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| Number | Title | Issue Date |
| 6495560 | Vitronectin receptor antagonist A compound of the formula (I) is disclosed which is a vitronectin receptor antagonist and is useful in the treatment of osteoporosis: ##STR1## or a pharmaceutically acceptable salt thereof.... | 12/17/2002 |
| 6458784 | Vitronectin receptor antagonists Pharmaceutically active benzodiazapine compounds of formula (I) are disclosed. These compounds inhibit the vitronectin receptor and are useful for treatment of osteoporosis. ##STR1##... | 10/01/2002 |
| 6369077 | Protease inhibitors This invention relates to compounds of formula (I): ##STR1## wherein: Y is Ar or NR1 R2 ; R1 is R", R"C(O), R"C(S), R"SO2, R"OC(O), R"R'NC(O), or R"R'NC(S); R2 is H, C1-6 alkyl, C2-6 ... | 04/09/2002 |
| 6262102 | Eprosartan monohydrate This invention relates to (E)--[2-n-butyl-1-[(4-carboxyphenyl)methyl]-1) H-imidazol-5-yl]methylene-2-thiophenepropionic acid monomethanfesulfonate monohydrate, compositions containing the compound and methods of using the compound to block ang... | 07/17/2001 |
| 6258958 | Procedure for producing formyl imidazoles A new procedure for the catalytic conversion of hydroxy methyl imidazoles to formyl imidazoles is described. The catalysis takes place in the presence of a peroxide. Formyl imidazoles are important intermediate products for pharmaceutical substances.... | 07/10/2001 |
| 6214854 | Method for inhibiting stress-activated protein kinases This invention relates to a method for inhibiting stress-activated protein kinases (SAPKs) which comprises administering to a mammal in need thereof an effective amount of a compound which is a dual non-selective ଲ-adrenoceptor and 댑 | 04/10/2001 |
| 6211107 | Process for expoxidizing prochiral olefins and a catalyst therefor and intermediates for making the catalyst This invention relates to the catalyst (III) and intermediates for its preparation in which M is a transition metal ion; A is a counter-ion if required; B, B', and E and E' are independently selected from the group consisting of hydrogen aryl, C1-6 | 04/03/2001 |
| 6211211 | Benzopyrans and their use as therapeutic agents This invention relates to substituted benzopyran amides useful in treating certain medical conditions and to processes for preparing these compounds.... | 04/03/2001 |
| 6191304 | Vitronectin receptor antagonists This invention relates to certain tricyclic compounds that are integrin receptor antagonists.... | 02/20/2001 |
| 6172237 | Process for preparing eprosartan This invention relates to a process for preparing eprosartan by reacting 4-[(2-n-butyl-5-formyl-1H-imidazol-1-yl)methyl]benzoic acid or the bisulfite addition compound of 4-[(2-n-butyl-5-formyl-1H-imidazol-1-yl)methyl]benzoic acid with (2-thienylmeth... | 01/09/2001 |
| 6159964 | Vitronectin receptor antagonists Compounds of formula (I) are disclosed, wherein: A is a fibrinogen antagonist template; W is a linking moiety of the form --(CHRg)a --U--(CHRg)b --V--; Q1, Q2, Q3 and Q4 ar... | 12/12/2000 |
| 6117910 | Bicyclic fibrinogen antagonists This invention relates to compounds of the formula: ##STR1## which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.... | 09/12/2000 |
| 6096777 | Method for inhibiting the expression of Fas The present invention relates to a new method of treatment using compounds which are dual non-selective beta-adrenoceptor and alpha-1-adrenoceptor antagonists, in particularly the carbazolyl-(4)-oxypropanolainine compounds of Formula 1, as defined herein,... | 08/01/2000 |
| 6069143 | Fibrinogen receptor antagonists This invention relates to compounds of the formula: ##STR1## which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.... | 05/30/2000 |
| 6034114 | Medicament The present invention relates to the use of an angiotensin II receptor antagonist in the manufacture of a medicament for the treatment of left ventricular hypertrophy regression.... | 03/07/2000 |
| 6031115 | Process for preparing epoxides A process for preparing compounds of formula (B) wherein: one of A1 ' or A2 ' represents hydrogen and the other represents a group CF3 --Y-- wherein Y represents --CF2 --, >C.dbd.O, or --CH(OH)--, or A1 ' ... | 02/29/2000 |
| 6028091 | Medicament The present invention relates to the use of an angiotensin II receptor antagonist in the manufacture of a medicament for the treatment of diabetic nephropathy.... | 02/22/2000 |
| 6025380 | Medicament The present invention relates to the use of an angiotensin II receptor antagonist in the manufacture of a medicament for the treatment of macular degeneration.... | 02/15/2000 |
| 6008214 | Bicyclic compounds This invention relates to compounds of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, which are effective for inhibiting platelet aggregation and bone resorption, pharmaceutical compositions for effecting such activity, and a me... | 12/28/1999 |
| 6008213 | Integrin receptor antagonists Compounds of formula (I) ##STR1## wherein A1 is C or N; E is a five- or six-membered heteroaromatic or six-membered aromatic ring optionally substituted by R3 or R4 ; X1 --X2 is CHR1 -... | 12/28/1999 |
| 5977101 | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity Vitronectin receptor antagonists having the formula: ##STR1## which are useful for the treatment of inflammation, cancer and cardiovascular disorders, such as atherosclerosis and restenosis, and diseases wherein bone resorption is a factor, such as o... | 11/02/1999 |
| 5973205 | Process for the preparation of 1, 3-diaminopropane derivatives and intermediates useful in this process A process for preparing a compound of formula (I) or an addition salt thereof and/or a solvate thereof: ##STR1## wherein R1, R2, R4 and R5 are each independently C1-4 alkoxy and R3 is ... | 10/26/1999 |
| 5929249 | Substituted imidazolyl-alkyethio-aldanoic acids Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and m... | 07/27/1999 |
| 5919953 | Process for the production of 2H-1-benzopyrans There is provided a 2-stage process for making 2H-1-benzopyrans wherein an alpha,beta-unsaturated aldehyde is reacted with an alkanol or an alkane-diol in the presence of a dehydrating compound which is an orthoformate and an aluminum oxide/silicon oxide ... | 07/06/1999 |
| 5908860 | Bicyclic compounds with pharmaceutical activity This invention relates to the method of treatment and/or prophylaxis of anxiety and/or disorders treatable and/or preventable with anti-convulsive agents, such as epilepsy, using compounds of the formula (Ia): ##STR1##... | 06/01/1999 |
