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| Number | Title | Issue Date |
| 7842808 | Anti-migraine spirocycles The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods... | 11/30/2010 |
| 7772244 | Therapeutic agents for the treatment of migraine The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods... | 08/10/2010 |
| 7754732 | Spirocyclic anti-migraine compounds The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods... | 07/13/2010 |
| 7569578 | Heterocyclic anti-migraine agents The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods... | 08/04/2009 |
| 7442792 | Process for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof The present invention provides novel processes and intermediates for preparing corticotropin releasing factor (CRF) receptor antagonists having the structure below which are useful in treating CRF-related disorders such as anxiety and depression. ... | 10/28/2008 |
| 7319100 | Substituted pyrazinones, pyridines and pyrimidines as corticotropin releasing factor ligands Compounds provided herein are novel substituted pyrazinones, pyridines and pyrimidines of Formula (I) and (II): Such compounds are particularly useful as CRF receptor ligands, and hence, in the treatment of vario... | 01/15/2008 |
| 7314883 | Anti-migraine treatments The present invention relates to methods of treating neurogenic vasodilation, neurogenic inflammaton, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstru... | 01/01/2008 |
| 7297708 | Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands Provided herein are novel heteroaromatic substituted cyclopropanes of the Formula (I): as well as compositions, including pharmaceutical compositions, containing the same, and the use thereof in the treatment of various neurologi... | 11/20/2007 |
| 7276526 | Substituted thiazoles and oxazoles as corticotropin releasing hormone ligands Provided herein are novel substituted thiazoles and oxazoles of the Formula (I): as well as compositions, including pharmaceutical compositions, containing the same, and the use thereof in the treatment of variou... | 10/02/2007 |
| 7244746 | Imidazolyl derivatives as corticotropin releasing factor inhibitors The present invention relates to novel heterocyclic antagonists of Formula (I) and pharmaceutical compositions comprising said antagonists of the corticotropin releasing factor receptor (“CRF receptor”) usefu... | 07/17/2007 |
| 7238699 | Imidazolyl derivatives as corticotropin releasing factor inhibitors The present invention relates to novel heterocyclic antagonists of Formula (I) and pharmaceutical compositions comprising said antagonists of the corticotropin releasing factor receptor (“CRF receptor”) usefu... | 07/03/2007 |
| 7220862 | Calcitonin gene related peptide receptor antagonists The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying th... | 05/22/2007 |
| RE39634 | Bisarylimidazoly fatty acid amide hydrolase inhibitors The present invention relates to bisarylimidazolyl derivatives and pharmaceutical compositions comprising said compounds inhibiting fatty acid amide hydrolase and useful for the treatment of pain, particularly neuropathic pain, psychomotor disorder, hypertension, ca... | 05/15/2007 |
| 7208596 | Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof The present invention provides novel processes and intermediates for preparing corticotropin releasing factor (CRF) receptor antagonists having the structure below which are useful in treating CRF-related disorders such as anxiety and depression | 04/24/2007 |
| 7205306 | Substituted pyrazinones, pyridines and pyrimidines as corticotropin releasing factor ligands Compounds provided herein are novel substituted pyrazinones, pyridines and pyrimidines of Formula (I) and (II): Such compounds are particularly useful as CRF receptor ligands, and hence, in the treatment of vario... | 04/17/2007 |
| 7157578 | 4-(2-butylamino)-2, 7-dimethyl-8-(2-methyl-6-methoxypyrid-3-YL) pyrazolo-[1,5-A]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands Corticotropin releasing factor (CRF) antagonists of Formula (I): and its use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or... | 01/02/2007 |
| 7153961 | Salt and crystalline form thereof of a corticotropin releasing factor receptor antagonist The present invention provides 4-(bis(2-methoxyethyl)amino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-[1,5-a]-pyrazolo-1,3,5-triazine benzenesulfonate salt and a crystalline polymorph thereof. Further provided are pharmaceutical compositions containing the salt and ... | 12/26/2006 |
| 7151180 | Potassium channel modulators This invention describes compounds of Formula (I) which are modulators of potassium channels and are useful for treating conditions affected by abnormal potassium channel activity including erectile dysfunction and irritable bowel syndrome. | 12/19/2006 |
| 7145013 | 3-thia-4-arylquinolin-2-one derivatives This invention describes compounds of Formula (I) which are modulators of potassium channels and are useful for treating conditions affected by abnormal potassium channel activity including erectile dysfunction and irritable bowel syndrome | 12/05/2006 |
| 7132542 | Compounds for the treatment of male erectile dysfunction This invention describes compounds of Formula (I) which are modulators of potassium channels and are useful for treating conditions affected by abnormal potassium channel activity including erectile dysfunction and irritable bowel syndrome. | 11/07/2006 |
