrogen or halogen, preferably chlorine; and R3 | 12/04/1984 |
| 4479958 | Methods and compositions for inhibiting herpes virus using pyridinyl ketones Methods and compositions for inhibiting herpes virus on living or non-living substrates by use of various pyridinyl ketones or a pharmaceutically-acceptable salt thereof.... | 10/30/1984 |
| 4454156 | 4-Amino-hepta-5,6-dienoic acid (R,S)- and (S)-4-amino-hepta-5,6-dienoic acid are novel inhibitors of gamma-aminobutyric acid transaminase (GABA-T).... | 06/12/1984 |
| 4454158 | Allyl amine MAO inhibitors Compounds of the formula ##STR1## wherein: R is phenyl, phenyl monosubstituted, disubstituted, or trisubstituted by (C1 -C8) alkyl, (C1 -C8)alkoxy, hydroxy, chlorine, bromine, iodine, fluorine, trifluoromet... | 06/12/1984 |
| 4447619 | 4-Alkanoylimidazol-2-ones 4-alkanoylimidazol-2-ones of the following general structure which are useful as cardiotonics in the treatment of cardiac failure ##STR1## wherein Q and T are each an oxygen atom or a divalent sulfur atom; R is hydrogen, lower alkyl, lower alkylcarbo... | 05/08/1984 |
| 4446151 | Decarboxylase-inhibiting fluorinated pentane diamine derivatives Novel fluorinated diamine derivatives are inhibitors of ornithine decarboxylase enzyme and have the following general Formula I: ##STR1## wherein: Rc represents hydrogen or carboxy; R1 represents hydrogen or C1 -C6 | 05/01/1984 |
| 4440764 | Water soluble esters of steroid-oxazole and pharmaceutical compositions containing them Water-soluble esters of steroid-oxazole derivatives of formula I ##STR1## wherein R is O or a H, (ଲ-OH) group, R1 is hydrogen, lower alkyl or phenyl, X is hydrogen, fluorine or chlorine, A stands for a direct carbon-carbon bond or a ... | 04/03/1984 |
| 4439619 | Fluorinated pentene diamine derivatives Fluorinated alkenylene diamine compounds are inhibitors of ornithine decarboxylase enzyme in vivo and have the following formula: ##STR1## wherein: Ra represents hydrogen or R2, where R2 is as defined below; Rb | 03/27/1984 |
| 4438270 | -Halomethyl derivatives of -amino acids Novel halomethyl derivatives of -amino acids of the following general structure: wherein Y is ClCH2, F2 CH--, F3 C--, ClCH2 --, Cl2 CH--; Z is ଲ-methylthioethyl, ଲ-thioethyl, ... | 03/20/1984 |
| 4437873 | Method of inhibiting algae -Substituted amines are described which are useful in controlling the growth of algae.... | 03/20/1984 |
| 4435425 | Fluorinated diaminobutane derivatives Fluorinated diaminobutane compounds in vivo are inhibitors of gamma-aminobutyric acid transaminase and have the following formula: ##STR1## wherein: R1 represents hydrogen, C1 -C6 alkyl, or phenyl-(C1 -C | 03/06/1984 |
| 4435420 | Anti-inflammatory agents and antiasthmatic agents N-(1,3-dithiolan-2-ylidene)-4-alkylanilines are useful as anti-inflammatory agents, as analgesic agents and as antiasthmatic agents. The compounds involved can be prepared by the reaction of an appropriate 4-alkylaniline with a methyl(1,3-dithiolan-2-ylid... | 03/06/1984 |
| 4427656 | Antibiotic A/16686 factor A2, the process for the preparation thereof and the co-produced antibiotic A/16686 factors A1 and A3 The present invention refers to a chlorine containing antibiotic substance, named antibiotic A/16686 factor A2, in an essentially pure form. The invention also relates to the process for the production of antibiotic A/16686 factors A2 | 01/24/1984 |
| 4423073 | Fluorinated diaminopentene derivatives Novel fluorinated alkenylene diamine derivatives are inhibitors of ornithine decarboxylase enzyme and have the following general Formula I: ##STR1## wherein: Rc represents hydrogen or --COR5, where R5 is as defined be... | 12/27/1983 |
| 4421768 | Fluorinated diamino-heptene and-heptyne derivatives Novel fluorinated diamino-heptene and-heptyne derivatives are inhibitors of ornithine decarboxylase enzyme involved in polyamine formation and have the following general Formula I: ##STR1## wherein: Y represents CH2 .dbd.CH-- or CH.tbd.C--... | 12/20/1983 |
| 4421767 | Compounds and methods for treating depression Compounds of the formula: ##STR1## wherein: X is fluorine, chlorine, or bromine; R is the group R2 as defined below; R1 is a group of the formula: ##STR2## or the group R2 as defined below; wherein R2 is: ... | 12/20/1983 |
| 4421736 | Sustained release diethylpropion compositions Sustained release formulations for the anorectic agent, diethylpropion hydrochloride, are disclosed which are suitable for use in capsules.... | 12/20/1983 |
