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| Number | Title | Issue Date |
| 6420152 | Recombinant DNase B derived from Streptococcus pyogenes The gene for Streptococcus pyogenes DNase B has been cloned and vectors incorporating the cloned DNA have been used to transform Escherichia coli, allowing efficient and rapid production of the DNase in E. coli without the necessity of growing large quant... | 07/16/2002 |
| 6183408 | Rotor shaft assembly having non-linear stiffness A rotor drive shaft assembly for use in a centrifugation system. The rotor drive shaft has a bearing material configured as a sleeve and mounted on the inside wall of a spindle hub with a clearance existing between the sleeve and a housing that surrounds ... | 02/06/2001 |
| 6184990 | Miniature multiple wavelength excitation and emission optical system and method for laser-induced fluorescence detectors in capillary electrophoresis An optical apparatus for and method of improving collection efficiency and signal strength of optical instruments used in capillary electrophoresis, such as laser-induced fluorescence detectors are provided. The apparatus and method provides a concave ref... | 02/06/2001 |
| 6171869 | Process for desalting and concentrating protein-containing solutions Protein-containing solutions requiring desalting and concentration are desalted and concentrated in a one step procedure. Ion exchange and ion retardation resins are used for desalting. A standard ultrafiltration device is modified to contain a mixed bed ... | 01/09/2001 |
| 6166371 | Diffuse reflective light curtain system A Diffuse Reflective Light Curtain System comprises at least one light curtain defining a border of a work zone for a robotic machine. Each light curtain comprises a primary board having multiple wells formed therein. Light emitting diodes (LEDs) and ligh... | 12/26/2000 |
| 6165796 | Pipettable ion detector and method A pipettable detector comprises an aqueous suspension of particles which are essentially insoluble in a sample of a body fluid containing at least one target ion analyte of interest, the particles having uniformly distributed therein target and indicator ... | 12/26/2000 |
| 6159749 | Highly sensitive bead-based multi-analyte assay system using optical tweezers An apparatus and method for chemical and biological analysis, the apparatus having an optical trapping means to manipulate the reaction substrate, and a measurement means. The optical trapping means is essentially a laser source capable of emitting a beam... | 12/12/2000 |
| 6149570 | Self-retaining rotor lid In a centrifuge rotor assembly, a self-retaining rotor lid which is designed to stay on the rotor even when the lid is not tied down or secured to the rotor. The lid has a lip formed on an outer edge of the major side of the lid that faces the open end of... | 11/21/2000 |
| 6146833 | Polymeric reagents for immobilizing biopolymers Reagents for the immobilization of biopolymers, processes for their preparation and their subsequent use in the immobilization of biopolymers for analytical and diagnostic procedures are described. One type of reagent includes a solid support fabricated o... | 11/14/2000 |
| 6110630 | Efficient activated cyanine dyes Activating groups based on N-hydroxynaphthalimide, are disclosed herein. The activating groups can mediate the coupling of labeling moieties, such as biotin or cyanine dyes, to a variety of components, including chain terminators, nucleoside triphosphates... | 08/29/2000 |
| 6110749 | System for simultaneously conducting multiple ligand binding assays A system for simultaneously conducting multiple ligand assays on a sample potentially containing target analytes uses as a detector a waveguide having a planar surface with a plurality of probes of known recognition to the target analytes thereon. The pro... | 08/29/2000 |
| 6099230 | Automated labware storage system An apparatus for storing and retrieving labware comprises at least one labware hotel having a frame, a plurality of support arms for receiving and supporting labware, and an elevator capable of moving the support arms in unison. The support arms are perio... | 08/08/2000 |
| 6090553 | Use of uracil-DNA glycosylase in genetic analysis The present invention relates to a process for detecting the presence of at least one specific nucleic acid sequence in a sample containing a nucleic acid or a mixture of nucleic acids by amplifying the nucleic acid using polymerase chain reaction, cleavi... | 07/18/2000 |
