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| Number | Title | Issue Date |
| 6288042 | Anti-viral guanosine-rich tetrad forming oligonucleotides Guanosine-rich oligonucleotides having sequences that favor the formation under physiological conditions of a stable four-stranded structure containing two stacked guanosine quartets (G4s) are disclosed. These oligonucleotides demonstrate enhanced nucleas... | 09/11/2001 |
| 6048529 | PVA or PEG conjugates of peptides for epitope-specific immunosuppression The invention relates to a procedure for synthesis of well-defined conjugates of peptides to the tolerogenic polymer monomethoxypolyethylene glycol (mPEG) or polyvinyl alcohol (PVA). This method results in the preparation of conjugates in which one molecu... | 04/11/2000 |
| 5759834 | Synthetic sterically-constrained pepzyme catalysts modeled on lysozyme and ribonuclease Pepzymes, chemically synthesized cyclic peptides, modeled on lysozyme and ribonuclease have been prepared which efficiently catalyze the same reaction as the native enzyme being modeled. The synthetic pepzymes have a sequence of amino acids which is subst... | 06/02/1998 |
| 5683443 | Implantable stimulation electrodes with non-native metal oxide coating mixtures The invention relates to an improved stimulation electrode for cardiac pacing and defibrillating, methods of manufacturing same, and methods of using same. Specifically, the electrodes of the invention by virtue of the methods of manufacturing and using, ... | 11/04/1997 |
| 5654030 | Method of making implantable stimulation electrodes The invention relates to methods of making an improved stimulation electrode for cardiac pacing and defibrillating. Specifically, the electrodes of the invention by virtue of the methods of manufacturing and using, demonstrate improved capabilities of sti... | 08/05/1997 |
| 5614503 | Amphipathic nucleic acid transporter A nucleic acid transporter to deliver a nucleic acids into cells, comprising a cationic compound having a cationic head group for binding the nucleic acid and a lipid tail for association with the membrane. A cationic compound usually is a polyamine or a ... | 03/25/1997 |
| 5612487 | Anti-viral vaccines expressed in plants The anti-viral vaccine of the present invention is produced in transgenic plants and then administered through standard vaccine introduction method or through the consumption of the edible portion of those plants. A DNA sequence encoding for the expressio... | 03/18/1997 |
| 5607455 | Method and apparatus for automatic shock electrode enabling Methods, circuits and devices useful for maximizing the likelihood of successful defibrillation or cardioversion using an automatic implantable cardioverter/defibrillator ("AICD") system are provided which are capable of monitoring the impedance of AICDs ... | 03/04/1997 |
| 5587458 | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof The present invention relates to novel antibodies, in particular monoclonal and single chain antibodies derived therefrom which specifically bind to erbB-2, as well as diagnostic and therapeutic uses thereof. The present invention also relates to a combin... | 12/24/1996 |
| 5578496 | Detection of autoantibodies associated with the disease myasthenia gravis This invention is directed towards peptidic compositions, methods, and diagnostic kits for the accurate and sensitive detection of human acetylcholine receptor (AChR) autoantibodies associated with the disease myasthenia gravis (MG). Eighteen synthetic ov... | 11/26/1996 |
| 5567604 | Anti-viral guanosine-rich oligonucleotides A method and compositions for treating viral infection in vitro and in vivo using a guanosine-rich oligonucleotides. The oligonucleotides are composed of at least about 50% guanosine nucleotides. Also provided are guanosine-rich oligonucleotides and metho... | 10/22/1996 |
| 5484719 | Vaccines produced and administered through edible plants The oral vaccine of the present invention is produced in edible transgenic plants and then administered through the consumption of the edible portion of those plants. A DNA sequence encoding for the expression of a surface antigen of a pathogen is isolate... | 01/16/1996 |
