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| Number | Title | Issue Date |
| 5574018 | Conjugates of vitamin B12 and proteins Therapeutically useful proteins are conjugated to vitamin B12 by covalent binding at the primary hydroxyl site of the ribose moiety. The resulting conjugates are biologically active and can be formulated into pharmaceutical compositions suitabl... | 11/12/1996 |
| 5538861 | DNA encoding a stimulating factor for the axl receptor A protein which is a stimulator of and presumed ligand for the axl receptor has been identified and sequenced. The protein, termed gas6, bears homology to human protein S and is a growth factor for tissues which express axl.... | 07/23/1996 |
| 5466447 | Method for treating psoriasis The present invention provides a therapeutic method of treating a human subject for psoriasis which comprises administering to the subject an effective psoriatic dermatosis-inhibiting amount of IL-2 and a pharmaceutically acceptable carrier.... | 11/14/1995 |
| 5350690 | Sucrose inducible expression systems This disclosure relates to a sucrose inducible expression system. The sucrose inducible expression system comprises a novel plasmid vector having a sacY gene of the sacS locus which binds to a transcription terminator to relieve transcription termination ... | 09/27/1994 |
| 5284656 | Pulmonary administration of granulocyte colony stimulating factor Granulocyte-colony stimulating factor (G-CSF) can be delivered systemically in therapeutically or prophylactically effective amounts by pulmonary administration using a variety of pulmonary delivery devices, including nebulizers, metered dose inhalers and... | 02/08/1994 |
| 4863920 | Imidazodiazepine derivatives for treatment of disorders of the central nervous system A compound for treating disorders of the central nervous system, which is of the formula wherein A taken together with the two carbon atoms denoted by and ଲ is one of the following groups: ##STR1## R1 is one of the following ... | 09/05/1989 |
| 4830470 | Liquid crystalline esters Compounds of the formula ##STR1## wherein m represents is the number 0 or 1; A is a single covalent bond, --CH2 --CH2 --, --OCH2 --, --COO-- or --OOC--; rings B, C and D are 1,4-phenylene optionally substituted with c... | 05/16/1989 |
| 4831130 | ଲ-lactam antibacterial agents Compounds of the formula ##STR1## wherein A is one of the following: ##STR2## in which R1, is acyl, R2 is hydrogen, lower alkyl, lower alkoxycarbonyl or aminocarbonyl, R3 is hydrogen or lower alkyl and R | 05/16/1989 |
| 4820734 | Phenethylamine derivatives The novel phenethylamine derivatives of the general formula ##STR1## wherein R1 and R2 each signify hydrogen, halogen, trifluoromethyl, lower alkoxy, lower alkyl, hydroxy or nitro, with the proviso that at least one of R1 | 04/11/1989 |
| 4816582 | Antimicrobial 2-oxo-1-azetidinesulphonic acids Antimicrobial 2-oxo-1-azetidinesulphonic acids of the formula ##STR1## in which H2 N ##STR2## represents an amino-substituted thiazolyl group, R1 is lower alkyl which is substituted by carbamoyl, lower alkylsuphonyl, azido,... | 03/28/1989 |
| 4816476 | Heterocyclic rodenticidal compounds, compositions containing the compounds, and methods of use Heterocyclic compounds of the formula ##STR1## wherein X is --CH.dbd.CH--, --O-- or --S--; R1 is a group Ar--R2 or --CH.dbd.CH--C(CH3).dbd.CH--R21 ; Ar is phenyl, pyridyl, furyl or thienyl; R2 is... | 03/28/1989 |
| 4788214 | 3,4-dihydro-2H-1-benzopyran derivatives The invention relates to compounds of the formula ##STR1## wherein R1 is hydrogen or lower alkyl; R2 is hydrogen or halogen; R3, R4 and R5 are hydrogen, acyl or lower alkyl; R6 and R | 11/29/1988 |
| 4785017 | 3,4-dihydro-2H-1-benzopyran derivatives The invention relates to compounds of the formula ##STR1## wherein R1 is hydrogen or lower alkyl; R2 is hydrogen or halogen; R3, R4 and R5 are hydrogen, acyl or lower alkyl; R6 and R | 11/15/1988 |