| 6087184 | Opposable-element chromatographic assay device for detection of analytes An assay device for detection or determination of an analyte in a sample uses opposable components and is suitable for assay of human chorionic gonadotropin and other protein or glycoprotein hormones. One embodiment of the device comprises: (1) a first op... | 07/11/2000 |
| 6080253 | Method and apparatus for sealing containers The present invention fulfills the above stated needs, as well as others, by providing a automated container sealing apparatus that automatically removes seals from a backing and applies the seals to the container. The seals are pre-cut and have a size co... | 06/27/2000 |
| 6069014 | Devices and methods for separating cellular components of blood from liquid portion of blood A device for the separation of the liquid portion of blood from the cellular components of blood comprises: (1) a pad of porous material permeable to the liquid portion of blood but capable of trapping the cellular components of blood; (2) a substrate sup... | 05/30/2000 |
| 6062407 | Centrifugally loaded self-sealing integral one-piece cap/closure A capping and sealing assembly for a sample-holding centrifuge container which features a self-sealing lid that forms a fluid-tight seal in an opening of the canister with a predetermined amount of force, with the force being dependent upon the centrifuga... | 05/16/2000 |
| 6060022 | Automated sample processing system including automatic centrifuge device A system for a clinical lab that is capable of automatically processing, including sorting, of multiple specimen containers. The system comprises a central controller, a workstation, one or more analyzers, and an automated centrifuge. The workstation has ... | 05/09/2000 |
| 6037124 | Carboxylated polyvinylidene fluoride solid supports for the immobilization of biomolecules and methods of use thereof The present invention relates to a method of immobilizing oligonucleotides and other biomolecules using a carboxylated polyvinylidene fluoride support membrane for the construction of geosensors and other array-based systems. The support membrane may be u... | 03/14/2000 |
| 6027691 | Automatic chemistry analyzer An automatic chemistry analyzer is provided having a high throughput and a high reliability. The analyzer uses nephelometric and turbimetric analyzers to analyze a wide variety of parameters within liquid samples typically generated in, for example, a lar... | 02/22/2000 |
| 6024687 | Centrifuge rotor lock A centrifuge rotor locking apparatus includes a C-shaped annular member for a snap-fit engagement about a drive hub. The member comprises first and second contacting segments and a third non-contacting segment. Centrifugation causes the contacting segment... | 02/15/2000 |
| 6017767 | Assay device A chromatographic assay device for use with immunoassays allows rapid and convenient assays of analytes of biological interest, and permits extractions to be carried out in situ, avoiding the use of separate extraction vessels. The device has a wide dynam... | 01/25/2000 |
| 6013789 | Covalent attachment of biomolecules to derivatized polypropylene supports Disclosed herein is a method for attaching pre-synthesized oligonucleotides to a polypropylene support medium. Most preferably, a polypropylene film is aminated by a plasma discharge in the presence of ammonia gas. An oligonucleotide having a terminal pho... | 01/11/2000 |
| 6008059 | Devices and methods for separating cellular components of blood from liquid portion of blood A device for the separation of the liquid portion of blood from the cellular components of blood comprises: (1) a pad of porous material permeable to the liquid portion of blood but capable of trapping the cellular components of blood; (2) a substrate sup... | 12/28/1999 |
| 6001230 | Automated capillary electrophoresis apparatus An integrated apparatus for capillary electrophoresis which is automated using conveyors which carry vials containing electrolytes and samples, a capillary contained in a modular, portable, and interchangeable cartridge, and actuators for bringing the cap... | 12/14/1999 |
| 5998220 | Opposable-element assay devices, kits, and methods employing them A chromatographic assay device for use with immunoassays allows rapid and convenient assays of analytes of biological interest, and permits extractions to be carried out in situ, avoiding the use of separate extraction vessels. The device has a wide dynam... | 12/07/1999 |
