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A self defense weapon formed as a memo pad and which is easily held by a person's fingers, therefore making it possible to provide protection from a mugger and also to quickly and easily write a record or a message without failure of missing or forgetting significant information under a stressful situation.
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| Number | Title | Issue Date |
| 7893217 | Isolated human antibodies that bind epitopes on RG1 The present invention relates to novel human extracellular matrix polypeptides, designated RG1, polynucleotides encoding the polypeptides, methods for producing the polypeptides, expression vectors and genetically engineered host cells for expression of the polypept... | 02/22/2011 |
| 7887804 | Methods for treating disease-states associated with RG1 using immunoconjugates The present invention relates to novel human extracellular matrix polypeptides, designated RG1, polynucleotides encoding the polypeptides, methods for producing the polypeptides, expression vectors and genetically engineered host cells for expression of the polypept... | 02/15/2011 |
| 7871996 | Methods of inhibiting nitric oxide synthase using corrin derivatives The present invention provides methods of inhibiting nitric oxide synthase (NOS) using corrin derivatives that bind NOS but do not bind NO. It also provides methods of inhibiting NOS in vivo by administering corrin derivatives, and methods of treating diseases and m... | 01/18/2011 |
| 7763580 | Methods for treating conditions associated with the accumulation of excess extracellular matrix The present invention is methods and compositions for reducing and preventing the excess accumulation of extracellular matrix in a tissue and/or organ or at a wound site using a combination of agents that inhibit TGFβ, or using agents that inhibit TGFβ in combinat... | 07/27/2010 |
| 7749976 | Isolated PTPMT1 protein which mediates insulin production and uses thereof The invention identifies a novel protein tyrosine phosphatase, PTPMT1. The complete nucleic acid and amino acid sequence encoding PTPMT1 is provided. Methods are provided for preventing and/or treating type II diabetes by regulating PTPMT1 levels, which in turn regu... | 07/06/2010 |
| 7713924 | Methods for treating conditions associated with the accumulation of excess extracellular matrix The present invention is methods and compositions for reducing and preventing the excess accumulation of extracellular matrix in a tissue and/or organ or at a wound site using a combination of agents that inhibit TGFβ, or using agents that inhibit TGFβ in combinat... | 05/11/2010 |
| 7611706 | RG1 antibodies and uses thereof The present invention relates to antibodies, and antigen-binding antibody fragments, directed against an RG1 polypeptide. The invention further relates to methods for utilizing the antibodies, and antibody fragments, for diagnostic and therapeutic applications. ... | 11/03/2009 |
| 7608263 | RG1 antibodies and uses thereof The present invention relates to antibodies, and antigen-binding antibody fragments, directed against an RG1 polypeptide. The invention further relates to methods for utilizing the antibodies, and antibody fragments, for diagnostic and therapeutic applications. ... | 10/27/2009 |
| 7470537 | Adipose-derived stem cells and lattices The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substant... | 12/30/2008 |
| 7451567 | Fishing lure retrieval device The present invention is directed to a device for retrieving a snagged fishing lure. ... | 11/18/2008 |
| 7335748 | RG1 antibodies and uses thereof The present invention relates to antibodies, and antigen-binding antibody fragments, directed against an RG1 polypeptide. The invention further relates to methods for utilizing the antibodies, and antibody fragments, for diagnostic and therapeutic applications. ... | 02/26/2008 |
| 7332332 | Buffer solution for electroporation and a method comprising the use of the same The invention relates to a buffer solution for suspending animal or human cells and for dissolving biologically active molecules in order to introduce biologically active molecules into cells using an electric current. The inventive buffer solution has a buffering c... | 02/19/2008 |
| 7320859 | Modular transfection systems The present invention relates to a method for transfection of cells using at least one protein capable of forming nucleoprotein filaments, wherein the protein is initially modified with at least one functional component which influences one or more steps of the tran... | 01/22/2008 |
