Martin; Alice O. - US Patent Attorneys and Agents

Attorney: Martin; Alice O.

Number of patents: 103
Last date: February 14, 2012

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Number	Title	Issue Date
8114638	Arabinitol dehydrogenase from Stable and active arabinitol dehydrogenases (LAD) from Neurospora crassa and mutants thereof are disclosed. Arabinitol dehydrogenases are useful in the production of xylitol and ethanol from an arabinose containing substrate. Recombinant and heterologously ex...	02/14/2012
8062874	GFP fusion proteins and their use The present invention provides fusion proteins including a green fluorescent protein inserted into the internal amino acid sequence of a Gαs protein and further provides method of using the fusion protein construct to follow activation of a G-protein receptor by a ...	11/22/2011
8034609	Ablation based laser machining of biomolecule patterns on substrates A method for patterning a one or more biomolecules on a substrate that includes coating the substrate with a coating of the one or more biomolecules, applying a laser to the coating, and ablating a portion of the one or more biomolecules with the laser in a predeter...	10/11/2011
8017576	Methods and compositions to treat mucositis Methods and compositions of AMP-18 derived peptides enablingly demonstrate that AMP-18 derived peptide compositions surprisingly reduce mucositis in mammals. Methods and peptide compositions treat mucositis, delays the onset or duration of mucositis, including cance...	09/13/2011
8001722	Enhancing yields of harvested plant seeds by treating sowing seeds with selected doses of a physical plant stressor The present invention relates to a method of enhancing the yield of harvested seed in plants by the application of selected doses of a physical plant stressor such as UV-C light (253.7 nm), X-rays, gamma ray, and electron beam irradiation to sowing seeds. This metho...	08/23/2011
7985716	Nucleic acid sample purification and enrichment with a thermo-affinity microfluidic sub-circuit Multiplexed affinity purification and thermal dissociation prior to biochip hybridization simplifies uncharacterized sample admixtures, thereby minimizing or eliminating sample interferents, improving hybridization specificity on a microarray detector, and minimizin...	07/26/2011
7968337	Neural precursor cells, method for the production and use thereof in neural defect therapy The invention relates to isolated and purified neural precursor cells, to methods for the generation of such precursor cells in unlimited quantities from embryonic stem cells, and to their use for the therapy of neural defects, particularly in mammals, preferably in...	06/28/2011
7954261	Joint load reducing footwear Footwear including a flexible sole having a series of flexure zones positioned to correspond to primary joint axes of the human foot approximating the characteristics of a bare foot in motion. ...	06/07/2011
7939314	Methods and compositions for rapidly detecting and quantifying viable Methods and compositions detect and quantify viable Legionella. Dip-slides that include an absorbent medium, growth promoting, and growth selective substances are useful in rapid detection and quantification of microcolonies of Legionella. Most probabl...	05/10/2011
7935874	Enhancing yields of harvested plant seeds by treating sowing seeds with selected doses of a physical plant stressor The present invention relates to a method of enhancing the yield of harvested seed in plants by the application of selected doses of a physical plant stressor such as UV-C light (253.7 nm), X-rays, gamma ray, and electron beam irradiation to sowing seeds. This metho...	05/03/2011
7935521	Methods and compositions for rapidly detecting and quantifying viable Methods and compositions detect and quantify viable Legionella. Dip-slides that include an absorbent medium, growth promoting, and growth selective substances are useful in rapid detection and quantification of microcolonies of Legionella. Most probabl...	05/03/2011
7910723	IG20 splice variants therapeutics for cancer Methods and compositions inhibit the growth of cancer cells by selectively down-regulating the expression of an IG20 splice variant including MADD. Specific knock-down of MADD splice variant resulted in the apoptosis of cancer cells. Interfering RNAs including small...	03/22/2011
7910543	Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designated AMP-18. AMP-18 genomic DNA, cDNA and the AMP-18 protein are sequenced for human, mouse and pig. The AMP-18 protein and active peptides derived fr...	03/22/2011