| 4782149 | Pyridazodiazepine derivatives Compounds of the formula ##STR1## wherein R1 and R2 each independently represent hydrogen, C1 -C10 -alkyl, adamantyl-(C1 -C4 -alkyl) or (C2 -C6 -alkanoyloxy)-(C | 11/01/1988 |
| 4774330 | Cephalosporin intermediates There is presented compounds of the formula ##STR1## wherein X represents the 1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl group or its corresponding tautomeric form, the 2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3-yl group, and t... | 09/27/1988 |
| 4772718 | Process for preparing 5-cyano-4-methyl-oxazole A process for the manufacture of 5-cyano-4-methyl-oxazole which comprises reacting a 5-(lower alkoxycarbonyl)-4-methyl-oxazole with ammonia in the gaseous phase, in the presence of a zirconium oxide or hafnium oxide catalyst.... | 09/20/1988 |
| 4760059 | Rectal dosage form The rectal absorption of the beta-lactam antibiotic ceftriaxone in a solid dosage form is enhanced with chenodeoxycholic acid or its sodium salt, in the presence of a carrier consisting of a mixture of two or more glycerides of C12 to C18 | 07/26/1988 |
| 4757824 | Method and apparatus for monitoring respiration A method and an apparatus are provided for monitoring waveforms representing the respiration of a patient and for detecting waveforms having characteristics indicative of apnea. The method comprises processing a first electrical signal having a waveform r... | 07/19/1988 |
| 4757069 | Pyridazodiazepine derivatives Compounds of the formula ##STR1## wherein R1 and R2 each independently represent hydrogen, C1 -C10 -alkyl, adamantyl-(C1 -C4 -alkyl) or (C2 -C6 -alkanoyloxy)-(C | 07/12/1988 |
| 4749791 | Benzo[f]quinoline intermediates Benzazecinediones of the formula ##STR1## wherein R1 and R2 are independently hydrogen or chlorine, R3 is hydrogen, fluorine, chlorine, bromine or methoxy, R4 is hydrogen, chlorine or methoxy and R5 | 06/07/1988 |
| 4745076 | Ruthenium complexes useful as carriers for immunologically active materials The invention relates to a ruthenium complex having the formula wherein L1, L2 and L3 are the same or different are equal to a bi- or polycyclic ligand with at least two nitrogen-containing heterocycles, whereby at least one of... | 05/17/1988 |
| 4739049 | Phosphorylation of cyclic amides Compounds of the general formula ##STR1## are reacted with a strong base followed by a phosphorylating agent, such as dicyclicaminophosphinic halide or bis-di-lower alkylaminophosphinic halide to produce an imine of the formula ##STR2## whe... | 04/19/1988 |
| 4734367 | Process to produce alpha-substituted derivatives of 3-hydroxypropionic acid The manufacture of optically active compounds of the formula ##STR1## wherein R1 signifies alkyl, phenyl or benzyl and R2 signifies hydrogen or a customary ester residue, by the fermentative reduction of compounds of the formula ... | 03/29/1988 |
| 4732979 | Benzazecine derivatives for cognitive and memory functions Benzazecinediones of the formula ##STR1## wherein R1 and R2 are independently hydrogen or chlorine, R3 is hydrogen, fluorine, chlorine, bromine or methoxy, R4 is hydrogen, chlorine or methoxy and R5 | 03/22/1988 |
| 4721137 | Apparatus for withdrawing liquid from closed receptacle An apparatus for withdrawing liquid from a receptacle which is closed with a penetrable cover, which comprises a puncturing tool for creating an aperture in the receptacle cover, a cannula for entering the receptacle through the aperture and withdrawing l... | 01/26/1988 |
| 4699986 | Imino compounds useful for making ଲ-lactams There is presented optically uniform ଲ-lactams of the formulae ##STR1## wherein Z is a readily cleavable acyl group, R1 is amino or a group convertible into amino, R2 is hydrogen or a readily cleavable protecting group and... | 10/13/1987 |
