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| Number | Title | Issue Date |
| 8173150 | Stable non-aqueous single phase viscous vehicles and formulations utlizing such vehicles This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperat... | 05/08/2012 |
| 8158150 | Two-piece, internal-channel osmotic delivery system flow modulator An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The flu... | 04/17/2012 |
| 8114437 | Solvent/polymer solutions as suspension vehicles A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The ... | 02/14/2012 |
| 8114430 | Polyoxaester suspending vehicles for use with implantable delivery systems Liquid polyoxaester polymer materials are provided as suspending vehicles suitable for dispensing of pharmaceutically active agents, such as proteins, from delivery devices, for example, pump-driven dosage forms. Polyoxaesters are made from at least one diacid and a... | 02/14/2012 |
| 8080259 | Sustained delivery of an active agent using an implantable system The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment i... | 12/20/2011 |
| 8052996 | Two-piece, internal-channel osmotic delivery system flow modulator An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The flu... | 11/08/2011 |
| 8048438 | Stable non- aqueous single phase viscous vehicles and formulations utilizing such vehicles This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperat... | 11/01/2011 |
| 7964183 | Composition and dosage form comprising a particle formulation and suspending vehicle A liquid composition in an osmotic drug delivery system and a dosage form in an osmotic drug delivery system is disclosed comprising an amphiphilic molecule, a non-aqueous liquid solvent, and a pharmaceutically active agent. ... | 06/21/2011 |
| 7959938 | Polyoxaester suspending vehicles for use with implantable delivery systems Liquid polyoxaester polymer materials are provided as suspending vehicles suitable for dispensing of pharmaceutically active agents, such as proteins, from delivery devices, for example, pump-driven dosage forms. Polyoxaesters are made from at least one diacid and a... | 06/14/2011 |
| 7919109 | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperat... | 04/05/2011 |
| 7879028 | Osmotic delivery systems and piston assemblies for use therein An osmotic delivery system is disclosed for delivering an active agent formulation to a fluid environment. The osmotic delivery system typically comprises a reservoir having a lumen that contains the active agent formulation and an osmotic agent formulation and a pi... | 02/01/2011 |
| 7731947 | Composition and dosage form comprising an interferon particle formulation and suspending vehicle A liquid composition in an osmotic drug delivery system and a dosage form in an osmotic drug delivery system is disclosed comprising an amphiphilic molecule, a non-aqueous liquid solvent, and a pharmaceutically active agent. ... | 06/08/2010 |
| 7727519 | Method for treating hepatitis C virus with omega interferon Methods for the treatment of interferon-response disorders by administration of an interferon alone or in combination with adjunctive therapy are described. The invention encompasses providing to a patient both a formulation of an interferon that is suitable for sho... | 06/01/2010 |
| 7682356 | Osmotic delivery systems and piston assemblies for use therein An osmotic delivery system is disclosed for delivering an active agent formulation to a fluid environment. The osmotic delivery system typically comprises a reservoir having a lumen that contains the active agent formulation and an osmotic agent formulation and a pi... | 03/23/2010 |
| 7655257 | Sustained delivery of an active agent using an implantable system The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment i... | 02/02/2010 |
| 7655254 | Implantable device for continuous delivery of interferon An implantable device includes a reservoir containing a suspension of an interferon in an amount sufficient to provide continuous delivery of the interferon at a therapeutically effective rate of 1 ng/day to 600 μg/day to maintain and achieve therapeutic blood or p... | 02/02/2010 |
| 7407499 | Osmotic pump with self-retaining, fast-start membrane plug An osmotic pump includes a capsule having at least one delivery port formed at a first end and a membrane plug retained in a second end of the capsule remote from the delivery port to provide a fluid-permeable barrier between an interior and an exterior of the capsu... | 08/05/2008 |
| 6941163 | Formulation and manipulation of databases of analyte and associated values The present invention relates to methods of formulating analyte data databases, the databases themselves, and methods of manipulating the same. In one aspect the present invention includes the formulation of analyte data points, derived data, and data attributes dat... | 09/06/2005 |
| RE38775 | Electrode with improved signal to noise ratio An electrode assembly for sensing an electrochemical signal diffused from a source to a working electrode which is comprised of a plurality of substantially separated working electrode surfaces is disclosed. The electrode of the invention is comprised of 1) a workin... | 08/16/2005 |
| 6902905 | Glucose measuring assembly with a hydrogel This invention relates to methods for reducing the presence of a compound in an ionically conductive material, e.g., for use in iontophoretic devices, wherein the presence of the compound interferes with detecting a selected analyte. Removal of the compound can typi... | 06/07/2005 |
| 6885883 | Methods for improving performance and reliability of biosensors The present invention relates to a predictive-kinetic method for use with data processing of a sensor-generated signal, as well as, microprocessors and monitoring systems employing such a predictive-kinetic method. Data from a transient region of a signal is used wi... | 04/26/2005 |