7901932	Methods and compositions for rapidly detecting and quantifying viable Methods and compositions detect and quantify viable Legionella and other heterotrophic aerobic bacteria. Dip-slides that include an absorbent medium, growth promoting, and growth selective substances are useful in rapid detection and quantification of microco...	03/08/2011
7893035	Multicistronic constructs with siRNA to inhibit tumors Multicistronic short interfering RNA constructs targeting in various combinations a human urokinase-type plasminogen activator receptor (uPAR), human urokinase-type plasminogen activator (uPA), human matrix metalloprotease 9 (MMP-9) and cathepsin B (CB) inhibit tumo...	02/22/2011
7892804	Arabinitol dehydrogenases from Stable and active arabinitol dehydrogenases (LAD) from Neurospora crassa and mutants thereof are disclosed. Arabinitol dehydrogenases are useful in the production of xylitol and ethanol from an arabinose containing substrate. Recombinant and heterologously ex...	02/22/2011
7847152	Use of tryptophan indole and anthranilate analogs as plant transformation selection agents Methods and compositions are described using tryptophan analogs, indole analogs, and mixtures thereof as agents for selecting plant cells that have been transformed with an anthranilate synthase (ASA2) gene or a fragment thereof, where the ASA2 gene encodes a feedba...	12/07/2010
7838512	DNA damaging agents in combination with tyrosine kinase inhibitors Methods and compositions for enhancing cancer cell death using therapeutically effective amounts of DNA damaging agent(s) that act in combination to enhance cancer cell death, e.g., nucleic acid precursors, and protein tyrosine kinase inhibitors, e.g., that inhibit ...	11/23/2010
7829644	Gel-forming reagents and uses thereof for preparing microarrays New gel-forming reagents including monomers and cross-linkers, which can be applied to gel-drop microarray manufacturing by using co-polymerization approaches are disclosed. Compositions for the preparation of co-polymerization mixtures with new gel-forming monomers...	11/09/2010
7811983	Increased T-cell tumor infiltration and eradication of metastases by mutant light Mutant LIGHT expressed in a tumor environment elicited high levels of chemokines and adhesion molecules, accompanied by massive infiltration of naïve T lymphocytes. Methods and compositions to elicit immune responses against tumors including tumor volume reduction ...	10/12/2010
7807784	Increased T-cell tumor infiltration by mutant LIGHT Mutant LIGHT expressed in a tumor environment elicited high levels of chemokines and adhesion molecules, accompanied by massive infiltration of naïve T lymphocytes. Methods and compositions to elicit immune responses against tumors including tumor volume reduction ...	10/05/2010
7803854	Plant PR-5 proteins as mammalian therapeutic agents The Proteins of the PR-5 family having a lectin-like β barrel domain control apoptosis in yeast through receptor binding. Receptors that specifically bind to PR-5 proteins having a lectin-like β barrel domain have been found to be homologous to mammalian adiponect...	09/28/2010
7803556	Plant PR-5 proteins as mammalian therapeutic agents The Proteins of the PR-5 family having a lectin-like β barrel domain control apoptosis in yeast through receptor binding. Receptors that specifically bind to PR-5 proteins having a lectin-like β barrel domain have been found to be homologous to mammalian adiponect...	09/28/2010
7799570	Methods for validating the presence of and characterizing proteins deposited onto an array A method of determining if proteins have been transferred from liquid-phase protein fractions to an array comprising staining the array with a total protein stain and imaging the array, optionally comparing the staining with a standard curve generated by staining kn...	09/21/2010
7790456	Scalable process for cultivating undifferentiated stem cells in suspension The invention relates to a process for cultivating undifferentiated stem cells in suspension and in particular to a method for cultivating stem cells on microcarriers in vessels. The method enables stem cells to be cultivated in a scalable process for the first time...	09/07/2010
7772275	Compositions and method for treating affective, painful or allergic disorders Therapeutic compositions of doxepin and having a preponderance of the cis doxepin isomer over the trans doxepin isomer provide therapeutic effects for affective, painful, or allergic disorders without the sedative effects commonly experienced with compositions havin...	08/10/2010