| 7125990 | Imidazolyl derivatives as corticotropin releasing factor inhibitors The present invention relates to novel heterocyclic antagonists of Formula (I) and pharmaceutical compositions comprising said antagonists of the corticotropin releasing factor receptor (“CRF receptor”) usefu... | 10/24/2006 |
| 7112585 | Pyrimidine derivatives as corticotropin releasing factor inhibitors The present invention relates to novel heterocyclic antagonists of Formula (I) and pharmaceutical compositions comprising said antagonists of the corticotropin releasing factor receptor (“CRF receptor”) usefu... | 09/26/2006 |
| 7112679 | Convergent synthesis of α-aryl-β-ketonitriles The present invention relates to processes for the production of α-aryl-β-ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) receptor antagonists.... | 09/26/2006 |
| 7105516 | Compounds for the treatment of premature ejaculation The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salts or solvates thereof and pharmaceutically acceptable formulations comprising said compounds useful for the treatment ... | 09/12/2006 |
| 7098217 | 3,7-dihydro-purine-2,6-dione derivatives as CRF receptor ligands 3,7-Dihydro-purine-2,6-dione derivatives of Formula (I) are provided wherein R1, R2, R3 and R4 are herein defined for use as CRF receptor ligands in the treatment of di... | 08/29/2006 |
| 7094782 | Azolo triazines and pyrimidines Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascu... | 08/22/2006 |
| 7067658 | Pyridino and pyrimidino pyrazinones The present invention provides compounds of Formula I: wherein the variables A, B, Ar, R1, R2, and R3 are as defined herein. The compounds of Formula (I) can function as corticotr... | 06/27/2006 |
| 7049314 | Cyclopentyl indole derivatives The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salts or solvates thereof and pharmaceutically acceptable formulations comprising said compounds useful for the treatment ... | 05/23/2006 |
| 7045529 | Imidazopyrimidinyl and imidazopyri dinyl derivatives Provided herein are compounds of the formula (I): as well as stereoisomers and pharmaceutically acceptable salts thereof. Such compounds are, because of their ability to antagonize CRF, useful in the treatment of a var... | 05/16/2006 |
| 7026317 | Pyrazolotriazines as CRF antagonists The present invention relates to pyrazolotriazines according to formula (I) and stereoisomers, isomers and salts thereof wherein R1-R5 are selected from certain alkyl, aryl and heteroaryl species ... | 04/11/2006 |
| 7002015 | 3-Thia-4-arylquinolin-2-one derivatives as smooth muscle relaxants This invention describes compounds of Formula (I) which are modulators of potassium channels and are useful for treating conditions affected by abnormal potassium channel activity including erectile dysfunction and irritable bowel syndrome. | 02/21/2006 |
| 6977257 | Aripiprazole oral solution The present invention provides for a pharmaceutical solution suitable for oral administration comprising aripiprazole, a pharmaceutically suitable solvent system, one or more taste-enhancing/masking agents and one or more agents selected from the group consisting of... | 12/20/2005 |
| 6974808 | CRF receptor antagonists and methods relating thereto CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke. ... | 12/13/2005 |
| 6960583 | Pyrazolotriazines as CRF antagonists The present invention relates to pyrazolotriazines according to formula (I) and stereoisomers, isomers and salts thereof wherein R1-R5 are selected from certain alkyl, aryl and heteroaryl species ... | 11/01/2005 |
| 6949574 | (Oxime)carbamoyl fatty acid amide hydrolase inhibitors The present invention relates to novel oxime carbamyl derivatives and pharmaceutical compositions comprising said derivatives which inhibit fatty acid amide hydrolase. These pharmaceutical compositions are useful for the treatment of conditions which can be effected... | 09/27/2005 |
| 6894045 | Tetrahydropurinones and derivatives thereof as corticotropin releasing factor receptor ligands Compounds provided herein are novel substituted tetrahydropurinones of Formula (I): wherein R3 is aryl substituted with 0-5 XAr or heteroaryl substituted with 0-4 XhAr. Such compounds a... | 05/17/2005 |
| 6888004 | Imidazolyl derivatives as corticotropin releasing factor inhibitors The present invention relates to novel heterocyclic antagonists of Formula (I) and pharmaceutical compositions comprising said antagonists of the corticotropin releasing factor receptor (“CRF receptor”) useful for ... | 05/03/2005 |
| 6869955 | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders Corticotropin releasing factor (CRF) antagonists of formula I: and their use in treating anxiety, depression, and other psychiatric and neurological disorders. ... | 03/22/2005 |
| 6822100 | Cyclopropylindole derivatives as selective serotonin reuptake inhibitors The present invention relates to processes for the preparation of Formula (I) and pharmaceutically acceptable salts or solvates thereof useful for the treatment of depression, anxiety disorders, premature ejaculation, ... | 11/23/2004 |
| 6777437 | Cyclopropylindole derivatives as selective serotonin reuptake inhibitors The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salts or solvates thereof and pharmaceutically acceptable formulations comprising said compounds useful for the treatment of depre... | 08/17/2004 |