| 6882940 | Methods and devices for prediction of hypoglycemic events Described herein are methods, devices, and microprocessors useful for predicting a hypoglycemic event in a subject. The hypoglycemic predictive approach described herein utilizes information obtained from a data stream, e.g., frequently obtained glucose values (curr... | 04/19/2005 |
| 6862466 | Methods of monitoring glucose levels in a subject and uses thereof Methods of frequently monitoring glucose amounts and/or concentrations in a subject who is at risk for hypoglycemia, hyperglycemia, and/or glucose level fluctuations that put the subject at risk are provided. Also provided are methods of monitoring the effects of on... | 03/01/2005 |
| 6850790 | Monitoring of physiological analytes Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. O... | 02/01/2005 |
| RE38681 | Electrode with improved signal to noise ratio An electrode assembly for sensing an electrochemical signal diffused from a source to a working electrode which is comprised of a plurality of substantially separated working electrode surfaces is disclosed. The electrode of the invention is comprised of 1) a workin... | 01/04/2005 |
| 6816742 | Biosensor and methods of use thereof An automated system for continual transdermal extraction of analytes present in a biological system is provided. The system can be used for detecting and/or measuring the concentration of the analyte using an electrochemical biosensor detection means. The system opt... | 11/09/2004 |
| 6771995 | Chemical signal-impermeable mask A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration of the mas... | 08/03/2004 |
| 6736777 | Biosensor, iontophoretic sampling system, and methods of use thereof The present invention relates generally to a sensor for use in monitoring the amount or concentration of target chemical analytes present in a biological system. For example, the invention relates to a sensor for measuring the amount or concentration of one or more ... | 05/18/2004 |
| 6438414 | Collection assemblies, laminates, and autosensor assemblies for use in transdermal sampling systems The invention relates generally to consumable components of a device used for continually or continuously measuring the concentration of target chemical analytes present in a biological system. More particularly, the invention relates to collection assemb... | 08/20/2002 |
| 6398562 | Device and methods for the application of mechanical force to a gel/sensor assembly Devices and methods are described for improving the contact of a conductive material, for example, a hydrogel, with a sensor, for example an electrode, by means of using mechanical force to apply the conductive material to the sensor before use of the con... | 06/04/2002 |
| 6391643 | Kit and method for quality control testing of an iontophoretic sampling system An automated system for continual transdermal extraction of analytes present in a biological system is described. The system optionally uses reverse iontophoresis to carry out the continual transdermal extraction of the analytes. The present invention des... | 05/21/2002 |
| 6393318 | Collection assemblies, laminates, and autosensor assemblies for use in transdermal sampling systems The invention relates generally to consumable components of a device used for continually or continuously measuring the concentration of target chemical analytes present in a biological system. More particularly, the invention relates to collection assemb... | 05/21/2002 |
| 6370410 | Methods of producing an assembly for use in a monitoring device A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration... | 04/09/2002 |
| 6356776 | Device for monitoring of physiological analytes Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sen... | 03/12/2002 |
| 6341232 | Methods of producing collection assemblies, laminates, and autosensor assemblies for use in transdermal sampling systems The invention relates generally to methods of producing consumable components of a device used for measuring the concentration of target chemical analytes present in a biological system. More particularly, the invention relates methods of producing collec... | 01/22/2002 |
| 6326160 | Microprocessors for use in a device for predicting physiological values The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. ... | 12/04/2001 |
| 6299578 | Methods for monitoring a physiological analyte A method for continual monitoring of a physiologic analyte in a subject includes steps of contacting the subject with a collection reservoir such that the analyte can move from the subject into the collection reservoir, the contents of the collection rese... | 10/09/2001 |
| 6298254 | Device for sampling substances using alternating polarity of iontophoretic current A method for sampling of a substance from a subject is provided, which comprises placing one or more sampling chambers on a collection site on a tissue surface on the subject; conducting electric current through the tissue to extract a substance from the ... | 10/02/2001 |
| 6284126 | Electrode with improved signal to noise ratio An electrode assembly for sensing an electrochemical signal diffused from a source to a working electrode which is comprised of a plurality of substantially separated working electrode surfaces is disclosed. The electrode of the invention is comprised of ... | 09/04/2001 |
| 6272364 | Method and device for predicting physiological values A method and device are provided for measuring the concentration of target chemical analytes present in a biological system, and then predicting a future or past concentration of an analyte using a series of such measurements. One important application of... | 08/07/2001 |