7763772	Activation of the arabidopsis hypertall (HYT1/YUCCA6) locus affects several auxin mediated responses The present invention provides nucleotide sequences and a corresponding amino acid sequence of auxin overproduction mutants. Also provided are methods to improve plant growth, development, differentiation, increased tolerance to drought and delayed senescence as wel...	07/27/2010
7713750	Ablation based laser machining of biomolecule patterns on substrates A method for patterning a one or more biomolecules on a substrate that includes coating the substrate with a coating of the one or more biomolecules, applying a laser to the coating, and ablating a portion of the one or more biomolecules with the laser in a predeter...	05/11/2010
7705136	Synthesis of 3′-, or 5′-, or internal methacrylamido-modified oligonucleotides New modifiers were synthesized for incorporation of a methacrylic function in 3′-, 5′- and internal positions of oligonucleotides during solid phase synthesis. A modifier was used for synthesis of 5′-methacrylated oligonucleotides for preparation of microarray...	04/27/2010
7655602	Peptides comprising aromatic D-amino acids and methods of use Disclosed are D-peptides and libraries of D-peptides comprising aromatic D-amino acids. Also disclosed are methods for identifying small D-peptides comprising aromatic D-amino acids that bind to proteins of interest. ...	02/02/2010
7638275	Gene expression profiles that identify genetically elite cattle Genetically elite ungulate mammals are identified on the basis of gene expression profiles from biological samples such as liver and blood. Methods and compositions are presented to select genetically elite animals with a desired phenotype such as high milk producti...	12/29/2009
7629378	Compositions and method for treating affective, painful or allergic disorders Therapeutic compositions of doxepin and having a preponderance of the cis doxepin isomer over the trans doxepin isomer provide therapeutic effects for affective, painful, or allergic disorders without the sedative effects commonly experienced with compositions havin...	12/08/2009
7629317	Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designated AMP-18. AMP-18 genomic DNA, cDNA and the AMP-18 protein are sequenced for human, mouse and pig. The AMP-18 protein and active peptides derived fr...	12/08/2009
7592163	Highly active xylose reductase from A new xylose reductase encoding gene from Neurspora crassa was heterologously expressed in E. coli as a His-tag fusion protein and subsequently purified in high yield. This xylose reductase was shown to have a high turnover rate and catalytic efficienc...	09/22/2009
7557083	Gastrokines and derived peptides including inhibitors A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designated AMP-18. AMP-18 genomic DNA, cDNA and the AMP-18 protein are sequenced for human, mouse and pig. The AMP-18 protein and active peptides derived fr...	07/07/2009
7555098	Method and apparatus for X-ray fluorescence analysis and detection A detector apparatus is disclosed that includes a housing and a multilayer disposed within the housing. The multilayer defining a leading edge and a trailing edge and is adapted to interact with a plurality of high-energy photons, impingent from the leading edge, to...	06/30/2009
7550438	Methods for production of growth-promoting proteins and peptides for kidney epithelial cells Novel growth peptides derived from protein factors having molecular weights of about 22 and 45 kDa stimulate mitogenic activity of epithelial, but not fibroblastic cells, in particular, kidney epithelial cells. A source of the factors is scrape-wounded kidney epithe...	06/23/2009
7527972	Uses of bispecific antibody coated dendritic cells pulsed with antigens and GM-CSF in immune regulation GM-CSF administered before immunization exerted a sustained suppressive effect against the induction of myasthenia gravis (MG). This suppression was associated with lowered serum autoantibody levels, reduced T cell proliferative responses to AChR, and an expansion i...	05/05/2009
7484712	Hoist assembly A hoist assembly for raising and lowering a load attached to a cable having a drum with a groove spirally disposed about its outer surface mounted within a frame. The groove having a predetermined pitch and configured to receive the cable wound about the drum. The d...	02/03/2009
7442378	Attenuated circovirus An isolated attenuated circovirus having a mutation in viral nucleic acid encoding viral protein 2 (VP2). The attenuated circovirus is particularly suitable for use in conferring immunity in an animal, particularly birds. ...	10/28/2008

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Attorney: Martin; Alice O.