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| Number | Title | Issue Date |
| 8088415 | Diffusion-controlled dosage form and method of fabrication including three dimensional printing The invention includes a core-and-shell dosage form or unit in which the core contains API and in which the shell substantially governs the release such as by controlling diffusion of API through the shell. The shell may comprise a release-blocking polymer, and part... | 01/03/2012 |
| 8052998 | Particulate vectors for improving oral absorption of active principles The invention concerns particulate vectors designed to improve oral absorption of active principles, characterized in that they consist of a polymeric matrix comprising at least a biodegradable polymer associated with at least a polycationic polymer. ... | 11/08/2011 |
| 8029822 | Rupturing controlled release device having a preformed passageway The present invention provides a simple and improved osmotic device that is capable of providing a controlled release of active agent contained in the core first through a preformed passageway and then through an in situ formed second passageway into an environment ... | 10/04/2011 |
| 7931914 | System and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form A uniaxially compressed dosage form manufactured by three-dimensional printing that preserves the predetermined internal architecture of the dosage form while producing an improved surface finish. The compression compacts the dosage form, eliminating at least some o... | 04/26/2011 |
| 7927618 | Implants, particles This invention relates to kits for the preparation of a composition, which comprises a carrier phase that forms an implant or particles in the body, on the body or under physiological conditions. The carrier phase comprises at least one solid carrier material and a ... | 04/19/2011 |
| 7875290 | Method and form of a drug delivery device, such as encapsulating a toxic core within a non-toxic region in an oral dosage form A drug delivery device such as an oral dosage form (ODF) with a toxic or potent core encapsulated by a non-toxic region. The non-toxic region may be a region including multiple layers, coatings, shells, and combinations thereof, which provides protection to and isol... | 01/25/2011 |
| 7874100 | Trellis and tool system A trellis system of the invention comprises a trellis and tool in combination. The trellis includes multiple legs and one or more horizontal supports. The tool includes a tray and a coning tool. The tray is adapted to slidably engage the legs by way of engagement me... | 01/25/2011 |
| 7863458 | Halogen-free ionic liquids An ionic liquid according to the invention is substantially halogen-free, has a low viscosity and is stable to hydrolytic degradation under test conditions. The ionic liquid is a compound of the formula (cation) (R′—O—SO3), (cation) (R′—SO3... | 01/04/2011 |
| 7820202 | Extended release particle dispersion The invention relates to extended release compositions that can be advantageously used as drug products, plant protection agents, in foods or other products. The invention especially relates to liquid compositions in which extended release particles are dispersed. T... | 10/26/2010 |
| 7820201 | System for manufacturing controlled release dosage forms, such as zero-order release profile dosage form manufactured by three-dimensional printing The present invention includes controlled release dosage forms and methods of designing and manufacturing dosage forms to obtain specific release profiles, for example, zero-order release profiles, escalating release profiles or decreasing release profiles. The dosa... | 10/26/2010 |
| 7774977 | Trellis and tool system A trellis system of the invention comprises a trellis and tool in combination. The trellis includes multiple legs and one or more horizontal supports. The tool includes a tray and a coning tool. The tray is adapted to slidably engage the legs by way of engagement me... | 08/17/2010 |
| 7709520 | Diindolylmethane and C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers Disclosed are methods and compositions for the treatment of a wide array of cancers and tumors. In illustrative embodiments, diindolylmethanes, C-substituted diindolylmethanes, and analogs thereof have been described, which when administered either alone, or in comb... | 05/04/2010 |
| 7655803 | Process for the preparation of ionic liquids with alkyl sulfate and functionalized alkyl sulfate anions The invention relates to a process for the preparation of ionic liquids of general formula (cation)(R′—O—SO3). The process includes the step of treating the compound of formula (cation)(R—O—SO3) with an alcohol, or mixture of differen... | 02/02/2010 |