| 4700009 | Process for preparing a substituted benzaldehyde The present disclosure is concerned with a novel process for the manufacture of substituted benzaldehydes, namely of benzaldehydes of the formula ##STR1## wherein R represents a methoxy or tert.butyl group. The compounds of formula I are known s... | 10/13/1987 |
| 4689227 | Antibacterial composition The antibacterially-active substance composition consisting of mecillinam and (2S,3S)-3-((Z)-2-(2-amino-4-thiazolyl)-2-((carboxymethoxy)imino)acetamido) -2-((carbamoyloxy)methyl-4-oxo-1-azetidinesulphonic acid (compound A), or pro-drugs and/or pharmac... | 08/25/1987 |
| 4680408 | Acyl derivatives There are presented compounds of the formula ##STR1## wherein R1 is one of the 3-substituents usable in cephalosporin chemistry, R2 is hydrogen, lower alkyl or COOR3 -lower alkyl, wherein R3 is hydrogen, a ... | 07/14/1987 |
| 4672033 | Antibiotics X-14889 A,C and D There is presented antibiotic compounds designated as Antibiotics X-14889 A, C and D of the formulas ##STR1## wherein (for X-14889A) R1 is methyl, R2 is methyl, R3 is hydrogen, R4 is methyl and R5 | 06/09/1987 |
| 4659735 | Benzofuranyl (thienyl) propenyl derivatives useful as rodenticides Heterocyclic compounds of the formula ##STR1## wherein X is --CH.dbd.CH--, --O--or --S--; R1 is a group Ar--R2 or --CH.dbd.CH--C(CH3).dbd.CH--R21 ; Ar is phenyl, pyridyl, furyl or thienyl; R2 is ... | 04/21/1987 |
| 4652651 | Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage The manufacture of 1-sulpho-2-oxazetidine derivatives of the formula ##STR1## in which Het is an optionally amino-substituted, 5- or 6-membered, aromatic heterocycle containing 1 or 2 nitrogen atoms and optionally also an oxygen or sulphur atom, R | 03/24/1987 |
| 4642318 | Method for decreasing radiation load in PUVA therapy The total radiation load on a subject being treated for psoriasis with a psoralen in conjunction with ultraviolet A radiation (PUVA) can be substantially reduced by at least pretreating said subject with an anti-psoriatic effective polyene compound such a... | 02/10/1987 |
| 4639135 | Cuvette A cuvette arrangement for use in a chemical analysis system, which cuvette arrangement comprises an integrally constructed unit which defines separate chambers, for the receipt of sample-reagent mixtures. In order to overcome difficulties which arise in the us... | 01/27/1987 |
| 4628738 | Ultrasonic imaging device An ultrasonic imaging apparatus for operation in either or both linear and sector scan modes is disclosed which employs a common array of transducers. Circuitry is provided for controlling the order and timing of pulse echo transmission and reception, whi... | 12/16/1986 |
| 4617150 | ଲ-lactams There is presented optically uniform ଲ-lactams of the formulae ##STR1## wherein Z is a readily cleavable acyl group, R1 is amino or a group convertible into amino, R2 is hydrogen or a readily cleavable protecting group and... | 10/14/1986 |
| 4616010 | Imidazodiazepine derivatives Compounds which are imidazodiazepine derivatives of the formula ##STR1## wherein A together with the carbon atoms denoted by and ଲ signifies the group ##STR2## one of R1 and R2 signifies hydrogen and the other... | 10/07/1986 |
| 4601984 | Process to produce antibiotics X-14873 A, G and H There are provided antibiotics X-14873 A, G and H of the formulas ##STR1## wherein for X-14873A, R1 is CO2 H and R2 is ##STR2## for X-14873G, R1 is hydrogen and R2 is ##STR3## and for X... | 07/22/1986 |
| 4593093 | Acyl derivatives There are presented compounds of the formula ##STR1## wherein R1 is one of the 3-substituents usable in cephalosporin chemistry, R2 is hydrogen, lower alkyl or COOR3 -lower alkyl, wherein R3 is hydrogen, a ... | 06/03/1986 |
| 4591636 | Anthracycline glycosides The invention relates to compounds of the formula ##STR1## wherein R is lower alkyl or a carboxy group or a group of the formula in which n stands for 1 or 2 and Y is hydrogen or alkyl and RY and Rz each are hydrogen or one of R | 05/27/1986 |