| 7312032 | Methods for screening ligands that activate the translocation of a steroid receptor to the nucleus in mammalian cells The present invention provides a method of screening for a compound that binds to a selected nucleic acid comprising contacting compound fluorescently labeled by a fluorescent protein with a cell having a plurality of copies of the nucleic acid in an array such that... | 12/25/2007 |
| 7311910 | Methods for treating cancer and infectious disease by blocking CTLA4-B7 interactions The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fus... | 12/25/2007 |
| 7307154 | DNA encoding a novel RG1 polypeptide The present invention relates to novel human extracellular matrix polypeptides, designated RG1, polynucleotides encoding the polypeptides, methods for producing the polypeptides, expression vectors and genetically engineered host cells for expression of the polypept... | 12/11/2007 |
| 7304033 | Methods for protecting allogeneic islet transplant using soluble CTLA4 mutant molecules The present invention is a method of inhibiting islet cell transplant rejection, particularly to treat diabetes, such as type-1 and type-2 diabetes, by administering to a subject an effective amount of a soluble CTLA4 mutant molecule. One example of a soluble CTLA4 ... | 12/04/2007 |
| 7300915 | Use of erythropoietin and erythropoietin mimetics for the treatment of neuropathic pain Erythropoietin (Epo), a member of the cytokine superfamily, is a pluripotent molecule that is involved in a number of signal transduction pathways that include the stimulation of the production of red blood cells and the protection of the central nervous system from... | 11/27/2007 |
| 7300761 | Methods and device for detecting prostate specific antigen (PSA) An immunoassay device and assay to detect an antigen, such as PSA, in a biological sample. The device comprises a solid support having multiple reaction zones containing capture antibodies directed to the antigen. Exposure of a test sample to a mixture of incubation... | 11/27/2007 |
| 7183255 | Method for stabilizing blood pressure in hemodialysis subjects The present invention provides a method for regulating blood pressure in a hemodialysis subject using a vasopressin receptor agonist, so as to facilitate removal of excessive extracellular fluid in the subject. ... | 02/27/2007 |
| 7048928 | Anti-allergic pharmaceutical composition containing at least one allergen and at least one antihistamine compound The present invention relates to an anti-allergic pharmaceutical composition containing at least two active agents chosen from among: (i) one allergen, (ii) one antihistamine compound, and (iii) one inhibitor of histamine synthesis. The active agents are associated ... | 05/23/2006 |
| 7030232 | E25A protein, methods for producing and use thereof The invention provides a human E25a protein which is upregulated in cancerous cells, including those of hormone refractory prostate cancer, colon cancer, breast cancer or other cancers of epithelial origin. The invention also provides nucleic acid molecules encoding... | 04/18/2006 |
| 6906026 | Methods for treating conditions associated with the accumulation of excess extracellular matrix The present invention is methods and compositions for reducing and preventing the excess accumulation of extracellular matrix in a tissue and/or organ or at a wound site using a combination of agents that inhibit TGFβ, or using agents that inhibit TGFβ in combinat... | 06/14/2005 |
| 6899895 | Lamellar gels and methods for making and regulating The invention provides novel compositions involving lamellar gels and methods for making them. These compositions and methods of the invention are significant improvements in the field of gels, macromolecular targeting and macromolecular delivery to various biologic... | 05/31/2005 |
| 6858150 | Water processing device with liquid seal A water processing device for removing contaminants from water for consumption, consisting of: 1) a heat exchanger; 2) a heater; 3) a boiler chamber; 4) a liquid level control device; 5) a demister; 6) a degasser; and, 7) a self-cleaning component. A water seal to p... | 02/22/2005 |
| 6838081 | Methods for enhancing antigen-presenting cells and anti-tumor responses in a human patient The present invention provides methods for enhancing the development of APC from precursor cells by administering a combination of GM-CSF and IL-4. The precursor cells include: cells contained in peripheral blood, CD14+ cells and precursors in bone... | 01/04/2005 |