| 7625878 | Sulfoalkyl ether-alkyl ether cyclodextrin derivatives A sulfoalkyl ether-alkyl ether cyclodextrin (SAE-AE-CD) derivative is provided. The SAE-AE-CD possesses advantages over known SAE-CD and AE-CD derivatives as well as over the parent cyclodextrin by being more water soluble and less membrane disturbing. The SAE-AE-CD... | 12/01/2009 |
| 7562033 | Integrated e-commerce sales & use tax exchange system and method A system and method for calculating, collecting and/or disbursing one or more third party payments owed to one or more third parties resulting from one or more electronic transactions occurring over a wide area network (WAN) between a customer and a merchant. The pr... | 07/14/2009 |
| 7553406 | Process for removing polar impurities from hydrocarbons and mixtures of hydrocarbons This invention relates to a process for removing polarizable impurities from hydrocarbons and mixtures of hydrocarbons using ionic liquids as an extraction medium. By way of extraction, the degree of contamination of the hydrocarbon or mixture of hydrocarbons is red... | 06/30/2009 |
| 7544807 | Ionic liquids Low melting ionic compounds of the general formula (cation) (R′SO4) in which R′ is a branched or linear, saturated or unsaturated, aliphatic or alicyclic functionalized or non-functionalized hydrocarbon chain with 3-36 carbon atoms are provided. These... | 06/09/2009 |
| 7462735 | Amino acid diamides in non α position which are useful as adjuvants for administration of biological active agents Amino acid diamides in non α position of formula (1), wherein R1 is selected from amongst the group consisting of the functional groups alkyl, halogen, NO2, OH, OCH3 alone or associated and R2 is selected from the group c... | 12/09/2008 |
| 7402325 | Supercritical carbon dioxide extract of pharmacologically active components from A method for the extraction of pharmacologically active components from the oleander plant using supercritical carbon dioxide and combining the extraction with other isolation methods. The extraction is carried out using carbon dioxide at supercritical conditions, w... | 07/22/2008 |
| 7398239 | E-commerce sales and use tax exchange system and method The invention provides a system and method for calculating, collecting and/or disbursing one or more third party payments owed to one or more third parties resulting from one or more electronic transactions occurring over a wide area network (WAN) between a customer... | 07/08/2008 |
| 7303756 | Multiphase system The invention relates to a preparation comprising a carrier phase and at least one further phase which cannot be mixed with the carrier phase or only partially mixed therewith, wherein the change in ambient conditions alters the viscosity of the carrier phase. The i... | 12/04/2007 |
| 7300668 | System for manufacturing controlled release dosage forms, such as a zero-order release profile dosage form manufactured by three-dimensional printing The present invention includes controlled release dosage forms and methods of designing and manufacturing dosage forms to obtain specific release profiles, for example, zero-order release profiles, escalating release profiles or decreasing release profiles. The dosa... | 11/27/2007 |
| 7276252 | Method and form of a drug delivery device, such as encapsulating a toxic core within a non-toxic region in an oral dosage form A drug delivery device such as an oral dosage form (ODF) with a toxic or potent core encapsulated by a non-toxic region. The non-toxic region may be a region including multiple layers, coatings, shells, and combinations thereof, which provides protection to and isol... | 10/02/2007 |
| 7252791 | Ionic liquids Low melting ionic compounds of the general formula (cation) (R′SO4) in which R′ is a branched or linear, saturated or unsaturated, aliphatic or alicyclic functionalized or non-functionalized hydrocarbon chain with 3-36 carbon atoms are provided. These... | 08/07/2007 |
| 7232843 | Compositions containing C-substituted diindolylmethane compounds Disclosed are methods and compositions for the treatment of a wide array of cancers and tumors. In illustrative embodiments, diindolylmethanes, C-substituted diindolylmethanes, and analogs thereof have been described, which when administered either alone, or in comb... | 06/19/2007 |
| 7208176 | Drug delivery device containing neuraminidase inhibitor and an H1 antagonist The present invention provides a dual release solid dosage form containing a first composition that releases a neuraminidase inhibitor, such as oseltamivir, zanamivir, or peramivir, in a controlled manner and a second composition that releases an H1 antagonist in a ... | 04/24/2007 |