| 5985567 | Hybridization detection by pretreating bound single-stranded probes An improved method for detecting hybridized biomolecules is provided which comprises the steps of, providing a plurality of probe biomolecules on a solid support surface; pre-treating the plurality of probe biomolecules with an effective amount of a pre-t... | 11/16/1999 |
| 5981185 | Oligonucleotide repeat arrays A solid support based hybridization assay is provided which allows for the systematic and reproducible analysis of repeat and tandem repeat oligonucleotide sequences of DNA and RNA by hybridization to a reverse dot blot array comprising strings of such re... | 11/09/1999 |
| 5969814 | Rate nephelometer A rate nephelometer of the type useful in automated chemical analyzers is provided. The nephelometer includes a laser for generating a polarized laser beam having an S-wave component and a P-wave component. The beam is split by a beam splitter specially c... | 10/19/1999 |
| 5955582 | Antibody against a 3-aminophenylboronic-glycated protein complex and its use in an immunoassay Methods of preparing a boronate-antigen complex for immunization of animals, a monoclonal antibody specific for the same, an immunoassay method for detection of the complex and a method of calculating the amount of a target glycated protein within the sam... | 09/21/1999 |
| 5922608 | Macromolecule sequencing packet and method of use A method, apparatus and article for sequencing polypeptides and proteins ("macromolecules") utilizes a sequencing packet comprised of a plurality of substrates having two different derivatization chemistries within a forarninous container. The sequencing ... | 07/13/1999 |
| 5879881 | Solid phase system for use in ligand-receptor assays A solid phase system for use in ligand-receptor assays, particularly immunoassays using monoclonal antibodies, is disclosed. The solid phase system comprises a porous matrix in which microspheres, bound with a receptor capable of capturing a target ligand... | 03/09/1999 |
| 5863746 | Method of measuring bilirubin An assay for detecting in a test sample, an analyte that undergoes auto-oxidation is disclosed. The assay comprises the steps of forming a reaction mixture by combining in an aqueous medium (i) a sample containing the analyte and (ii) a stabilizer that re... | 01/26/1999 |
| 5863506 | Automatic chemistry analyzer with improved heated reaction cup assembly The invention provides an automatic analyzing machine comprising a unique reaction cup combination for running high volume chemical analyses, such as analyses for sodium, potassium, glucose, creatinine and BUN (blood urea nitrogen). The reaction cup combi... | 01/26/1999 |
| 5856182 | Monoclonal antibodies specific for the PSA-ACT complex Monoclonal antibodies have been developed which specifically bind the PSA-ACT complex without significant cross-reactivity with PSA, ACT or CG-ACT. The antibodies were generated using a unique immunogen comprising a PSA-ACT complex having bound to monoclo... | 01/05/1999 |
| 5851778 | Analyte assay using a trifunctional conjugate A trifunctional conjugate is provided having three chemical moieties attached through a spacer moeity. At least two of the chemical moieties are relatively small molecules, usually less than about 7,000 Daltons in size. The spacer moiety is selected to im... | 12/22/1998 |
| 5849599 | Method for making a preconjugate A method for making a preconjugate which includes immunogenic species of a polymorphic analyte. The method is carried out by reacting an activated binding moiety, and a polymorphic analyte at room temperature for between about 10 hours and about 60 hours.... | 12/15/1998 |
| 5783407 | Method of measuring bilirubin An assay for detecting in a test sample, an analyte that undergoes auto-oxidation is disclosed. The assay comprises the steps of forming a reaction mixture by combining in an aqueous medium (i) a sample containing the analyte and (ii) a stabilizer that re... | 07/21/1998 |
| 5753094 | Borate storage buffer and sample diluent A composition, which has utility as a storage buffer and as a sample diluent before analysis by capillary zone electrophoresis (CZE), is comprised of water, a borate compound, a buffer compound and a pH modifier for maintaining a physiological pH. In addi... | 05/19/1998 |
| 5747256 | Homogeneous DNA probe titration assay An assay for detecting the presence or amount of a target polynucleotide sequence of interest in a test sample is disclosed. The assay comprises the steps of forming a reaction mixture by combining in an assay medium (i) a first reagent and (ii) an aliquo... | 05/05/1998 |