| 6777231 | Adipose-derived stem cells and lattices The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The cells can ... | 08/17/2004 |
| 6764825 | Methods and device for detecting prostate specific antigen (PSA) An immunoassay device and assay to detect an antigen, such as PSA, in a biological sample. The device comprises a solid support having multiple reaction zones containing capture antibodies directed to the antigen. Exposure of a test sample to a mixture of incubation... | 07/20/2004 |
| 6756036 | Methods for treating cancer using PSCA antibodies and fragments thereof The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and an... | 06/29/2004 |
| 6686196 | Recombinant, modified adenoviral vectors for tumor specific gene expression and uses thereof This invention provides modified recombinant Ad vectors (e.g., AdE1- vectors) undergoing defined homologous recombination in order to create predictably rearranged genomic derivatives in a host cell. Genomic rearrangements can be achieved, for example, by... | 02/03/2004 |
| 6666684 | Impression and foundation system for implant-supported prosthesis A system and method for forming a framework of foundation elements as a component of and foundation for an impression and to support a prosthesis to form a final restoration in a patient. The foundation elements and the prosthesis may be made of the same ... | 12/23/2003 |
| 6663770 | Water processing device A water processing device for removing contaminants from water for consumption, consisting of: 1) a heat exchanger; 2) a heater; 3) a boiler chamber; 4) a liquid level control device; 5) a demister; 6) a degasser; and, 7) a self-cleaning component. A wate... | 12/16/2003 |
| 6663857 | In vivo gene transfer using implanted retroviral producer cells The present invention is directed to methods of transferring therapeutic genes to brain tumor cells in order to kill the cells. In general, the method of the present invention comprises: (1) introducing a retrovirus containing a selectable marker and at l... | 12/16/2003 |
| 6663858 | In Vivo gene transfer using implanted retroviral producer cells The present invention is directed to methods of transferring therapeutic genes to brain tumor cells in order to kill the cells. In general, the method of the present invention comprises: (1) introducing a retrovirus containing a selectable marker and at l... | 12/16/2003 |
| 6645728 | Inhibitor of the inflammatory response induced by TNF and IL-1 The present invention provides the molecular basis for cytokine induction of NF-.kappa.B-dependent immune and inflammatory responses, emphasizing a role for both NIK-NIK and NIK-IKK protein--protein interactions. A relatively small region of NIK selective... | 11/11/2003 |
| 6641809 | Method of regulating cellular processes mediated by B7 and CD28 The invention identifies the B7 antigen as a ligand that is reactive with the CD28 receptor on T cells. Fragments and derivatives of the B7 antigen and CD28 receptor, including fusion proteins having amino acid sequences corresponding to the extracellular... | 11/04/2003 |
| 6627200 | Utilization of CD 137 in order to promote the proliferation of peripheral monocytes The invention relates to the utilization of monocytes growth factor CD137 or of a functional analogue thereof in order to produce a medicament for promoting the proliferation of peripheral monocytes of a mammal. The invention especially relates to the uti... | 09/30/2003 |
| 6623940 | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell The present invention provides an expression vector encoding monospecific or bispecific fusion protein. In one embodiment the expression vector encodes a monospecific fusion protein, which vector comprises a recombinant monospecific single chain cassette ... | 09/23/2003 |
| 6609017 | Processed neural signals and methods for generating and using them The present invention provides a processed neural signal that encodes a reach plan, comprising the target location of the planned encoded relative to an eye-centered reference frame. The present invention also provides methods for generating and decoding ... | 08/19/2003 |
| 6565889 | Bilayer structure which encapsulates multiple containment units and uses thereof The present invention provides compositions and methods of preparing a bilayer structure for encapsulating multiple containment units. These containment units can contain therapeutic, diagnostic agents or imaging agents that can be released through the bi... | 05/20/2003 |