| 7182568 | Bale handling apparatus The invention provides a bale handling apparatus capable of being used to lift and transport two similar bales in a substantially side-by-side manner. The apparatus includes at least two vertically and horizontally offset main spears. Each main spear is grouped with... | 02/27/2007 |
| 7147870 | Osmotic device containing pseudoephedrine and an H1 antagonist The present invention provides an osmotic device containing controlled release pseudoephedrine in the core in combination with a rapid release H1 antagonist in an external coat. A wide range of H1 antagonist antihistamines, especially fexofenadine, can be used in th... | 12/12/2006 |
| 7106676 | Disc player system The present invention provides a disc player comprising one or more light sources that project a constant or pulsing light onto the upper portion of a disc being played by the disc player. If a constant light source is used, the a pulsing viewing port for the disc r... | 09/12/2006 |
| 7041785 | B-bradykinin receptor antagonists and use thereof The present invention relates to novel antagonists to a B1-bradykinin (B1-BK) receptor which have a good affinity and selectivity therefor, some of which being at least partially resistant to enzymatic degradation. The synthesis of the B1 ... | 05/09/2006 |
| 7034013 | Formulations containing propofol and a sulfoalkyl ether cyclodextrin An injectable formulation of a sedative hypnotic drug, such as the anesthetic drug propofol, that is pharmaceutically stable and demonstrates a reduced incidence of pain upon injection. The formulation of the present invention employs a sulfoalkyl ether cyclodextrin... | 04/25/2006 |
| RE39069 | Multi-layered osmotic device The present invention provides a simple and improved multi-layered osmotic device (1) that is capable of delivering a first active agent in an outer lamina (2) to one environment of use and a second active agent in the core (5) to another enviro... | 04/18/2006 |
| 7008641 | Osmotic device containing venlafaxine and an anti-psychotic agent The present invention provides an osmotic device containing controlled release venlafaxine in the core in combination with an anti-psychotic agent in a rapid release external coat. A wide range of anti-psychotic agents can be used in this device. Particular embodime... | 03/07/2006 |
| 6986323 | Inland aquaculture of marine life using water from a saline aquifer A method and system for the inland aquaculture of marine species using water from a saline aquifer having a heavy metals content within the acceptable limits of the EPA guidelines for drinking water. The aquifer is preferably the Coconino aquifer located in Arizona ... | 01/17/2006 |
| 6923444 | Encoded image puzzle/decoder A puzzle/decoder for decoding and viewing lens resolvable encoded images. The decoder includes an encoded image which can be decoded with one or more decoding lenses. A retainer is also included in the decoder for retaining the decoding lenses in proximity to the en... | 08/02/2005 |
| 6869939 | Formulations containing amiodarone and sulfoalkyl ether cyclodextrin The present invention provides aqueous parenteral formulations containing an antiarrhythmic agent, such as amiodarone, and a sulfoalkyl ether cyclodextrin. The liquid formulations are clear, sterilizable, and chemically and physically stable. The liquid formulations... | 03/22/2005 |
| 6809288 | Laser drilling system and method The present invention provides a laser drilling system for drilling holes or cavities in a solid, in particular a solid dosage form. The system includes a loading zone, firing zone, inspection zone and delivery zone. The system also includes optional components such... | 10/26/2004 |
| 6753011 | Combined diffusion/osmotic pumping drug delivery system Delivery devices capable of delivering one or more active substances by diffusion through plural micropores in the membrane (4) or by osmotic pumping through one or more preformed passageways (5) in the membrane are provided. The device (1) has ... | 06/22/2004 |
| 6749867 | Delivery system for omeprazole and its salts The present invention provides a time-release dosage form for delivering an acid-labile pharmaceutical, such as omeprazole, into the upper portion of the gastrointestinal tract downstream of the stomach. The dosage form includes a drug-containing core surrounded by ... | 06/15/2004 |
| 6676933 | Pharmaceutical composition containing mosapride and pancreatin A pharmaceutical composition contains mosapride, pancreatin and optionally simethicone and is used for treating, preventing or alleviating the symptoms of a gastrointestinal disorder. The pharmaceutical composition is provided in an oral dosage form for a... | 01/13/2004 |
